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Articles 3001 - 3030 of 4001
Full-Text Articles in Medicine and Health Sciences
Sensory Intervention To Improve Sleep Behaviors And Social Participation Of Children In Israel With Sensory Modulation Disorder, Geela Spira
Occupational Therapy Program Student Theses, Dissertations and Capstones
The aim of this study was to investigate a sensory intervention of moderate pressure touch on children with sensory modulation disorder on the outcomes of sleep behaviors and social participation. 50 children, aged 6-11 years, with both sensory modulation disorder and sleep difficulties were randomly divided into an experimental group and a control group. The experimental group participants received three weeks of nightly massage by their parents. The parents filled out questionnaires reporting on sleep behaviors, sensory modulation, and social participation, as well as recording a sleep log, and determining goal attainment scaling goals. The questionnaires used were the Short …
Influence Of Immediate Dentin Sealing On The Bond Strength Of Indirect Bonded Restorations, Alexander Duque
Influence Of Immediate Dentin Sealing On The Bond Strength Of Indirect Bonded Restorations, Alexander Duque
Student Theses, Dissertations and Capstones
Introduction: A critical issue and concern that has been documented in dentistry is the complexity of bonding to dentin, a fact that has been referred to as a less reliable technique due to the intrinsic characteristics of the dentin substrate. Effectiveness on dentin bonding is a clinical important approach for indirect bonded restorations in order to achieve a good adhesion that can surpass the test of time. Long-term clinical trials have shown that indirect bonded restorations have an increased risk of failure when using dentin as the major substrate. Consequently, an effort should be made to improve techniques and materials …
Contextual Aspects Influencing Mothers' Placement Considerations For Their Children With Autism, Margaret E. Moffett Boyd
Contextual Aspects Influencing Mothers' Placement Considerations For Their Children With Autism, Margaret E. Moffett Boyd
Occupational Therapy Program Student Theses, Dissertations and Capstones
"Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Occupational Therapy Department, College of Health Care Sciences, Nova Southeastern University."
Abstract Background: In 2005, the Centers for Disease Control and Prevention recognized autism as an urgent public health concern understanding families would need supports services at many levels. Parents are the most prominent caregivers of children with disabilities and inadequacy of support services often influences the placement outside of the home. Federal mandates require that states actively avoid placements based on costs, community connections, and least restrictive environments; however, unsustainable family life potentially …
Distribution Of Non-At1, Non-At2 Binding Of 125i-Sarcosine1, Isoleucine8 Angiotensin Ii In Neurolysin Knockout Mouse Brains, Robert C. Speth, Eduardo J. Carrera, Catalina Bretón, Andrea Linares, Luz Gonzalez-Reiley, Jamala D. Swindle, Kira L. Santos, Ines Schadock, Michael Bader, Vardan T. Karamyan
Distribution Of Non-At1, Non-At2 Binding Of 125i-Sarcosine1, Isoleucine8 Angiotensin Ii In Neurolysin Knockout Mouse Brains, Robert C. Speth, Eduardo J. Carrera, Catalina Bretón, Andrea Linares, Luz Gonzalez-Reiley, Jamala D. Swindle, Kira L. Santos, Ines Schadock, Michael Bader, Vardan T. Karamyan
HPD Articles
The recent identification of a novel binding site for angiotensin (Ang) II as the peptidase neurolysin (E.C. 3.4.24.16) has implications for the renin-angiotensin system (RAS). This report describes the distribution of specific binding of 125I-Sarcosine1, Isoleucine8 Ang II (125I-SI Ang II) in neurolysin knockout mouse brains compared to wild-type mouse brains using quantitative receptor autoradiography. In the presence of p-chloromercuribenzoic acid (PCMB), which unmasks the novel binding site, widespread distribution of specific (3 µM Ang II displaceable) 125I-SI Ang II binding in 32 mouse brain regions was observed. Highest levels of binding >700 fmol/g initial wet weight were seen in …
Lasting Impressions, Winter 2014, College Of Dental Medicine
Lasting Impressions, Winter 2014, College Of Dental Medicine
Newsletters
No abstract provided.
