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Articles 2941 - 2970 of 4001

Full-Text Articles in Medicine and Health Sciences

The Walking Interview: An Ethnographic Approach To Understanding Disability, Mary Butler, Sarah Derrett Jul 2014

The Walking Interview: An Ethnographic Approach To Understanding Disability, Mary Butler, Sarah Derrett

Internet Journal of Allied Health Sciences and Practice

The purpose of this paper is to describe a method of interviewing where walking is explicitly the focus. The interviews were one element of a qualitative study, which was part of a multi-method prospective outcomes of injury study. Four participants were purposively chosen for follow up because they had an injury following a pre-existing disability. The results of this study indicate walking as a method of interviewing has the capacity to add depth and richness to the kind of information obtained. The process of walking lends itself a range of affordances, including shifting the power balance implicit in the research …


Integrated Clinical Experiences In A Campus Onsite Clinic: A Self-Contained Model Of Physical Therapy Clinical Education, Ann M. Wilson Jul 2014

Integrated Clinical Experiences In A Campus Onsite Clinic: A Self-Contained Model Of Physical Therapy Clinical Education, Ann M. Wilson

Internet Journal of Allied Health Sciences and Practice

Purpose: This paper describes a self-contained model of integrated clinical experiences (ICEs) that take place during the academic portion of an entry-level physical therapist education program in a campus onsite clinic. Description of Model: Students participate in ICEs for three consecutive semesters. Students provide pro bono physical therapy services to individuals with impairments, functional limitations, or changes in physical function resulting from a variety of health conditions. In addition, students participate in an exercise/wellness program for individuals who wish to improve or maintain their current levels of fitness. The first ICE consists of second-year students observing/assisting third-year students in the …


Using Debriefing To Foster Task Management Among Anesthesiologist Assistant Students, Llalando Austin Jul 2014

Using Debriefing To Foster Task Management Among Anesthesiologist Assistant Students, Llalando Austin

Internet Journal of Allied Health Sciences and Practice

Purpose: This study evaluated the effect of video-aided oral debriefing on task management of anesthesiologist assistant students through the use of high-fidelity anesthesia crisis simulation scenarios. This information describes an evaluation of student learning that is valuable in student educational and workplace competency. Method: A total of 18 graduate students in an anesthesiologist assistant program voluntarily participated in two anesthesia simulation scenarios separated by one of two debriefing methods (oral debriefing versus video-aided oral debriefing). Task management scores of the scenarios were assessed through the Anesthetists’ Nontechnical Skills system. Task management scores after the pre-intervention scenario were compared to the …


Effect Of Cueing On Learning Transfer Among Health Profession Students Engaged In A Case-Based Analogical Reasoning Exercise, Timothy Speicher, Alexandra Bell, Marijke Kehrhahn, Douglas Casa Jul 2014

Effect Of Cueing On Learning Transfer Among Health Profession Students Engaged In A Case-Based Analogical Reasoning Exercise, Timothy Speicher, Alexandra Bell, Marijke Kehrhahn, Douglas Casa

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to examine the effect of cueing on learning transfer among pre-professional, health profession undergraduates engaged in a case-based analogical reasoning exercise. Methods: The study design was a quasi-experimental, randomized post-test design. Volunteer undergraduate pre-professional health profession students (N = 192) were assigned to either an experimental group, which received two written clinical cases with cues or the control, which received the same cases, but no cues. After participants read the cases, a target case was provided for solution based on the previous cases. Target case solutions were scored by content experts for extent …


A Qualitative Evaluation Of Blood Pressure Screening Procedures In The Illinois Wisewomen Program, James Broadbear, Barbara Broadbear, Adrian Lyde, Sharon Mills Jul 2014

A Qualitative Evaluation Of Blood Pressure Screening Procedures In The Illinois Wisewomen Program, James Broadbear, Barbara Broadbear, Adrian Lyde, Sharon Mills

