Behavioral Neurobiology Commons^™

Investigating The Role Of Dynamic Signaling Of Nrg3-Erbb4 In The Prefrontal Cortex In Mediating Nicotine Withdrawal Phenotypes, Emily Prantzalos

Theses and Dissertations--Pharmacy

While several pharmacotherapies are currently available for nicotine use disorder (NUD), smoking cessation success rates remain below 10% each year. The molecular mechanisms underlying failed quit attempts continue to represent a critical gap in our knowledge. However, recent advances in understanding the genetic contributions to nicotine dependence offer a promising avenue for developing more effective cessation therapies. Prior research has identified genetic variation in Neuregulin 3 (Nrg3) and its cognate receptor ErbB4 as potential contributors to affective nicotine withdrawal (WD) phenotypes and cessation outcomes. Therefore, this dissertation aims to systematically investigate the region-specific, functional role of the Neuregulin Signaling Pathway …

The Impact Of Traumatic Brain Injury On Noradrenergic Innervation Of The Prefrontal Cortex, Jil P. Modi, Christopher P. Knapp, Rachel L. Navarra

Rowan-Virtua Research Day

Traumatic Brain Injury (TBI) is a common cause of death and disability in the United States, and it can occur due to varied reasons including motor vehicle accidents, gunshot wounds, and falls. Following TBIs, patients are often left with lifelong disabilities and cognitive problems that can lead to increased risk-taking behaviors. The main goal of my research was to understand the neural mechanisms that drive increased risk-taking behaviors due to TBIs. The specific areas of the brain I was interested in looking at were the medial prefrontal cortex (mPFC), orbitofrontal cortex (OFC), and/or anterior cingulate cortex (ACC) of the prefrontal …

Cortical Representation Of Learning Social Interactions In Freely Moving Non-Human Primates, Melissa Franch

Dissertations and Theses (Open Access)

The motivation and capacity to be social is necessary for human survival. Successful learning of complex, prosocial behavior stems from the ability to perceive and respond to visual cues, such as the body language and facial expressions, from others in our environment. This dependence on visual information to guide social interaction is especially true for humans and non-human primates. Although recent studies in primate neurophysiology discovered neurons that can encode socially relevant variables, like reward and social actions, the underlying neural mechanisms of learning advanced social concepts, such as cooperation, are not well understood. Further, previous work has identified …

The Effect Of Pubertal Stress On Prefrontal Cortex Related Behavior In Adult And Adolescent Mice, Bryan Rodriguez

Graduate Theses, Dissertations, and Problem Reports (ETD)

The prefrontal cortex (PFC) is an area of associated with cognitive flexibility, decision making, and value processing. The most common neuropsychiatric disorders globally, including generalized anxiety disorder, major depressive disorder, schizophrenia, and substance abuse disorders, have been associated with dysfunction in the PFC. One of the environmental factors that may lead to increased risk for developing these disorders is exposure to stressful or traumatic situations during key developmental periods, such as adolescence. Human studies found that individuals who were faced with early adverse events but had some form of social interaction or support during that time, had a lower risk …

Extended Functional Connectivity Of Convergent Structural Alterations Among Individuals With Ptsd: A Neuroimaging Meta-Analysis, Brianna S. Pankey, Michael C. Riedel, Isis Cowan, Jessica E. Bartley, Rosario Pintos Lobo, Lauren D. Hill-Bowen, Taylor Sato, Erica D. Musser, Matthew T. Sutherland, Angela R. Laird

Psychology Faculty Publications

Background: Post-traumatic stress disorder (PTSD) is a debilitating disorder defined by the onset of intrusive, avoidant, negative cognitive or affective, and/or hyperarousal symptoms after witnessing or experiencing a traumatic event. Previous voxel-based morphometry studies have provided insight into structural brain alterations associated with PTSD with notable heterogeneity across these studies. Furthermore, how structural alterations may be associated with brain function, as measured by task-free and task-based functional connectivity, remains to be elucidated.