Electronic Practical Skills Assessments In The Health Professions: A Review, Suzanne J. Snodgrass, Samantha E. Ashby, Laura Onyango, Trevor Russell, Darren A. Rivett
Electronic Practical Skills Assessments In The Health Professions: A Review, Suzanne J. Snodgrass, Samantha E. Ashby, Laura Onyango, Trevor Russell, Darren A. Rivett
Internet Journal of Allied Health Sciences and Practice
Objective Structured Clinical Examinations (OSCEs) evaluate the practical skills of students training in the health professions. OSCEs have several limitations, including a large administrative burden, potential inaccuracies when transferring student scores from paper to electronic mediums, and difficulties providing individualised student feedback. The “eOSCE,” an electronic version of the traditional paper-based OSCE, potentially addresses these issues. In the eOSCE, examiners use electronic means (e.g. computer, personal digital assistant) to record student scores and comments about their performance, and the system provides students with individualised feedback. The literature from 12 databases was searched to identify articles discussing the use of electronic …
Coming Out, Coming Together, Coming Around: An Interpretative Phenomenological Analysis Of Families' Experiences Adjusting To A Young Family Member's Disclosure Of Non-Heterosexuality, Denise M. Fournier Rodriguez
Coming Out, Coming Together, Coming Around: An Interpretative Phenomenological Analysis Of Families' Experiences Adjusting To A Young Family Member's Disclosure Of Non-Heterosexuality, Denise M. Fournier Rodriguez
Department of Family Therapy Dissertations and Applied Clinical Projects
Young people who identify as lesbian, gay, or bisexual (LGB) are disclosing their sexual identity--or coming out--at progressively younger ages, making it more important than ever for the general population to understand, tolerate, and accept diversity in sexual identity. This study was designed to fill the gap in the existing literature about how the coming out process affects LGB young people's families of origin. Three LGB young people participated in the study, along with a member of each of their families. The researcher conducted semi-structured interviews with each of the participants, as well as a conjoint interview with each of …
Living With Uncertainty: The Impact On Breast Cancer Survivors And Their Intimate Partners, Kimberley Dockery
Living With Uncertainty: The Impact On Breast Cancer Survivors And Their Intimate Partners, Kimberley Dockery
Department of Family Therapy Dissertations and Applied Clinical Projects
This study explored the lived experiences of breast cancer survivors and their intimate partners. The research was informed by a social constructionist framework and phenomenological method of inquiry. While the body of literature on the physical, psychological, and social health of breast cancer survivors is growing, only a few studies have focused solely on the lived experience of survivorship and the uncertainty of recurrence. This study sought to explore the construction of meaning in the couples' context and experiences of surviving breast cancer. The present study examined how breast cancer survivors make meaning of their survivorship in context of living …
Planning For The Future : A Grounded Theory Study Of Well Older Adults' Decision-Making Regarding Home Modifications, Kathleen Subasic
Planning For The Future : A Grounded Theory Study Of Well Older Adults' Decision-Making Regarding Home Modifications, Kathleen Subasic
Occupational Therapy Program Student Theses, Dissertations and Capstones
The purpose of this dissertation research was to understand the decision-making process that well older adults use when deciding whether to make a home modification. The researcher also sought to understand the views of well older adults concerning the use of home modification to prevent injury and declines in occupational performance. The researcher used the Person-Environment-Occupation (PEO) model (Law et al., 1996) from occupational therapy and occupational science as the orienting framework.
