Pharmacology, Toxicology and Environmental Health Commons^™

Chiral Liquid Membrane Containinga Dipentyl-P-Cyclodextrin : Enantioselective Partition Of Racemic Pseudoephedrine(ไครัลลิควิดเมมเบรนที่มีไดเพนทิลบีต้าใซโคลเด็กต..., Teerapol Srichana, Roongnapa Suedee

The Thai Journal of Pharmaceutical Sciences

This study was designed to examine enantioselective transport of pseudoephedrine through a two phase and chiral liquid membrane containing heptakis (di-o-pentyl)-P-cyclodextrin (dipentyl-P-CD). The molar ratio of dipentyl-P-CD to pseudoephedrine and pH o...

Efficacy And Safety Of Once-Daily Versus 12-Hour Dosing Of Amikacin In Thai Children At Queen Sirikit National Institute Of Child Health(ประสิทธิผลและความปลอดภัยของการให้ยาอะมิ..., Jutamat Titipankul, Wanchai Treyaprasert, Nans Waranawat

The Thai Journal of Pharmaceutical Sciences

The objective of this study was to compare the serum level, efficacy and nephrotoxicity of amikacin administrated as once-daily dosing versus every 12-hour dosing in pediatric patients at Queen Sirikit National Institute of Child Health (The Children Hos...

Once Daily Versus Twice Daily Dosing Of Gentamicin In Thai Neonates(การให้ยาเจนตามัยชินวันละครั้งเปรียบเทียบกับการให้ยาวันละสองครั..., Ampom Narongsanti, Uraiwan Chotigeat, Duangchit Panomvana Na Ayudhya

The Thai Journal of Pharmaceutical Sciences

The prospective, random ized trial of this study was conducted in 54 neonates w ith a gestation age of >34 weeks under 7 days of age at Queen Sirikit N ational Institute of Child H ealth from September to December 1998 to investigate the serum gentam ici...

Modulation Of The Pharmacokinetics And Pharmacodynamics Of Proteins By Polyethylene Glycol Conjugation, Reza Mehvar

Pharmacy Faculty Articles and Research

With the rapid advances in the field of biotechnology during the last decade, many peptides and proteins have been produced and evaluated for therapy of various diseases, including cancer. However, rapid clearance and the possibility of immunogenicity after the in vivo administration of these biotechnology-driven products have impeded their marketing. To circumvent these problems, synthetic and natural polymers such as polyethylene glycol (PEG) and dextrans, respectively, have been covalently attached to proteins, and some of these protein-polymer conjugates have shown promising therapeutic results. The conjugation of proteins with polymers usually causes a reduction in the recognition of the protein by …

Signaling Mechanisms For Muscarinic Receptor-Mediated Coronary Vasoconstriction In Isolated Rat Hearts, Yi Zhang

Electronic Theses and Dissertations

The signaling mechanisms for muscarinic receptor-mediated vasoconstriction in coronary resistance arteries were studied in KCl-arrested isolated rat hearts perfused at a constant flow rate. The cholinergic agonists acetylcholine and bethanechol were given by bolus injection or constant infusion. The coronary vascular resistance was monitored by measuring the changes in perfusion pressure. The selective muscarinic agonist bethanechol caused a similar vasoconstrictor response as ACh, but with less potency and efficacy. Bolus injection of bethanechol evoked a phasic vasoconstriction in a dose-dependent manner, while infusion of bethanechol evoked a tonic vasoconstriction without producing tachyphylaxis. Coronary vascular responses to bethanechol were further examined …

Cholera Toxin Mediated Regulation Of The Expression Of Gq Alpha And G11 Alpha Gtp Binding Proteins, B H. Shah

Department of Biological & Biomedical Sciences

Previously it has been shown that persistent activation of the stimulatory adenylyl cyclase pathway with cholera toxin (CT) downregulates the Gs alpha polypeptide (80%) in a cAMP-independent manner in C6 glioma cells (Shah, 1997). This study was conducted to examine the short and long term effects of CT on the regulation of pertussis toxin-sensitive and -insensitive G proteins and their transcripts in C6 glioma cells. Treatment of C6 cells with CT (100 ng/ml) up to 16 h had no effect on either Gi or Gq/11 alpha proteins. However, prolonged exposure (24-48 h) caused increased expression of Gi (20-30%) and Gq/11 …

Drug, Pharmaceutical, And Pharmacy-Related Sites: A Webliography Of Core Sites, Paul G. Haschak

E-JASL: Electronic Journal of Academic and Special Librarianship (1999-2009, Volumes 1-10)

The World Wide Web (WWW) increasingly is becoming an important learning, teaching, and research tool for teachers and students, alike, who are seeking useful drug, pharmaceutical, and pharmacy-related sites on the Web, for their research. However, the seemingly inexhaustible number of WWW links can be daunting even to the most experienced Web user.

