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2005

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Articles 1141 - 1170 of 2796

Full-Text Articles in Medicine and Health Sciences

Ecg Quiz, Chollada Buranakarl, Kris Angkanaporn Jun 2005

Ecg Quiz, Chollada Buranakarl, Kris Angkanaporn

The Thai Journal of Veterinary Medicine

No abstract provided.


Effect Of Herbal Plant Quillaja Saponaria Supplementation In Feed On Growth Rate, Fcr, Fecal Ammonia And Blood Urea Nitrogen Of Weanling Pigs, Supol Luengyosluechakul, Athipoo Nuntaprasert, Supot Wattanaphansak, Siam Sengtrakul, Sirirak Sirichaiya, Suthida Leelatanont Jun 2005

Effect Of Herbal Plant Quillaja Saponaria Supplementation In Feed On Growth Rate, Fcr, Fecal Ammonia And Blood Urea Nitrogen Of Weanling Pigs, Supol Luengyosluechakul, Athipoo Nuntaprasert, Supot Wattanaphansak, Siam Sengtrakul, Sirirak Sirichaiya, Suthida Leelatanont

The Thai Journal of Veterinary Medicine

A hundred twenty weaned crossbred pigs of Duroc Jersey and Landrace-Largewhite, weighing an average of 6.55 ± 0.62 kg were divided into three groups. The forty animals of each group were kept separately in four battery cages; each cage consisted of five males and five females. Group allotment was conducted by randomized complete block design (RCBD). Animals of the control group were fed basal diet. Animals of the second and the third group were fed supplemental extract of Quillaja saponaria with basal diet in doses of 125 ppm and 250 ppm respectively for a period of 7 weeks. The parameters …


Gross Anatomy Of The Pygmy Killer Whale Heart Found In Thailand, Wuthichai Klomkleaw, Punnarat Viboonjan, Nantarika Chunsue, Ajchariya Sailasuta Jun 2005

Gross Anatomy Of The Pygmy Killer Whale Heart Found In Thailand, Wuthichai Klomkleaw, Punnarat Viboonjan, Nantarika Chunsue, Ajchariya Sailasuta

The Thai Journal of Veterinary Medicine

The pygmy killer whale (Feresa attenuata) is the smallest killer whale similar in size to dolphins. This mammal lives deep down in warm sea far from the shore and avoids human contact. Since the number of pygmy killer whales are gradually decreasing it could become an endangered species so it’s morphological study is an important to provide fundamental data for future study and research. The heart of a male pygmy killer whale found in the Petchaburi province of Thailand was studied anatomically. It was triangular-in shape with flattened sides being, short and wide, with a pointed apex. Subepicardial fat was …


Ultrasound Diagnosis, Phiwipha Kamonrat Jun 2005

Ultrasound Diagnosis, Phiwipha Kamonrat

The Thai Journal of Veterinary Medicine

No abstract provided.


Prevalence Of Non-Helicobacter Pylori Duodenal Ulcer In Karachi, Pakistan., Javed Yakoob, Wasim Jafri, Nadim Jafri, Muhammad Islam, Shahab Abid, Saeed Hamid, Syed H Shah, Hizbullah Shaikh Jun 2005

Prevalence Of Non-Helicobacter Pylori Duodenal Ulcer In Karachi, Pakistan., Javed Yakoob, Wasim Jafri, Nadim Jafri, Muhammad Islam, Shahab Abid, Saeed Hamid, Syed H Shah, Hizbullah Shaikh

Section of Gastroenterology

AIM:

To determine the prevalence of non-Helicobacter pylori (H pylori)-related duodenal ulcer in patients with acid-peptic diseases.

METHODS:

Medical records of patients who attended the Gastroenterology Department at Aga Khan University Hospital from 1999 to 2001 and had endoscopic diagnosis of duodenal ulcers were reviewed. Duodenal ulcer associated with H pylori was diagnosed on the basis of endoscopy, rapid urease test and histopathology whereas histories of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) related duodenal ulcers. Non-H pylori, non-NSAID duodenal ulcers were those without H pylori infection and history of NSAID intake. Co-morbid conditions associated were noted.

