Medicine and Health Sciences Commons^™

Dump Truck Driver Dies After Unintentional Release Of Asphalt, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

On June 6, 2005 a 55-year-old male dump truck driver (Driver 1) died when he was buried waist deep in 400-degree Fahrenheit asphalt. Driver 1 stopped along the highway to help another dump truck driver (Driver 2), (both were independent truck drivers), who had experienced brake problems. As the two men were examining the pneumatic brake system at the rear of the disabled dump truck, the tailgate opened unexpectedly, spilling hot asphalt onto the decedent who was under the rear of the truck.

To prevent similar incidents, the following recommendations have been made:

Recommendation No. 1: Tailgate chains should always …

Intimate Partner Violence And Disabilities Among Women Attending Family Practice Clinics, Ann L. Coker, Paige H. Smith, Mary Kay Fadden

CRVAW Faculty Journal Articles

Purpose: To estimate the frequency and type of disabilities preventing work among those experiencing intimate partner violence (IPV) compared with those never experiencing IPV.

Methods: We used a large cross-sectional survey of women, ages 18–65, attending family practice clinics from 1997 through 1998. Participation included a 5–10-minute in-clinic survey assessing IPV experience and a longer telephone survey assessing health status and chronic disabilities that prevented work outside the home or housework.

Results: Of 1,152 eligible women surveyed, 54% experienced some type of IPV, and 24% were currently in a violent relationship. Women who had ever experienced IPV …

Seventeen Amino Acid Peptide (Peptide P) For Treating Ischemia And Reperfusion Injury, Peter R. Oeltgen, Mark S. Kindy

Molecular and Cellular Biochemistry Faculty Patents

Peptide P, having the amino acid sequence Tyr-D-Ala-Phe-Ala-Asp-Val-Ala-Ser-Thr-Ile-Gly-Asp-Phe-His-Ser-Ile-NH2-SEQ ID NO:1, is useful to treat ischemia.

Dump Truck Driver Crushed Between Trackhoe And Dump Truck, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

On November 11, 2004, a 33-year-old male dump truck driver died when he was crushed between the driver’s side of the dump truck and the swinging counter-weight of an excavator (trackhoe). His dump truck became stuck in mud after the trackhoe loaded dirt into it so he walked to the on-site office and informed the owner. The owner located a bulldozer on site and drove it to the dump truck while the driver retrieved a chain from his personal pickup truck. The owner raised the blade so the driver could attach the chain to it. Raising the blade of the …

Evaluation Of Stature Development During Childhood And Adolescence In Individuals With Familial Hypophosphatemic Rickets, Mauro M. S. Borghi, Verônica Coates, Hatim A. Omar

Pediatrics Faculty Publications

This review was conducted to study the diagnosis, treatment, and growth progression in infants and adolescents with familial hypophosphatemic rickets. The bibliographic search was carried out utilizing the electronic databases MEDLINE, OVID, and LILACS and by direct research within the last 15 years using the keywords rickets, familial hypophosphatemia, vitamin D deficiency, stature growth, childhood, and adolescence. Article selection was done by comparing the evaluation of the growth in patients with familial hypophosphatemic rickets, including the variables that might affect them, for possible future therapeutic proposals. It is concluded that the most significant fact in the treatment of familial hypophosphatemic …

Murine Monoclonal Anti-Idiotype Antibody 11d10 And Methods Of Use Thereof, Malaya Chatterjee, Kenneth A. Foon, Sunil K. Chatterjee

Microbiology, Immunology and Molecular Genetics Faculty Patents

The present invention provides a monoclonal anti-idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D10 was selected by specific procedures. 11D10 induces an immunological response to HMFG in nice, rabbits, monkeys and patients with advanced HMFG-associated tumors. This invention provides compositions derived from polynucleotide sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 11D10, as well as polypeptides encoded thereby. The invention also provides compositions which can be used in …

Cis-2,6-Disubstituted Piperidines For The Treatment Of Psychostimulant Abuse And Withdrawal, Eating Disorders, And Central Nervous System Diseases And Pathologies, Linda P. Dwoskin, Peter A. Crooks, Marlon D. Jones

Pharmaceutical Sciences Faculty Patents

Cis-2,6-disubstituted piperdine analogs, or lobeline analogs, having the general formula...

To see the remainder of this abstract, please download this patent.