Internet Journal of Allied Health Sciences and Practice

Hypertension is a major modifiable risk factor for cardiovascular disease and various other conditions. Approximately 70 million Americans are hypertensive. Among women age 18 and over, 31.7% have high blood pressure (BP) and only about 60% of those women have it under control. The purpose of this evaluation was to understand blood pressure screening procedures among Illinois WISEWOMAN Program (IWP) providers. Procedures at primary care providers (PCP) compared to obstetrician/gynecologists (OB/GYN) were of interest. A qualitative approach was used featuring interviews with allied health staff members who conduct blood pressure screenings. The focus of the interviews included the use and …


Health Promotion Strategies Derived From A Metropolitan Police Weight Loss Competition With Weight Loss Comparisons By Gender And Bmi Category, Robert Boyce, Tyler Willett, Allen Mullins, Glenn Jones, Randy Cottrell Jul 2014

Health Promotion Strategies Derived From A Metropolitan Police Weight Loss Competition With Weight Loss Comparisons By Gender And Bmi Category, Robert Boyce, Tyler Willett, Allen Mullins, Glenn Jones, Randy Cottrell

Internet Journal of Allied Health Sciences and Practice

Background: Weight management is critical in police work. It can have both legal and life-saving implications as it is linked to the health and physical readiness of the officers. A weight loss competition is one way to address weight management in police work. Among the factors to consider is gender impact, as females forge forward within a male environment. Also, assessing weight loss among obesity categories is essential for designing effective programing. Purpose: To compare mass changes among body mass index (BMI) categories and between genders at biweekly weigh-ins during a 12-week competition with recommendations for professionals. Methods: Before the …


Issue Of Adjustment To Continuous Subcutaneous Insulin Infusion Devices, Emily F. Piven, Ursel Lovett, Homer Nazeran, Julia Bader Jul 2014

Issue Of Adjustment To Continuous Subcutaneous Insulin Infusion Devices, Emily F. Piven, Ursel Lovett, Homer Nazeran, Julia Bader

Internet Journal of Allied Health Sciences and Practice

Introduction: Continuous subcutaneous insulin infusion with an insulin pump provides best practice for prevention of tertiary complications of insulin-dependent diabetes. Purpose: The aim of the study was to identify self-care adjustment issues to pump technology via a computer-based survey. Method: Internal reliability of the Adaptation to Insulin Pumps Survey was 0.765 (Cronbach’s alpha). The validated survey was emailed to a convenience sample of 10,000 users. Logistic regression analysis was done on each binary variable, testing for Group effect, while controlling for age and gender. Results: There were 959 responders. Seventeen survey statements relating to barriers, intrusiveness, attitude, and adaptations had …


Global Summation Of Radial Frequency Patterns And The Effect Of Sudden Onset Glare On Shape Discrimination, Edgar Ekure Jun 2014

Global Summation Of Radial Frequency Patterns And The Effect Of Sudden Onset Glare On Shape Discrimination, Edgar Ekure

Student Theses, Dissertations and Capstones

ABSTRACT Global summation of radial frequency patterns and the effect of sudden onset glare on shape discrimination The purpose of this study was to provide evidence of global pooling around the circumference of the Radial frequency (RF) pattern, and to study the effect of sudden onset glare on shape discrimination. The RF stimuli were generated by the amplitude modulation of the radius of a circle which deforms them from circularity, while the cross sectional luminance profile was the fourth derivative of Gaussians (D4). The amplitude of the stimuli determines how distinct the pattern is and thus measures the degree of …


Cytokine Production But Lack Of Proliferation In Peripheral Blood Mononuclear Cells From Chronic Chagas' Disease Cardiomyopathy Patients In Response To T. Cruzi Ribosomal P Proteins, Silvia A. Longhi, Augusto Atienza, Graciela Perez Prados, Alcinette Buying, Virginia Balouz, Carlos A. Buscaglia, Radleigh Santos, Laura M. Tasso, Ricardo Bonato, Pablo Chiale, Clemencia Pinilla, Valeria A. Judkowski, Karina A. Gomez Jun 2014

