Behavioral Neurobiology Commons^™

Carbon Dioxide Attracts Nesting Behavior In Captive African Naked Mole-Rats, Dan Mccloskey

Publications and Research

This dataset contains raw Radio Frequency Identification data for a 185 hour gas infusion study conducted in the TT-2 colony at the College of Staten Island in May-June 2019. The purpose of this experiment was to determine whether colony members would be attracted to a chamber with elevated carbon dioxide levels matching the highest values recorded in the typical colony nest. The results show a significant attraction to the CO2-infused chamber during and after the period of CO2 in=fusion, with the relocation of the colony nest to this site for the first time in the history of this colony. These …

Experience-Dependent Changes In Nucleus Accumbens Activity Predict Cued Approach Learning: Contribution Of Nmda Receptors, Mercedes Vega Villar

Dissertations, Theses, and Capstone Projects

Animals learn associations between environmental cues and the natural rewards they predict (e.g., food, water, sex). As a result, reward-predictive cues come to trigger vigorous reward-seeking responses. Many neurons in the nucleus accumbens (NAc) become excited upon presentation of an already-learned reward-predictive cue. These NAc responses encode the motivational value of the cue and are necessary for the expression of the subsequent approach behavior. However, the precise temporal relationship between the emergence of cue-evoked excitations in the NAc and the acquisition of cued approach behavior remains unknown. In Experiment 1, NAc activity was recorded as rats learned to approach a …

Activation Of The Sonic Hedgehog Effector Smoothened Counteracts L-Dopa Induced Dyskinesia By Restoring Cholinergic Interneuron Function, Lauren Malave

Dissertations, Theses, and Capstone Projects

Many types of neurons act as multimodal signaling centers. Yet, we have only limited insight into the regulation and functional consequences of neuronal co-transmission. For example, dopamine (DA) neurons, whose degeneration causes motor deficits characteristic of Parkinson’s Diseases (PD), communicate with all their targets by DA but only a selective subset of their targets using GABA, Glutamate, and the secreted cell signaling protein Sonic Hedgehog (Shh). It is unknown whether Levo-dopamine (L-Dopa) induced dyskinesia (LIDs), a severely debilitating side effect of DA supplementation in PD, might appear because DA neuron targets are exposed to high DA- but low Shh- signaling …

Implicit Bias Through The Lens Of Electroencephalography, Hope Cooper

Behavioral Neuroscience Honors Papers

Unconscious or implicit bias is a part of everyday life. All human beings both exhibit implicit bias and (some more than others) are also the victims of it. Due to the way humans have evolved implicit bias will never be something that ceases to exist. Thus, it is important that neuroscience and social science closely study how it works and how to curb the behaviors caused by implicit bias. In the following research EEG (electroencephalography) was used alongside a weapons IAT (Implicit Association Test) to examine specific neural components that may correlate with higher bias scores on the IAT. Specific …

Individual Differences In Cocaine-Conditioned Avoidance Behavior And Implication For Addiction Vulnerability, Maya Eid

MUSC Theses and Dissertations

Decades of studies have examined the mechanisms by which drugs of abuse produce strong rewarding effects that drive addictive behavior. However, these drugs also produce aversive effects that are less well understood, but that also strongly influence drug-seeking, and may contribute to individual variation in addiction liability. For example, individuals with particularly strong aversive responses to nicotine or alcohol may be less likely to acquire smoking or drinking habits, with these protective effects arising from specific biological differences in nicotinic receptor function or alcohol metabolism, respectively. These aversive effects can also be exploited therapeutically, as in widely available treatments for …

Role Of Dynorphin/Kappa Opioid Receptor Activity Within The Extended Amygdala In Binge Alcohol Drinking, Harold Lewis Haun

MUSC Theses and Dissertations

Alcohol Use Disorder (AUD) is a significant national and global public health problem. Of concern, binge drinking is the most common pattern of excessive alcohol consumption and serves as a risk factor for the development of AUD. Recent studies have implicated the dynorphin/kappa opioid receptor (DYN/KOR) neuropeptide system in this pattern of drinking but the precise circuitry mediating these effects are poorly understood. The central amygdala (CeA) and bed nucleus of the stria terminalis (BNST) are two interconnected structures within the extended amygdala macrostructure that are rich in DYN/KOR and thought to contribute to binge drinking behavior. In the present …

Whether Invertebrates Are Sentient Matters To Bioethics And Science Policy, Michael L. Woodruff

Animal Sentience

Mikhalevich & Powell provide convincing empirical evidence that at least some invertebrates are sentient and hence should be granted moral status. I agree and argue that functional markers should be the primary indicators of sentience. Neuroanatomical homologies provide only secondary evidence. Consensus regarding the validity of these functional markers will be difficult to achieve. To be effective in practice, functional markers of sentience will have to be tested and accepted species by species to overcome the implicit biases against extending moral status to invertebrates.

