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Articles 6781 - 6810 of 8080
Full-Text Articles in Medicine and Health Sciences
Antitumor Effects Of Tnf-\Beta, 5-Fu And Their Combinations On Cervical Carcinoma Cell Lines, Hakan Akça, Osman Ni̇dai̇ Özeş
Antitumor Effects Of Tnf-\Beta, 5-Fu And Their Combinations On Cervical Carcinoma Cell Lines, Hakan Akça, Osman Ni̇dai̇ Özeş
Turkish Journal of Medical Sciences
Cervical carcinoma is one type of cancer with a high mortality rate in females. In this study, we investigated the cytotoxic effects of TNF-\beta, 5-FU and their combinations on human cervical carcinoma cell lines, ME180 and HeLa. The highest degree of cytotoxic effect was obtained with 5-FU on both cell lines. While high concentrations of TNF-\beta showed cytotoxic effects on both cell lines, the lowest dose induced growth. Combination treatment of 5-FU and TNF-\beta gave a slightly higher cytotoxic and antiproliferative response compared to individual use of 5-FU and TNF-\beta on both cell lines.
The Dosimetric Verification Of Commercial Two- And Three- Dimensional Radiation Treatment Planning Systems, Ayhan Kiliç, Lütfi̇ Özkan, Kayihan Engi̇n
The Dosimetric Verification Of Commercial Two- And Three- Dimensional Radiation Treatment Planning Systems, Ayhan Kiliç, Lütfi̇ Özkan, Kayihan Engi̇n
Turkish Journal of Medical Sciences
For the quality assurance (QA) of radiation treatment planning systems (RTPSs) and planning computed tomography (CT), a simple cylindrical phantom was developed. The phantom was constructed by using materials and geometries appropriate for the routine clinic setups. A Siemens Somatom HiQ CT, two-dimensional (2D) and three-dimensional (3D) RTPS and a linear accelerator Siemens Mevatron MD2 were used in this study. The 2D and 3D RTPSs gave good results when compared to actual doses measured in the phantom. While the 3D system showed accuracy similar (-1.0% vs. -0.8%) to that of the 2D system for 6 MV and better accuracy (+1.4% …
Thymidine Labeling Index In Laryngeal Squamous Cell Carcinoma, Murat Ünal, Ayhan Bi̇li̇r, Mesut Can Karatay, İsmai̇l Çölhan
Thymidine Labeling Index In Laryngeal Squamous Cell Carcinoma, Murat Ünal, Ayhan Bi̇li̇r, Mesut Can Karatay, İsmai̇l Çölhan
Turkish Journal of Medical Sciences
The aim of this study was to investigate the prognostic value of the thymidine labeling index (TLI) in laryngeal squamous cell carcinoma (SCC). The TLI in tumor tissue and adjacent healthy tissue was assessed prospectively in 31 patients and these values were correlated with age, TNM, grade and recurrence statistically. The tissues (tumoral and adjacent tumor-free tissue) that were obtained during surgery were labeled with ^3H-Thymidine. TLI was calculated as the number of labeled tumor cells * 100 / total number of tumor cells. A statistically significant difference was observed between tumor tissue (mean TLI value = 17.62± 6.39%) and …
Centromeric Smn Deletions In Various Congenital Muscular Dystrophies, Hayat Erdem Yurter, Di̇dem Dayangaç Erden, Saci̇de Pehli̇van, Beri̇l Tali̇m, Haluk Topaloğlu
Centromeric Smn Deletions In Various Congenital Muscular Dystrophies, Hayat Erdem Yurter, Di̇dem Dayangaç Erden, Saci̇de Pehli̇van, Beri̇l Tali̇m, Haluk Topaloğlu
Turkish Journal of Medical Sciences
We studied centromeric SMN gene deletions in various forms of congenital muscular dystrophies. Our study cohort consisted of 48 patients (43 families): 24 with merosin-positive CMD, 18 with merosin-deficient CMD and 6 with muscle-eye-brain (MEB) disease. None of the patients showed deletions of the telomeric gene; however, the deletion frequency of the centromeric gene was 27%. In a multiplex family, the mildly affected sibling, who is ambulant, had a preserved centromeric copy of the SMN gene, whereas in the severely affected sibling the copy was missing. The centromeric copy of the SMN gene may have a contributing role in the …