Cytokine Production But Lack Of Proliferation In Peripheral Blood Mononuclear Cells From Chronic Chagas' Disease Cardiomyopathy Patients In Response To T. Cruzi Ribosomal P Proteins, Silvia A. Longhi, Augusto Atienza, Graciela Perez Prados, Alcinette Buying, Virginia Balouz, Carlos A. Buscaglia, Radleigh Santos, Laura M. Tasso, Ricardo Bonato, Pablo Chiale, Clemencia Pinilla, Valeria A. Judkowski, Karina A. Gomez

Mathematics Faculty Articles

Background

Trypanosoma cruzi ribosomal P proteins, P2β and P0, induce high levels of antibodies in patients with chronic Chagas' disease Cardiomyopathy (CCC). It is well known that these antibodies alter the beating rate of cardiomyocytes and provoke apoptosis by their interaction with β1-adrenergic and M2-muscarinic cardiac receptors. Based on these findings, we decided to study the cellular immune response to these proteins in CCC patients compared to non-infected individuals.

Methodology/Principal findings

We evaluated proliferation, presence of surface activation markers and cytokine production in peripheral blood mononuclear cells (PBMC) stimulated with P2β, the C-terminal portion of P0 (CP0) proteins and T. …


The Effects Of Consuming A High Protein Diet (4.4 G/Kg/D) On Body Composition In Resistance-Trained Individuals, Jose Antonio, Corey Peacock, A. Ellerbroek, B. Fromnoff, Tobin A. Silver May 2014

The Effects Of Consuming A High Protein Diet (4.4 G/Kg/D) On Body Composition In Resistance-Trained Individuals, Jose Antonio, Corey Peacock, A. Ellerbroek, B. Fromnoff, Tobin A. Silver

Department of Health and Human Performance Faculty Articles

BACKGROUND:

The consumption of dietary protein is important for resistance-trained individuals. It has been posited that intakes of 1.4 to 2.0 g/kg/day are needed for physically active individuals. Thus, the purpose of this investigation was to determine the effects of a very high protein diet (4.4 g/kg/d) on body composition in resistance-trained men and women.

METHODS:

Thirty healthy resistance-trained individuals participated in this study (mean ± SD; age: 24.1 ± 5.6 yr; height: 171.4 ± 8.8 cm; weight: 73.3 ± 11.5 kg). Subjects were randomly assigned to one of the following groups: Control (CON) or high protein (HP). The CON …


Medical Education Digest, Vol. 16 No. 3 (May/June 2014), Nova Southeastern University May 2014

Medical Education Digest, Vol. 16 No. 3 (May/June 2014), Nova Southeastern University

Medical Education Digest

No abstract provided.


Selective Inhibition Of Angiotensin Receptor Signaling Through Erk1/2 Pathway By A Novel Peptide, Jun Liu, Gina L. Yosten, Hong Ji, Dan Zhang, Wei Zheng, Robert C. Speth, Willis K. Samson, Kathryn Sandberg Apr 2014

Selective Inhibition Of Angiotensin Receptor Signaling Through Erk1/2 Pathway By A Novel Peptide, Jun Liu, Gina L. Yosten, Hong Ji, Dan Zhang, Wei Zheng, Robert C. Speth, Willis K. Samson, Kathryn Sandberg

HPD Articles

A seven-amino acid peptide (PEP7) is encoded within a short open reading frame within exon 2 (E2) in the 5'-leader sequence (5'LS) upstream of the rat ANG 1a-receptor (rAT1aR) mRNA. A chemically synthesized PEP7 markedly inhibited ANG II-induced Erk1/2 activation in cell culture by 62% compared with a scrambled PEP7 (sPEP7) [pErk1/2/Erk1/2 (AU): ANG II, 1.000 ± 0.0, ANG II+PEP7, 0.3812 ± 0.086, ANG II+sPEP7, 1.069 ± 0.18; n = 3]. Under these same conditions, PEP7 had no effect on ANG II-stimulated inositol-trisphosphate production. PEP7 also had no effect on epidermal growth factor- and phorbol methyl ester-induced Erk1/2 activation, suggesting …