RESULTS:

Of 2 …


Effects Of Combining The Fungi Beauveria Bassiana And Metarhiziumanisopliae On The Mortality Of The Tick Amblyomma Variegatum (Ixodidae) In Relation To Seasonal Changes, R. O. Maranga, G. P. Kaaya, J. M. Mueke, A. Hassanali Jun 2005

Effects Of Combining The Fungi Beauveria Bassiana And Metarhiziumanisopliae On The Mortality Of The Tick Amblyomma Variegatum (Ixodidae) In Relation To Seasonal Changes, R. O. Maranga, G. P. Kaaya, J. M. Mueke, A. Hassanali

All Peer-Reviewed Publications

The effect of formulation, fungal concentration, type and seasonal changes on the mortality of the tick Amblyomma variegatum was investigated. A previous study demonstrated high pathogenicity of strains of the fungi Beauveria bassiana and Metarhizium anisopliae against the ticks Rhipicephalus appendiculatus and Amblyomma variegatum (Kaaya et al. J Invertebr Pathol 1996; 67: 15-20). The present study was undertaken to explore possible additive or synergistic effects of the two fungi on A. variegatum. The effects of oil and water formulations at different concentrations of each fungus and combination of the two on the mortality of A. variegatum in the laboratory and …


A New Interpretation Of The Drug Levodopa In The Treatment Of Parkinson's Disease, Joanne T. Vannah Jun 2005

A New Interpretation Of The Drug Levodopa In The Treatment Of Parkinson's Disease, Joanne T. Vannah

Graduate Masters Theses

An argument for levodopa induced dyskinesias (LID) as an expression of long term potentiation (LTP) in the striatum is presented. Normally, with an intact nigrostriatal dopamine (DA) input, long term depression (LTD) is expressed in the striatum, however, striatal LTD is lost following DA denervation and chronic levodopa treatment. It is possible that these changes in synaptic efficacy are due to two other chemical modulators, achetylcholine (ACh) and glutamate, which in turn leads to the induction of striatal LTP. ACh and glutamate may produce these changes in motor behavior by affecting the striosomal pathway in addition to their effect on …


The Effects Of Long Term Walnut Consumption On Levels Of Plasma Tocopherols And Inflammatory Mediators, Suwimol Sapwarobol Jun 2005

The Effects Of Long Term Walnut Consumption On Levels Of Plasma Tocopherols And Inflammatory Mediators, Suwimol Sapwarobol

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to determine the effects of long term walnut consumption on plasma levels of tocopherols and the inflammatory mediators interleukin-1β (IL-1β ), interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) and Creactive protein (CRP) in healthy participants. Ninety participants were recruited into a 12-month randomized crossover intervention study, which consisted of two phases, the walnut supplemented diet and the habitual diet. Participants were randomly assigned to either of these two phases for six months and then switched to the other phase for the second six months. During the walnut supplemented diet phase, participants incorporated walnuts (28-56 g/d) …


Comparison Of Different Methods Of Assessing Ridge Width Prior To Implant Placement, Lung-Cheng Chen Jun 2005

Comparison Of Different Methods Of Assessing Ridge Width Prior To Implant Placement, Lung-Cheng Chen

Loma Linda University Electronic Theses, Dissertations & Projects

The aim of this study was to compare the following 3 methods of assessing alveolar ridge dimensions prior to placement of dental implants: 1) ridge mapping measurement before surgical flap reflection using a caliper; 2) direct caliper measurement following surgical exposure of the bone, and 3) measurement using images from cone beam computerized tomography.

Sixteen subjects having 25 sites for planned implant placement or ridge augmentation were recruited. An acrylic stent was fabricated for each patient. The stent provided 3 buccal/lingual pairs of consistent measurement points for each implant site, located 4, 7 and 10 mm from the summit of …


The Identification Of Kappa Casein Genotypes In The Hair Roots Of Dairy Cattle, Duangsmorn Suwattana, Chortip Aroondechachai, Jutarat Jeerasuppachok, Chatree Khatiworavage Jun 2005

The Identification Of Kappa Casein Genotypes In The Hair Roots Of Dairy Cattle, Duangsmorn Suwattana, Chortip Aroondechachai, Jutarat Jeerasuppachok, Chatree Khatiworavage

