Life Sciences Commons^™

A Criterion For The Solvability Of The Cauchy Problem For The System Of Thermoelasticity Equations, Iqbol Niyozov, Olimjan Maxmudov

Scientific Journal of Samarkand University

In this paper, we considered the problem of analytical continuation of the solution of the system equations of the thermoelasticity in bounded domain from its values and values of its strains on part of the boundary of this domain, i.e., the Cauchy’s problem and we give a criterion for the solvability of the Cauchy problem.

Raman Scattering Spectra Of Α-Alanine Molecular Complexes, Hakim Hushvaktov

Scientific Journal of Samarkand University

The article presents the results of studying the complexity of the Raman spectra of a-alanine in the crystalline state. It has been shown by ab initio calculations that the change in the Raman spectra is explained by the formation of several types of hydrogen bonds. In Raman spectra, the presence of a hydrogen bond between molecules is manifested in the form of asymmetry and splitting of vibrational bands.

On Properties Of Some Singular Surfaces, Salim Usmanov

Scientific Journal of Samarkand University

В данной статье рассматриваются некоторые особые поверхности, задаваемые параметрическими уравнениями. Доказано, что хотя бы одна из главных кривизн не обращается в нуль в каждой регулярной точке этих поверхностей.

The Clean Air Act: How It Can Be Localized To Promote Both Environmental And Social Justice, Tate Kirk

Seattle Journal of Technology, Environmental, & Innovation Law

Legislators attempt to achieve intended goals by enacting laws that provide for regulatory enforcement. However, many times laws are unable to achieve their stated goals and in some ways may create new or exacerbate existing issues. Luckily, upon review, many of these issues can be fixed with quick modifications to either their implementation or enforcement mechanisms. In its current form, the Clean Air Act does not effectively account for differences in regional climate patterns, and, moreover, it perpetuates environmental injustice. If local governments were given more autonomy to enforce the Clean Air Act, they could shape its enforcement to more …

Assessing Moringa Oleifera Plants As Exposure Pathways For Heavy Metals In Highly Contaminated Areas, Marissa Louise Mayfield*

Biology Theses

This study examined the uptake of heavy metals by Moringa oleifera trees in both field and laboratory settings. The main goal of this study was to determine whether using Moringa, grown in heavily contaminated areas, as food or herbal supplements increases the risk of heavy metal exposure. The field component of this study was carried out in the Southern part of Kabwe, Zambia where a lead-zinc mine has left a legacy of severe environmental pollution in the neighboring areas. Moringa trees have several medicinal properties which is one of the reasons they were first introduced to the area. The trees …

Prenatal Alcohol Exposure Alters Transcriptional Expression Of Stress And Tlr4-Related Immune Signaling Factors In The Brain Following Early Life Stress, Chaselyn D. Ruffaner-Hanson

Biomedical Sciences ETDs

Background: Depression and anxiety disorders, believed to be caused by stress-related neuropeptides and pro-inflammatory molecules in the brain, are prevalent comorbidities of fetal alcohol spectrum disorders (FASD).

Methods: Brain tissue was collected following a 4-hour maternal separation stress during the early postnatal period, postnatal days 10 and 12, from mice subjected to 1^st and 2^nd trimester prenatal alcohol exposure (PAE).

Hypothesis: We hypothesized that PAE leads to glucocorticoid receptor insensitivity, stress molecule overexpression, and potentiated toll-like receptor 4 (TLR4) pathway inflammatory responses in the brain following early life stress.

Results: PAE and stress increased mRNA expression of TLR4 …

An Invasive Species As A Threat To Native Biodiversity: Larval Competition Between Native Anurans And An Invasive Treefrog, Mckenzie Wasley

Electronic Theses and Dissertations

Cuban Treefrogs (Osteopilus septentrionalis) are established in Florida and Louisiana and have invasive potential further westward, possibly impacting native anurans at multiple life stages. In anurans, competition at the larval stage can decrease adult fitness through slower development and smaller size at metamorphosis, ultimately decreasing recruitment rates. To examine the potential impacts of O. septentrionalis at the larval life-history stage, I quantified activity levels and growth of their tadpoles and those of two anurans native to eastern Texas: Green Treefrogs (Hyla cinerea) and Gulf Coast Toads (Incilius nebulifer). Tadpoles of the three species were …

Dissecting Regulation Mechanism Of Interdomain Electron Transfer In Nitric Oxide Synthases, Huayu Zheng

Chemistry and Chemical Biology ETDs

Nitric oxide (NO) is generated by one of the three isoforms of mammalian NO synthases (NOSs), neuronal, endothelial and inducible NOS (nNOS, eNOS, and iNOS, respectively). Dysregulated NOS is implicated in pathologies of numerous severe diseases including Alzheimer and Parkinson’s diseases. Molecular mechanisms of NOS regulation, once fully understood, are potentially key targets for development of selective new pharmaceuticals for treating these diseases that currently lack effective treatments.