13th Annual Undergraduate Student Symposium, Farquhar Honors College Apr 2014

13th Annual Undergraduate Student Symposium, Farquhar Honors College

Undergraduate Student Symposium

The Undergraduate Student Symposium, sponsored by the Farquhar College of Arts and Sciences, presents student projects through presentations, papers, and poster displays. The event serves as a “showcase” demonstrating the outstanding scholarship of undergraduate students at NSU. The Symposium is open to undergraduate students from all disciplines. Projects cover areas of student scholarship ranging from the experimental and the applied to the computational, theoretical, artistic, and literary. They are taken from class assignments as well as from independent projects. The projects do not have to be complete; presentations can represent any stage in the concept’s evolution, from proposal and literature …


Com Outlook Spring 2014, College Of Osteopathic Medicine Apr 2014

Com Outlook Spring 2014, College Of Osteopathic Medicine

COM Outlook

No abstract provided.


The Lli Chronicle Volume 5 Number 2, Nova Southeastern University Apr 2014

The Lli Chronicle Volume 5 Number 2, Nova Southeastern University

Lifelong Learning Institute Newsletters

No abstract provided.


The Edward Bliss Emerson Journal Project: Qualitative Research By A Non-Hierarchical Team, José G. Rigau-Pérez, Silvia E. Rabionet, Annette B. Ramírez De Arellano, Wilfredo A. Géigel, Alma Simounet, Raúl Mayo-Santana Apr 2014

The Edward Bliss Emerson Journal Project: Qualitative Research By A Non-Hierarchical Team, José G. Rigau-Pérez, Silvia E. Rabionet, Annette B. Ramírez De Arellano, Wilfredo A. Géigel, Alma Simounet, Raúl Mayo-Santana

The Qualitative Report Books

Edward Bliss Emerson (1805-1834), a younger brother of the renowned essayist and poet Ralph Waldo Emerson, lived in the Caribbean for the final three years of his life. His journal and letters are a rich manuscript source for the history of the Danish Virgin Islands (1831-1832) and Puerto Rico (1831-1834). The texts also reflect the contemporary political and cultural situation in the United States, and Edward's search for health, economic independence, intellectual stimulation and metaphysical fulfillment.

These writings ignited an intellectual passion in José G. Rigau-Pérez, a physician, medical epidemiologist, and historian in Puerto Rico. Furthering access to these unique …


The Fda Funding Crisis, Judith Alphonse, Sireesha Bellam, Marlene Fernandez, Anishka Gilbert, Lauren Roper, Antonia Zapantis, Robert C. Speth Apr 2014

The Fda Funding Crisis, Judith Alphonse, Sireesha Bellam, Marlene Fernandez, Anishka Gilbert, Lauren Roper, Antonia Zapantis, Robert C. Speth

HPD Articles

The role of the Food and Drug Administration (FDA) is to ensure the safety of prescription and nonprescription drugs, dietary supplements, and the food supply, representing more than 20% of US consumer spending. The increased need to monitor imported drugs, drug products and foods, drug shortages, and compounding pharmacies bring the adequacy of FDA funding into question. Performing even at status quo cannot be accomplished if responsibilities increase without equitable funding increases: both from the federal government and fees imposed on FDA-regulated industries. Additionally, scientific advancement, new legislation, and new industries are continually increasing the FDA workload, necessitating commensurate budget …


Evidence-Based Health Literacy Training Program For Occupational Therapy Professionals : Program Development And Evaluation, Cheryl Miller-Scott Apr 2014

Evidence-Based Health Literacy Training Program For Occupational Therapy Professionals : Program Development And Evaluation, Cheryl Miller-Scott

Occupational Therapy Program Student Theses, Dissertations and Capstones

This capstone project is a training program development and evaluation project. The purpose of the project was to develop, pilot, and evaluate an

evidence-based health literacy training program for occupational therapy professionals. Occupational therapy strives to be a science-driven profession, which provides client-centered care. Health literacy is a client-centered factor for which occupational therapy professionals require additional training to best serve their clients in all settings and across the lifespan. A review of health literacy literature was used in this project to develop the training program and offers a science-driven approach to this client-centered factor for occupational therapists to better …


