Medicine and Health Sciences Commons^™

Out Of Africa: Origins Of The Taenia Tapeworms In Humans, Eric P. Hoberg, Nancy L. Alkire, Alan De Queiroz, Arlene Jones

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Phylogenetic and divergence date analyses indicate that the occurrence of Taenia tapeworms in humans pre-dates the development of agriculture, animal husbandry and domestication of cattle (Bos spp.) or swine (Sus scrofa) Taeniid tapeworms in Africa twice independently colonized hominids and the genus Homo prior to the origin of modern humans. Dietary and behavioural shifts, from herbivory to scavenging and carnivory, as early Homo entered the carnivore guild in the Pliocene/Pleistocene, were drivers for host switching by tapeworms to hominids from carnivores including hyaenids and felids. Parasitological data provide a unique means of elucidating the historical ecology, foraging behavior …

Legionella Pneumophila Entry Gene Rtxa Is Involved In Virulence, Suat L. G. Cirillo, Luis E. Bermudez, Sahar H. El-Etr, Gerald Duhamel, Jeffrey D. Cirillo

School of Veterinary and Biomedical Sciences: Faculty Publications

Successful parasitism of host cells by intracellular pathogens involves adherence, entry, survival, intracellular replication, and cell-to-cell spread. Our laboratory has been examining the role of early events, adherence and entry, in the pathogenesis of the facultative intracellular pathogen Legionella pneumophila. Currently, the mechanisms used by L. pneumophila to gain access to the intracellular environment are not well understood. We have recently isolated three loci, designated enh1, enh2, and enh3, that are involved in the ability of L. pneumophila to enter host cells. One of the genes present in the enh1 locus, rtxA, is homologous to repeats …

Mutation Of The Gene Encoding Cytotoxic Necrotizing Factor Type 1 (Cnf1) Attenuates The Virulence Of Uropathogenic Escherichia Coli, Karen E. Rippere-Lampe, Alison D. O'Brien, Richard Conran, Hank A. Lockman

Uniformed Services University of the Health Sciences

Cytotoxic necrotizing factor type 1 (CNF1) is a 115-kDa toxin that activates Rho GTPases and is produced by uropathogenic Escherichia coli (UPEC). While both epidemiological studies that link CNF1 production by E. coli with urinary tract disease and the cytopathic effects of CNF1 on cultured urinary tract cells are suggestive of a role for the toxin as a UPEC virulence factor, few in vivo studies to test this possibility have been reported. Therefore, in this investigation, we evaluated the importance of CNF1 in a murine model of urinary tract infection (UTI) by comparing the degree of colonization and damage induced …

Salmonella Typhimurium Translocates Flagellin Across Intestinal Epithelia, Inducing A Proinflammatory Response, Andrew T. Gewirtz, Peter O. Simon Jr., Clare K. Schmitt, Laura J. Taylor, Curt H. Hagedorn, Alison D. O'Brien, Andrew S. Neish, James L. Madara

Uniformed Services University of the Health Sciences

This study investigated whether soluble paracrine factors mediated Salmonella-induced IL-8 expression in polarized model intestinal epithelia. We found that the basolateral media of model epithelia that had been apically infected with Salmonella typhimurium for a short period (10 minutes) could activate IL-8 secretion in virgin model epithelia, demonstrating that a proinflammatory factor (PIF) was indeed present. Initial characterization found that PIF was a heat-stable protein with a molecular mass of about 50 kDa that acts on the basolateral, but not apical, surface of model intestinal epithelia to elicit IL-8 secretion. PIF was not present in the media of model …

Kronos [2001], State University Of New York At Stony Brook, School Of Medicine

Kronos (School of Medicine)

This edition of Kronos, published in 2001, is the official yearbook of the State University of New York at Stony Brook, School of Medicine. Hard-bound.

