Pharmacology, Toxicology and Environmental Health Commons^™

Barriers To The Elimination Of Plastic In Single Use Beverage Containers In Byron Bay, Nsw, Katherine Senechal

Independent Study Project (ISP) Collection

Plastic debris is a global threat to the natural environment. The accumulation of plastic debris has resulted in the destruction of marine habitat as well as a threat to marine wildlife. Single use plastics, including plastics associated with single use food and beverage containers are contributing to a considerable amount of debris and other litter in the world’s oceans. As awareness of this issue spreads, both large corporations and small businesses are beginning to transition to plastic alternatives for their single use beverage containers. In Byron Bay, Australia, an area of increasing environmental awareness, businesses are beginning to reduce single …

Effects Of Radiation On Neurite Morphology And Cytoskeleton Structure, Melissa Sassman

Student Scholarship

Long-term manned space exploration to the moon, Mars, and other areas beyond Earth's protective magnetic field poses possible acute and late central nervous systems (CNS) risks. Of particular concern for astronauts is exposure to high atomic number, high energy particles known as HZE particles, a component of galactic cosmic radiation (GCR). Although NASA has radiation safety requirements, the possible effects of GCR and HZE particles on the central nervous systems of astronauts remains unknown. Understanding the risks and effects of galactic cosmic radiation and HZE particles on the central nervous system will allow for safer space exploration.

Additionally, and perhaps …

Signal Detection Of Adverse Drug Reaction Using The Adverse Event Reporting System: Literature Review And Novel Methods, Minh H. Pham

USF Tampa Graduate Theses and Dissertations

One of the objectives of the U.S. Food and Drug Administration is to protect the public health through post-marketing drug safety surveillance, also known as Pharmacovigilance. An inexpensive and efficient method to inspect post-marketing drug safety is to use data mining algorithms on electronic health records to discover associations between drugs and adverse events.

The purpose of this study is two-fold. First, we review the methods and algorithms proposed in the literature for identifying association drug interactions to an adverse event and discuss their advantages and drawbacks. Second, we attempt to adapt some novel methods that have been used in …

Agriculture In The Classroom Farm Day Lesson Plan, Tessa Nicole Thompson

Agricultural Education and Communication

Nontraditional educational programs have been proclaimed desirable by many teachers, and proven effective through data collection and feedback (Coombs and Ahmed, 1974). Of the more popular unconventional educational programs, outside learning activities are commonly implemented as they are not only advantageous to students, but to teachers as well (Cengelci, 2013; Knoblock, 2008). Though nontraditional, much thought must be put into creating lesson plans for these educational programs.

El Dorado County’s Agriculture in the Classroom program utilizes nontraditional outdoor learning activities to conduct “Farm Day.” This lesson plan, created for Farm Day, is to teach third graders the importance of composting …

The Pharmacogene Variation (Pharmvar) Consortium: Incorporation Of The Human Cytochrome P450 (Cyp) Allele Nomenclature Database, Andrea Gaedigk, Magnus Ingelman-Sundberg, Neil A. Miller, J Steven Leeder, Michelle Whirl-Carrillo, Teri E. Klein

Manuscripts, Articles, Book Chapters and Other Papers

The Human Cytochrome P450 (CYP) Allele Nomenclature Database, a critical resource to the pharmacogenetics and genomics communities, will be transitioning to the Pharmacogene Variation (PharmVar) Consortium. In this report we provide a summary of the current database, provide an overview of the PharmVar consortium and highlight the PharmVar database which will serve as the new home for pharmacogene nomenclature.

Uncovering Discursive Framings Of The Bangladesh Shipbreaking Industry, S. M. Mizanur Rahman, Chelsea Schelly, Audrey L. Mayer, Emma S. Norman

College of Forest Resources and Environmental Science Publications

Shipbreaking in the Chittagong region of Bangladesh supplies metal to meet the needs of the nation’s construction sector. The shipbreaking industry has received international attention for environmental contamination and workers’ insecurity. However, these issues have been framed without considering the actors that produce them and their associated motives. This paper illuminates the conflicting discourses regarding the industry between two divergent groups of actors. On the one hand, national and international NGOs collaborate to enforce a discourse focused on negative localized impacts. On the other hand, yard owners, yard workers, and local community members forge a counter discourse, focused on positive …