The Thai Journal of Veterinary Medicine

Twenty-two dairy cattle, kept at the Demonstration Farm, Department of Animal Husbandry, Faculty of Veterinary Sciences, Chulalongkorn University, Nakorn Pathom, were genotyped using hair roots, for the Kappa-casein gene, using a Polymerase Chain Reaction - Restriction Fragment Length Polymorphism (PCR-RFLP) technique. The method for obtaining total DNA was simple, requiring only the digestion of the root of the hair end in a buffer compatible with the subsequent PCR, without any prior purification or extraction step. Two types of alleles, A and B, were in the frequencies of 0.77 and 0.23, espectively. Genotypes AA, AB and BB were demonstrated with the …


A Retrospective Study Of The Treatment Of Paraplegic Dogs, Marissak Kalpravidh Jun 2005

A Retrospective Study Of The Treatment Of Paraplegic Dogs, Marissak Kalpravidh

The Thai Journal of Veterinary Medicine

The case records of 11 dogs recovering from paraplegia, caused by vertebral fracture, vertebral luxation, spondylosis deformans or intervertebral disk protrusion, were studied. The dogs were examined and treated at the animal hospital of the Faculty of Veterinary Science, Chulalongkorn University from June 2000 to October 2004. Upon presentation, all dogs were paraplegic and had weak superficial or deep pain sensations. Only 9 dogs had voluntary motor function in their hindlimbs or tails. Two dogs received both surgical and medical treatment, while the others received only medical treatment, consisting of the administrations of corticosteroids, aescin, vitamin B1 and antibiotics for …


The Effect Of Cypermethrin On Laying Chicks (Gallus Domesticus) When Used At Therapeutic Doses For Ectoparasitic Treatment, By Measuring Serum Cholinesterase Activity, Piyarat Chansiripornchai, Niwat Chansiripornchai, Jiroj Sasipreeyajan Jun 2005

The Effect Of Cypermethrin On Laying Chicks (Gallus Domesticus) When Used At Therapeutic Doses For Ectoparasitic Treatment, By Measuring Serum Cholinesterase Activity, Piyarat Chansiripornchai, Niwat Chansiripornchai, Jiroj Sasipreeyajan

The Thai Journal of Veterinary Medicine

The effect of cypermethrin at therapeutic doses for ectoparasitic treatment in laying chicks was evaluated by the measurement of serum cholinesterase (ChE) activity. The chicks were divided into 5 groups, 20 in each group. All chicks in groups 2 and 3 were bathed with 0.05 ppm cypermethrin for 2 min, while the chicks in group 4 and 5 were bathed with 200 ppm cypermethrin for 2 min. Group 1 acted as a control group. Serum ChE activity in all the chicks in groups 2 and 4 were measured 24 hr after exposure. ChE activity in the chicks in groups 3 …


An Immunohistochemical Study Of The Progesterone Receptor (Pr) Expression In Pyometra Cases And Normal Uteri At The Time Of Dioestrus In The Bitch, Kongkiat Srisuwatanasagul, Sayamon Sukjumlong, Sudson Sirivaidyapong, Sinchai Pianchop Jun 2005

An Immunohistochemical Study Of The Progesterone Receptor (Pr) Expression In Pyometra Cases And Normal Uteri At The Time Of Dioestrus In The Bitch, Kongkiat Srisuwatanasagul, Sayamon Sukjumlong, Sudson Sirivaidyapong, Sinchai Pianchop

The Thai Journal of Veterinary Medicine

The aims of the present study were to investigate the expression of the progesterone receptor (PR) and to compare whether there was any difference between pyometra cases and normal bitch uteri, during dioestrus, by means of immunohistochemistry. The uterine samples were collected from bitches which clients had submitted for spaying and for pyometra treatment. The results showed that a difference was obvious in the connective tissue stroma and myometrium in which a higher expression of PR was observed in the pyometra group.It may be postulated that the difference in PR expression in these uterine compartments may be involved in the …


Social Class And Art Therapy, Heather B. Ring Jun 2005

Social Class And Art Therapy, Heather B. Ring

EVMS School of Health Professions Theses & Dissertations

Research regarding social class and its effects is limited in mental health services, including art therapy. The purpose of this study was to increase awareness about social class differences and their effects on therapeutic services by exploring how social class impacts adolescents’ attitudes and approach toward artmaking as a form of expression and communication. Two artmaking workshops were conducted with two groups of adolescents from contrasting socioeconomic settings. A sample of 14 volunteers participated. It was hypothesized that adolescents from both groups would use art as an effective and desirable means of personal communication and expression.