Transfusion-Related Acute Lung Injury: What The Allied Health Professional Needs To Know About This Life -Threatening Hazard Of Blood Transfusion, Kevin P. Collins, Thomas L. Patterson Apr 2014

Transfusion-Related Acute Lung Injury: What The Allied Health Professional Needs To Know About This Life -Threatening Hazard Of Blood Transfusion, Kevin P. Collins, Thomas L. Patterson

Internet Journal of Allied Health Sciences and Practice

Transfusion-Related Acute Lung Injury (TRALI) is a rare, life-threatening hazard of blood transfusion. In the intensive care unit, 37% to 44% of admitted patients are transfused with at least one blood component. The opportunity for health professionals and students from nursing, respiratory care, and clinical laboratory science to interact directly with patients receiving a blood transfusion is likely to present itself on a daily basis. It is imperative for those caring for critically ill patients to be fully aware of the clinical signs of TRALI and have knowledge in the prevention and treatment of this clinical syndrome. Common clinical signs …


Consideration For Lumbar Disc Degeneration And Herniation In Sports, Ziva Majcen, Tanja Rauter Pungartnik, Nejc Sarabon Apr 2014

Consideration For Lumbar Disc Degeneration And Herniation In Sports, Ziva Majcen, Tanja Rauter Pungartnik, Nejc Sarabon

Internet Journal of Allied Health Sciences and Practice

Lower-back related injuries in an athletic population are common and may have severe implications for the athletes sporting career. The focus of this work was to review epidemiology, intervention strategies, and recommendations for return to practice and competition for athletes with lumbar disc degeneration and herniated disc. Conservative treatments for discogenic degeneration and lumbar spine herniation are generally sufficient for athletic populations to restore functional movement. Athletes that fail to respond to conservative measures may consider lumbar discectomy, with high levels of return to pre-competition levels observed following effective surgery. Surgical procedures such as spinal fusion and disc replacement require …


Professional Behavior In Physical Therapist Educational Programs: Perspectives Of Selected Senior Faculty, Tamara L. Phelan Apr 2014

Professional Behavior In Physical Therapist Educational Programs: Perspectives Of Selected Senior Faculty, Tamara L. Phelan

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to analyze how selected senior instructors in physical therapist educational programs define and seek to impart information on professional behavior. Methods: A qualitative case study approach was used to gather data from eight instructors teaching in four physical therapist educational programs in a selected region. Each interview was analyzed as an individual case study, followed by a cross case analysis to identify common themes. Results: Interpretational analysis using a process of constant comparison revealed nine common themes: 1) Instructors found it difficult to broadly define professional behavior. 2) Instructors expect students to be …


Community Peer-Led Exercise Groups: Reasons For Success, Linda Robertson, Beatrice Hale, Debra Waters, Leigh Hale, Alexa Andrew Apr 2014

Community Peer-Led Exercise Groups: Reasons For Success, Linda Robertson, Beatrice Hale, Debra Waters, Leigh Hale, Alexa Andrew

Internet Journal of Allied Health Sciences and Practice

Purpose: This paper considers reasons for the successful maintenance of community based, falls-prevention programs. While the physical achievement of such programs has been demonstrated through randomized trials, other features influential in ongoing membership have received less attention. This study examined the sustainability of a specific model of a community-based program in a New Zealand city: SAYGO, the strength and balance classes for older adults lead by older volunteer leaders recruited from local communities. Method: A qualitative, descriptive approach was used and first-hand knowledge of the experiences of those involved in the groups gathered. Data collection methods included individual interviews of …


A Study Of Knowledge And Practical Skill Performance In University Students: A Comparison Of Technology Enriched Versus Traditional Classroom Instruction, Adrian W. Eads, J. Jordan Hamson-Utley Apr 2014

