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Articles 451 - 480 of 1134

Full-Text Articles in Medicinal Chemistry and Pharmaceutics

Effect Of Water Cooking On Antioxidant Capacity Of Carotenoid-Rich Vegetables In Taiwan, F.-J. Kao, Y.-S. Chiu, W.-D. Chiang Jul 2020

Effect Of Water Cooking On Antioxidant Capacity Of Carotenoid-Rich Vegetables In Taiwan, F.-J. Kao, Y.-S. Chiu, W.-D. Chiang

Journal of Food and Drug Analysis

Carotenoid-rich green leafy vegetables including cilantro, Thai basil leaves, sweet potato leaves, and choy sum were selected to evaluate the effects of water cooking or boiling on their total carotenoid content (TCC), total phenolic content (TPC), and total antioxidant capacity (TAC). The percentage inhibition of peroxidation (%IP), Trolox equivalent antioxidant capacity (TEAC), and metal-chelating effect were used to evaluate TAC. The results indicated that TCC reached the maximum after boiling cilantro, Thai basil leaves, and sweet potato leaves for 10 minutes, 5 minutes, and 5 minutes, respectively, and choy sum remained almost unchanged after 30 minutes of boiling. Boiling cilantro …

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Tetrodotoxin And Paralytic Shellfish Poisons In Gastropod Species From Vietnam Analyzed By Highperformance Liquid Chromatography And Liquid Chromatography-Tandem Mass Spectrometry, H.-C. Jen, Nguyen T. Anh-Tuyet, Y.-J. Wu, T. Hoang, O. Arakawa, W.-F. Lin, D.-F. Hwang Jul 2020

Tetrodotoxin And Paralytic Shellfish Poisons In Gastropod Species From Vietnam Analyzed By Highperformance Liquid Chromatography And Liquid Chromatography-Tandem Mass Spectrometry, H.-C. Jen, Nguyen T. Anh-Tuyet, Y.-J. Wu, T. Hoang, O. Arakawa, W.-F. Lin, D.-F. Hwang

Journal of Food and Drug Analysis

notorious neurotoxins that induce serious food poisoning incidents in the Southeast Asia region. The aim of this study was to investigate whether TTX and PSP toxins are important issues of seafood safety. Paralytic toxicity was observed in mice exposed to 34 specimens from five species of gastropods using a PSP bioassay. Five species of gastropods, Natica vitellus, Natica tumidus, Oliva hirasei, Oliva lignaria, and Oliva annulata, were collected from the coastal seawaters in Nha Trang City, Vietnam, between August 2007 and October 2007. The average lethal potency of gastropod specimens was 90 ± 40 (mean ± standard deviation) mouse units …

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Forced Degradation Behavior Of Epidepride And Development Of A Stability-Indicating Method Based On Liquid Chromatography-Mass Spectrometry, W.-H. Chen, Y.-Y. Lin, Y. Chang, K.-W. Chang, Y.-C. Shia, K.-T. Liu Jul 2020

Forced Degradation Behavior Of Epidepride And Development Of A Stability-Indicating Method Based On Liquid Chromatography-Mass Spectrometry, W.-H. Chen, Y.-Y. Lin, Y. Chang, K.-W. Chang, Y.-C. Shia, K.-T. Liu

Journal of Food and Drug Analysis

A reversed-phase high performance liquid chromatography (RP-HPLC) and LC-tandem mass spectrometry (LC-MS/MS) method was applied to study the forced degradation behavior and stability of epidepride. 123I radioisotope-labeled epidepride, ((-)-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-5-iodo-2,3-dimethoxybenzamide) is a radio-tracer with a very high affinity for dopamine D2 receptors in the brain and has been used as an imaging agent for single-photon emission computed tomography (SPECT). HPLC studies were performed using 127I-epidepride (the non-radioactive compound), instead of 123I-epidepride, with an RP-18 column using a mobile phase consisting of methanol, acetonitrile, and ammonium acetate (pH 7.0, 10 mM). The eluent flow rate and the wavelength for HPLC detection were …