A qualitative grounded theory approach based on that proposed by Strauss and Corbin (1998) was used to structure data collection and analysis. Participants were obtained using purposive and …
Measuring The Playfulness Of Children With Special Needs In Occupational Therapist Led, Caregiver-Included Community Playgroups, Sarah Fabrizi
Measuring The Playfulness Of Children With Special Needs In Occupational Therapist Led, Caregiver-Included Community Playgroups, Sarah Fabrizi
Occupational Therapy Program Student Theses, Dissertations and Capstones
The aim of this study was to investigate the effectiveness of community playgroups on the playfulness of children ages 15 months to 3 years with special needs. In addition to playfulness of the child, the sensitivity and responsiveness of the caregiver were examined. A quasi-experimental, pretest-and-posttest, repeated measures design was used to follow eight children and their caregivers receiving early intervention services and taking part in a community playgroup. The children and their caregivers were measured during a 4-week standard-of-care baseline, before and after an 8-week intervention period, and 4 week post-intervention. The Test of Playfulness (ToP) was utilized to …
Adapting The Resources For Enhancing Alzheimer’S Caregivers Health (Reach) Program For Use In A Nursing Home Setting, Edward Golden
Adapting The Resources For Enhancing Alzheimer’S Caregivers Health (Reach) Program For Use In A Nursing Home Setting, Edward Golden
Occupational Therapy Program Student Theses, Dissertations and Capstones
Adapting the Resources for Enhancing Alzheimer’s Caregivers Health (REACH) program for use in a nursing home setting
OCT 7003 Capstone Paper
Certificate Program In Anatomical Studies 2014, Nova Southeastern University
Certificate Program In Anatomical Studies 2014, Nova Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
Same-Sex Couples' Lived Experiences Of The Repeal Of The Defense Of Marriage Act's (Doma) Section Three, Alicia Anne Bosley
Same-Sex Couples' Lived Experiences Of The Repeal Of The Defense Of Marriage Act's (Doma) Section Three, Alicia Anne Bosley
Department of Family Therapy Dissertations and Applied Clinical Projects
Same-sex couples are affected by the social and political climates in which they live, as these create the difference between acceptance and legalization, and discrimination and prohibition, of their relationships. This contingence is made increasingly impactful by the privileges and protections afforded to married couples by the federal government; same-sex couples, along with other couples that choose not to, or cannot, marry, are excluded from these benefits. Following the June 26, 2013 ruling that Section Three of the Defense of Marriage Act (DOMA), which defined marriage as between a man and a woman, was unconstitutional, same-sex couples were given access …
The Effects Of A Single Event Interprofessional Education (Ipe) Experience On Occupational Therapy Students, Jodi Schreiber, Anthony Goreczny, Melissa L. Bednarek, Susan R. Hawkins, Mark L. Hertweck, Susan E. Sterrett
The Effects Of A Single Event Interprofessional Education (Ipe) Experience On Occupational Therapy Students, Jodi Schreiber, Anthony Goreczny, Melissa L. Bednarek, Susan R. Hawkins, Mark L. Hertweck, Susan E. Sterrett
Internet Journal of Allied Health Sciences and Practice
Purpose: The purpose of the study was to evaluate the impact of a single interprofessional education (IPE) seminar on student attitudes toward interprofessional education (IPE) at a small northeastern university that housed an entry-level Master in Occupational Therapy (MOT) program. Method: Investigators used the Readiness for Interprofessional Learning Scale (RIPLS) to determine attitudes of thirty-six MOT students after attending an interprofessional seminar.Results: Participant response rate of MOT students was 88.9% percent. The analysis of data revealed no significant differences between MOT student attitudes toward IPE pre and post IPE seminar. Conclusion: Several factors are discussed that may have contributed to …
Perspectives Volume 1: Number 1, Winter 2014, College Of Health Care Sciences
Perspectives Volume 1: Number 1, Winter 2014, College Of Health Care Sciences
Perspectives
No abstract provided.