Outdoor Air Quality, Taylor Curley

Global Issues in Public Health

Outdoor air quality is a significant issue for the entire world. It affects any and all people, but is more of an issue in low-income countries and among people that are more susceptible to respiratory issues such as young children, pregnant women, the elderly, and people who already suffer from respiratory problems like asthma. Poor air quality is caused by the burning of fossil fuels which releases particles and chemicals into the air like carbon dioxide, particulate matter, and nitrogen to name a few. It can cause multiple health issues such as respiratory problems to people who are exposed to …

Regulation Of Radioactive Fracking Waste, Elizabeth Ann Glass Geltman, Nichole Leclair

Publications and Research

Natural gas extracted form shale reached record production totals in 2015 in the United States and the US Energy Information Administration (EIA) forecasts natural gas production will continue to increase. Wastes from shale gas extraction can contain the radioactive isotopes radium-226 (Ra-226) and radium-228 (Ra-228), which decay further into radon (Rn). Exposure to radon, a form of naturally occurring radioactive materials (NORM), is the leading cause of lung cancer in the United States, after smoking. This article explores how states handle the disposal of technologically enhanced naturally occurring radioactive materials (TENORM) and/or NORM waste from oil and gas operations to …

The Clean Air Act And Its Impact On Ground Level Ozone Pollution Levels In Los Angeles, California, Rebecca Ford

Bridges: A Journal of Student Research

Ozone (O3) occurs as a photochemically produced pollutant in the troposphere and its emission and concentration is regulated by the Clean Air Act (CAA) of 1970. The Los Angeles area is an example of how O3 can be a public health hazard and taint a city’s aesthetics and quality of life through photochemical smog. This study was conducted to observe the overall effectiveness of the CAA. I explored daily O3 concentrations from 1980 to the present at three air quality monitoring stations in LA from the AirData database of the U.S. Environmental Protection Agency. National O3 standards were only exceeded …

Drug Delivery Strategies For The Treatment Of Advanced Lung Cancer And Various Lung Metastases, Elizabeth Bielski

Wayne State University Dissertations

Lung cancer remains the leading cause of cancer-related deaths in the United States. Secondary lung tumors metastasized from other cancer sites also remains highly prevalent, in which most metastatic tumors cannot be cured with existing therapies. Chemoresistance (multi drug resistance – MDR) that develops intrinsically or acquired is one of the key factors leading to fatality in these patients. MDR develops form a variety of resistance mechanisms that can occur consecutively or concurrently, therefore, making most current treatments unsuccessful. Current therapies have known to slow tumor growth, but rarely provide a cure. Immunotherapy has seen some promise, including the use …

Watered Down: The Challenges Of Managing Water Resources In Montana, Beau E. Baker

Graduate Student Theses, Dissertations, & Professional Papers

Like much of the American West, Montana sits in the cross hairs of climate change. State drought resiliency projects and cooperative watershed management are on the rise in the face of decreased snowpack, early runoff, precipitation variability and lower seasonal stream flows. Population growth, land use practices, recreation and tourism all contribute to pressures on state water supplies.

Montana is faced with the arrival of invasive species that threaten the ecological health of its lakes, rivers and streams. State budget constraints and depressed agency capacity are hurting our ability to fend off these threats. There’s a lack of public education …

Fate Of Methoprene In Temperate Salt Marsh Ditches Following Aerial Applications, David J. Tonjes, Anne E. Mcelroy, Robin K. Barnes, Dominick V. Ninivaggi, Walter Dawydiak, Gregory T. Greene, Bruce J. Brownawell

Technology & Society Faculty Publications

Aerial applications of liquid methoprene are used in salt marshes to control mosquitoes by preventing adult emergence. Despite concern about toxicity to non-target organisms, little is known about environmental concentrations after applications, nor methoprene's persistence in salt marsh environments. Aqueous and sediment samples were collected from two marshes receiving weekly applications. Aqueous samples were collected as early as 30 minutes after applications and as long as nine days afterwards; sediment samples were taken within hours of application and as long as 19 days post-application. Use of time-of-flight liquid chromatography – mass spectral analysis allowed for ultra low detection limits (0.5 …

5-Ht2b Receptor-Mediated Cardiac Valvulopathy, Pallavi Nistala

Theses and Dissertations

5-HT_2B receptor agonism causes cardiac valvulopathy, a condition characterized by thickening of the heart valves and as a result, regurgitation of blood within the heart. The anti-obesity drug fenfluramine, which was originally prescribed as an anorectic, was withdrawn from the market due to causing cardiac valvulopathy. Fenfluramine, after metabolism by N-dealkylation, produces the metabolite norfenfluramine, which acts as a more potent valvulopathogen. The same was seen with MDMA (ecstasy), a popular drug of abuse, which is metabolized by N-dealkylation to produce MDA, a more potent valvulopathogen. Glennon and co-workers. studied a series of 2,5-dimethoxy-4- substituted phenylisopropylamines (DOX type) hallucinogens …