Cleaner Falls 35 Feet To His Death Through Temporary Roof Opening, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Falls

On February 23, 2004, a 50-year-old male cleaner died when he fell approximately 35 feet through a temporary roof opening and was impaled on a piece of equipment on the factory floor. He had been cleaning an exhaust fan on a factory roof with a pressure washer. He and two coworkers had removed the fan from its casing creating a temporary roof opening and set the fan beside the roof opening for cleaning. Facing the fan with his back to the opening, the cleaner apparently stepped backwards and fell through the opening. He fell onto a 1200-ton die-casting machine on …

The Chemical Species Of Aluminum Influences Its Paracellular Flux Across And Uptake Into Caco-2 Cells, A Model Of Gastrointestinal Absorption, Yuzhao Zhou, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

Aluminum (Al) can cause neurotoxicity, a low-turnover osteomalacia, and microcytic anemia. To test the null hypothesis that the chemical form (species) of Al does not influence its mechanism or rate of absorption from the gastrointestinal tract, Al flux across and uptake into Caco-2 cells was investigated. Caco-2 cells were grown on porous membranes mounted in vertical diffusion chambers or in 35-mm-diameter plastic cell culture dishes. When 8 mM ²⁷Al was introduced as the ion, citrate, maltolate, fluoride, or hydroxide, the apical to basolateral apparent permeability (P_app) of Al correlated highly with the P_app of lucifer yellow …

C-Jun N-Terminal Kinase (Jnk) Is Required For Survival And Proliferation Of B-Lymphoma Cells, Murali Gururajan, Roger Chui, Anbu K. Karuppannan, Jiyuan Ke, C. Darrell Jennings, Subbarao Bondada

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Several primary murine and human B lymphomas and cell lines were found to constitutively express high levels of the activated form of c-jun N-terminal kinase (JNK), a member of the mitogen-activated protein (MAP) kinase family. Proliferation of murine B lymphomas CH31, CH12.Lx, BKS-2, and WEHI-231 and the human B lymphomas BJAB, RAMOS, RAJI, OCI-Ly7, and OCI-Ly10 was strongly inhibited by SP600125, an anthrapyrazolone inhibitor of JNK, in a dose-dependent manner. The lymphoma cells underwent apoptosis and arrested at the G2/M phase of cell cycle. Furthermore, JNK-specific small interfering RNA (siRNA) inhibited the growth of both murine and human B lymphomas. …

Methods And Compositions Useful In Enhancing Oxygen Delivery To Cells, Elaine L. Jacobson, Myron Jacobson, Jaber G. Qasem, Hyuntae Kim, Moonsun Kim

Graduate Center for Nutritional Sciences Faculty Patents

The invention discloses compositions and methods which are useful in improving delivery of oxygen to cells. The compositions require at least one derivative of a compound. The derivatives are chosen to have log P values below about 6.0.

A Brief History And Current Status Of A Dental Therapy Initiative In The United States, David A. Nash, Ron J. Nagel

Oral Health Science Faculty Publications

No abstract provided.

Nurse Anesthetists In Southeastern Kentucky: A Survey Of Supply Versus Demand, Judy Owens, David A. Gross, Peggy Lewis

Center of Excellence in Rural Health Reports

Examines the geographic maldistribution of nurse anesthetists in Kentucky and the status of their positions and vacancies at all 19 hospitals in the southeastern part of the state. UK Center for Excellence in Rural Health-Hazard researchers found that southeastern Kentucky has 12.5 percent of Kentucky’s total population and performs 11.5 percent of the state’s total surgeries - but has only 6.5 percent of the state’s total resident nurse anesthetists.

Chronic Obstructive Pulmonary Disease In 2025 - Where Are We Headed?, David M. Mannino

David M. Mannino

Comment on

A dynamic population model of disease progression in COPD. [Eur Respir J. 2005]

Expression Of Cd68 And Macrophage Chemoattractant Protein-1 Genes In Human Adipose And Muscle Tissues: Association With Cytokine Expression, Insulin Resistance, And Reduction By Pioglitazone, Gina B. Di Gregorio, Aiwei Yao-Borengasser, Neda Rasouli, Vijayalakshmi Varma, Tong Lu, Leslie M. Milrd, Gouri Ranganathan, Charlotte A. Peterson, Robert E. Mcgehee Jr., Philip A. Kern

