Pharmacology, Toxicology and Environmental Health Commons^™

Vegetables And Yoghurt Fermentation Of Lactobacillus Strains(การหมักผักและโยเกิร์ตของสายพันธุ์แล็กโตบาซิลลัส), Suchada Jongrungruangchok, Somboon Tanasupawat, Surai Saisorn

The Thai Journal of Pharmaceutical Sciences

Lactobacillus sp. L2-1, Lactobacillus farciminis 73-1, and Lactobacillus plantarum P7-1 were used for fermenting green mustard and mixed vegetables in comparison to natural fermentation. The salt and sugar concentration were varied to 1-2% and 2-4%, resp...

Keyword Index, Author Index(ดรรชนีกุญแจคำ, ดรรชนีผู้แต่ง), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Efficacy And Safety Of Fluconazole Combined With Amphotericin B For Treatment Of Cryptococcal Meningitis In Patients With Aids(ประสิทธิผลและความปลอดภัยของการใช้ฟลูโคนาโซ..., Chankig Puttilerpong, Somsit Tansuphaswadikul, Duangchit Panomvana Na Ayudhya

The Thai Journal of Pharmaceutical Sciences

Cryptococcal meningitis (CM) is the most common life-threatening opportunistic fungal infection in patients with AIDS. The purpose of this study was to compare the efficacy and safety of giving high dose of amphotericin B for the first two weeks of thera...

In Vitro Hepatotoxicity Study Of Barakol Using Human Hepatoma Cell Line Hepg2(การศึกษาความเป็นพิษของบาราคอลต่อตับ โดยการทดสอบด้วยเซลล์มะเ..., Somsong Lawanprasert, Chaiyo Chaichantipyuth, Surachai Unchern, Yupin Lawanprasert, Daret St.Clair

The Thai Journal of Pharmaceutical Sciences

Human hepatoma cell line HepG2 was used to assess the hepatotoxic effects of barakol, isolated from young leaves of Cassia siamea. Barakol at concentrations of 0.25, 0.50, 0.75 and 1 mM were added to HepG2 cells for 24, 48, 72 and 96 hours. Cytotoxicity ...

Production Of Colchicine From Root Cultures Of Gloriosa Superba L.(สารโคลชิซีนจากรากเพาะเลี้ยงดองดึง), Waraporn Putalun, Boonyean Kitvijarn

The Thai Journal of Pharmaceutical Sciences

The plant Gloriosa superba L. is a source of colchicine which is used in medicine and agriculture. Study of G. superba using plant tissue and cell culture technique was performed in vitro in order to observe its ability to produce colchicine. The medium ...

Heavy Metals And Organic Pollutants In Sediments Of Dar Es Salaam Harbour Prior To Dredging In 1999, J F Machiwa

Tanzania Journal of Science

Heavy metals and organic contaminants were analysed in the sediments of the inner area of the Dar es Salaam harbour. Complementary analytical parameters, such as, the organic carbon content and the silt/clay fraction of the sediments showed good positive correlation (r = 0.64). Stations that had high content of fine grain material in the sediment also indicated relatively high level of organic carbon and pollutants. The Florida criteria (MacDonald 1993) for assessment of pollution of tropical marine sediments was adopted in oredr to evaluate the extent of pollution in Dar es Salaam harbour sediments. The Florida criteria is one of …

Towards Gene Therapy Of Parkinson’S Disease: Implantation Of Ruc-Gdnf Secreting Mammalian Cell Lines Into Rat Brain, Hua Liu

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study is to develop a new approach for monitoring the function of implanted cells by a Renilla luciferase -glial cell line derived neurotrophic factor (RUC-GDNF) fusion protein in CSF. The RUC-GDNF protein is expected to report GDNF secreted from the cell by bioluminescence through luciferase activity.

Current ex vivo gene therapy using GDNF is limited by lack of a monitoring mechanism to determine the expression of GDNF once transformed cells or vector DNA are injected into animal models. Since the therapeutic concentration of GDNF secreted into cerebrospinal fluid (CSF) by implanted cells is too low for …

Mechanisms Of Calcium Buffering And Aging In Neurons: Testing The Limits Of Homeostasis, William James Pottorf Ii

Loma Linda University Electronic Theses, Dissertations & Projects

Intracellular calcium ([Ca²⁺]i) is an ubiquitous second messenger that integrates multiple and diverse neuronal pathways that include development and maturation, gene expression, synaptic plasticity, transmitter release, excitability, and even cell death. Upon neuronal excitation the [Ca²⁺]i increases rapidly and the calcium buffering system reacts quickly to restore [Ca²⁺]i to basal levels in order to reset the cell for the next stimulus and avoid prolonged exposure to cytotoxic levels of high [Ca²⁺]i. The aging process appears to causes multiple changes in the ability of neurons to regulate [Ca²⁺]i homeostasis and an …

Investigations On The Use Of Ion Mobility Spectrometry For Clinical Chemistry Applications, Henri Parson Patten

Theses and Dissertations in Biomedical Sciences

The major objective of this research is to examine ion mobility spectrometry as a rapid screening tool for specific application to clinical chemistry research and laboratory use. Methodology was developed for target analytes representing several classes of physiologically active substances, including anesthetics, illicit drugs, and their metabolites. The IMS characteristics of animal tissues and other compounds such as amino acids and proteins were determined. Quality assurance and control procedures were developed for specific quality data objectives. Criteria were established relating to use of IMS for assessing the precision and accuracy of data, qualitative screening, and semi-quantitative analyses.