Effects Of Perinatal Factors On The Duration And Cost Of Hospitalisation For Preterm Infants In A Neonatal Intensive Care Unit In Istanbul, İpek Akman, Di̇lşad Cebeci̇, Eren Özek, Sebahat İmamoğlu
Effects Of Perinatal Factors On The Duration And Cost Of Hospitalisation For Preterm Infants In A Neonatal Intensive Care Unit In Istanbul, İpek Akman, Di̇lşad Cebeci̇, Eren Özek, Sebahat İmamoğlu
Turkish Journal of Medical Sciences
Long hospitalisation and high hospital charges of premature infants are important concerns for parents and health providers. In this study we determined the length of stay and hospital cost of preterm babies and assessed the predictive value of perinatal factors on the duration and the cost of hospitalisation. We reviewed hospital charges and length of stay for a retrospective cohort of 72 premature infants discharged from the neonatal intensive care unit of Marmara University Hospital between January 1999 and January 2000. The perinatal factors were analysed using forward stepwise multiple linear regression analysis. The median gestational age and birth weight …
A Cadaveric Polycystic Kidney Donor, Tanju Acar, Mahmood Arshad
A Cadaveric Polycystic Kidney Donor, Tanju Acar, Mahmood Arshad
Turkish Journal of Medical Sciences
AR Mahmood ARSHAD Department of Renal Transplantation, Guy's and St Thomas Hospital, London - UK
Wound Closure By Skin Traction, Ramazan Köymen, Keri̇m Ortakoğlu, Kemal Murat Okçu, Hasan Ayberk Altuğ, Yavuz Si̇nan Aydintuğ
Wound Closure By Skin Traction, Ramazan Köymen, Keri̇m Ortakoğlu, Kemal Murat Okçu, Hasan Ayberk Altuğ, Yavuz Si̇nan Aydintuğ
Turkish Journal of Medical Sciences
KÖYMEN Kerim ORTAKOĞLU Kemal Murat OKÇU Hasan Ayberk ALTUĞ Yavuz Sinan AYDINTUĞ Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy, Dental Sciences Center, Etlik, Ankara, Turkey
Primary Intestinal Malignant Melanoma, Tanju Acar, Ramazan Taçyildiz, Şevki̇ Karakayali, Haldun Vahapoğlu, Raci̇ Aydin
Primary Intestinal Malignant Melanoma, Tanju Acar, Ramazan Taçyildiz, Şevki̇ Karakayali, Haldun Vahapoğlu, Raci̇ Aydin
Turkish Journal of Medical Sciences
AR^1 Ramazan TAÇYILDIZ^1 Şevki KARAKAYALI^1 Haldun VAHAPOĞLU^2 Raci AYDIN^1 ^1Department of General Surgery. Emergency Aid and Traumatology Hospital, Balgat, ^2Department of Pathology, SSK Ankara Hospital. Dışkapı, Ankara, Turkey
Papillary Adenocarcinoma Of The Epiglottis, Sema Hücümenoğlu, Nur Çeli̇k, Gülben Erdem, Si̇nan Kocatürk
Papillary Adenocarcinoma Of The Epiglottis, Sema Hücümenoğlu, Nur Çeli̇k, Gülben Erdem, Si̇nan Kocatürk
Turkish Journal of Medical Sciences
ÜMENOĞLU^1 Nur ÇELİK^1 Gülben ERDEM^1 Sinan KOCATÜRK^2 Departments of ^1Pathology, ^2Otorhinolaryngology, SSK Training and Research Hospital, Ankara, Turkey
Acrodermatitis Enteropathica, Şi̇nasi̇ Özsoylu
Acrodermatitis Enteropathica, Şi̇nasi̇ Özsoylu
Turkish Journal of Medical Sciences
No abstract provided.
Morphologic Comparison Of The Elastic Fibers Found In The Submucosal Layer In Different Portions Of The Stomach, Ahmet Kalaycioğlu, Mi̇that Keri̇m Arslan
Morphologic Comparison Of The Elastic Fibers Found In The Submucosal Layer In Different Portions Of The Stomach, Ahmet Kalaycioğlu, Mi̇that Keri̇m Arslan
Turkish Journal of Medical Sciences
This study was carried out on 30 human stomachs (from cadavers) obtained from different medical faculties. The elastic fibers in the submucosal layer in the pylorus, corpus and antrum were studied and compared in terms of their length, and density per unit area. The submucosal layer containing elastic fibers was longer and their densities per unit area were greater in the pylorus than those in the corpus and the antrum. Another feature of this study is the use of the vizopan microscop, which is used in the field of forestry engineering for measurements.