Methods: Using emergent meta-analytic techniques, we sought to first identify a consensus of structural alterations in PTSD using the anatomical likelihood estimation (ALE) approach. Next, we generated functional …

Wild Mice With Different Social Network Sizes Vary In Brain Gene Expression, Patricia C. Lopes, Barbara König

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Background

Appropriate social interactions influence animal fitness by impacting several processes, such as mating, territory defense, and offspring care. Many studies shedding light on the neurobiological underpinnings of social behavior have focused on nonapeptides (vasopressin, oxytocin, and homologues) and on sexual or parent-offspring interactions. Furthermore, animals have been studied under artificial laboratory conditions, where the consequences of behavioral responses may not be as critical as when expressed under natural environments, therefore obscuring certain physiological responses. We used automated recording of social interactions of wild house mice outside of the breeding season to detect individuals at both tails of a distribution …

Effects Of The Abused Inhalant Toluene On Mpfc-Dependent Cognitive Behaviors And Associated Neural Activity, Kevin Michael Braunscheidel

MUSC Theses and Dissertations

Volatile organic solvents like toluene induce euphoria and intoxication when inhaled at high concentrations. Inhalant misuse is linked to behavioral, cognitive, and anatomical deficits in humans leading to a reduced productivity and quality of life. Yet, preclinical studies on the effect of inhalants on executive control in animal models are limited. We address this gap in knowledge using rodent models in two ways: first, by examining the long-lasting effects of repeated toluene inhalation during adolescence on several measures of executive function in adulthood and second, by studying the effects of acute toluene inhalation on risk/reward decision making and related neurocircuitry. …

The Effect Of Adolescent Alcohol On Dopaminergic And Gabaergic Neurotransmission In The Adult Prefrontal Cortex, Samuel W. Centanni

MUSC Theses and Dissertations

The prefrontal cortex (PFC) is thought to play an important role in cognitive processes that are negatively impacted by alcohol exposure. Compared to other brain regions, the neuronal connections of the PFC undergo a critical period of reorganization and refinement during adolescence that coincides with improvements in cognitive control and decision-making. Environmental insults that occur during this period may be particularly damaging to the PFC, resulting in aberrant neurodevelopment along with long-lasting effects on cognitive functioning that negatively impacts decision-making and behavioral control. Experimentation with alcohol typically begins during adolescence when it is often consumed in excessive binge-like episodes resulting …

Aiming Attention Using Selective Stimulation Of Locus Coeruleus And Its Medial Prefrontal Efferents, Zackary A. Cope

MUSC Theses and Dissertations

Appropriate modification of behavior in response to dynamic environmental conditions is essential for the adaptation and survival of most biological organisms. This adaptability allows for organisms to maximize the benefit of behavior related energy expenditure (utility) while minimizing cost. Modern theories of locus coeruleus (LC) function implicate a pivotal role for the noradrenergic (NA) nucleus in mediating switches between focused behavior during periods of high utility (exploit) versus disengagement of behavior and exploration of other, more rewarding opportunities. Two modes of activity in LC neurons have been well characterized. During periods of accurate and focused behavior, LC neurons exhibit suppressed …

The Role Of Bdnf Within The Medial Prefrontal Cortex On Relapse To Cocaine-Seeking Behavior, William J. Berglind

MUSC Theses and Dissertations

Glutamatergic pyramidal cells arising from the prefrontal cortex (PFC) are critical mediators of reinstatement to cocaine-seeking. A potent modulator of PFC activity is brain derived neurotrophic factor (BDNF), a molecule that has been implicated in the regulation of glutamatergic neurotransmission. In this study, the role of BDNF in the PFC was investigated in an animal model of cocaine addiction. First, a cocaine-induced decrease in BDNF mRNA within the PFC was documented following 22 h of abstinence, followed by an increase in BDNF protein expression within the PFC following 21 d of extinction training. Second, an intra-PFC infusion of BDNF attenuated …