Investing In Practice Infrastructure Influences Practice Progress, Mardi Lowe-Heisted, Deann Adams, Michael Giesbrecht, Esther Krahn
Investing In Practice Infrastructure Influences Practice Progress, Mardi Lowe-Heisted, Deann Adams, Michael Giesbrecht, Esther Krahn
Internet Journal of Allied Health Sciences and Practice
Purpose: “The Influence of Practice Infrastructure on Practice Progress” was an evaluation review project designed to determine if investment in the infrastructure of an allied health profession would result in improved practice progress within that profession. Practice infrastructure included robust, profession-specific practice councils; local and regional practice leadership; and support for education infrastructure. Method: This review consisted of selecting three professions (psychology, therapeutic recreation, and respiratory therapy) that were at different stages in their practice evolution. Health care providers in these three professions participated in an online survey. Their practice progress was measured against 32 established professional practice benchmarks. Separate …
Percentile Ranks For Walking Speed In Subjects 70-79 Years: A Meta-Analysis, James Roush, R. Curtis Bay
Percentile Ranks For Walking Speed In Subjects 70-79 Years: A Meta-Analysis, James Roush, R. Curtis Bay
Internet Journal of Allied Health Sciences and Practice
It has been suggested that walking speed is the sixth vital sign. To adequately assess the status of walking speed of patients, normative data or percentile ranks are required. The purpose of this study was to develop percentile ranks for walking speed using a meta-analytic approach for independent, community-dwelling males and females between 70 and 79 years of age. Using PubMed and CINAHL, articles were included in the analysis if: 1) subjects were between 70 and 79 years of age; 2) “walking speed” was described as “comfortable,” “preferred,” “usual,” “normal,” or “self-selected”; 3) subjects were classified as independent and community-dwelling; …
Using Learning Style Preferences To Enhance The Education And Training Of Allied Health Professionals, Thomas Sinnerton, Laurence Leonard, Katherine M. A. Rogers
Using Learning Style Preferences To Enhance The Education And Training Of Allied Health Professionals, Thomas Sinnerton, Laurence Leonard, Katherine M. A. Rogers
Internet Journal of Allied Health Sciences and Practice
Paramedics-in-training enter the service from a variety of academic backgrounds; this is similar to a pattern observed in the training of other allied health professions such as nursing. Given the diverse academic backgrounds of these students, the purpose is to investigate how an educator’s awareness of learning style preferences could help students to engage more deeply with the training material and reduce the pattern of shallow learning sometimes observed in these students because of the protocol-nature of certain aspects of the paramedic (and other allied health) courses. By encouraging paramedic trainers and allied health educators to become aware of the …
The Correlation Between Sleep Efficiency And The Risk Of Obstructive Sleep Apnea, Mazen Munaji Homoud
The Correlation Between Sleep Efficiency And The Risk Of Obstructive Sleep Apnea, Mazen Munaji Homoud
Internet Journal of Allied Health Sciences and Practice
Purpose: The purpose of this correlation research was to identify the relationship between Obstructive Sleep Apnea (OSA) and sleep efficiency. Subjects: A total of six men and twelve women (N=18) form the College of Health Professions fulfilled the requirements for inclusion in this study. Method: This research integrated two investigation methods. 1) STOP-BANG questionnaire was completed by students and faculty from the College of Health Professions at Texas State University. Then, 2) each participant wore an Actigraphy watch for seven days. The result of the STOP-BANG questionnaire was compared to the result of the Actigraphy in regard to low or …
Evaluation And Integration Of Genetic Signature For Prediction Risk Of Nasopharyngeal Carcinoma In Southern China, Xiuchan Guo, Cheryl Winkler, Ji Li, Li Guan, Minzhong Tang, Jian Liao, Hong Deng, Guy De The, Yi Zeng, Stephen J. O'Brien
Evaluation And Integration Of Genetic Signature For Prediction Risk Of Nasopharyngeal Carcinoma In Southern China, Xiuchan Guo, Cheryl Winkler, Ji Li, Li Guan, Minzhong Tang, Jian Liao, Hong Deng, Guy De The, Yi Zeng, Stephen J. O'Brien
Biology Faculty Articles
Genetic factors, as well as environmental factors, play a role in development of nasopharyngeal carcinoma (NPC). A number of single nucleotide polymorphisms (SNPs) have been reported to be associated with NPC. To confirm these genetic associations with NPC, two independent case-control studies from Southern China comprising 1166 NPC cases and 2340 controls were conducted. Seven SNPs in ITGA9 at 3p21.3 and 9 SNPs within the 6p21.3 HLA region were genotyped. To explore the potential clinical application of these genetic markers in NPC, we further evaluate the predictive/diagnostic role of significant SNPs by calculating the area under the curve (AUC). Results …