The Effects Of Pentoxifylline In Experimental Nerve Injury, Süleyman Baykal, Cavi̇t Boz, Ertuğrul Çakir, Şükrücan H. Baytan, Murat Karakuş, Kayhan Kuzeyli̇
The Effects Of Pentoxifylline In Experimental Nerve Injury, Süleyman Baykal, Cavi̇t Boz, Ertuğrul Çakir, Şükrücan H. Baytan, Murat Karakuş, Kayhan Kuzeyli̇
Turkish Journal of Medical Sciences
Several studies have suggested that pentoxifylline, a theophylline-related drug that decreases erytrhocyte stiffness, may be useful in treatment of ischaemia reperfusion injuries of brain, liver and small intestine in animal experiments. Fourteen Wistar-Albino rats weighing between 180-250 g were used for the experiment and divided equally to two groups. Before the injury, electroneuromyographic (ENMG) data were recorded from right and left sciatic nerves. Right sciatic nerves of the seven rats of group 1 were crushed with a clip. Same lesions were performed on seven rats of group 2 and also pentoxifylline (50mg/kg/day) was applied intraperitoneally once in a day for …
Genetic Polymorphisms In Steroid Hormone Metabolizing Enzymes In Human Breast Cancer, Nesli̇han Aygün Kocabaş
Genetic Polymorphisms In Steroid Hormone Metabolizing Enzymes In Human Breast Cancer, Nesli̇han Aygün Kocabaş
Turkish Journal of Medical Sciences
Epidemiologic studies indicate that most risk factors for breast cancer are related to reproductive and hormonal factors. The evaluation of associations between breast cancer risk and genetic polymorphisms in enzymes involved in hormone metabolism may be a cost effective manner in which to determine individual breast cancer susceptibility. A number of molecular epidemiologic studies have been conducted to evaluate associations between polymorphic genes involved in steroid hormone metabolism (i.e., CYP17, CYP19, CYP1A1, CYP1B1, MnSOD, COMT, and GST) that may account for a proportion of enzymatic variability. An evaluation of associations between breast cancer risk and genetic polymorphisms in enzymes involved …
Detection Of Human Papillomavirus Infection In Esophageal Carcinomas By The Histopathological Method And Polymerase Chain Reaction Technique, İlhami̇ Ki̇ki̇, Mehmet Gündoğdu, Muhammet Fevzi̇ Polat, Cemal Gündoğdu
Detection Of Human Papillomavirus Infection In Esophageal Carcinomas By The Histopathological Method And Polymerase Chain Reaction Technique, İlhami̇ Ki̇ki̇, Mehmet Gündoğdu, Muhammet Fevzi̇ Polat, Cemal Gündoğdu
Turkish Journal of Medical Sciences
A series of 30 surgical resection materials of patients with squamous cell carcinoma (SCC) and 10 with adenocarcinoma (AC) were analyzed histologically and by polymerase chain reaction (PCR) to demonstrate whether human papillomavirus (HPV) has a role in the etiology of esophageal cancers. Epithelial changes suggesting HPV infection were histopathologically detected in 19 of 30 (63.3%) SCC and in 4 of 10 (40%) AC cases. By PCR, HPV type 16 and/or type 18 DNA were detected in 10 of 30 (33.3%) SCC and HPV type 18 DNA alone was detected in 1 of 10 (10%) AC cases. Histopathologic findings related …
An Analysis Of Anatolian Human Femur Anthropometry, Taner Zi̇ylan, Khalil Awadh Murshed
An Analysis Of Anatolian Human Femur Anthropometry, Taner Zi̇ylan, Khalil Awadh Murshed
Turkish Journal of Medical Sciences
Femoral anthropometry from two different ages of Anatolian population groups was evaluated according to normal parametric measurements. Eleven femoral measurements with collo-diaphyseal angles were obtained from 36 right and 36 left intact human adult femora of a contemporary Central Anatolian population. For this purpose, a sliding caliper, osteometric board, tapeline and gonometer were used. Obtained data were statistically analyzed by Student's t-test and the Pearson correlation coefficient. Our results were compared with a previous study's results obtained from human femora from the Şeyh Höyük area (southern Anatolia) dating back to the Chalcolithic Age (5100-3000 B.C). The results of this study …