Results are based on …


The Effects Of Dextromethorphan On Response Acquisition With Delayed Reinforcement, Thomas B. Morgan Jun 2005

The Effects Of Dextromethorphan On Response Acquisition With Delayed Reinforcement, Thomas B. Morgan

Dissertations

The current study examined in 2-h sessions the effects of intraperitoneal injections of dextromethorphan (DM) (0.0, 40.0, 60.0, and 80.0 mg/kg) on the acquisition of lever-press responding in rats that were exposed to a two-lever procedure in which responses on the reinforcement lever (RL) were reinforced with food after a 15-s resetting delay and responses on the cancellation lever cancelled a scheduled reinforcer. Response acquisition was observed at all drug doses. A decrease in RL responses, food deliveries, and the number of subjects that acquired responding was observed at the highest dose of DM. All doses of DM increased latency …


Attributable Risk Function In The Proportional Hazards Model, Ying Qing Chen, Chengcheng Hu, Yan Wang May 2005

Attributable Risk Function In The Proportional Hazards Model, Ying Qing Chen, Chengcheng Hu, Yan Wang

UW Biostatistics Working Paper Series

As an epidemiological parameter, the population attributable fraction is an important measure to quantify the public health attributable risk of an exposure to morbidity and mortality. In this article, we extend this parameter to the attributable fraction function in survival analysis of time-to-event outcomes, and further establish its estimation and inference procedures based on the widely used proportional hazards models. Numerical examples and simulations studies are presented to validate and demonstrate the proposed methods.


Protection Against Ischemia And Reperfusion Injury, Peter R. Oeltgen, Paul D. Bishop, Mark S. Kindy, Juan A. Sanchez May 2005

Protection Against Ischemia And Reperfusion Injury, Peter R. Oeltgen, Paul D. Bishop, Mark S. Kindy, Juan A. Sanchez

Molecular and Cellular Biochemistry Faculty Patents

A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound, either Deltorphin A and/or Dermorphin H, may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.


Improving The Experience Of Hospitalization For Hawaiian Children On The Mainland Through Cultural Sensitivity To Hawaiian Ways Of Healing, Jane H. Lassetter, Joan H. Baldwin May 2005

Improving The Experience Of Hospitalization For Hawaiian Children On The Mainland Through Cultural Sensitivity To Hawaiian Ways Of Healing, Jane H. Lassetter, Joan H. Baldwin

Faculty Publications

The experience of hospitalization for Hawaiian children on the mainland might be improved through the understanding and development of cultural sensitivity to Hawaiian ways of healing. This article contains a selected review of the literature on meeting the cultural health care needs of Hawaiian children and their families, a discussion of some of the challenges of caring for Hawaiian children in Utah, and suggestions for practice that may improve the experience of hospitalization for Hawaiian children in general.


Endothelial Cell Pseudopods And Angiogenesis Of Breast Cancer Tumors, Ivan L. Cameron, Nicholas Short, Luzhe Sun, W. Elaine Hardman May 2005

Endothelial Cell Pseudopods And Angiogenesis Of Breast Cancer Tumors, Ivan L. Cameron, Nicholas Short, Luzhe Sun, W. Elaine Hardman

Biochemistry and Microbiology

Background

A neoplastic tumor cannot grow beyond a millimeter or so in diameter without recruitment of endothelial cells and new blood vessels to supply nutrition and oxygen for tumor cell survival. This study was designed to investigate formation of new blood vessels within a human growing breast cancer tumor model (MDA MB231 in mammary fat pad of nude female mouse). Once the tumor grew to 35 mm3, it developed a well-vascularized capsule. Histological sections of tumors greater than 35 mm3were stained with PAS, with CD-31 antibody (an endothelial cell maker), or with hypoxia inducible factor 1α …


7th Annual Pacific Research Day Abstracts, University Of The Pacific May 2005

7th Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.