A Study Of Knowledge And Practical Skill Performance In University Students: A Comparison Of Technology Enriched Versus Traditional Classroom Instruction, Adrian W. Eads, J. Jordan Hamson-Utley

Internet Journal of Allied Health Sciences and Practice

Context: Technology is increasingly utilized in the delivery of athletic training education. Hand-held technology affords continued education outside the classroom. Purpose: To determine the effect of mobile technology on the acquisition of knowledge and practical skills in a university upper extremity evaluation course. Design and Setting: A cohort retrospective archival assessment in a university office environment of grades and performance on written and practical examinations in an upper extremity evaluation course. Participants: Sixty-four college age participants (male n=35, 54.69%, female n=29, 45.31%) previously enrolled in an undergraduate or graduate athletic training program who completed the upper extremity evaluation course between …


Perceptions Of Assessment Among Undergraduate And Postgraduate Students Of Four Health Science Disciplines, Wayne J. Wilson, Anne Bennison, Wendy Arnott, Clair Hughes, Rosemary Isles, Jenny Strong Apr 2014

Perceptions Of Assessment Among Undergraduate And Postgraduate Students Of Four Health Science Disciplines, Wayne J. Wilson, Anne Bennison, Wendy Arnott, Clair Hughes, Rosemary Isles, Jenny Strong

Internet Journal of Allied Health Sciences and Practice

The use of different types of assessment to improve student learning needs to be balanced with reports that student perception, rather than the objective features of the task, significantly influences how students approach learning. The present study surveyed 492 undergraduate and postgraduate students from four health science disciplines (occupational therapy, physiotherapy, speech pathology, and audiology) at a large Australian university on how helpful different types of assessment had been in assisting their learning. Between 73.4% and 90.4% of the students valued practical exams, individual tasks, written assignments, and written exams requiring application of knowledge. Between 29.1% and 59.7% of the …


Reliability And Feasibility Of The Four Square Step Test For Use In Children With Cerebral Palsy: A Pilot Study, Edward James R. Gorgon, Gilbert O. Madriaga, Minerva Z. Gomez-Cailao, Levin S. Abdon, Mary Ann D. Boniquit Apr 2014

Reliability And Feasibility Of The Four Square Step Test For Use In Children With Cerebral Palsy: A Pilot Study, Edward James R. Gorgon, Gilbert O. Madriaga, Minerva Z. Gomez-Cailao, Levin S. Abdon, Mary Ann D. Boniquit

Internet Journal of Allied Health Sciences and Practice

Purpose: The ability to maintain standing balance with a moving base of support and while making rapid postural adjustments is important for independence in various functional activities. Clinical tests and measures have not addressed this ability in children with disability. This pilot study examined the feasibility and reliability of the Four Square Step Test (FSST) as a test of dynamic balance in children with cerebral palsy (CP). Method: Four children with CP (Gross Motor Function Classification Scale levels I-II) were tested on the FSST by 3 assessors on the first occasion (interrater reliability) and repeat-tested by 1 assessor after 2 …


Assimilation Of The Patient Rights Law And Code Of Ethics Into Israeli Physical Therapy Services, Tamar Jacob, Ilana Zilberstein Apr 2014

Assimilation Of The Patient Rights Law And Code Of Ethics Into Israeli Physical Therapy Services, Tamar Jacob, Ilana Zilberstein

Internet Journal of Allied Health Sciences and Practice

The ethical conduct of physical therapists is usually based on intuition rather than on theoretical knowledge. This study aimed to examine to what degree rules of ethics anchored in the Patient Rights Law and in the Physical Therapy Code of Ethics in Israel have been assimilated in physical therapy (PT) services. A qualitative study based on personal semi structured interviews with national directors of PT services in Israel was conducted. The directors think that the ethical conduct of physical therapists is based mainly on intuition and on self-perceived ethics rather than on learned principles. In their opinion, the Patient Rights …