The following webliography is presented specifically for educators and students seeking a concise, annotated core list of WWW links on pharmaceutical, drug, and pharmacy-related topics.

Co-Activation Of Gi And Gq Proteins Exerts Synergistic Effect On Human Platelet Aggregation Through Activation Of Phospholipase C And Ca2+ Signalling Pathways, B H. Shah, A Siddiqui, K A. Qureshi, M Khan, S Rafi, V A. Ujan, M Y. Yakoob, Y Yaqub, H Rasheed, S A. Saeed

Department of Biological & Biomedical Sciences

Our previous studies have shown that subthreshold concentrations of two platelet agonists exert synergistic effects on platelet aggregation. Here we studied the mechanism of synergistic interaction of 5-hydroxytryptamine (5-HT) and epinephrine mediated platelet aggregation. We show that 5-HT had no or little effect on aggregation but it did potentiate the aggregation response of epinephrine. The synergistic interaction of 5-HT (1-5 microM) and epinephrine (0.5-2 microM) was inhibited by alpha2-adrenoceptor blocker (yohimbine; IC50= 0.4 microM), calcium channel blockers (verapamil and diltiazem with IC50 of 10 and 48 mM, respectively), PLC inhibitor (U73122; IC50=6 microM) and nitric oxide (NO) donor, SNAP (IC50=1.6 …

Atherosclerosis And Plaque Rupture: An Update, M N. Afzal, S A. Saeed, B H. Shah

Department of Biological & Biomedical Sciences

No abstract provided.

Understanding Pharmacy Administration: The Applied Research In Pharmaceutical Sciences, Nawarut Charupatanapong

The Thai Journal of Pharmaceutical Sciences

This paper presented a historical overview of pharmacy administration as an academic, research, and professional discipline of pharmacy in the United States. It also described pharmacy administration as an applied research in pharmaceutical sciences, and...

Force-Sensor Modules And Punch-Displacement Instrumentation For Tableting Machine(การติดตั้งหัววัดแรงและอุปกรณ์วัดระยะเคลื่อนที่ของสาก สำหรั..., Jakkapan Sirithunyalug, Thawan Sucharitakul, Wiwat Klongpanich, Choochat Krudtong

The Thai Journal of Pharmaceutical Sciences

Force-sensors modules with metal-foil resistance strain gauge were designed and fixed in the upper-and lower punch holders of single-stroke tableting machine. The velocity of the upper punch was determined by using a linear displacement transducer. Signa...

Future Pharmacist: Key Determinant Of The Direction Of Pharmacy Education(เภสัชกรในอนาคต:ปัจจัยกำหนดทิศทางเภสัชศาสตร์ศึกษา), Sauwakon Ratanawijitrasin

The Thai Journal of Pharmaceutical Sciences

A series of consultative meetings organized by international organizations during the past decade attempted to examine the role of the pharmacists within the rapidly changing social and health environments, and to formulate proposals for the development ...

Chemical Constituents Of The Leaves Of Harpullia Cupanioides Roxb.(องค์ประกอบทางเคมีของใบหงอนไก่ดง), Rutt Suttisri, Atthachai Homhaun, Amornrat Srangpol, Pornpimol Yamchamuang, Thitima Pengsuparp, Ekarin Saifah

The Thai Journal of Pharmaceutical Sciences

Two flavonoids, 3-hydroxy-4',5,7-trimethoxyflavone and flavokavain A, and a steroid, stigmasterol, have been isolated from the hexane-soluble fraction of the leaves of Harpullia cupanioides Roxb. The structures of these compounds were determined by spect...

An Antibacterial Cream Containing The Extract From Tinospora Crispa(ครีมต้านแบคทีเรียที่มีสารสกัดจาก‘นอระเพ็ด (Tinospora Crispa)), Siriporn Burapadaja, Manassanunt Bunchoo

The Thai Journal of Pharmaceutical Sciences

Crude ethanol extract from the stem of Tinospora crispa (Linn.) was separated into fractions by chromatographic technique. The extractive fractions were examined for antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, bacteri...