Maternal Serum Vitamin D Levels In The Third Trimester Of Pregnancy, İsmai̇l Pehli̇van, Şükrü Hatun, Meti̇n Aydoğan, Kadi̇r Babaoğlu, Gülcan Türker, Ayşe Sevi̇m Gökalp
Maternal Serum Vitamin D Levels In The Third Trimester Of Pregnancy, İsmai̇l Pehli̇van, Şükrü Hatun, Meti̇n Aydoğan, Kadi̇r Babaoğlu, Gülcan Türker, Ayşe Sevi̇m Gökalp
Turkish Journal of Medical Sciences
Aim: To measure serum vitamin D levels of pregnant women in the last trimester and to determine factors affecting serum levels. Methods: Seventy-eight pregnant women, 19-39 years old and having their third trimester between March and May 2000, were enrolled. Serum Ca, P and alkaline phosphatase and 25-hydroxyvitamin D_3 levels were measured in venous blood samples during the third trimester. Maternal age, education, socioeconomic status, number of gravida, nutrition, dressing habits and daily exposure time to sunlight were determined and their correlation with serum vitamin D levels were analyzed statistically. Results: The mean age of mothers was 26.1±5.1 years. The …
Autotransplantation Of A Kidney Due To Retroperitoneal Fibrosis, Tanju Acar, Mahmood Arshad
Autotransplantation Of A Kidney Due To Retroperitoneal Fibrosis, Tanju Acar, Mahmood Arshad
Turkish Journal of Medical Sciences
AR Mahmood ARSHAD Guy's & St Thomas Hospital, Renal Transplantation Department, London, United Kingdom
The Rupture Of A Large Isolated Iliac Artery Aneurysm, Yahya Ünlü, Ünsal Vural, Sami̇ Karapolat, Münacetti̇n Cevi̇z, Hi̇kmet Koçak
The Rupture Of A Large Isolated Iliac Artery Aneurysm, Yahya Ünlü, Ünsal Vural, Sami̇ Karapolat, Münacetti̇n Cevi̇z, Hi̇kmet Koçak
Turkish Journal of Medical Sciences
LÜ Ünsal VURAL Sami KARAPOLAT Münacettin CEVİZ Hikmet KOÇAK Department of Cardiovascular Surgery, Faculty of Medicine, Atatürk University, Erzurum, Turkey
Pedodontic Complete Dentures, Mehmet Dalkiz, Bedri̇ Beydemi̇r
Pedodontic Complete Dentures, Mehmet Dalkiz, Bedri̇ Beydemi̇r
Turkish Journal of Medical Sciences
ALKIZ Bedri BEYDEMİR Department of Prosthetic Dentistry, Dental Sciences Center, Gülhane Military Medical Academy, Ankara - Turkey
Examination Of Coronary Artery Anomalies In An Adult Turkish Population, Eray Tüccar, Alai̇tti̇n Elhan
Examination Of Coronary Artery Anomalies In An Adult Turkish Population, Eray Tüccar, Alai̇tti̇n Elhan
Turkish Journal of Medical Sciences
The objective of this study was to determine the frequency of anomalous aortic origins of coronary arteries, to classify these anomalies and to define their consequences. Therefore, 5000 coronary artery angiograms were analysed. Twenty-five (0.5%) coronary arteries with anomalous origins were found, and these anomalies were classified in four main groups. Origin of the circumflex artery from the right side was the most frequent anomaly (12 cases). In 8 cases the right coronary artery originated from the left side, in 3 cases the left coronary artery originated from the right side and finally we found 2 left anterior descending arteries …
A Comparison Of Erythrocyte Superoxide Dismutase And Catalase Activity In Patients With Hepatitis C Infection, Aysun Bay Karabulut, Emi̇ne Sönmez, Yaşar Bayindir, Engi̇n Gözükara
A Comparison Of Erythrocyte Superoxide Dismutase And Catalase Activity In Patients With Hepatitis C Infection, Aysun Bay Karabulut, Emi̇ne Sönmez, Yaşar Bayindir, Engi̇n Gözükara
Turkish Journal of Medical Sciences