Characteristics Of Effective Employment Services: The Consumers’ Perspective, Jaimie Ciulla Timmons, Jennifer Schuster, Doris Hamner, Jennifer Bose

All Institute for Community Inclusion Publications

This monograph reports on a study investigating the characteristics of effective state service systems. Findings are based on the experiences of individuals with disabilities who have used a state agency (Vocational Rehabilitation, Department of Mental Retardation, Department of Mental Health, or One Stop Center) to find employment. Interviews were conducted to examine individuals' experiences with employment services including job search, job entry, strategies that facilitated involvement, supports provided, and barriers experienced. Findings indicated five key components to effective service delivery, including agency culture, consumer-directedness, access to resources, quality personnel, and coordinated services. Obstacles faced during the employment process and personal …

Vocational Rehabilitation Outcomes For People With Mental Retardation, Cerebral Palsy, And Epilepsy: An Analysis Of Trends From 1985 To 1998, Dana Scott Gilmore, Jennifer Schuster, John Butterworth

All Institute for Community Inclusion Publications

This monograph presents the results of secondary analysis of the RSA-911 database from the Rehabilitation Services Administration. All successful VR closures for individuals with mental retardation, cerebral palsy, and epilepsy for six data points between 1985 and 1998 were investigated. Trends in competitive labor market and extended employment (sheltered workshops) closures were examined. The use of supported employment in the VR system and its outcomes were also discussed. Findings include increased incidence of competitive labor market closures and supported employment services, with a decrease in extended employment closures.

Comparisons of successful VR closure outcomes to trends in the general labor …

The Effects Of Mentoring On Staff Nurses' Job Satisfaction, Karen Delrue

Masters Theses

The shortage of registered nurses in the nation’s healthcare organizations calls for an exploration of avenues that can impact recruitment and retention. The practice of mentoring has demonstrated a positive impact on job satisfaction in previous studies. The purpose of this study was to determine if RNs would identify having mentors in their professional careers and to examine differences in levels of job satisfaction compared to those without a mentor. This study also explored whether or not the perceived quality of the mentor affected job satisfaction. Data were collected through the use of standardized questionnaires from a probability sample of …

Crossing The Line: Case Studies Of Identity Development In First Generation College Women, Phyllis A. Wentworth, Bill E. Peterson

Psychology: Faculty Publications

In this paper we present four case studies of adult women from working class backgrounds who attended Hillside College (a pseudonym for one of the “seven-sister” colleges) during the early 1990s. Although research on women has led, over the past few decades, to a more complex picture of the contexts in which women develop their identities, one important context that has been underexplored is social class. Drawing on data from three lengthy interviews with each of our four participants, our purpose was to explore the identity concerns of adult women from working class backgrounds in their experience getting to and …

Reovirus 1/L As A Model To Study The Induction Of Optimal Immunity At Mucosal And Systemic Sites, Sherry Renee Crowe

MUSC Theses and Dissertations

Achieving protective immunity at mucosal sites is critically important for effective immunization against pathogens that colonize the host via the wet epithelium. We utilized reovirus 1/L infection of mice to study immunization strategies for the induction of optimal humoral and cell-mediated immunity at mucosal surfaces. The humoral and cell-mediated responses at mucosal and systemic sites were monitored following upper respiratory tract, or systemic inoculation. Utilizing these models, we found that the combined upper and lower respiratory tract inoculation resulted in optimal humoral immunity proximally (in the respiratory tract), distrally (in the oral, gastrointestinal, and urogenital tracts), and systematically. This immune …

2001 Transactions, American Dental Association

ADA Transactions

This item is part of the Transactions of the ADA, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT). It is from the Transactions section, one of three subtitles that make up the full publication. Generally, the ADA Transactions are published in multiple volumes throughout the year. Pages from the Annual Reports and the Transactions are numbered consecutively (e.g. Annual Reports volume ends pg. 500 and Transactions volume starts at pg. 501). NOTE: All three subtitles are collectively known as the Transactions of the ADA or, alternatively, the ADA Transactions. Transactions refers …

2001 Annual Reports And Resolutions, American Dental Association

ADA Transactions

This item is part of the Annual Reports and Resolutions subtitle of the ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and Transactions. Generally, the ADA Transactions are published in multiple volumes throughout the year. Older versions include reports from all departments as subsections, while more recent versions include only those of councils, commissions, and committees.