Primary Screening For Local Anesthetic Activity Of Semipurified Compound Isolated From Cha-Plu (Piper Sarmentosum Roxb.)(การทดสอบเบี้องต้นในการมีฤทธิ์เป็นยาซาเฉพาะที..., Mayuree H. Tantisira, Boonyong Tantisira, Thongchai Sooksawate, Piyarat Nimpitakpong, Pornthip Boonchaipanitvattana, Roongtip Theplertboon

The Thai Journal of Pharmaceutical Sciences

Isolated frog sciatic nerve preparations were used to investigate the local anesthetic activity of semipurified compound isolated from Cha-plu (Piper sarmentosum Roxb.) in relation to lidocaine. The test compound which was dissolved in 70% polyethylene g...

Intestinal Drug Metabolism And Drug Exsorption(เมตาบอลิสมของยาในลำไส้และการขับยาจากเซลล์ เยื่อบุผนังลำไส้เข้าสู่ช่อง..., Nusara Piyapolrungroj

The Thai Journal of Pharmaceutical Sciences

Oral bioavailability of drugs is often limited by first-pass elimination. The occurrence of low bioavailability due to significant metabolism or poor absorption of orally administered drugs has been well recognized. Although the content of drug metaboliz...

Emergency Postcoital Contraception(การดุมกำเนิดแบบฉุกเฉินหลังร่วมเพศ), Wantana Reanmongkol, Sanguan Lerkiatbundit

The Thai Journal of Pharmaceutical Sciences

Postcoital emergency contraception is the use of a drug or device to prevent pregnancy after intercourse. The word “emergency” indicates that it should not be used as a regular contraception. It is intended to be used in the case of emergency such as...

Stability Study Of Povidone - Iodine Topical Solution(การศึกษาความคงสภาพของยาน้ำที่ใช้ภายนอก โพวิโดน-ไอโอดีน), Yaowalak Wattanapisit, Wilawan Soontraruk, Churirat Rakwatin

The Thai Journal of Pharmaceutical Sciences

Five out of 33 povidone-iodine topical solutions from local manufacturers were randomly selected for stability studies. They were stored for 4 months at 45°c, 75% relative humidity for accelerated stability study and at 25-30°C up to 12 months for long...

Preparation Of Pirkle (Brush Type) Column For Analytical Separation Of Enantiomers(การเตรียมคอลัมน์แบบ Pirkle สำหรับแยก Enantiomer ในเซิงวิเคราะห์), Bunleu Sungthong, Chavi Yenjai, Chantana Aromdee

The Thai Journal of Pharmaceutical Sciences

A synthesized chiral stationary phase (CSP-S) was prepared by the reaction of silica and triethoxy-3-aminopropylsilane, followed by further derivatising with f/?J-N-(3,5-dinitrobenzoyl)- phenylglycine. The same type of CSP (CSP-P) was also prepared from ...

Instrumentation Of Adhesive Strength Measurement And Effects Of Formulation Factors On Adhesive Strength Of Film-Coated Tablets(การพัฒนาเครื่องมือวัดแรงยึดเกาะของฟิล์มบนย..., Tudsong Tourtip, Bunyapa Wangwattana, Pretirat Srikul, Narong Sarisuta

The Thai Journal of Pharmaceutical Sciences

The study was designed to develop an instrument for measuring the adhesive strength of polymeric film to tablet surface by means of removing the film coated on tablet surface vertically utilizing the air pressure. The core tablets were mainly composed of...

เภสัชบำบัดของ โรคแผลเปื่อยเป๊ปติก, มยุรี ตันติสิระ

The Thai Journal of Pharmaceutical Sciences

รูปแบบของเภสัชบำบัดสำหรับแผลเปื่อยเป๊ปติกชึ่งแต่เดิมเป็นการรักษาแผล,โดยการให้ยาที่มีฤ...

Survey Of The Community Pharmacy Practices As Stipulated By The Council Of Pharmacy And Factors Affecting Them(การสำรวจการ,ปฏิบัติงานเภสัชกรรมชุมชนตามข้อบังคับ..., Nuttasiri Thanawuth, Malee Rojpibulstit, Chonladda Sopharat, Thammawan Thaisomboon, Pripaka Suwithayarat, Sanguan Lerkiatbundit

The Thai Journal of Pharmaceutical Sciences

The objectives of this survey were to determine the attitudes of community pharmacists toward the practice stipulation issued by the Council of Pharmacy, to determine the frequency of practices in each area identified in the stipulation, and factors affe...