Inhibition Of Pain Or Response To Injury In Invertebrates And Vertebrates, Matilda Gibbons, Sajedeh Sarlak

Animal Sentience

In certain situations, insects appear to lack a response to noxious stimuli that would cause pain in humans. For example, from the fact that male mantids continue to mate while being eaten by their partner it does not follow that insects do not feel pain; it could be the result of modulation of nociceptive inputs or behavioural outputs. When we try to infer the underlying mental state of an insect from its behaviour, it is important to consider the behavioural effects of the associated physiological and neurobiological mechanisms.

Young African American Men's Conception Of Fatherhood Among Survivors Of Childhood Abuse, Ohan Patricia Carter

Walden Dissertations and Doctoral Studies

Male survivors of abuse who become fathers themselves face challenges different from female survivors, such as conceptualizing their roles as providers and heads of households after the traumatic and often belittling experiences of abuse. However, very few researchers have studied the connection between child abuse and fatherhood, and none specific to young African American fathers. An interpretative phenomenological approach enabled exploration of how African American fathers who were abused as children, conceptualized and perceived their own experiences with fatherhood. The theoretical framework for this study was identity theory, which indicates that how people conceptualize a social role influences their actions …

Assessing A Two-Hit Model Of Schizophrenia: Prenatal Choline Deficiency And Induced Hypofunction Of Nmda Receptors In Male And Female Long Evans Rats, Samuel Gray, Samuel W. Gray

Honors Theses

Choline is an essential dietary nutrient essential to the development and function of the central nervous system. Prenatal choline deficiency alters hippocampal development as well as acetylcholine metabolism, leading to cognitive impairments and attentional and sensory processing deficits into adulthood. MK-801 is an NMDA receptor antagonist frequently used in rodent models of neuropsychiatric conditions, particularly schizophrenia. Acutely and sub- chronically, it causes hyperlocomotion and social withdrawal. One primary goal of the present study were to investigate prenatal choline deficiency induces a biological vulnerability to the motor deficits, anhedonia, and social impairment precipitated by low-dose sub-chronic MK-801 administration in adulthood. Another …

Executive Function Deficit As A Precursor To Memory Impairments In Hapoe4 Transgenic Rats, Kaitlin Mcmanus

Honors Theses

The hApoE4 allele is one of the strongest genetic risk factors for Alzheimer’s disease (AD). It underlies amyloid-bdeposits and neurofibrillary tangles, the two hallmarks associated with AD pathology, and is subsequently associated with AD symptomology. Despite its importance, no rat animal studies to date use hApoE4 knock-ins. In addition to this deficit in the field of AD literature, the vast majority of AD studies focus on memory, even though executive function deficits may precede memory impairments in AD, and may be a predictor of AD development. Thus, the present study addressed these gaps in AD research by investigating the behavioral …

Effects Of The Abused Inhalant Toluene On Mpfc-Dependent Cognitive Behaviors And Associated Neural Activity, Kevin Michael Braunscheidel

MUSC Theses and Dissertations

Volatile organic solvents like toluene induce euphoria and intoxication when inhaled at high concentrations. Inhalant misuse is linked to behavioral, cognitive, and anatomical deficits in humans leading to a reduced productivity and quality of life. Yet, preclinical studies on the effect of inhalants on executive control in animal models are limited. We address this gap in knowledge using rodent models in two ways: first, by examining the long-lasting effects of repeated toluene inhalation during adolescence on several measures of executive function in adulthood and second, by studying the effects of acute toluene inhalation on risk/reward decision making and related neurocircuitry. …

The Role Of Melatonin In Biological Rhythms Of Songbirds, Clifford E. Harpole

Theses and Dissertations--Biology

In vertebrates, melatonin is a hormone that is produced and secreted at night and inhibited by light. This unique “darkness-only” expression profile makes it an intellectually appealing candidate for a means of transmitting temporal information to an individual, both time of day and time of year.