Report Of The Data Workgroup Of The Florida Commission On Mental Health And Substance Abuse, Data Workgroup Of The Florida Commission On Mental Health And Substance Abuse

FMHI Publications

This abridged technical report contains the findings and recommendations of the Data and Needs Assessment Workgroup of the Florida Commission on Mental Health and Substance Abuse. The Commission was created by House Bill 2003 for the purpose of conducting a systematic review of the overall management of the state's mental health (MH) and substance abuse (SA) system. Through this review, the Commission will make recommendations to the Governor and Legislature regarding change and improvement in planning, service strategies, funding, accountability, emergency behavioral health services, and the unique needs of older persons.

Florida Commission On Mental Health & Substance Abuse Final Report, Florida Commission On Mental Health & Substance Abuse

FMHI Publications

The Florida Commission on Mental Health and Substance Abuse was created in 1999 to conduct a systematic review of the state’s mental health and substance abuse system. The Commission was asked to make recommendations in areas including planning, service strategies, funding, accountability, emergency behavioral health services, and the unique needs of older persons.

Twenty-three Commissioners from throughout Florida were appointed by the governor and the legislature to broadly represent the key constituencies in mental health and substance abuse. Four workgroups were formed to examine and report on special issues including: 1) information needs and technology; 2) children’s; 3) adults’; and …

Report Of The Older Adult Workgroup Of The Florida Commission On Mental Health And Substance Abuse, Older Adult Workgroup Of The Florida Commission On Mental Health And Substance Abuse

FMHI Publications

No abstract provided.

The Girl Who Cried Pain: A Bias Against Women In The Treatment Of Pain, Diane E. Hoffmann, Anita J. Tarzian

Faculty Scholarship

In general, women report more severe levels of pain, more frequent incidences of pain, and pain of longer duration than men, but are nonetheless treated for pain less aggressively. The authors investigate this paradox from two perspectives: Do men and women in fact experience pain differently - whether biologically, cognitively, and/or emotionally? And regardless of the answer, what accounts for the differences in the pain treatment they receive, and what can we do to correct this situation?

Physician Assistant Class Of 2001, Philadelphia College Of Osteopathic Medicine

All Yearbooks

Includes the White Coat Ceremony, Retreat at Camp Ockanickon, National Physician Assistant Day 1999, Classroom candids.

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 2001), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 2001 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• In the Mail
• PCOM Updates
• Meet the Prez
• This Doctor Gets Personal
• Founders Day Honorees
• PCOM MEDNet
• Board Profile
• Alumni Board Profile
• Off to Camp – With Some Very Special Children
• Class Notes
• In Memoriam
• My Turn: New Essay Section
• 2^nd Annual PCOM Alumni Weekend
• Coming Events

Stereospecific Pharmacokinetics And Pharmacodynamics Of Beta-Adrenergic Blockers In Humans, Reza Mehvar, Dion R. Brocks

Pharmacy Faculty Articles and Research

The beta-blockers comprise a group of drugs that are mostly used to treat cardiovascular disorders such as hypertension, cardiac arrhythmia, or ischemic heart disease. Each of these drugs possesses at least one chiral center, and an inherent high degree of enantioselectivity in binding to the b-adrenergic receptor. For beta-blockers with a single chiral center, the (-) enantiomer possesses much greater affinity for binding to the b-adrenergic receptors than antipode. The enantiomers of some of these drugs possess other effects, such as antagonism at alpha-adrenergic receptors or Class III antiarrhythmic activity. However, these effects generally display a lower level of stereoselectivity …

Receptor Number And Caveolar Co-Localization Determine Receptor Coupling Efficiency To Adenylyl Cyclase, Rennolds S. Ostrom, Caroline Gregorian, Ryan M. Drenan, Yang Xiang, John W. Regan, Paul A. Insel

Pharmacy Faculty Articles and Research

Recent evidence suggests that many signaling molecules localize in microdomains of the plasma membrane, particularly caveolae. In this study, overexpression of adenylyl cyclase was used as a functional probe of G protein-coupled receptor (GPCR) compartmentation. We found that three endogenous receptors in neonatal rat cardiomyocytes couple with different levels of efficiency to the activation of adenylyl cyclase type 6 (AC6), which localizes to caveolin-rich membrane fractions. Overexpression of AC6 enhanced the maximal cAMP response to β1-adrenergic receptor (β1AR)-selective activation 3.7-fold, to β2AR-selective activation only 1.6-fold and to prostaglandin E2 (PGE2) not at all. Therefore, the rank order of efficacy in …