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Genotoxicity Of Titanium Dioxide Nanoparticles, T. Chen, J. Yan, Y. Li Jul 2020

Genotoxicity Of Titanium Dioxide Nanoparticles, T. Chen, J. Yan, Y. Li

Journal of Food and Drug Analysis

Titanium dioxide nanoparticles (TiO2-NPs, < 100 nm) are increasingly being used in pharmaceuticals and cosmetics due to the unique properties derived from their small sizes. However, their large surface-area to mass ratio and high redox potential may negatively impact human health and the environment. TiO2-NPs can cause inflammation, pulmonary damage, fibrosis, and lung tumors and they are possibly carcinogenic to humans. Because cancer is a disease involving mutation, there are a large number of studies on the genotoxicity of TiO2-NPs. In this article, we review the results that have been reported in the literature, with a focus on data generated from the standard genotoxicity assays. The data include genotoxicity results from the Ames test, in vitro and in vivo Comet assay, in vitro and in vivo micronucleus assay, sister chromatid exchange assay, mammalian cell hypoxanthine-guanine phosphoribosyl transferase gene assay, the wing somatic mutation and recombination assay, and the mouse phosphatidylinositol glycan, class A gene assay. Inconsistent results have been found in these assays, with both positive and negative responses being reported. The in vitro systems for assessing the genotoxicity of TiO2-NPs have generated a greater number of positive results than the in vivo systems, and tests for DNA and chromosome damage have produced more positive results than the assays measuring gene mutation. Nearly all tests for measuring the mutagenicity of TiO2-NPs were negative. The current data indicate that the genotoxicity of TiO2-NPs is mediated mainly through the generation of oxidative stress in cells.

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Raman Spectroscopy In The Analysis Of Food And Pharmaceutical Nanomaterials, Y.-S. Li, J.S. Church Jul 2020

Raman Spectroscopy In The Analysis Of Food And Pharmaceutical Nanomaterials, Y.-S. Li, J.S. Church

Journal of Food and Drug Analysis

Raman scattering is an inelastic phenomenon. Although its cross section is very small, recent advances in electronics, lasers, optics, and nanotechnology have made Raman spectroscopy suitable in many areas of application. The present article reviews the applications of Raman spectroscopy in food and drug analysis and inspection, including those associated with nanomaterials. Brief overviews of basic Raman scattering theory, instrumentation, and statistical data analysis are also given. With the advent of Raman enhancement mechanisms and the progress being made in metal nanomaterials and nanoscale metal surfaces fabrications, surface enhanced Raman scattering spectroscopy has become an extra sensitive method, which is …

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Reactive Oxygen Species-Related Activities Of Nano-Iron Metal And Nano-Iron Oxides, H. Wu, J.-J. Yin, W.G. Wamer, M. Zeng, Y.M. Lo Jul 2020

Reactive Oxygen Species-Related Activities Of Nano-Iron Metal And Nano-Iron Oxides, H. Wu, J.-J. Yin, W.G. Wamer, M. Zeng, Y.M. Lo

Journal of Food and Drug Analysis

Nano-iron metal and nano-iron oxides are among the most widely used engineered and naturally occurring nanostructures, and the increasing incidence of biological exposure to these nanostructures has raised concerns about their biotoxicity. Reactive oxygen species (ROS)-induced oxidative stress is one of the most accepted toxic mechanisms and, in the past decades, considerable efforts have been made to investigate the ROS-related activities of iron nanostructures. In this review, we summarize activities of nano-iron metal and nano-iron oxides in ROS-related redox processes, addressing in detail the known homogeneous and heterogeneous redox mechanisms involved in these processes, intrinsic ROS-related properties of iron nanostructures …

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Electron Spin Resonance Spectroscopy For The Study Of Nanomaterial-Mediated Generation Of Reactive Oxygen Species, W. He, Y. Liu, W.G. Wamer, J.-J. Yin Jul 2020