Pressure-Driven Stabilization Of Capacitive Deionization, Landon S. Caudill

Theses and Dissertations--Mechanical and Aerospace Engineering

The effects of system pressure on the performance stability of flow-through capacitive deionization (CDI) cells was investigated. Initial data showed that the highly porous carbon electrodes possessed air/oxygen in the micropores, and the increased system pressure boosts the gases solubility in saline solution and carries them out of the cell in the effluent. Upon applying a potential difference to the electrodes, capacitive-based ion adsorption occurs in competition with faradaic reactions that consume oxygen. Through the addition of backpressure, the rate of degradation decreases, allowing the cell to maintain its salt adsorption capacity (SAC) longer. The removal of oxygen from the …

Scalable Feature Selection And Extraction With Applications In Kinase Polypharmacology, Derek Jones

Theses and Dissertations--Computer Science

In order to reduce the time associated with and the costs of drug discovery, machine learning is being used to automate much of the work in this process. However the size and complex nature of molecular data makes the application of machine learning especially challenging. Much work must go into the process of engineering features that are then used to train machine learning models, costing considerable amounts of time and requiring the knowledge of domain experts to be most effective. The purpose of this work is to demonstrate data driven approaches to perform the feature selection and extraction steps in …

Carbazole Based Multifunctional Dopamine Agonists And Related Molecules As Potential Symptomatic And Disease Modifying Therapeutic Agents For Parkinson’S Disease, Asma S.Mohamed Elmabruk

Wayne State University Dissertations

Parkinson’s disease (PD) is a progressive neurodegenerative disease that develops from gradual depletion of dopamine (DA) and dopaminergic neurons in the substantia nigra pars compacta (SNc) with the accumulation of intraneuronal proteinaceous matter named as Lewy bodies. The four cardinal symptoms associated with PD are tremor, rigidity, bradykinesia, and postural instability. Although the exact mechanism and etiology of PD are not fully understood, several factors have been implicated in the pathogenesis and progression of PD including protein aggregation, oxidative stress, mitochondrial dysfunction, environmental, and genetic factors.

The current therapy of Parkinson’s disease is categorized into four classes: levodopa, DA agonists, …

The Forensic Characterization Of Bacterial And Fungal Organisms In Traditional Chinese Medicine, Julia Grzymkowski, Christopher J. Ehrhardt, Justin L. Poklis, Michelle R. Peace

UROP Posters

There has been an increase in use of Traditional Chinese Medicine (TCM) in the United States because they are less expensive and believed to be more effective with less adverse effects in comparison to traditional pharmaceutics. Therefore, sales have increased in the US, despite articles and case studies demonstrating the dangers, such as injury and death, related to TCM, stemming from improper labelling, toxic contaminants, and, in some cases, the presence of pathogenic bacteria. The aim of this study was to perform a survival experiment to demonstrate the importance of proper herbal brewing technique and to conduct a molecular and …

Examining The Issue Of Compliance With Personal Protective Equipment Among Wastewater Workers Across The Southeast Region Of The United States, Tamara L. Wright

College of Graduate Studies: Theses & Dissertations

Wastewater workers are exposed to different occupational hazards such as chemicals, gases, viruses, and bacteria. Personal Protective Equipment (PPE) is a significant factor that can reduce or increase the probability of an accident from hazardous exposures to chemicals and microbial contaminants. The purpose of this study was to identify wastewater worker’s beliefs and practices on wearing PPE and protections offered by PPE through the integration of the Health Belief Model (HBM). Participants were workers in the wastewater industry, which included wastewater operators, laboratory analysts, maintenance workers, wastewater collection workers, equipment operators, managers, and supervisors (n=272). The instrument was a self-administered …

Testing The Underlying Chemical Principles Of The Biotic Ligand Model (Blm) To Marine Copper Systems: Measuring Copper Speciation Using Fluorescence Quenching, Tara N. Tait, James C. Mcgeer, Scott Smith

Chemistry Faculty Publications

Speciation of copper in marine systems strongly influences the ability of copper to cause toxicity. Natural organic matter (NOM) contains many binding sites which provides a protective effect on copper toxicity. The purpose of this study was to characterize copper binding with NOM using fluorescence quenching techniques. Fluorescence quenching of NOM with copper was performed on nine sea water samples. The resulting stability con- stants and binding capacities were consistent with literature values of marine NOM, show- ing strong binding with log K values from 7.64 to 10.2 and binding capacities ranging from 15 to 3110 nmole mg C ^{−1 …}

