Medicinal Chemistry and Pharmaceutics Commons^™

Copper(Ii) Complexes Of Coumarin-Derived Schiff Bases And Their Anti-Candida Activity, Bernadette S. Creaven, Michael Devereux, Dariusz Karcz, Andrew Kellett, Malachy Mccann, Andy Noble, Maureen Walsh

Articles

The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a–2k) in good yields. Subsequent reaction of these ligands with copper( II) acetate yielded Cu(II) complexes (3a–3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity.

Trans-Resveratrol Inhibits Calcium Influx In Thrombin-Stimulated Human Platelets, Yuliya Dobrydneva, Roy L. Williams, Peter F. Blackmore

Chemistry & Biochemistry Faculty Publications

1 The phytoestrogenic compound trans-resveratrol (trans-3,5,4'-trihydroxystilbene) is found in appreciable quantities in grape skins and wine. It has been shown that both products rich in trans-resveratrol and pure trans-resveratrol inhibit platelet aggregation both in vivo and in vitro. However the mechanism of this action still remains unknown.

2 An essential component of the aggregation process in platelets is an increase in intracellular free Ca²⁺ ([Ca²⁺]_i). Ca²⁺ must enter the cell from the external media through specific and tightly regulated Ca²⁺ channels in the plasma membrane. The objective …

The Effect Of 48 Hr Glucose Administration On The Hepatic P-450 System, John N. Buchholz

Loma Linda University Electronic Theses, Dissertations & Projects

The administration of glucose for 48 hrs to mice resulted in a shift of the dose response curve of phenobarbital, an indication that glucose administration significantly sensitized the animals to the effects of the drug. Glucose administration produced a reduction in the catalytic activity of hepatic microscopical P-450 as measured by the in vitro conversion of p-Nitrocellulose to p-Nitrophenol.

The administration of glucose to rats for 48 hrs resulted in prolonged anesthesia after the administration of pentobarbital. The spectral binding of hexobarbital and methadone to hepatic microsomal P-450 was found to be significantly reduced following glucose administration. The changes in …