Electron Spin Resonance Spectroscopy For The Study Of Nanomaterial-Mediated Generation Of Reactive Oxygen Species, W. He, Y. Liu, W.G. Wamer, J.-J. Yin

Journal of Food and Drug Analysis

Many of the biological applications and effects of nanomaterials are attributed to their ability to facilitate the generation of reactive oxygen species (ROS). Electron spin resonance (ESR) spectroscopy is a direct and reliable method to identify and quantify free radicals in both chemical and biological environments. In this review, we discuss the use of ESR spectroscopy to study ROS generation mediated by nanomaterials, which have various applications in biological, chemical, and materials science. In addition to introducing the theory of ESR, we present some modifications of the method such as spin trapping and spin labeling, which ultimately aid in the …

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Introduction To The Special Issue: Nanomaterials - Toxicology And Medical Applications, P.P. Fu Jul 2020

Introduction To The Special Issue: Nanomaterials - Toxicology And Medical Applications, P.P. Fu

Journal of Food and Drug Analysis

[No abstract available]

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Neurotoxicity Of Nanoscale Materials, A. Karmakar, Q. Zhang, Y. Zhang Jul 2020

Neurotoxicity Of Nanoscale Materials, A. Karmakar, Q. Zhang, Y. Zhang

Journal of Food and Drug Analysis

Nanotechnology has been applied in consumer products and commercial applications, showing a significant impact on almost all industries and all areas of society. Significant evidence indicates that manufactured nanomaterials and combustion-derived nanomaterials elicit toxicity in humans exposed to these nanomaterials. The interaction of the engineered nanomaterials with the nervous system has received much attention in the nanotoxicology field. In this review, the biological effects of metal, metal oxide, and carbon-based nanomaterials on the nervous system are discussed from both in vitro and in vivo studies. The translocation of the nanoparticles through the blood-brain barrier or nose to brain via the …

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Mechanistic Characterization Of Titanium Dioxide Nanoparticle-Induced Toxicity Using Electron Spin Resonance, M. Li, J.-J. Yin, W.G. Wamer, Y.M. Lo Jul 2020

Mechanistic Characterization Of Titanium Dioxide Nanoparticle-Induced Toxicity Using Electron Spin Resonance, M. Li, J.-J. Yin, W.G. Wamer, Y.M. Lo

Journal of Food and Drug Analysis

Titanium dioxide nanoparticles (TiO2 NPs) are one of the most widely used nanomaterials that have been manufactured worldwide and applied in different commercial realms. The well-recognized ability of TiO2 to promote the formation of reactive oxygen species (ROS) has been extensively studied as one of the important mechanisms underlying TiO2 NPs toxicity. As the "gold standard" method to quantify and identify ROS, electron spin resonance (ESR) spectroscopy has been employed in many studies aimed at evaluating TiO2 NPs safety. This review aims to provide a thorough discussion of current studies using ESR as the primary method to unravel the mechanism …

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Molecular Toxicity Mechanism Of Nanosilver, D. Mcshan, P.C. Ray, H. Yu Jul 2020

Molecular Toxicity Mechanism Of Nanosilver, D. Mcshan, P.C. Ray, H. Yu

Journal of Food and Drug Analysis

Silver is an ancient antibiotic that has found many new uses due to its unique properties on the nanoscale. Due to its presence in many consumer products, the toxicity of nanosilver has become a hot topic. This review summarizes recent advances, particularly the molecular mechanism of nanosilver toxicity. The surface of nanosilver can easily be oxidized by O2 and other molecules in the environmental and biological systems leading to the release of Ag+, a known toxic ion. Therefore, nanosilver toxicity is closely related to the release of Ag+. In fact, it is difficult to determine what portion of the toxicity …

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Assessment Of The Toxic Potential Of Graphene Family Nanomaterials, X. Guo, N. Mei Jul 2020

Assessment Of The Toxic Potential Of Graphene Family Nanomaterials, X. Guo, N. Mei