In Vitro Interaction Of Pseudomonas Aeruginosa With Human Middle Ear Epithelial Cells, Rahul Mittal, M'Hamed Grati, Robert Gerring, Patricia Blackwelder, Denise Yan, Jian-Dong Li, Xue Zhong Liu Mar 2014

In Vitro Interaction Of Pseudomonas Aeruginosa With Human Middle Ear Epithelial Cells, Rahul Mittal, M'Hamed Grati, Robert Gerring, Patricia Blackwelder, Denise Yan, Jian-Dong Li, Xue Zhong Liu

Marine & Environmental Sciences Faculty Articles

Background: Otitis media (OM) is an inflammation of the middle ear which can be acute or chronic. Acute OM is caused by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis whereas Pseudomonas aeruginosa is a leading cause of chronic suppurative otitis media (CSOM). CSOM is a chronic inflammatory disorder of the middle ear characterized by infection and discharge. The survivors often suffer from hearing loss and neurological sequelae. However, no information is available regarding the interaction of P. aeruginosa with human middle ear epithelial cells (HMEECs).

Methodology and Findings: In the present investigation, we demonstrate that P. …


Medical Education Digest, Vol. 16 No. 2 (March/April 2014), Nova Southeastern University Mar 2014

Medical Education Digest, Vol. 16 No. 2 (March/April 2014), Nova Southeastern University

Medical Education Digest

No abstract provided.


Role Of Erk1, 2, And 5 In Dopamine Neuron Survival During Aging, Mayur S. Parmar, Juliann D. Jaumotte, Stephanie L. Wyrostek, Michael J. Zigmond, Jane E. Cavanaugh Mar 2014

Role Of Erk1, 2, And 5 In Dopamine Neuron Survival During Aging, Mayur S. Parmar, Juliann D. Jaumotte, Stephanie L. Wyrostek, Michael J. Zigmond, Jane E. Cavanaugh

HPD Articles

Extracellular signal-regulated kinases (ERKs) 1, 2, and 5 have been shown to play distinct roles in proliferation, differentiation, and neuronal viability. In this study, we examined ERK1, 2, and 5 expression and activation in the substantia nigra (SN), striatum (STR), and ventral tegmental area (VTA) during aging. An age-related decrease in phosphorylated ERK5 was observed in the SN and STR, whereas an increase in total ERK1 was observed in all 3 regions. In primary cultures of the SN and VTA, inhibition of ERK5 but not ERK1 and 2 decreased dopamine neuronal viability significantly. These data suggest that ERK5 is essential …


Identification Of Tetrapeptides From A Mixture Based Positional Scanning Library That Can Restore Nm Full Agonist Function Of The L106p, I69t, I102s, A219v, C271y, And C271r Human Melanocortin-4 Polymorphic Receptors (Hmc4rs), Erica M. Haslach, Huisuo Huang, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Skye R. Doering, Michael A. Walters, Richard A. Houghten, Carrie Haskell-Luevano Feb 2014

Identification Of Tetrapeptides From A Mixture Based Positional Scanning Library That Can Restore Nm Full Agonist Function Of The L106p, I69t, I102s, A219v, C271y, And C271r Human Melanocortin-4 Polymorphic Receptors (Hmc4rs), Erica M. Haslach, Huisuo Huang, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Radleigh Santos, Marc Giulianotti, Clemencia Pinilla, Jon R. Appel, Skye R. Doering, Michael A. Walters, Richard A. Houghten, Carrie Haskell-Luevano

Mathematics Faculty Articles

Human obesity has been linked to genetic factors and single nucleotide polymorphisms (SNPs). Melanocortin-4 receptor (MC4R) SNPs have been associated with up to 6% frequency in morbidly obese children and adults. A potential therapy for individuals possessing such genetic modifications is the identification of molecules that can restore proper receptor signaling and function. These compounds could serve as personalized medications improving quality of life issues as well as alleviating diseases symptoms associated with obesity including type 2 diabetes. Several hMC4 SNP receptors have been pharmacologically characterized in vitro to have a decreased, or a lack of response, to endogenous agonists …