Goal-Subgoal Conflict As The Core Feature Of Delay Of Gratification, Violet Cheung-Blunden, Jennifer L. Zahm
Goal-Subgoal Conflict As The Core Feature Of Delay Of Gratification, Violet Cheung-Blunden, Jennifer L. Zahm
Archives of Assessment Psychology
While delay of gratification is a well-established individual difference, its assessment is limited by the original delay paradigm, which is only valid in the age range of four to 11 years. If delay of gratification were to be construed as a competence of resolving goal-subgoal conflicts, a specific type of puzzle games, with a feature called ambiguous subgoal ordering, can be used as an alternative assessment tool. While the child version of this type of puzzle, the Dog-Cat-Mouse task (DCM), is available; an adult version, the Dog-Cat-Mouse-Rabbit task (DCMR), had to be developed. Two studies were conducted to establish the …
Visuospatial, Visuoperceptual And Visuoconstructing Abilities In Traumatic Brain Injury: The Effects Of Injury Severity And Effort, Luis E. Aguerrevere, Kevin W. Greve, Kevin J. Bianchini, Jonathan S. Ord
Visuospatial, Visuoperceptual And Visuoconstructing Abilities In Traumatic Brain Injury: The Effects Of Injury Severity And Effort, Luis E. Aguerrevere, Kevin W. Greve, Kevin J. Bianchini, Jonathan S. Ord
Archives of Assessment Psychology
The study's objective was to determine the effects of Traumatic Brain Injury (TBI) on visuospatial, visuoperceptual and visuoconstructing skills while controlling for effort. TBI cases were classified by injury severity as mild or moderate-severe, and by effort measured based on performance on four validity-indicators. TBI cases were also compared to demographically-matched healthy control subjects. Visuospatial, visuoperceptual and visuoconstructing abilities scores were obtained from the performance on five common neuropsychological tests: Rey-Osterrieth Complex Figure, Benton Facial Test as well as Matrix Reasoning, Picture Completion and Block Design from the Wechsler Adult Intelligence Test-III. Patients classified as mild TBI good effort demonstrated …
The Factor Structure And Psychometric Properties Of The Greek Version Of Career Motivational Types (Cmt-Q): Cross-Cultural Comparison In Greece And Bulgaria, Vaitsa Giannouli, Stanislava Stoyanova
The Factor Structure And Psychometric Properties Of The Greek Version Of Career Motivational Types (Cmt-Q): Cross-Cultural Comparison In Greece And Bulgaria, Vaitsa Giannouli, Stanislava Stoyanova
Archives of Assessment Psychology
The psychometric properties of a Career Motivational Types Questionnaire based on Moses (2003) typology of major career motivators were studied in a Greek sample of 123 subjects (workers and unemployed people) in 2013. The results were compared with those coming from a Bulgarian sample of 132 subjects (workers, unemployed people and students) studied in 2013. A cohort comparison was performed on major Bulgarian career motivational types between the years 2007 and 2013. The similarities in the major motivators in both countries concerned prevalence of Personal developers, Stability seekers and Authenticity seekers as career motivational types and more diverse career motivators …
Genome-Wide And Differential Proteomic Analysis Of Hepatitis B Virus And Aflatoxin B1 Related Hepatocellular Carcinoma In Guangxi, China, Lu-Nan Qi, Le-Qun Qi, Yuan-Yuan Chen, Zhao-Hong Chen, Tao Bai, Bang-De Xiang, Xiao Qin, Kai-Yin Xiao, Min-Hao Peng, Zhi-Ming Liu, Tang-Wei Liu, Xue Qin, Shan Li, Ze-Guang Han, Zeng-Nan Mo, Regina M. Santella, Cheryl Winkler, Stephen J. O'Brien, Tao Peng
Genome-Wide And Differential Proteomic Analysis Of Hepatitis B Virus And Aflatoxin B1 Related Hepatocellular Carcinoma In Guangxi, China, Lu-Nan Qi, Le-Qun Qi, Yuan-Yuan Chen, Zhao-Hong Chen, Tao Bai, Bang-De Xiang, Xiao Qin, Kai-Yin Xiao, Min-Hao Peng, Zhi-Ming Liu, Tang-Wei Liu, Xue Qin, Shan Li, Ze-Guang Han, Zeng-Nan Mo, Regina M. Santella, Cheryl Winkler, Stephen J. O'Brien, Tao Peng
Biology Faculty Articles
Both hepatitis B virus (HBV) and aflatoxin B1 (AFB1) exposure can cause liver damage as well as increase the probability of hepatocellular carcinoma (HCC). To investigate the underlying genetic changes that may influence development of HCC associated with HBV infection and AFB1 exposure, HCC patients were subdivided into 4 groups depending upon HBV and AFB1 exposure status: (HBV(+)/AFB1(+), HBV(+)/AFB1(-), HBV(-)/AFB1(+), HBV(-)/AFB1(-)). Genetic abnormalities and protein expression profiles were analyzed by array-based comparative genomic hybridization and isobaric tagging for quantitation. A total of 573 chromosomal aberrations (CNAs) including 184 increased and 389 decreased were detected in our study population. Twenty-five recurrently …
Medical Education Digest, Vol. 15 No. 6 (November-December 2013), Nova Southeastern University
Medical Education Digest, Vol. 15 No. 6 (November-December 2013), Nova Southeastern University
Medical Education Digest
No abstract provided.