Journal of Food and Drug Analysis

Graphene, a single-atom-thick carbon nanosheet, has attracted great interest as a promising nanomaterial for a variety of bioapplications because of its extraordinary properties. However, the potential for widespread human exposure raises safety concerns about graphene and its derivatives, referred to as graphene-family nanomaterials. This review summarizes recent findings on the toxicological effects and the potential toxicity mechanisms of graphene-family nanomaterials in bacteria, mammalian cells, and animal models. Graphene, graphene oxide, and reduced graphene oxide elicit toxic effects both in vitro and in vivo, whereas surface modifications can significantly reduce their toxic interactions with living systems. Standardization of terminology and the …

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Using A Holistic Approach To Assess The Impact Of Engineered Nanomaterials Inducing Toxicity In Aquatic Systems, X. He, W.G. Aker, J. Leszczynski, H.-M. Hwang Jul 2020

Using A Holistic Approach To Assess The Impact Of Engineered Nanomaterials Inducing Toxicity In Aquatic Systems, X. He, W.G. Aker, J. Leszczynski, H.-M. Hwang

Journal of Food and Drug Analysis

In this report, we critically reviewed selected intrinsic physicochemical properties of engineered nanomaterials (ENMs) and their role in the interaction of the ENMs with the immediate surroundings in representative aquatic environments. The behavior of ENMs with respect to dynamic microenvironments at the nanoebioeeco interface level, and the resulting impact on their toxicity, fate, and exposure potential are elaborated. Based on this literature review, we conclude that a holistic approach is urgently needed to fulfill our knowledge gap regarding the safety of discharged ENMs. This comparative approach affords the capability to recognize and understand the potential hazards of ENMs and their …

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Theranostic Nanomedicine For Cancer Detection And Treatment, Z. Fan, P.P. Fu, H. Yu, P.C. Ray Jul 2020

Theranostic Nanomedicine For Cancer Detection And Treatment, Z. Fan, P.P. Fu, H. Yu, P.C. Ray

Journal of Food and Drug Analysis

Cancer is the second leading cause of death in the USA according to the American Cancer Society. In the past 5 years, "theranostic nanomedicine", for both therapeutics and imaging, has shown to be "the right drug for the right patient at the right moment" to manage deadly cancers. This review article presents an overview of recent developments, mainly from the authors' laboratories, along with potential medical applications for theranostic nanomedicine including basic concepts and critical properties. Finally, we outline the future research direction and possible challenges for theranostic nanomedicine research. Copyright © 2014, Food and Drug Administration, Taiwan. Published by …

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Mechanisms Of Nanotoxicity: Generation Of Reactive Oxygen Species, P.P. Fu, Q. Xia, H.-M. Hwang, P.C. Ray, H. Yu Jul 2020

Mechanisms Of Nanotoxicity: Generation Of Reactive Oxygen Species, P.P. Fu, Q. Xia, H.-M. Hwang, P.C. Ray, H. Yu

Journal of Food and Drug Analysis

Nanotechnology is a rapidly developing field in the 21st century, and the commercial use of nanomaterials for novel applications is increasing exponentially. To date, the scientific basis for the cytotoxicity and genotoxicity of most manufactured nanomaterials are not understood. The mechanisms underlying the toxicity of nanomaterials have recently been studied intensively. An important mechanism of nanotoxicity is the generation of reactive oxygen species (ROS). Overproduction of ROS can induce oxidative stress, resulting in cells failing to maintain normal physiological redox-regulated functions. This in turn leads to DNA damage, unregulated cell signaling, change in cell motility, cytotoxicity, apoptosis, and cancer initiation. …

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Cell Microenvironment Stimuli-Responsive Controlled-Release Delivery Systems Based On Mesoporous Silica Nanoparticles, C.-L. Zhu, X.-W. Wang, Z.-Z. Lin, Z.-H. Xie, X.-R. Wang Jul 2020

Cell Microenvironment Stimuli-Responsive Controlled-Release Delivery Systems Based On Mesoporous Silica Nanoparticles, C.-L. Zhu, X.-W. Wang, Z.-Z. Lin, Z.-H. Xie, X.-R. Wang