In passerine birds, “time of day” information is certainly transmitted via melatonin secretion. The primary producer of systemic melatonin in this family of birds is the pineal gland, and surgical removal of it causes a bird to become arrhythmic in constant conditions. I find that as pinealectomized house sparrows (Passer domesticus) become …

Tribal Brains In The Global Village: Deeper Roots Of The Pandemic, Robert Gerlai

Animal Sentience

I briefly recap the messages of the target article by Wiebers & Feigin (2020) and the accompanying peer commentaries about what we learn from the COVID-19 pandemic. Using the rapid evolution of viruses as an example of the importance of prevention, I explore why it is difficult for our species to foresee and prevent unintended global changes resulting from human activity. I end with a discussion about the long-term future, the ultimate problem inherent in our current mindset and the structure of our economy: growth.

Moderators Of Depression And Self-Management In Type 2 Diabetes Patients, Cynthia Elaine Fraser

Walden Dissertations and Doctoral Studies

Although Type 2 diabetes can be reversed or controlled, many individuals choose not to adhere to treatment regimens, nor do they engage in self-management practices. The purpose of this cross-sectional study was to explore self-management among individuals with Type 2 diabetes, examining whether some psychosocial variables have a moderating effect on self-management. The psychosocial variables explored in this research were perception of body image, fear of hypoglycemia, level of family support, and depression. The biopsychosocial model was the theoretical framework. Using the Body Appreciation Scale, Diabetes Self-Management Questionnaire, The Family Relationship Scale, Hypoglycemic Fear Survey (HFS-II), and the Beck Depression …

Young African American Men's Conception Of Fatherhood Among Survivors Of Childhood Abuse, Ohan Patricia Carter

Walden Dissertations and Doctoral Studies

Male survivors of abuse who become fathers themselves face challenges different from female survivors, such as conceptualizing their roles as providers and heads of households after the traumatic and often belittling experiences of abuse. However, very few researchers have studied the connection between child abuse and fatherhood, and none specific to young African American fathers. An interpretative phenomenological approach enabled exploration of how African American fathers who were abused as children, conceptualized and perceived their own experiences with fatherhood. The theoretical framework for this study was identity theory, which indicates that how people conceptualize a social role influences their actions …

Barrels Xxxii Meeting Report: Whiskers In The Windy City, Giuseppe Cataldo, Chia-Chien Chen, Alicia C. Barrientos, Joshua C. Brumberg

Publications and Research

The 32^nd Annual Barrels meeting was hosted at the Northwestern University Feinberg School of Medicine in Chicago, Illinois on October 17^th and 18^th, 2019. The annual meeting brings together researchers who utilize the rodent whisker-to-barrel system as a means to understand cortical function and development. This year’s meeting focused on social behaviors, development and cerebellar functions within the barrel system and beyond.

Learning And Motivation For Rewards In Schizophrenia: Implications For Behavioral Rehabilitation, Victoria Martin, Alexandra Brereton, Jicheng Tang

Publications and Research

Purpose of review: Impaired reward processing and amotivation are well documented in schizophrenia. We aim to review the current state of neuroimaging and behavioral research addressing components of motivational deficits in this complex and impairing syndrome. Evidence will be integrated to inform the ongoing development of effective strategies for behavioral rehabilitation. Recent findings: While striatal dopamine and aberrant reward prediction errors have been connected to amotivation in schizophrenia, they are not sufficiently full explanations of reward processing impairments. Frontal dysfunction and associated cognitive control deficits also have evidenced involvement in atypical reward prediction, learning, and valuation. Ongoing work supports the …

Neuroscience Of Stress & Addiction: A Digitally Animated Video On How These Brain Systems Interact And Influence Each Other From Early Life Stress To Withdrawal, Claire Bacon-Brenes

Scripps Senior Theses

Alcohol addiction and stress are both highly prevalent health conditions impacting our society. With stress on the rise in college students and alcohol addiction impacting 19.7 million Americans as of 2017, communication around the science of these issues is ever important because of stigma around them. This digitally animated video effectively explains alcohol addiction and stress on a neurobiological level with college science students as the audience, including two important examples of how stress and alcohol addiction interact. Stress experienced early in life is a known risk factor in developing addiction due to dysregulation of the reward pathway and altered …