A Genome-To-Genome Analysis Of Associations Between Human Genetic Variation, Hiv-1 Sequence Diversity, And Viral Control, Istvan Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. Mclaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio Lopez-Galindez, Concepcion Casado, Andri Rauch, Huldrych F. Gunthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltan Kutalik, Todd M. Allen, Viktor Muller, P. Richard Harrigan, David Heckerman, Amalio Telenti, Jacques Fellay
A Genome-To-Genome Analysis Of Associations Between Human Genetic Variation, Hiv-1 Sequence Diversity, And Viral Control, Istvan Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. Mclaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio Lopez-Galindez, Concepcion Casado, Andri Rauch, Huldrych F. Gunthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltan Kutalik, Todd M. Allen, Viktor Muller, P. Richard Harrigan, David Heckerman, Amalio Telenti, Jacques Fellay
Biology Faculty Articles
HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence variation and plasma viral load (VL), while considering human and viral population structure. We observed significant human SNP associations to a total of 48 HIV-1 amino acid variants (p<2.4 × 10−12). All associated SNPs mapped to the HLA class I region. Clinical relevance of host and pathogen variation was assessed using VL results. We identified two critical advantages to the use of viral variation …2.4>
Com Outlook Fall 2013, College Of Osteopathic Medicine
Com Outlook Fall 2013, College Of Osteopathic Medicine
COM Outlook
No abstract provided.
The Lli Chronicle Volume 4 Number 3, Nova Southeastern University - Shepard Broad College Of Law
The Lli Chronicle Volume 4 Number 3, Nova Southeastern University - Shepard Broad College Of Law
Lifelong Learning Institute Newsletters
No abstract provided.
Allied Health Students’ Perceptions Of Class Difficulty: The Case Of Undergraduate Human Anatomy And Physiology Classes, Diana Sturges, Trent Mauner
Allied Health Students’ Perceptions Of Class Difficulty: The Case Of Undergraduate Human Anatomy And Physiology Classes, Diana Sturges, Trent Mauner
Internet Journal of Allied Health Sciences and Practice
Purpose: The Human Anatomy and Physiology (HAP) course is required of all allied health majors. Students need to earn a grade of “C” or better, and many students find this class academically challenging. This study investigated allied health students’ perceptions of what makes the undergraduate class difficult. Methods: A 28-question survey targeted 403 students enrolled in three HAP sections taught by the same instructor. Results: Students returned 279 surveys (68% return rate). Qualitative and quantitative data supported a three factor model in making this class difficult: discipline, student, and teaching related factors. Students consider that discipline factors are more important …
Pharmacological Characterization Of A Novel Non-At1, Non-At2 Angiotensin Binding Site Identified As Neurolysin, Jamala D. Swindle, Kira L. Santos, Robert C. Speth
Pharmacological Characterization Of A Novel Non-At1, Non-At2 Angiotensin Binding Site Identified As Neurolysin, Jamala D. Swindle, Kira L. Santos, Robert C. Speth
HPD Articles
The discovery of a novel non-AT1, non-AT2 binding site for angiotensins in the rodent brain and testis that is unmasked by the organomercurial compound para-chloromercuribenzoic acid (PCMB) has catalyzed efforts to purify and characterize this protein. We recently reported that this protein is neurolysin and now report upon the specificity of this binding site for various neuropeptides. Competition binding assays in rat brain and testis used (125)I-Sar(1), Ile(8) angiotensin II (Ang II) as the radioligand in the presence of saturating concentrations of AT1 and AT2 receptor antagonists and 100 μM parachloromercuribenzoate. Primary screening of 36 peptides and other compounds at …