Journal of Food and Drug Analysis

To develop novel tumor cell microenvironment stimuli-responsive smart controlled-release delivery systems is one of the current common interests of materials science and clinical medicine. Meanwhile, mesoporous silica nanoparticles as a promising drug carrier have become the new area of interest in the field of biomedical application in recent years because of their unique characteristics and abilities to efficiently and specifically entrap cargo molecules. This review describes the more recent developments and achievements of mesoporous silica nanoparticles in drug delivery. In particular, we focus on the stimuli-responsive controlled-release systems that are able to respond to tumor cell environmental changes, such as …

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Effects Of Drying On Caffeoylquinic Acid Derivative Content And Antioxidant Capacity Of Sweet Potato Leaves, T.L. Jeng, C.C. Lai, T.C. Liao, S.Y. Lin, J.M. Sung Jul 2020

Effects Of Drying On Caffeoylquinic Acid Derivative Content And Antioxidant Capacity Of Sweet Potato Leaves, T.L. Jeng, C.C. Lai, T.C. Liao, S.Y. Lin, J.M. Sung

Journal of Food and Drug Analysis

Caffeoylquinic acid (CQA) derivatives are known to possess antioxidative potential and have many beneficial effects on human health. The present study compared the CQA contents and antioxidant activities of aerial parts of sweet potato plants. The effects of drying methods (freeze drying, and drying at 30°C, 70°C, and 100°C) on these two parameters of the first fully expanded leaves were also assessed. The results indicated that the CQA derivatives were detectable in leaves, stem, and flowers of sweet potato plants (varied from 39.34 mg/g dry weight to 154.05 mg/g dry weight), with the leaves (particularly expanding and first fully expanded …

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Impact Of Chitosan Composites And Chitosan Nanoparticle Composites On Various Drug Delivery Systems: A Review, M.A. Elgadir, M.S. Uddin, S. Ferdosh, A. Adam, A.J.K. Chowdhury, M.Z.I. Sarker Jul 2020

Impact Of Chitosan Composites And Chitosan Nanoparticle Composites On Various Drug Delivery Systems: A Review, M.A. Elgadir, M.S. Uddin, S. Ferdosh, A. Adam, A.J.K. Chowdhury, M.Z.I. Sarker

Journal of Food and Drug Analysis

Chitosan is a promising biopolymer for drug delivery systems. Because of its beneficial properties, chitosan is widely used in biomedical and pharmaceutical fields. In this review, we summarize the physicochemical and drug delivery properties of chitosan, selected studies on utilization of chitosan and chitosan-based nanoparticle composites in various drug delivery systems, and selected studies on the application of chitosan films in both drug delivery and wound healing. Chitosan is considered the most important polysaccharide for various drug delivery purposes because of its cationic character and primary amino groups, which are responsible for its many properties such as mucoadhesion, controlled drug …

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Separation And Speciation Analysis Of Zinc From Flammulina Velutipes, F. Liu, F. Pei, A.M. Mariga, L. Gao, G. Chen, L. Zhao Jul 2020

Separation And Speciation Analysis Of Zinc From Flammulina Velutipes, F. Liu, F. Pei, A.M. Mariga, L. Gao, G. Chen, L. Zhao

Journal of Food and Drug Analysis

Orthogonal experiment was applied to optimize the water extraction parameters of zinc from Flammulina velutipes, and then the extracts were separated by membrane filter (0.45 μm) and D101 macroporous resin. Six different species of Zn were obtained and the Zn content of various species were determined by flame atomic absorption spectrometry. The optimized conditions for the extraction of Zn were: ratio of dried material to water, 1:30; extraction temperature, 75°C; extraction time, 120 minutes. About 34.43 μg Zn was extracted from 1 g dried F. velutipes powder under the optimal conditions. The recovery value for Zn was 96.5% with a …

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Oxidant Stress Evoked Damage In Rat Hepatocyte Leading To Triggered Nitric Oxide Synthase (Nos) Levels On Long Term Consumption Of Aspartame, I. Ashok, R. Sheeladevi Jul 2020