Clinical and Translational Science Faculty Publications

To examine the role of adipose-resident macrophages in insulin resistance, we examined the gene expression of CD68, a macrophage marker, along with macrophage chemoattractant protein-1 (MCP-1) in human subcutaneous adipose tissue using real-time RT-PCR. Both CD68 and MCP-1 mRNAs were expressed in human adipose tissue, primarily in the stromal vascular fraction. When measured in the adipose tissue from subjects with normal glucose tolerance, covering a wide range of BMI (21-51 kg/m²) and insulin sensitivity (S_I) (0.6-8.0 × 10^-4 min^-1 · μU^-1 · ml^-1), CD68 mRNA abundance, which correlated with the number …

A Model Program For Youth Suicide Prevention, Hatim A. Omar

Pediatrics Faculty Publications

Youth suicide continues to be one of the leading causes of death in the United States. Nation wide it is the third leading cause of death in the 10-24 year old age group. The rate of suicide varies somewhat from state to state. In the state of Kentucky, youth suicide is the second leading cause of death. This article describes a grass root, community-based program for youth suicide prevention and its impact on the community. The Stop Youth Suicide Campaign was launched in October 2000 and included more than 30 local agencies. This program worked. through public education, education of …

Genes Encoding Several Poly (Adp-Ribose) Glycohydrolase (Parg) Enzymes, The Proteins And Fragments Thereof, And Antibodies Immnoreactive Therewith, Myron Jacobson, Elaine L. Jacobson, Jean-Christoph Amé, Winston Lin

Graduate Center for Nutritional Sciences Faculty Patents

The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's response to neoplastic disorder inducing agents and oxidative stress. Expression vectors containing the cDNAs and cells transformed with the vectors are described. Probes and primers that hybridize with the cDNAs are described. Expression of the cDNA in E. coli results in an enzymatically active protein of about 111 kDa and an active fragment of about 59 kDa. Methods …

Gonadal Steroids Differentially Modulate Neurotoxicity Of Hiv And Cocaine: Testosterone And Ici 182,780 Sensitive Mechanism, Sherie L. Kendall, Caroline F. Anderson, Avindra Nath, Jadwiga Turchan-Cholewo, Cantey L. Land, Charles F. Mactutus, Rosemarie M. Booze

Behavioral Science Faculty Publications

BACKGROUND: HIV Associated Dementia (HAD) is a common complication of human immunodeficiency virus (HIV) infection that erodes the quality of life for patients and burdens health care providers. Intravenous drug use is a major route of HIV transmission, and drug use is associated with increased HAD. Specific proteins released as a consequence of HIV infection (e.g., gp120, the HIV envelope protein and Tat, the nuclear transactivating protein) have been implicated in the pathogenesis of HAD. In primary cultures of human fetal brain tissue, subtoxic doses of gp120 and Tat are capable of interacting with a physiologically relevant dose of cocaine, …

Horse Farm Owner Dies When Pinned Under Golf Cart, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On January 31, 2004, a 45-year old female horse farm owner (decedent) died when she was pinned under a golf cart. The woman had driven a gas-powered golf cart from her house on the farm to the horse barn to muck stalls and put horses in the barn. After driving the golf cart into the barn, the farm owner placed two square bales of hay on the golf cart; one on the back and one on the passenger side of the front seat. Leaving the ignition key of the golf cart in the “on” position, she left the golf cart …

Manganese Distribution Across The Blood-Brain Barrier. Iv. Evidence For Brain Influx Through Store-Operated Calcium Channels, Janelle S. Crossgrove, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

Manganese (Mn) is a required co-factor for many ubiquitous enzymes; however, chronic Mn overexposure can cause manganism, a parkinsonian-like syndrome. Previous studies showed Mn influx into brain is carrier-mediated, though the putative carrier(s) were not established. Studies conducted with cultured bovine brain microvascular endothelial cells (bBMECs), which comprise the blood–brain barrier, revealed ⁵⁴Mn (II) uptake positively correlated with pH, was temperature-dependent, and was sodium- and energy-independent. Brain ⁵⁴Mn uptake correlated inversely with calcium (Ca) concentration, but ⁴⁵Ca uptake was unaltered by high Mn concentration. Lanthanum (La), a non-selective inhibitor of several Ca channel types, as well as …

Protection Against Ischemia And Reperfusion Injury, Peter R. Oeltgen, Paul D. Bishop, Mark S. Kindy, Juan A. Sanchez

Molecular and Cellular Biochemistry Faculty Patents

A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound, either Deltorphin A and/or Dermorphin H, may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.