Characteristics And Relative Factors Of Consumer Purchasing By Drug Names In Community Pharmacy(ลักษณะและปัจจัยที่เกี่ยวข้องในการเลือกซื้อยาในร้านยา..., Vachiraporn Sreprasert, Sukanya Chaicharoen, Orawan Suitthimeathegorn, Sathitpong Thanaviriyakul

The Thai Journal of Pharmaceutical Sciences

The study was to describe the characteristics and relative factors of consumer purchasing by drug names in community pharmacy. A convenient sampling of 300 consumers who bought drugs by drug names in Bangkok’s drugstores was conducted during December 1...

Trans-Resveratrol Inhibits Calcium Influx In Thrombin-Stimulated Human Platelets, Yuliya Dobrydneva, Roy L. Williams, Peter F. Blackmore

Chemistry & Biochemistry Faculty Publications

1 The phytoestrogenic compound trans-resveratrol (trans-3,5,4'-trihydroxystilbene) is found in appreciable quantities in grape skins and wine. It has been shown that both products rich in trans-resveratrol and pure trans-resveratrol inhibit platelet aggregation both in vivo and in vitro. However the mechanism of this action still remains unknown.

2 An essential component of the aggregation process in platelets is an increase in intracellular free Ca²⁺ ([Ca²⁺]_i). Ca²⁺ must enter the cell from the external media through specific and tightly regulated Ca²⁺ channels in the plasma membrane. The objective …

The Use Of Conferencing Software For The Distance Education Of Renal Pharmacotherapy, Sirada Maphanta, Curtis A. Johnson

The Thai Journal of Pharmaceutical Sciences

Pharmacy educators have become increasingly interested in distance education methods. This interest has been stimulated by the advent of the nonlraditional doctor of pharmacy program that relies heavily on various means of distance technology. At the Uni...

Stability Of Furosemide In Extemporaneously Compounded Oral Suspensions: Effect Of Vehicle, Ph, And Storage Conditions(ความคงตัวของฟูโรซีใมด์ในรูปแบบยาแขวนตะกอนรับป..., Detpon Preechagoon, Wiyada Maha-Orankul, Nattiya Pongphasuk, Preeya Areemit, Usa Sripanyawichya

The Thai Journal of Pharmaceutical Sciences

The stability of furosemide in extemporaneously prepared oral suspensions from commercially available tablets was studied. Suspensions of furosemide in syrup, sorbitol and phosphate buffer (pH 4, 6 and 8) were compounded and stored at 4 °c and ambient t...

Contributions Of Social Sciences To Pharmacy(ความสำคัญของสังคมศาสตร์ต่อเภสัชกรรม), Sanguan Lerkiatbundit

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Fourier Transform Infrared Spectrometric Determination Of Benzyl Alcohol And Benzaldehyde(การวิเคราะห์หาปริมาณเบนซิลแอลกอฮอล์และเบนซาลดีโฮด์ ด้วย..., Vimon Tantishaiyakul, Thitima Chuchom

The Thai Journal of Pharmaceutical Sciences

Fourier transform infrared spectrometry (FTTR) was developed for the determination of benzyl alcohol and benzaldehyde. The method for quantification of benzyl alcohol is based on the second derivative FTIR measurement at 1205.28 cm'1 which is the zero cr...

A Model For The Number Of Industrial Pharmacists(แบบจำลองจำนวนเภสัชกรโรงงาน), Sathitpong Thanaviriyakul, Paradon Ponyares

The Thai Journal of Pharmaceutical Sciences

This study was to develop a model to determine the number of industrial pharm acists. A questionnaire survey of 175 industrial pharmacists was carried out on January 1998. The response rate was 37.7% . The results showed the current status of pharmaceuti...

Comparisons Of American, Taiwan, And Thai Pharmacy Students’ Perceptions Of Factors Affecting Their Academic Performance, Nawarut Charupatanapong

The Thai Journal of Pharmaceutical Sciences

This study examined pharmacy students' perceptions of factors affecting their academic performance among the United States, Taiwan, and Thailand. The Study also compared two groups of factors that American, Taiwan, and Thai pharmacy students perceived as...