Specific Functions Of Synaptically Localized Potassium Channels In Synaptic Transmission At The Neocortical Gabaergic Fast-Spiking Cell Synapse, Ethan Goldberg, Shigeo Watanabe, Su Ying Chang, Rolf Joho, Z Josh Huang, Christopher S. Leonard, Bernardo Rudy May 2005

Specific Functions Of Synaptically Localized Potassium Channels In Synaptic Transmission At The Neocortical Gabaergic Fast-Spiking Cell Synapse, Ethan Goldberg, Shigeo Watanabe, Su Ying Chang, Rolf Joho, Z Josh Huang, Christopher S. Leonard, Bernardo Rudy

NYMC Faculty Publications

Potassium (K+) channel subunits of the Kv3 subfamily (Kv3.1-Kv3.4) display a positively shifted voltage dependence of activation and fast activation/deactivation kinetics when compared with other voltage-gated K+ channels, features that confer on Kv3 channels the ability to accelerate the repolarization of the action potential (AP) efficiently and specifically. In the cortex, the Kv3.1 and Kv3.2 proteins are expressed prominently in a subset of GABAergic interneurons known as fast-spiking (FS) cells and in fact are a significant determinant of the fast-spiking discharge pattern. However, in addition to expression at FS cell somata, Kv3.1 and Kv3.2 proteins also are expressed prominently at …


Nurses Perceptions Of Barriers And Facilitators To Research Utilization In Their Nursing Practice, David Ray Renfro May 2005

Nurses Perceptions Of Barriers And Facilitators To Research Utilization In Their Nursing Practice, David Ray Renfro

Master's Projects

Today in nursing we are driven in the direction of evidence based practices. The nursing profession must continue to encourage nurses to ask "Why" when providing interventions. We must ensure that the interventions provided are both warranted, and the most efficacious intervention achievable. As a profession, we can no longer stand on our methods of practice simply because it is the way we have always practiced. It is a challenge for nursing leaders to implement a culture of evidence based practice, and to promote research utilization. The purpose of this study was to identify nurse's perceptions of barriers and facilitators …


Oligonucleotide Delivery Systems For Camptothecins, Thomas Burke, Ayhan S. Demir, Ashok J. Chavan, Danzhou Yang May 2005

Oligonucleotide Delivery Systems For Camptothecins, Thomas Burke, Ayhan S. Demir, Ashok J. Chavan, Danzhou Yang

Pharmaceutical Sciences Faculty Patents

Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be incorporated within a macromolecular assembly including both viral and non-viral oligonucleotide vectors. The invention allows combination gene and camptothecin drug therapy.


Association Between Archaeal Prolyl- And Leucyl-Trna Synthetases Enhances TrnaPro Aminoacylation, Mette Praetorius-Ibba, Theresa E. Rogers, Rachel Samson, Zvi Kelman, Michael Ibba May 2005

Association Between Archaeal Prolyl- And Leucyl-Trna Synthetases Enhances TrnaPro Aminoacylation, Mette Praetorius-Ibba, Theresa E. Rogers, Rachel Samson, Zvi Kelman, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Aminoacyl-tRNA synthetase-containing complexes have been identified in different eukaryotes, and their existence has also been suggested in some Archaea. To investigate interactions involving aminoacyl-tRNA synthetases in Archaea, we undertook a yeast two-hybrid screen for interactions between Methanothermobacter thermautotrophicus proteins using prolyl-tRNA synthetase (ProRS) as the bait. Interacting proteins identified included components of methanogenesis, protein-modifying factors, and leucyl-tRNA synthetase (LeuRS). The association of ProRS with LeuRS was confirmed in vitro by native gel electrophoresis and size exclusion chromatography. Determination of the steady-state kinetics of tRNAPro charging showed that the catalytic efficiency (kcat/Km) of ProRS increased 5-fold …


Performance Intensity Functions For Digitally Recorded Japanese Speech Audiometry Materials, Tanya Crawford Mangum May 2005

Performance Intensity Functions For Digitally Recorded Japanese Speech Audiometry Materials, Tanya Crawford Mangum

Theses and Dissertations

The purpose of this study was to develop digitally recorded speech audiometry materials in the Japanese language to evaluate Speech Reception Threshold (SRT) and speech discrimination. Trisyllabic words were used to evaluate the SRT and bisyllabic words were used for speech discrimination. Words were recorded by one native female talker and one native male talker who were judged as having standard Japanese dialects. Twenty native Japanese speakers between the ages of 20 and 32 were used as subjects to evaluate 69 trisyllabic words across 13 different intensity levels. The 25 trisyllabic words with the steepest psychometric function (%/dB) were selected …


Self-Efficacy And Sexual Transmitted Disease Prevention Among College Women, Dominique M. Ly May 2005