Hepatitis C virus (HCV) infection remains important due to difficulties in treatment up to a chronic state. It is considered that free radicals, lipid peroxidation and antioxidant defense play a role in various tissue damages, just as in certain types of viral hepatitis. Since only limited data has been reported concerning oxidative stress in viral hepatitis, a comparative study was planned for patients with hepatitis C. In this study, we searched for erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities in patients with HCV infection who had received and not received recombinant interferon alpha. Four groups of patients [Group I: …
The Effects Of Ticlopidine In Acute Myocardial Infarction As An Adjunctive Treatment To Aspirin In An Intermediate Term Setting, V. Gökhan Ci̇n, Ahmet Temi̇zhan, Hasan Pekdemi̇r, Mehmet Tokaç, Okan Tartanoğlu
The Effects Of Ticlopidine In Acute Myocardial Infarction As An Adjunctive Treatment To Aspirin In An Intermediate Term Setting, V. Gökhan Ci̇n, Ahmet Temi̇zhan, Hasan Pekdemi̇r, Mehmet Tokaç, Okan Tartanoğlu
Turkish Journal of Medical Sciences
Antiplatelet therapy reduces the risk of subsequent ischemic events in patients suffering from acute myocardial infarction (AMI). In this respect, the multi-agent therapy to be used along with aspirin remains to be determined. In this study, ticlopidine was tried in AMI for its potential additive effects over aspirin. Ninety patients with similar clinical characteristics were involved and were followed up for 3 and 6 months. All patients were assigned to receive ticlopidine plus aspirin or aspirin alone. Major cardiac events such as death and reinfarction were primary end-points whereas the need for revascularization was the secondary end-point at 3 and …
Inhibition Of Leukemia Cell Proliferation Using C-Myb Antisense Oligonucleotides, Edi̇z Demi̇rpençe, Janina Ratajczak
Inhibition Of Leukemia Cell Proliferation Using C-Myb Antisense Oligonucleotides, Edi̇z Demi̇rpençe, Janina Ratajczak
Turkish Journal of Medical Sciences
Antisense oligodeoxynucleotides (AS-ODNs) are short DNA sequences synthesized complementary to the mRNA and they inhibit the expression of the target gene by forming a mRNA-DNA duplex. This strategy can be considered to be an alternative therapy for cancers characterized by amplified oncogene activity. The purpose of this study was to evaluate the inhibitory effect of AS-ODNs on two human leukemia cell lines (HL-60 and K562). Cells were treated with c-myb AS-ODNs at two different concentrations and cell proliferation was monitored on the 5^{th} and 7^{th} days of culture. Sense and scrambled ODNs were used as the control. In both cell …
Prevalence Of Coronary Heart Disease Risk Factors Among Women In Köstence, Ankara, Luna Aksoy, Serhan Küpeli̇, Ali̇ Bayram Kasim, Bariş Kuşkonmaz, Umut Kartal, Erpulat Özi̇ş, Naci̇ Yildiz, Nazmi̇ Bi̇li̇r
Prevalence Of Coronary Heart Disease Risk Factors Among Women In Köstence, Ankara, Luna Aksoy, Serhan Küpeli̇, Ali̇ Bayram Kasim, Bariş Kuşkonmaz, Umut Kartal, Erpulat Özi̇ş, Naci̇ Yildiz, Nazmi̇ Bi̇li̇r
Turkish Journal of Medical Sciences
Cardiovascular disease is progressively becoming a major cause of morbidity and mortality in women generally after menopause. In contrast to this general conception, the coronary morbidity and mortality in premenopausal Turkish women approaches that of Turkish men. In this study, our aim was to detect the prevalence of risk factors for coronary heart disease (CHD) among 200 women aged 30 or over who live in the Köstence area and to inform individuals presenting with CHD risk factors. Twenty-seven women (13,5%) were current smokers. The body mass index of 168 participants (84%) was greater than 24.9 kg/m2 and 32.5% of women …
Outpatient Satisfaction With Health Centers In Urban Areas, Sai̇d Bodur, Yusuf E. Özdemi̇r, Fati̇h Kara