Oxidant Stress Evoked Damage In Rat Hepatocyte Leading To Triggered Nitric Oxide Synthase (Nos) Levels On Long Term Consumption Of Aspartame, I. Ashok, R. Sheeladevi

Journal of Food and Drug Analysis

This study investigates how long-term (40 mg/kg b.wt) consumption of aspartame can alter the antioxidant status, stress pathway genes, and apoptotic changes in the liver of Wistar albino rats. Numerous controversial reports are available on the use of aspartame as it releases methanol as one of its metabolites during metabolism. To mimic the human methanol metabolism the methotrexate treated rats were included to study the aspartame effects. The aspartame treated methotrexate (MTX animals showed a marked significant increase in the superoxide dismutase (SOD), catalase (CAT), lipid peroxidation (LPO), and Glutathione peroxidase (GPx) activity in the liver from control and MTX …

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Quercetin Uptake And Metabolism By Murine Peritoneal Macrophages In Vitro, C.-J. Liu, Y.-R. Liao, J.-Y. Lin Jul 2020

Quercetin Uptake And Metabolism By Murine Peritoneal Macrophages In Vitro, C.-J. Liu, Y.-R. Liao, J.-Y. Lin

Journal of Food and Drug Analysis

Quercetin (Q), a bioflavonoid ubiquitously distributed in vegetables, fruits, leaves, and grains, can be absorbed, transported, and excreted after oral intake. However, little is known about Q uptake and metabolism by macrophages. To clarify the puzzle, Q at its noncytotoxic concentration (44μM) was incubated without or with mouse peritoneal macrophages for different time periods. Medium alone, extracellular, and intracellular fluids of macrophages were collected to detect changes in Q and its possible metabolites using high-performance liquid chromatography. The results showed that Q was unstable and easily oxidized in either the absence or the presence of macrophages. The remaining Q and …

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Evaluation Of Iron-Binding Activity Of Collagen Peptides Prepared From The Scales Of Four Cultivated Fishes In Taiwan, C.-Y. Huang, C.-H. Wu, J.-I. Yang, Y.-H. Li, J.-M. Kuo Jul 2020

Evaluation Of Iron-Binding Activity Of Collagen Peptides Prepared From The Scales Of Four Cultivated Fishes In Taiwan, C.-Y. Huang, C.-H. Wu, J.-I. Yang, Y.-H. Li, J.-M. Kuo

Journal of Food and Drug Analysis

Iron deficiency is one of the most concerning deficiency problems in the world. It may generate several adverse effects such as iron deficiency anemia (IDA) and reduced physical and intellectual working capacity. The aim of this study is to evaluate the Fe(II)-binding activity of collagen peptides from fishery by-products. Lates calcarifer, Mugil cephalus, Chanos chanos, and Oreochromis spp are four major cultivated fishes in Taiwan; thousands of scales of these fish are wasted without valuable utilization. In this study, scales of these fish were hydrolyzed by papain plus flavourzyme. Collagen peptides were obtained and compared for their Fe(II)-binding activity. Collagen …

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Effects Of Blending Wheatgrass Juice On Enhancing Phenolic Compounds And Antioxidant Activities Of Traditional Kombucha Beverage, T.-Y. Sun, J.-S. Li, C. Chen Jul 2020

Effects Of Blending Wheatgrass Juice On Enhancing Phenolic Compounds And Antioxidant Activities Of Traditional Kombucha Beverage, T.-Y. Sun, J.-S. Li, C. Chen

Journal of Food and Drug Analysis

Traditional kombucha is a fermented black tea extract and sugar. Sweetened black tea (10% w/v) and wheatgrass juice (WGJ) were mixed in various ratios and used as fermentation substrate for enhancing phenolic compounds and antioxidant activity. Starter, comprising of yeast (Dekkera bruxellensis) and acetic acid bacteria (Gluconacetobacter rhaeticus and Gluconobacter roseus), was inoculated at 20% (v/v), and fermented statically at 29 ± 1°C for 12 days. The results showed that the total phenolic and flavonoid contents and antioxidant activity of the modified kombucha were higher than those of traditional preparations. All WGJ-blended kombucha preparations were characterized as having higher concentrations …