Despite recent developments, there are significant gaps in current understanding of the regulation mechanism of the FMN-heme interdomain electron transfer (IET), an essential step in NOS, by its key regulators such as …

The Role Of Anti-Inflammatory Cytokine Interleukin-10 (Il-10) In Tauopathies, Lea L. Weston

Biomedical Sciences ETDs

Tauopathies are neurodegenerative diseases, including Alzheimer’s disease, that are associated with pathological accumulation of the microtubule associated protein tau (MAPT, or tau) (Lee et al., 2001). Abnormal hyperphosphorylated tau (pTau) strongly correlate with cognitive impairment (Nelson et al., 2012). Neuroinflammation is also associated with tauopathies (Gerhard et al., 2006b; Edison et al., 2008) and is implicated in driving tau pathology (Yoshiyama et al., 2007, Maphis et al., 2015b). Therefore, it is compelling to understand the role of anti-inflammatory cytokines in limiting neuroinflammation and tau pathology. Interleukin-10 (IL-10) is a well-established anti-inflammatory cytokine with roles in limiting inflammation in the central …

Impact Of Italian Ryegrass (Lolium Multiflorum Lam.) Management On The Parasite Burden In Sheep, Cesar H. E. C. Poli, E. J. Pegorar, P. C. De F. Carvalho, M. J. T. De M. Gomes, V. Fischer, D. B. Montano

IGC Proceedings (1977-2023)

No abstract provided.

Pastoral Systems Changing From Conventional To Social Agriculture In Mediterranean Italy, Andrea Pardini, V. Pratesi, F. Baronti

IGC Proceedings (1977-2023)

No abstract provided.

Forage Mass, Carrying Capacity And Daily Weight Gain Of Crossbred Heifers In Silvopastoral System Or Exclusive Signalgrass Pasture, Domingos S. C. Paciullo, L. J. M. Aroeira, M. J. Alvim, F. J. N. Costa

IGC Proceedings (1977-2023)

No abstract provided.

Deep Learning-Based Cross-Classifications Reveal Conserved Spatial Behaviors Within Tumor Histological Images., Javad Noorbakhsh, Saman Farahmand, Ali Foroughi Pour, Sandeep Namburi, Dennis Caruana, David Rimm, Mohammad Soltanieh-Ha, Kourosh Zarringhalam, Jeffrey Chuang

Faculty Research 2020

Histopathological images are a rich but incompletely explored data type for studying cancer. Manual inspection is time consuming, making it challenging to use for image data mining. Here we show that convolutional neural networks (CNNs) can be systematically applied across cancer types, enabling comparisons to reveal shared spatial behaviors. We develop CNN architectures to analyze 27,815 hematoxylin and eosin scanned images from The Cancer Genome Atlas for tumor/normal, cancer subtype, and mutation classification. Our CNNs are able to classify TCGA pathologist-annotated tumor/normal status of whole slide images (WSIs) in 19 cancer types with consistently high AUCs (0.995 ± 0.008), as …

Holidays And Healthy Choices, Jamie Baum

Diet, Food, Exercise, and Nutrition (D-FEND)

Objectives:

Healthy holiday eating

Incorporating physical activity into the holiday season

Budget friendly healthy holiday ideas

George Argus’S List Of Salix References, Yulia Kuzovkina-Eischen

Plant Science Articles

This bibliographical list, containing more than 3600 publications related to the genus Salix, was compiled by Dr. Argus during his long scientific career.

December 11, 2020: Letter From The President- Covid Update, Kettering University

Communication Updates

No abstract provided.

Prevalence Of Snake Fungal Disease Caused By Ophidiomyces Ophiodiicola In East Texas, Alan Lizarraga

Biology Theses

Fungal pathogens and resultant disease are credited with the decline of many species across all branches of the tree of life. Fungal diseases such as Snake Fungal Disease (SFD), primarily caused by the fungus Ophidiomyces ophiodiicola (Oo), have been strongly associated with the cause of the decrease/disappearance of many snake populations in North America. To date SFD in the wild has been described as far southwest as central Louisiana. Due to similar conditions and the proximity of East Texas to central Louisiana, a survey of local snake populations provided crucial information about the spread and presence of this emerging pathogen. …

Mass Cytometry Defines Virus-Specific Cd4 + T Cells In Influenza Vaccination, Priyanka B Subrahmanyam, Tyson H Holmes, Dongxia Lin, Laura F Su, Gerlinde Obermoser, Jacques Banchereau, Virginia Pascual, Adolfo García-Sastre, Randy A Albrecht, Karolina Palucka, Mark M Davis, Holden T Maecker

Faculty Research 2020

The antiviral response to influenza virus is complex and multifaceted, involving many immune cell subsets. There is an urgent need to understand the role of CD4+ T cells, which orchestrate an effective antiviral response, to improve vaccine design strategies. In this study, we analyzed PBMCs from human participants immunized with influenza vaccine, using high-dimensional single-cell proteomic immune profiling by mass cytometry. Data were analyzed using a novel clustering algorithm, denoised ragged pruning, to define possible influenza virus-specific clusters of CD4+ T cells. Denoised ragged pruning identified six clusters of cells. Among these, one cluster (Cluster 3) was found to increase …

Wildlife Conservation And Hunting Nrs 455, Michael Cerbo

Library Impact Statements

No abstract provided.

