Pharmacology, Toxicology and Environmental Health Commons^™

The Guacamole Fund Presents...

Native American Forum on Nuclear Issues

Special Bonnie Raitt Benefit Tickets

Iron(Iii)-Salophene: An Organometallic Compound With Selective Cytotoxic And Anti-Proliferative Properties In Platinum-Resistant Ovarian Cancer Cells, Thilo S. Lange, Kyu Kwang Kim, Rakesh K. Singh, Robert M. Strongin, Carolyn Mccourt, Laurent Brard

Chemistry Faculty Publications and Presentations

Background: In this pioneer study to the biological activity of organometallic compound Iron(III)-salophene (Fe-SP) the specific effects of Fe-SP on viability, morphology, proliferation, and cell-cycle progression on platinum-resistant ovariancancer cell lines were investigated.

Methodology/Principal Findings: Fe-SP displayed selective cytotoxicity against SKOV-3 and OVCAR-3 (ovarian epithelial adenocarcinoma) cell lines at concentrations between 100 nM and 1 μM, while the viability of HeLa cells (epithelial cervix adenocarcinoma) or primary lung or skin fibroblasts was not affected. SKOV-3 cells in contrast to fibroblasts after treatment with Fe-SP revealed apparent hallmarks of apoptosis including densely stained nuclear granular bodies within fragmented nuclei, highly condensed …

Nrc’S Decision Process: Judging The Safety Of A Proposed Repository, Janet Kotra

Native American Forum on Nuclear Issues

Abstract:

-Provide an overview of the role of the U.S. Nuclear Regulatory Commission (NRC) at Yucca Mountain

-Describe the process NRC will use to decide whether or not to authorize construction of a repository at Yucca Mountain

-Explain options and highlight important milestones that apply to Tribes as potential participants in NRC’s process

Fighting Nuclear Waste At Skull Valley, Margene Bullcreek

Native American Forum on Nuclear Issues

Abstract:

-Reasons We Oppose Nuclear Waste

-Sovereignty

-Traditional values must be protected

-Protect sacredness of our culture, plants,

animals, air, and water

-Affects on community health

-Protect reservation and homeland

-To protect the air and water

-To protect future generations

-Environmental Justice

Development And Recycling Of Novel Arsenic Removal Technology, Morgan Jones

Mahurin Honors College Capstone Experience/Thesis Projects

As of 2006, the U.S. Environmental Protection Agency (EPA) changed the Maximum Contaminant Level (MCL) for arsenic from 50 parts per billion (ppb), to 10ppb because of links to cancer. Current remediation technologies are expensive; therefore, this change will result in increased economic pressure on rural communities with high levels of arsenic in their drinking water. Lowering of the standard has spurred the development of a novel remediation technology that has shown the ability to reduce arsenic in drinking water at the source, with the added benefit of low-cost disposal of a stable and benign waste product in ordinary landfills. …

Application Of Genomics To Regulatory Ecological Risk Assessments For Pesticides, Steven P. Bradbury, Sigmund J. Degitz, Robert A. Hoke, Richard Brennan, Lee Ferguson, Rebecca Klaper, Laszlo Orban, David Spurgeon, Susan Tilton

Steven P. Bradbury

Substantial advances in human health and ecological risk assessment have been achieved by the risk assessment community; however, challenges remain, such as providing credible scientific information on a timely, efficient basis to support decisions for industrial chemicals and pesticides. Current risk assessment data generation requirements-including animal welfare concerns and the volume, appropriateness, and cost of required data-and the large number of chemicals requiring evaluation are a challenge confronting the chemical industry, national and international regulatory agencies, and associated stakeholders (Bradbury et al. 2004). The lack of hazard data for many chemicals and the need to improve the efficiency and quality …

Toxic Responses Of The Fish Nervous System, Steven P. Bradbury, Richard W. Carlson, Tala R. Henry, Stephanie Padilla, John Cowden

Steven P. Bradbury

Few of the approximately 70,000 chemicals on the Toxic Substances Control Act inventory or the 1000 to 1600 new chemicals introduced each year in the United States have been tested for neurotoxicity to support risk assessments (NRC, 1992), even though it is estimated that 5 to 10% of them are likely to be neurotoxic. Neurotoxicity has been defined as adverse effects of physical, biological, or chemical agents on the structure or function of the nervous system in developing or adult organisms (Philbert et al., 2000). From a human health risk assessment perspective, the potential for neurotoxic effects associated with synthetic …