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Degradation Of Histamine By Bacillus Polymyxa Isolated From Salted Fish Products, Y.-C. Lee, C.-S. Lin, F.-L. Liu, T.-C. Huang, Y.-H. Tsai Jul 2020

Degradation Of Histamine By Bacillus Polymyxa Isolated From Salted Fish Products, Y.-C. Lee, C.-S. Lin, F.-L. Liu, T.-C. Huang, Y.-H. Tsai

Journal of Food and Drug Analysis

Histamine is the causative agent of scombroid poisoning, a foodborne chemical hazard. Histamine is degraded by the oxidative deamination activity of certain microorganisms. In this study, eight histamine-degrading bacteria isolated from salted fish products were identified as Rummeliibacillus stabekisii (1 isolate), Agrobacterium tumefaciens (1 isolate), Bacillus cereus (2 isolates), Bacillus polymyxa (1 isolate), Bacillus licheniformis (1 isolate), Bacillus amyloliquefaciens (1 isolate), and Bacillus subtilis (1 isolate). Among them, B. polymyxa exhibited the highest activity in degrading histamine than the other isolates. The ranges of temperature, pH, and salt concentration for growth and histamine degradation of B. polymyxa were 25-37°C, pH …

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Camel Milk As A Potential Therapy For Controlling Diabetes And Its Complications: A Review Of In Vivo Studies, A.B. Shori Jul 2020

Camel Milk As A Potential Therapy For Controlling Diabetes And Its Complications: A Review Of In Vivo Studies, A.B. Shori

Journal of Food and Drug Analysis

Diabetes is a condition in which there is an elevation of blood glucose. Insulin, which is produced by the pancreas, is an important hormone needed by the body because it enables glucose to be transported into cells. Under the diabetic condition, the cells may not respond properly to insulin or the body does not produce a sufficient amount of insulin, or both. This situation will cause glucose accumulation in the blood that leads to major complications. Oral insulin therapy has been used for many years; however, coagulation in an acidic environment decreases the efficacy of insulin by neutralizing its actions. …

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Determination Of Cholesterol And Four Phytosterols In Foods Without Derivatization By Gas Chromatography-Tandem Mass Spectrometry, Y.-Z. Chen, S.-Y. Kao, H.-C. Jian, Y.-M. Yu, J.-Y. Li, W.-H. Wang, C.-W. Tsai Jul 2020

Determination Of Cholesterol And Four Phytosterols In Foods Without Derivatization By Gas Chromatography-Tandem Mass Spectrometry, Y.-Z. Chen, S.-Y. Kao, H.-C. Jian, Y.-M. Yu, J.-Y. Li, W.-H. Wang, C.-W. Tsai

Journal of Food and Drug Analysis

In this study, a method for determination of cholesterol and four phytosterols by gas chromatography coupled with electron impact ionization mode-tandem mass spectrometry without derivatization in general food was developed. The sample was saponified with 7.5% KOH in methanol. After heating on hot plate and reflux for 60 minutes, the saponified portion was extracted with n-hexane/petroleum ether (50:50, v/v). The extracts were evaporated with rotary evaporator and then redissolved with tetrahydrofuran. The tetrahydrofuran layer was transferred into an injection vial and analyzed by gas chromatography on a 30 m VF-5 column. Limit of quantification was 2 mg/kg. Recoveries of cholesterol …

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Nutritional And Nutraceutical Characteristics Of Sageretia Theezans Fruit, T.K. Hyun, S.C. Song, C.-K. Song, J.-S. Kim Jul 2020

Nutritional And Nutraceutical Characteristics Of Sageretia Theezans Fruit, T.K. Hyun, S.C. Song, C.-K. Song, J.-S. Kim