Challenges In Characterizing The Environmental Fate And Effects Of Carbon Nanotubes And Inorganic Nanomaterials In Aquatic Systems, Peter Laux, Christian Riebeling, Andy M. Booth, Joseph D. Brain, Josephine Brunner, Cristina Cerrillo, Otto Creutzenberg, Irina Estrela-Lopis, Thomas Gebel, Gunnar Johanson, Harald Jungnickel, Heiko Kock, Jutta Tentschert, Ahmed Tlili, Andreas Schäffer, Adriënne J. A. M. Sips, Robert A. Yokel, Andreas Luch

Pharmaceutical Sciences Faculty Publications

The current lack of commonly used protocols for dispersion, characterization, and aquatic toxicity testing of nanomaterials (NMs) has resulted in inconsistent results, which make meaningful comparisons difficult. The need for standardized sample preparation procedures that allow the reproducible generation of relevant test conditions remains a key challenge for studies of the environmental fate and aquatic toxicity of NMs. Together with the further development of optimized and cost-effective analytical techniques for physicochemical characterization that depend on reproducible sample preparation, such methods have the potential to overcome the current uncertainties with regard to NM dispersion properties, effective dose, and particle dissolution. In …

Investigating The Toxicity And Accumulation Of 2,4-Dichlorophenoxyacetic Acid (2,4-D) And Glyphosate In Eisenia Fetida, Caitlin Lazurick, Nicole Lidzbarski, Rachel Owings, Jeff Brotherton, Edna Steele

Journal of the South Carolina Academy of Science

Glyphosate, the main ingredient in Roundup^®, is the most widely used herbicide in the world. It is also used in combination with another effective herbicide, 2,4-D, in the formulation called Enlist Duo^®. The EPA approved the use of Enlist Duo^® on certain crops including those genetically modified to be resistant to both herbicides. The predicted significant increase in the use of these herbicides raised concerns from the general public because both compounds have been classified as possibly or probably carcinogenic. Since herbicides are applied directly to vegetation, the safety of organisms that come in contact …

Randomized Trial Of Interventions To Improve Childhood Asthma In Homes With Wood-Burning Stoves, Curtis W. Noonan, Erin O. Semmens, Paul Smith, Solomon W. Harrar, Luke Montrose, Emily Weiler, Marcy Mcnamara, Tony J. Ward

Statistics Faculty Publications

BACKGROUND: Household air pollution due to biomass combustion for residential heating adversely affects vulnerable populations. Randomized controlled trials to improve indoor air quality in homes of children with asthma are limited, and no such studies have been conducted in homes using wood for heating.

OBJECTIVES: Our aims were to test the hypothesis that household-level interventions, specifically improved-technology wood-burning appliances or air-filtration devices, would improve health measures, in particular Pediatric Asthma Quality of Life Questionnaire (PAQLQ) scores, relative to placebo, among children living with asthma in homes with wood-burning stoves.

METHODS: A three-arm placebo-controlled randomized trial was conducted in homes with …

Prozac In The Water: Chronic Fluoxetine Exposure And Predation Risk Interact To Shape Behaviors In An Estuarine Crab, Joseph R. Peters, Elise F. Granek, Catherine E. De Rivera, Matthew Rollins

Environmental Science and Management Faculty Publications and Presentations

Predators exert considerable top-down pressure on ecosystems by directly consuming prey or indirectly influencing their foraging behaviors and habitat use. Prey is, therefore, forced to balance predation risk with resource reward. A growing list of anthropogenic stressors such as rising temperatures and ocean acidification has been shown to influence prey risk behaviors and subsequently alter important ecosystem processes. Yet, limited attention has been paid to the effects of chronic pharmaceutical exposure on risk behavior or as an ecological stressor, despite widespread detection and persistence of these contaminants in aquatic environments. In the laboratory, we simulated estuarine conditions of the shore …

Trends In The Environmental Health Job Market For New Graduates, Jason W. Marion, Timothy J. Murphy Phd, Anne Marie Zimeri Phd