Outpatient Satisfaction With Health Centers In Urban Areas, Sai̇d Bodur, Yusuf E. Özdemi̇r, Fati̇h Kara
Turkish Journal of Medical Sciences
Objective: The purpose of this study was to estimate the level of patient satisfaction with health center services and related factors. Methods: This study was performed on eight randomly selected health centers in urban areas of Ankara and Konya by interviewing patients who were about to go home after examination. The questionnaire consisted of demographic data and a four-point rating scale of 13 items measuring the satisfaction of outpatients. The chi-square test was used to assess differences in proportions. Results: Satisfaction score was 3.11 ± 0.41 and 70% of the patients were satisfied with the patient care of health centers. …
Telomerase Mrna Expression In Ductal Carcinomas Of The Breast, Handan Kaya, Sema Hücümenoğlu, Esi̇n Koti̇loğlu, Gülsün Eki̇ci̇oğlu, Sevgi̇ Küllü
Telomerase Mrna Expression In Ductal Carcinomas Of The Breast, Handan Kaya, Sema Hücümenoğlu, Esi̇n Koti̇loğlu, Gülsün Eki̇ci̇oğlu, Sevgi̇ Küllü
Turkish Journal of Medical Sciences
AYA^1 Sema HÜCÜMENOĞLU^2 Esin KOTİLOĞLU^1 Gülsün EKİCİOĞLU^1 Sevgi KÜLLÜ^1 ^1Department of Pathology, Faculty of Medicine, Marmara University Hospital, 81190, Altunizade, İstanbul ^2SSK Ankara Training Hospital, Dışkapı, Ankara - Turkey
Insulin-Like Growth Factor (Igf-I) In Mauriac Syndrome Or Diabetic Dwarfism, Enver Şi̇mşek, Kenan Kocabay
Insulin-Like Growth Factor (Igf-I) In Mauriac Syndrome Or Diabetic Dwarfism, Enver Şi̇mşek, Kenan Kocabay
Turkish Journal of Medical Sciences
MŞEK Kenan KOCABAY Department of Pediatrics, Faculty of Medicine Abant Izzet Baysal University, Düzce - Turkey
A Solitary Metachronous Bladder Metastasis After Nephron Sparing Surgery For Renal Cell Carcinoma: A Case Report, Fazil Tuncay Aki, Serkan Gökkaya, Öztuğ Adsan, Si̇bel Erdoğan, Selda Seçki̇n
A Solitary Metachronous Bladder Metastasis After Nephron Sparing Surgery For Renal Cell Carcinoma: A Case Report, Fazil Tuncay Aki, Serkan Gökkaya, Öztuğ Adsan, Si̇bel Erdoğan, Selda Seçki̇n
Turkish Journal of Medical Sciences
ncay AKI^1 Serkan GÖKKAYA^1 Öztuğ ADSAN^1 Sibel ERDOĞAN^2 Selda SEÇKİN^2 Departments of ^1Clinics of II. Urology, ^2Pathology, Ankara Numune Education and Research Hospital, Ankara - Turkey
Accidental Displacement Of Impacted Third Molar Into Lateral Pharyngeal Space, Keri̇m Ortakoğlu, Kemal Murat Okçu, Hakan Alpay Karasu, Yilmaz Günaydin
Accidental Displacement Of Impacted Third Molar Into Lateral Pharyngeal Space, Keri̇m Ortakoğlu, Kemal Murat Okçu, Hakan Alpay Karasu, Yilmaz Günaydin
Turkish Journal of Medical Sciences
TAKOĞLU^1 Kemal Murat OKÇU1 Hakan Alpay KARASU^2 Yılmaz GÜNAYDIN^1 ^1Department of Oral and Maxillofacial Surgery, Dental Sciences Center, Gülhane Military Medical Academy, Etlik, Ankara, ^2Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ankara University, Beşevler, Ankara - Turkey
Nitric Oxide Ii: Therapeutic Uses And Clinical Applications, Ayşe Baysal
Nitric Oxide Ii: Therapeutic Uses And Clinical Applications, Ayşe Baysal
Turkish Journal of Medical Sciences
Nitric oxide is a biological mediator in human organisms which plays important roles in tissue and organ hemostasis. Recent advances in the therapeutic uses of inhaled nitric oxide in lung diseases and other pathologic states urges the efficient and appropriate use of nitric oxide in hospitals. This study is a literature search based on a keyword search and the abstracts in English in Medline. The therapeutic indications for inhaled nitric oxide and various clinical applications are summarized. Subsequently, adverse effects and toxicity for inhaled nitric oxide and contraindications for its use are discussed.