It was found …

เทคโนโลยียาไทย: ปัจจัยกำหนดการแข่งขันระหว่างประเทศ, ไกรสีห์ อัมพรายน์, นิจศิริ เรืองรังษี

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ปัจจัยส่งเสริมวิวัฒนาการทางเทคโนโลยีและแนวทางในการพัฒนาคุณค่า สมุนไพรไทย, ไกรสีห์ อัมพรายน์, นิจศิริ เรืองรังษี

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Enantiomeric Separation Of Salbutamol From Spiked Urine Extracted With Solid Stationary Phase(การแยกอิแนนทิโอเมอร์ของ Salbutamol ที่เติมในตัวอย่างปัสสาวะโด..., Teerapol Srichana, Roongnapa Suedee

The Thai Journal of Pharmaceutical Sciences

A solid phase extraction procedure followed by a fluorescence HPLC assay was developed for the determination of salbutamol enantiomers in urine. The extraction method employing silica cartridge made in house, was proved to be able to eliminate the matrix...

Self-Efficacy And Nonadherence In Post Renal Transplant Patients(ความมั่นใจในสมรรถนะของตนกับการไม่ใช้ยาตามสั่งในผู้ป่วยหลังผ่าตั..., Titinun Auamnoy, Bernard Sorofman, John Bertolatus, John Brooks, William Doucette, David Min

The Thai Journal of Pharmaceutical Sciences

This study investigated health behaviors in post renal transplant patients to examine the correlation between Self-efficacy (confidence in one's readiness to perform a specific thing in a specific situation) and adherence to medical regimens. Our purpos...

Artificial Neural Network : A Different Computational Paradigmand Applicationin Pharmaceutical Technology(เครือข่ายประสาทเทียม: กระบวนทัศน์ของการคำนวณที่แตก..., Phuriwat Leesawat

The Thai Journal of Pharmaceutical Sciences

This review describes the fundamental of Artificial Neural Network (ANN) as well as its application in pharmaceutical technology. The article starts with the historical background of ANN and the foundation of the neural computing. ANN is a new computatio...

Methicillin Resistance In Coagulase-Negative Staphylococci(การดื้อยา Methicillin ในเชื้อพวก Coagulase-Negative Staphylococci), Mali Wirotesangthong, Pintip Pongpech

The Thai Journal of Pharmaceutical Sciences

To investigate prevalence of methicillin-resistant, coagulase- negative staphylococci (MRCoNS), CoNS were explored from various sources in the following study population: healthy non-medical personnel (147), healthy medical personnel (115), patients with...

Development Of A Quality Of Life Questionnaire: Sf-36 (Thai Version)(การพัฒนาแบบสอบถามคุณภาพชีวิต Sf-36 ฉบับภาษาไทย), Watcharee Leurmamkul, Paranee Meetam

The Thai Journal of Pharmaceutical Sciences

SF-36 is one of the most widely used instruments for the health-related quality of life assessment. It has been validated and studied in various groups of patients and general population. The main objective of this study was to develop a Thai version of ...

Application Of Combinatorial Synthesis In Drug Discovery Process(การประยุกต์ใช้การสังเคราะห์สารแบบคอมบินาทอเรียลในกระบวนการค้นหา..., Panadda Yaipakdee

The Thai Journal of Pharmaceutical Sciences

Combinatorial synthesis is a novel synthetic method developed for rapidly generating a large number of related compounds. The synthetic process can be carried out in solution or on solid phase. The compounds produced by combinatorial synthesis are genera...

Professionalism And Motivation To Work In Pharmacy Externs(ลักษณะของผู้ประกอบวิชาชีพและแรงจูงใจในการทำงานของนักศึกษา เภสัชศา..., Sanguan Lerkiatbundit

The Thai Journal of Pharmaceutical Sciences

This study was designed to analyze and describe the change in professionalism as an outcome of the externship requirement in pharmacy students, and to determine the factors that can predict their motivation to work in various practice settings. Eighty-on...

Newborn Porcine Skin As A Model Membrane For In Vitro Percutaneous Absorption(การใช้หนังสุกรเป็นแบบจำลองของการดูดซึมผ่านผิวหนัง), Tanasait Ngawhirunpat, Suwannee Panomsuk, Praneet Opanasopit, Sayan Junsook, Supapom Pompinatepong

The Thai Journal of Pharmaceutical Sciences

The ill vitro skin permeation of six hydrophilic drugs (1-dopa, nicorandil, antipyrine, 5- fluorouracil, diclofenac sodium and dopamine hydrochloride) and six lipophilic drugs (ketoprofen, isosorbide dinitrate, indomethacin, ibuprofen, flurbiprofen and c...