Fitness And The Elderly, David B. Mingo

Theses

Statistics show the American population is aging at an explosive rate. The correlation between fitness and the aging process is once again becoming a ripe area for study. Previous studies show that fitness can improve quality of life and health for the elderly. A new defined category of seniors known as the young-old has emerged. This category is comprised of seniors that range in age from 55- 65. This study focuses on the relationship between routine exercise and quality of life issues for the young-old. Subjects for this study were 15 retired military soldiers. Subjects were asked to complete a …

Pro-Aging Vs. Anti-Aging: A Comparative Study Of Attitudes Toward Older Adults, Vanessa Lee Benavidez

Theses

A comparative study was conducted on the attitudes toward older adults between Counselors and Non Counselors. The participants included 50 Licensed Professional Counselors from the state of Missouri, who are registered members of the American Counseling Association (ACA), and 33 Graduate students from Lindenwood University in Saint Charles, Missouri, who are enrolled in graduate programs unrelated to professional counseling. The participants completed a demographic questionnaire and the Facts on Aging Quiz' (FAQl). The demographic questionnaire contained personal data, and the FAQ 1 measured attitudes and knowledge in five areas: correct answer, negative bias, positive bias, neutral, and don't know. The …

Adult Attachment Styles And Their Relationship To Marital Satisfaction In Couples In First Marriages Of Seven (7) Years Or Longer, Melanie Whiteway

Seton Hall University Dissertations and Theses (ETDs)

.

Persistently And Seriously Mentally Ill Individuals' Perception Of The Working Alliance And Caseworker Characteristics, Letizia A. Duncan

Seton Hall University Dissertations and Theses (ETDs)

.

Sensitivity, Specificity, And Probability Calculations For 6 Tests Of Attention With A Mood Disordered Population, Joanne Azulay

Seton Hall University Dissertations and Theses (ETDs)

.

A Phenomenological Analysis Of The Psychotherapist's Experience Of Delivering Psychotherapy In A Managed Behavioral Health Care Environment, Jami M. Messina-Connolly

Seton Hall University Dissertations and Theses (ETDs)

.

The Relationship Between Personality Factors And Drug-Of-Choice Among Adolescent Drug Abusers, Phillip Yucht

Seton Hall University Dissertations and Theses (ETDs)

.

J Am Coll Dent 2001 68 4

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

Production Of Monoclonal Antibody Specific For Human Hemoglobin, Selma Öztürk, Beyazit Çirakoğlu

Turkish Journal of Medical Sciences

Hemoglobin is not normally present in sputum, urine or feces except in minute amounts. Demonstration of the presence of hemoglobin in these materials is an important diagnostic clue that usually implies bleeding within the respiratory, urinary or gastroentestinal tract, respectively. In this work, a hybridoma line secreting monoclonal antibody (Mab) highly specific for human hemoglobin A (hHbA) was generated by fusion of immunized BALB/c mouse splenic lymphocytes with non-secreting mouse myeloma cells followed by selection in hypoxanthine-aminopterin-thymidine (HAT) medium and the screening of culture fluids for hHb A affinity in ELISA. The Mab produced by MAM 2/3B6 is highly specific …

Flow Cytometric Analysis Of The Effects Of Methotrexate And Vepesid On The Hep-2 Cell Cycle, Ni̇zami̇ Duran, Adi̇l M. Allahverdi̇yev, Sali̇h Çeti̇ner

Turkish Journal of Medical Sciences

Objective: To determine the mechanism of action of Methotrexate and Vepesid on the HEp-2 cells isolated from human laryngeal cancer cells morphologically and flow cytometrically (G1, G2, S and PI). Materials and Methods: The HEp-2 continuous cell line was used. Cultivation of the cells was realized in EMEM medium with 10% fetal bovine serum at an atmosphere of 37ºC with 5% CO_2. Six different concentrations of Vepesid and Methotrexate were prepared by diluting with deionized water (5 µg/ml, 50 mg/ml, 500 µg/ml). The morphological and cell cycle parameters of HEp-2 cells were determined by inverted microscope and flow cytometer respectively. …