Behavioral Ecology Of A Desert Ambush Predator: Assessing Movement Patterns, Habitat And Microhabitat Use, And The Innate Feeding Response Of Eastern Black-Tailed Rattlesnakes (Crotalus Ornatus) In The Northern Chihuahuan Desert, James Emerson

Open Access Theses & Dissertations

Research on the ecology and evolution of rattlesnakes has been sporadic over the past 80 years, but has seen recent expansion into the diverse fields of physiology, physiological ecology, life history, behavioral ecology, ethology, reproductive biology, chemical ecology, venom biochemistry and medicine, conservation, and many other subdisciplines. The development of small, implantable VHF radiotransmitters in the 1980s revolutionized research in the field of behavioral ecology for rattlesnakes, which are uniquely suited for radiotelemetry studies because they possess several morphological, physiological, and behavioral characteristics that are unique among terrestrial vertebrates. The widespread application of radiotelemetry by the mid-1980s advanced the model …

Ketamine Pre-Exposure Does Not Influence Later-Life Responses To Reward-Related Stimuli In Female C57bl/6 Mice, Israel Garcia

Open Access Theses & Dissertations

Preclinical work indicates that exposure to traditional antidepressant medications, in adolescent and adult female subjects, alters reward-related behavior later in life. In recent years, the anesthetic ketamine (KET), now used as a fast-acting antidepressant, has shown promising therapeutic efficacy for the management of depression. However, the potential long-term behavioral consequences of KET exposure across development have not been thoroughly assessed. Thus, to address this issue, we examined if KET exposure, during adolescence or early adulthood, results in enduring alterations in responsivity to the rewarding properties of sucrose and cocaine later in life. Specifically, female C57BL/6 mice were randomly assigned to …

Validation Of Ninein As An Ethanol-Related Quantitative Trait Gene: Reassessment, Design, And Functional Validation Of Reference Genes For Qpcr Analysis Of Brain Tissue In Mice, Jessica L. Jurmain

Theses and Dissertations

The increasing use of quantitative real-time polymerase chain reaction (qPCR) as a method for quantifying gene expression has led to an increased demand for standardization of data analysis methods to ensure accurate reporting and robust, reproducible results. The exponential nature of qPCR amplification results in the potential magnification of what are usually very small sources of error. Relative gene expression calculations circumvent this issue by normalizing target gene expression data to within-sample expression of a previously validated, stably expressed reference gene or genes. Multiple studies discussed herein have found that qPCR data are more reliable and reproducible when multiple reference …

Role Of Clic4 And The Synaptic Transcriptome In The Behavioral And Molecular Neurobiology Of Ethanol, Rory M. Weston

Theses and Dissertations

Alcohol use disorder (AUD) is a prevalent neuropsychiatric disease with profound health, social, and economic consequences. With an estimated 50% heritability, identifying genes that engender risk and contribute to the underlying neurobiological mechanisms represents an important first step in developing effective treatments. Gene expression studies are an important source of candidate genes for studying AUD, providing windows into the molecular machinery engaged by the brain in response to ethanol. Published studies have identified chloride intracellular channel 4 (Clic4) as an ethanol-regulated gene in brain capable of modulating sensitivity to sedation in multiple species. The functions of Clic4 are …

Depression And Anxiety In A Female Adolescent Population With Sources Of Social Support Latent Profiles, Kathleen Kelly

Graduate Research Theses & Dissertations

Social support is associated with various outcomes such as depression and anxiety. Less work has investigated how support received from various sources cumulatively is associated with internalizing symptoms. Research suggests that above other sources, parents and peers are the most strongly associated with internalizing outcomes. Looking at female adolescents specifically, the current study explored 1) what patterns of social support across sources emerge in a female adolescent sample, and 2) how do depressive and anxiety symptoms vary based on those patterns of social support? The study utilized Latent Profile Analysis (LPA) on data collected from a female high school sample …

Genetic Evidence, Maoa, And State V. Yepez, Nita A. Farahany, Roderick T. Kennedy, Brandon L. Garrett

Faculty Scholarship

No abstract provided.