EKU Faculty and Staff Scholarship

The question of whether the job market can support future graduates of environmental health programs remains an important and difficult question for environmental health programs, current and prospective students, parents, and other stakeholders. Our previous report using 2014 data from the U.S. Bureau of Labor Statistics demonstrated anticipated growth and higher than average pay in the profession through at least 2022 for baccalaureate degree holders (Marion & Sinde, 2015). Growth in the profession does not necessarily translate into job availability if the market is saturated with job candidates. While university programs produce graduates, local health departments (LHDs) have suffered tremendous …

Lyme Disease And Youtube™: A Cross-Sectional Study Of Video Contents, Corey H. Basch, Lindsay A. Mullican, Kwanza D. Boone, Jingjing Yin, Alyssa Berdnik, Marina E. Eremeeva, Isaac Chun-Hai Fung

Environmental Health Sciences: Faculty Publications

Objectives: Lyme disease is the most common tick-borne disease. People seek health information on Lyme disease from YouTubeTM videos. In this study, we investigated if the contents of Lyme disease-related YouTubeTM videos varied by their sources.

Methods: Most viewed English YouTubeTM videos (n = 100) were identified and manually coded for contents and sources.

Results: Within the sample, 40 videos were consumer-generated, 31 were internet-based news, 16 were professional, and 13 were TV news. Compared with consumer-generated videos, TV news videos were more likely to mention celebrities (odds ratio [OR], 10.57; 95% confidence interval [CI], 2.13–52.58), prevention of Lyme disease …

Mobility Characteristics Of Azithromycin In Soil, Ryan Minter, Jihyun Kim, Linda Lee

The Summer Undergraduate Research Fellowship (SURF) Symposium

The presence of pharmaceutical and personal care products (PPCPs) in the environment has become a widespread problem in recent decades. Azithromycin, a macrolide antibiotic commonly prescribed for infections in humans, has been detected in waste treatment plant discharge and surface waters across the world. Data on the mobility characteristics of azithromycin in soil is scarce, and further studies must be performed to explore the potential for azithromycin leaching to groundwater or becoming available for plant uptake. In this study, azithromycin sorption isotherms were measured on eight soils varying in pH, organic carbon content, and clay content. Soil was equilibrated with …

A Comparison Of Outdoor Bioaerosol And Particulate Measurements In Las Vegas, Tanviben Yogeshkumar Patel

UNLV Theses, Dissertations, Professional Papers, and Capstones

The urbanization of the Las Vegas Valley has turned the desert into a green oasis by introducing many non-native plant species, some of which are allergenic. Outdoor bioaerosols consist of microorganisms, pollen, spores, and other agents that could cause infections or affect the health of humans. Studies have suggested that exposure to bioaerosols through inhalation can lead to various human health risks. Typically, one monitoring station is established per city to obtain pollen and mold counts for an entire metropolitan area, and the site may not be representative of community exposures. The objective of this study was to measure and …

The Impact Weather Has On Nyc Citi Bike Share Company Activity, Mark Martinez

Journal of Environmental and Resource Economics at Colby

This paper seeks to figure out the effect weather has on individuals’ behavior. A more focused approach to determining this effect is seeing how different weather conditions ranging from the temperature, the precipitation, the amount of inches of snowfall and the wind speed effect the ridership of Citi Bikes throughout all four seasons. The approach of this research paper is using data from the National Climatic Data Center that focuses in on the weather found in Manhattan, New York and correlates each of the weather conditions to the total number of trips per day that is provided by the Citi …

Electricity Demand Due To Policy Change In The U.K., Kevin W. Doherty

Journal of Environmental and Resource Economics at Colby

This paper examines United Kingdom Electricity Demand with regards to the Climate Change Act, which was enacted in November of 2008. Through actual demand data obtained from Nationalgrid, a U.K. based gas and electric utility company, this paper seeks to find out if the Climate Change Act has started to achieve its goal of reducing carbon emissions by looking at trends of electricity demand. Burning fossil fuels to produce electricity is a major contributor to global warming in the U.K. and policies enacted do not always live up to their ultimate goals. This paper tests how on track the Climate …

The Demographic Drivers Of California’S Environmental Voting, Lukas Yasuda

Journal of Environmental and Resource Economics at Colby

This study examines the demographics of California’s 53 congressional districts and the relationship with the voting patterns on three environmentally focused propositions in the 2008 and 2010 elections. Previous literature on the topic is mixed as some studies suggest that select attributes are found among environmental voting centers, yet other research describes the relationship as more complex than simple characteristics. Previous literature on the topic is mixed, with some studies suggesting that select attributes are found among environmental vote support hubs, whereas alternative research suggests the problem is more complex than simple characteristics. I collected data on income, education, age, …