Oligonucleotide Delivery Systems For Camptothecins, Thomas Burke, Ayhan S. Demir, Ashok J. Chavan, Danzhou Yang

Pharmaceutical Sciences Faculty Patents

Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be incorporated within a macromolecular assembly including both viral and non-viral oligonucleotide vectors. The invention allows combination gene and camptothecin drug therapy.

Traffic Technician Dies From Fall While Changing Traffic Signal Bulb, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

On Monday, March 31, 2003, a 39-year-old male (decedent) highway traffic technician, working alone, received fatal head injuries after falling out of the bucket of an aerial boom truck. Injuries sustained in the fall resulted in his death four days later. He was changing a burned-out green traffic bulb in a traffic signal suspended over 2 lanes of traffic. As he worked from the aerial lift suspended over traffic to change the burned out bulb, a cargo truck drove underneath the bucket, striking it, and causing the decedent to fall to the asphalt below. As the worker fell approximately 10 …

Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase. with or without a substrate bound in the active site.

Osler And The Infected Letter, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

The spread of infectious agents through the mail has concerned public health officials for 5 centuries. The dissemination of anthrax spores in the US mail in 2001 was a recent example. In 1901, two medical journals reported outbreaks of smallpox presumably introduced by letters contaminated with variola viruses. The stability and infectivity of the smallpox virus are reviewed from both a historical (anecdotal) perspective and modern virologic studies. Bubonic plague was the contagious disease that led to quarantines as early as the 14th century in port cities in southern Europe. Later, smallpox, cholera, typhus, and yellow fever were recognized as …

Exposure To Secondhand Smoke And Nicotine Dependence, Chizimuzo T.C. Okoli, Ellen J. Hahn, Steven R. Browning, Mary Kay Rayens

Nursing Presentations

Background

• Nicotine dependence (ND) : “the smoking behavior accompanied by a reluctance to quit (Khurana, Batra, Patkar, & Leone, 2003).

• The US Public Health Service Clinical Practice Guideline ‘Treating Tobacco Use and Dependence’: A chronic condition that often requires repeated interventions (Office of the Surgeon General, 2000).

• Secondhand Smoke (SHS) is a potential source of exposure to high levels of nicotine. (Dimich-Ward, Gee, Brauer, Leung,1997)

• No current studies addressing the contribution of SHS to Nicotine Dependence (ND) or smoking behaviors

Landscaping Laborer Dies When Struck By Bouncing Log, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

On March 5, 2004, a 57-year-old male laborer died when a 19 inch wide x 31 inch long log rolled down a mountain hitting him in his head and chest. The laborer had been employed for three days by a landscaping company contracted to clear the tree canopy over a gas line right-of-way. At approximately 2:20 pm, the company owner and five laborers were felling trees and bucking downed trees with chain saws and pole saws to remove the trees and limbs hanging over and growing in the gas line right-of-way. Two of the laborers were working topside at the …

Cardiorespiratory Hospitalizations Associated With Smoke Exposure During The 1997, Southeast Asian Forest Fires, Joshua A. Mott, David M. Mannino, Clinton J. Alverson, Andrew Kiyu, Jamilah Hashim, Tzesan Lee, Kenneth Falter, Stephen C. Redd

David M. Mannino

We investigated the cardiorespiratory health effects of smoke exposure from the 1997 Southeast Asian Forest Fires among persons who were hospitalized in the region of Kuching, Malaysia. We selected admissions to seven hospitals in the Kuching region from a database of all hospital admissions in the state of Sarawak during January 1, 1995 and December 31, 1998. For several cardiorespiratory disease classifications we used Holt-Winters time-series analyses to determine whether the total number of monthly hospitalizations during the forest fire period (August 1 to October 31, 1997), or post-fire period (November 1, 1997 to December 31, 1997) exceeded forecasted estimates …

Microsomal Prostaglandin E Synthase-1: The Inducible Synthase For Prostaglandin E2, Annaleise V. Sampey, Seetha Monrad, Leslie J. Crofford

Internal Medicine Faculty Publications

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of mPGES-1 in the increased local production of PGE2 observed in inflammatory arthritis. The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis.

Method For Treating Cytokine Mediated Hepatic Injury, Peter R. Oeltgen, Paul D. Bishop, Craig J. Mcclain, Shirish Barve

Graduate Center for Nutritional Sciences Faculty Patents

A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.