Roles Of Autism Gene Arid1b In Murine Brain Development And Behavior, Amanda L. Smith

Theses & Dissertations

Autism spectrum disorder (ASD) and intellectual disability (ID) are highly prevalent neurodevelopmental disorders characterized by social and communication deficits, stereotyped behaviors, cognitive dysfunction, and deficits in adaptive behaviors. The pathogenesis underlying these disorders remains unknown, and thus no pharmacologic or genetic therapies are currently available. Recent progress in the field has shown that haploinsufficiency of the AT-rich interactive domain-containing 1B (ARID1B) gene is a genetic cause of ASD and ID. Our lab recently developed an Arid1b knockout mouse model to better study its role in the pathogenesis of these disorders. One theory regarding the cause of neurodevelopmental disorders …

Validation Of Metabolic And Immunologic Biomarkers Tnf-A, Igf, Il-6, Crp And Hair Cortisol In The Common Marmoset, Sushmita Adhikari, Mariah Wulf, Aaryn Mustoe Phd, Jeffrey French Phd

Theses/Capstones/Creative Projects

The common marmoset is a good model for research because they are easy to house and have complex social relationships (French et al., 2019). Marmosets are sensitive to social isolation, and when introduced to a stressor, the HPA axis is activated (Saltzman & Abbott, 2011). The purpose of this experiment is to validate marmosets as a translational model for stress due to social relationships in humans. This is done by validating biomarker concentration levels at baseline, then comparing the concentration when introduced to a stressor. The biomarkers IL-6, CRP, IGF-1 and TNF-a were tested using a serum assay, then running …

Characterization Of Sensory And Shelter Enrichment In The Rodent Research Habitat, Amber M. Paul, Yasaman Shirazi-Fard, America Reyes, Moniece Lowe, Margareth Cheng-Campbell, Sungshin Choi, Eduardo Almeida, April Ronca, Ruth K. Globus

Publications

The ISS provides a platform for conducting Rodent Research (RR) in microgravity and 9 missions have been successfully conducted. The results from these experiments have begun to provide new insights into the effects of spaceflight on mammalian physiological systems. After RR-1-4, the Flight IACUC required inclusion of additional cage enrichment into the Rodent Habitats (RH) to “enhance animal well-being by providing animals with sensory and motor stimulation, through structures and resources that facilitate the expression of species typical behaviors”. A Hut, in the form of a rigid, mesh igloo-like shelter was implemented beginning with RR-5. The potential influence of the …

Overexpression Of Corticotropin-Releasing Factor In The Nucleus Accumbens Enhances The Reinforcing Effects Of Nicotine In Female Versus Male Rats., Uribe, Victor Correa, Briana Pinales, Rodolfo Flores, Bryan Cruz, Zhiyin Shan, Adriaan Bruijnzeel, Arshad Khan, Laura O'Dell

Departmental Papers (Biology)

This study assessed the role of stress systems in the nucleus accumbens (NAc) in promoting sex differences in the reinforcing effects of nicotine. Intravenous self-administration (IVSA) of various doses of nicotine was compared following overexpression of corticotropin-releasing factor (CRF) in the NAc of female and male rats. Ovariectomized (OVX) females were also included to assess the role of ovarian hormones in promoting nicotine reinforcement. Rats received intra-NAc administration of an adeno-associated vector that overexpressed CRF (AAV2/5-CRF) or green fluorescent protein (AAV2/5-GFP). All rats were then given extended access (23 h/day) to an inactive and an active lever that delivered nicotine. …

Influence Of Social Isolation During Prolonged Simulated Weightlessness By Hindlimb Unloading, Candice G.T. Tahimic, Amber M. Paul, Ann-Sofie Schreurs, Samantha M. Torres, Linda Rubinstein, Sonette Steczina

Publications

The hindlimb unloading (HU) model has been used extensively to simulate the cephalad fluid shift and musculoskeletal disuse observed in spaceflight with its application expanding to study immune, cardiovascular and central nervous system responses, among others. Most HU studies are performed with singly housed animals, although social isolation also can substantially impact behavior and physiology, and therefore may confound HU experimental results. Other HU variants that allow for paired housing have been developed although no systematic assessment has been made to understand the effects of social isolation on HU outcomes. Hence, we aimed to determine the contribution of social isolation …