Keyword Index, Author Index (ดรรชนีกุญแจคำ, ดรรชนีผู้แต่ง), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Comparative Study Of Blood, Vitreous Humor And Urine Alcohol Concentrations In Thai Postmortem Traffic Accidental Victims(การศึกษาเปรียบเทียบระหว่างความเข้มข้นของแอลก..., Wichian Tungtananuwat, Somsong Lawanprasert, Niti Suwongthrom

The Thai Journal of Pharmaceutical Sciences

To utilize alcohol (referring to ethanol) concentrations in other biological specimens to estimate a blood alcohol concentration (BAC) when suitable postmortem blood sample is unavailable or contaminated, a good correlation between alcohol concentrations...

Quality Evaluation Of Liquid Paraffin Emulsion Produced In Hospitals(การประเมินคุณภาพของยา Liquid Paraffin Emulsion ที่ผลิตใน โรงพยาบาล), Chantana Aromdee, Sumon Sakolchai, Unchalee Tattawasart, Thanee Tessiri, Yaowares Suwanphaiboon

The Thai Journal of Pharmaceutical Sciences

Liquid Paraffin Emulsion, an effective, mild and cheap feacal softener, is compounded and widely dispensed in hospitals. Twenty-nine samples were obtained from various sizes of hospitals and from every part of the country. Two samples were produced by a ...

Key Word Index, Author Index(ดรรชนีกุญแจคำ, ดรรชนีผู้แต่ง), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Health - Related Quality Of Life Questionnaire Development(การสร้างแบบสอบถามวัดคุณภาพชีวิตด้านสุขภาพ), Watcharee Leurmamkul

The Thai Journal of Pharmaceutical Sciences

This paper in intended to enlighten clinicians about methods for development of a new quality of life instrument. The proper process involves two sets of operational strategies: development and testing. Four stages of development: specifying measurement ...

Novel Prostacyclin Analogues(สารออกฤทธิ์คล้ายพลอสตาไซคลินชนิดใหม่), Leena Suntomsuk

The Thai Journal of Pharmaceutical Sciences

Prostacyclin (PGI2) is a natural prostaglandin synthesized from the cyclooxygenase pathway of arachidonic acid metabolism which exhibits potent vasodilating and anti-platelet aggregation activities. PGI2 is susceptible to p-oxidation due to the enol-ethe...

Synthesis And Evaluation Of Chromone Derivatives As Potential Hiv-1 Protease Inhibitors(การสังเคราะห์และประเมินประสิทธิผลของอนุพันธ์โครโมนในการ..., Jirapom Ungwitayatorn, Chanpen Wiwat, Weerasak Samee

The Thai Journal of Pharmaceutical Sciences

A new class of non-peptide analogues in chromone series, were synthesized as potential HIV-1 protease inhibitors. The general structure of compounds consists of chromone nucleus with different substituents at position 2, 3, 7, and 8. The in vitro inhibit...

Establishing The Specifications Of Cassia Tom Linn. Seeds(การจัดทำข้อกำหนดเฉพาะของเมล็ดชุมเห็ดไทย), Nantana Sittichai, Sirichai Rrabesri, Ekamol Suthison

The Thai Journal of Pharmaceutical Sciences

The quality of Cassia tara Linn, seeds was investigated in order to set up specifications. The sample estimates at the significance level (a) of 0.05 with desired limits of error of 10 % and 20 % were determined. The 95 % confidence intervals for the sam...

Investigations Of The Absorption And Metabolismof Antioxidant Flavonols, Abdul Aziz Azlina

Student Works (2000-2009)

Flavonols are polyphenols, secondary plant metabolites commonly found in plants and foods of plant origin. They have widespread biological properties in the human body. The recent discovery of their potential antioxidant activities has prompted extensive research. Flavonols particularly quercetin are potent antioxidants with higher antioxidant properties than the well known antioxidant vitamins C and E. Several epidemiology studies have demonstrated a strong inverse association between flavonoid intake and risk of coronary heart disease. The association with cancer is less defined with only some studies showing an inverse association and others not. In view of their potential to act as antioxidants …

Polycythemia Of Newborn Infant : Normal Saline Partial Exchange Transfusion(ภาวะเลือดขนในเด็กแรกเกิด : การเปลี่ยนถ่ายเลือดบางส่วนด้วย นํ้า..., Petcharindr Yamarat, Suparach Karnjanavanich

The Thai Journal of Pharmaceutical Sciences

Polycythemia can cause abnormalities in many systems such as nervous system, cardiovascular system and pulmonary system. The standard treatment for polycythemia is plasma partial exchange transfusion. However, the use of blood and components of blood in ...

Relicensing: Are Thai Pharmacists Ready?(การต่ออายุใบอนุญาตประกอบวิชาชีพ: เภสัชกรพร้อมหรือยัง), Sauwakon Ratanawijitrasin, Sawat Seega, Sirikwan Loongban

The Thai Journal of Pharmaceutical Sciences

Resolutions of the Thai Pharmaceutical Council in February and March 1998 set to institute a relicensing system for Thai pharmacists with continuing education as its requirement. A study was conducted between October 1998 and January 1999 to survey the o...