Journal of Food and Drug Analysis

The fruit of Sageretia theezans is one of many underutilized edible fruits that grow along the southern seashores of East Asia. In this study, to evaluate the nutritional and nutraceutical values of S. theezans fruit, the composition of minerals, organic acids, and proximate and fatty acids, the total phenolic, total flavonoid, and total anthocyanin content, and the antioxidant and antidiabetic activities of S. theezans fruit were analyzed. The results indicate that S. theezans fruit could be classified as a potential potassium-, malic acid-, and linoleic/oleic acid-rich fruit. In addition, The ethyl acetate (EtOAc) fraction of the 70% ethanol (EtOH) crude …

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Recent Trends In Specialty Pharma Business Model, M.S. Ku Jul 2020

Recent Trends In Specialty Pharma Business Model, M.S. Ku

Journal of Food and Drug Analysis

The recent rise of specialty pharma is attributed to its flexible, versatile, and open business model while the traditional big pharma is facing a challenging time with patent cliff, generic threat, and low research and development (R&D) productivity. These multinational pharmaceutical companies, facing a difficult time, have been systematically externalizing R&D and some even establish their own corporate venture capital so as to diversify with more shots on goal, with the hope of achieving a higher success rate in their compound pipeline. Biologics and clinical Phase II proof-of-concept (POC) compounds are the preferred licensing and collaboration targets. Biologics enjoys a …

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Identification Of Biosynthetic Intermediates Of Teaghrelins And Teaghrelin-Like Compounds In Oolong Teas, And Their Molecular Docking To The Ghrelin Receptor, S.-K. Hsieh, Y.-H. Lo, C.-C. Wu, T.-Y. Chung, J.T.C. Tzen Jul 2020

Identification Of Biosynthetic Intermediates Of Teaghrelins And Teaghrelin-Like Compounds In Oolong Teas, And Their Molecular Docking To The Ghrelin Receptor, S.-K. Hsieh, Y.-H. Lo, C.-C. Wu, T.-Y. Chung, J.T.C. Tzen

Journal of Food and Drug Analysis

Teaghrelins are unique acylated flavonoid tetraglycosides found in Chin-shin oolong tea, and have been demonstrated to be promising oral ghrelin analogues. The biosynthetic pathway of teaghrelins from quercetin-3-O-rutinoside (rutin) or kaempferol-3-O-rutinoside (nicotiflorin) was proposed to comprise three enzymatic steps according to the identification of putative intermediates in Chin-shin oolong tea. In addition to the two known teaghrelins in Chin-shin oolong tea, four teaghrelin-like compounds with different attachments of glycosides were identified in various oolong teas. Molecular modeling and docking were used to evaluate theoretically whether the putative biosynthetic intermediates of teaghrelins and the four teaghrelin-like compounds could be potential candidates …

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A Rapid And Sensitive Spectrophotometric Method For The Determination Of Benzoyl Peroxide In Wheat Flour Samples, K. Ponhong, S.-A. Supharoek, W. Siriangkhawut, K. Grudpan Jul 2020

A Rapid And Sensitive Spectrophotometric Method For The Determination Of Benzoyl Peroxide In Wheat Flour Samples, K. Ponhong, S.-A. Supharoek, W. Siriangkhawut, K. Grudpan

Journal of Food and Drug Analysis

A simple, rapid, and sensitive spectrophotometric method for the determination of benzoyl peroxide (BPO) in wheat flour samples was developed. The detection principle is based on BPO reacted with 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) to obtain a blue-green colored product that was detected at 415 nm by spectrophotometry. The effect of factors influencing the color reaction was investigated. Under the selected conditions, the linear range for quantification of BPO was observed between 0.2-1.0 mg L-1 with r2 = 0.998. The limit of detection (LOD) was 0.025 mg L-1. The developed method obtained superior precision (relative standard deviation < 2%) using 11 repeatability at 0.2 mg L-1, 0.6 mg L-1, and 0.8 mg L-1. The proposed methodology was successfully applied to determine BPO in wheat flour samples. © 2015, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.

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