Self-Efficacy And Sexual Transmitted Disease Prevention Among College Women, Dominique M. Ly

Master's Projects

According to the Center of Disease Control (2002), sexual transmitted diseases (STDs) are on the rise, especially among women. By far, women bear the greatest burden of STDs because they suffer more frequently and develop more serious complications than men. This study explored the relationship between self-efficacy and safe sex behaviors among college women. The data was collected by using questionnaires from the General Perceived Self-Efficacy Scale (GPSE) and the Condom Use Self-Efficacy Scale(CUSES). The sample was composed of 38 unmarried female college students between the ages of 18 and 25 years-of-age who had been sexually active within the last …


A Survey Of California Nurse Practitioners' Health Practices And Counseling Habits, Jessica Malone May 2005

A Survey Of California Nurse Practitioners' Health Practices And Counseling Habits, Jessica Malone

Master's Projects

Morbidity and mortality due to obesity continues to rise in the United States despite well known Healthy People 2010 and American College of Sports Medicine guidelines on physical activity. In the U.S. today, more than 60 percent of Americans aged 20 years and older are overweight (Hedley et al., 2004). This study investigated the exercise practices of California nurse practitioners (NPs }, how their practices compare to recommended guidelines, and to what extent California NPs prescribe aerobic exercise and strength training to their clients. The California Nurse Practitioners Physical Activity Questionnaire was self-administered at the annual2005 California Association for Nurse …


Female Breast Cancer Incidence And Survival In Utah According To Religious Preference, 1985-1999, Ray M. Merrill, Jeffrey A. Folsom May 2005

Female Breast Cancer Incidence And Survival In Utah According To Religious Preference, 1985-1999, Ray M. Merrill, Jeffrey A. Folsom

Faculty Publications

Female breast cancer incidence rates in Utah are among the lowest in the U.S. The influence of the Church of Jesus Christ of Latter-day Saint (LDS or Mormon) religion on these rates, as well as on disease-specific survival, will be explored for individuals diagnosed with breast cancer in Utah from 1985 through 1999. Methods: Population-based records for incident female breast cancer patients were linked with membership records from the LDS Church to determine religious affiliation and, for LDS Church members, level of religiosity. Incidence rates were age-adjusted to the 2000 U.S. standard population using the direct method. Cox proportional hazards …


Prognosis Of Stage Ii Colon Cancer By Non-Neoplastic Mucosa Gene Expresssion Profiling, Alain Barrier, Sandrine Dudoit, Et Al. May 2005

Prognosis Of Stage Ii Colon Cancer By Non-Neoplastic Mucosa Gene Expresssion Profiling, Alain Barrier, Sandrine Dudoit, Et Al.

U.C. Berkeley Division of Biostatistics Working Paper Series

Aims. This study assessed the possibility to build a prognosis predictor, based on non-neoplastic mucosa microarray gene expression measures, in stage II colon cancer patients. Materials and Methods. Non-neoplastic colonic mucosa mRNA samples from 24 patients (10 with a metachronous metastasis, 14 with no recurrence) were profiled using the Affymetrix HGU133A GeneChip. The k-nearest neighbor method was used for prognosis prediction using microarray gene expression measures. Leave-one-out cross-validation was used to select the number of neighbors and number of informative genes to include in the predictor. Based on this information, a prognosis predictor was proposed and its accuracy estimated by …


Colon Cancer Prognosis Prediction By Gene Expression Profiling, Alain Barrier, Sandrine Dudoit, Et Al. May 2005

Colon Cancer Prognosis Prediction By Gene Expression Profiling, Alain Barrier, Sandrine Dudoit, Et Al.

U.C. Berkeley Division of Biostatistics Working Paper Series

Aims. This study assessed the possibility to build a prognosis predictor, based on microarray gene expression measures, in stage II and III colon cancer patients. Materials and Methods. Tumour (T) and non-neoplastic mucosa (NM) mRNA samples from 18 patients (9 with a recurrence, 9 with no recurrence) were profiled using the Affymetrix HGU133A GeneChip. The k-nearest neighbour method was used for prognosis prediction using T and NM gene expression measures. Six-fold cross-validation was applied to select the number of neighbours and the number of informative genes to include in the predictors. Based on this information, one T-based and one NM-based …