Classification Of Small Ruminant Lentivirus Subtype A2, Subgroups 1 And 2 Based On Whole Genome Comparisons And Complex Recombination Patterns, Aaron M. Dickey, Timothy P.L. Smith, Michael L. Clawson, Michael P. Heaton, Aspen M. Workman

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Background: Small ruminant lentiviruses (SRLVs) cause a multisystemic chronic wasting disease in sheep across much of the world. SRLV subtype A2 is prevalent in North America and further classified into multiple subgroups based on variation in the group antigens gene (gag) and envelope (env) genes. In sheep, the ovine transmembrane protein 154 (TMEM154) gene is associated with SRLV susceptibility. Ewes with at least one copy of TMEM154 encoding a fulllength protein with glutamate at position 35 (E35; haplotypes 2 and 3), are highly susceptible to SRLV infection while ewes with any combination of TMEM154 …

The Flowering Of Ecology: Maria Sibylla Merian's Caterpillar Book, Kay Etheridge

Gettysburg College Faculty Books

The Flowering of Ecology presents an English translation of Maria Sibylla Merian’s 1679 ‘caterpillar’ book, Der Raupen wunderbare Verwandelung und sonderbare Blumen–Nahrung. Her processes in making the book and an analysis of its scientific content are presented in a historical context. Merian raised insects for five decades, recording the food plants, behavior and ecology of roughly 300 species. Her most influential invention was an 'ecological' composition in which the metamorphic cycles of insects (usually moths and butterflies) were arrayed around plants that served as food for the caterpillars. Kay Etheridge analyzes the 1679 caterpillar book from the viewpoint of …

Impact Of Cd82 Expression On Acute Myeloid Leukemia Chemosensitivity And Quiescence, Muskan Floren

Biomedical Sciences ETDs

Acute Myeloid Leukemia (AML) patients respond favorably to induction chemotherapy, however, long-term outcomes remain poor due to a high rate of chemoresistance and bone marrow minimal residual disease. To improve long-term patient outcomes, it’s critical to identify regulators of chemotherapy resistance in AML and develop therapies that are directed towards bone marrow resident AML cells. In Chapter 2, we uncover the impact of CD82 expression in AML response to chemotherapeutic treatment and the contribution of Protein Kinase C α (PKCα) and β1 integrin signaling in promoting p38 MAPK activation to support CD82-mediated AML cell survival. In Chapter 3, we …

Functional Investigations Of Proteins And Enzymatic Toxins From Full-Length-Enriched Cdna Of Timber Rattlesnake (Crotalus Horridus), Joshua Osula

Theses

Snake Venom is a highly modified form of saliva, contains hundreds of zootoxins, necrotoxins, cytotoxins, neurotoxins, and mytotoxins, all of which are primarily made up of mostly proteins, polypeptides, and other components such as enzymes, lipids, and carbohydrates. Although snake venom is known for its harmful effects, it has also had a positive impact in scientific discovery and medicine. Some toxins from snakes function to inhibit pain, and this means they can be very effective analgesics. For instance, crotalphine is considered a 14-amino-acid-peptide that has a disulfide bond and shows analgesic properties through TRPA1 desensitization. This …

Ultracontinuous Single Haplotype Genome Assemblies For The Domestic Cat (Felis Catus) And Asian Leopard Cat (Prionailurus Bengalensis), Kevin R. Bredemeyer, Andrew J. Harris, Gang Li, Le Zhao, Nicole M. Foley, Melody E. Roelke-Parker, Stephen James O'Brien, Leslie A. Lyons, Wesley C. Warren, William J. Murphy

Biology Faculty Articles

In addition to including one of the most popular companion animals, species from the cat family Felidae serve as a powerful system for genetic analysis of inherited and infectious disease, as well as for the study of phenotypic evolution and speciation. Previous diploid-based genome assemblies for the domestic cat have served as the primary reference for genomic studies within the cat family. However, these versions suffered from poor resolution of complex and highly repetitive regions, with substantial amounts of unplaced sequence that is polymorphic or copy number variable. We sequenced the genome of a female F1 Bengal hybrid cat, the …

Exposing Lettuce Plants To Cyanobacteria In A Closed Hydroponics System To Reduce Cyanobacterial Growth And Production, Emily Eberly

Honors Projects

Sandusky Bay is largely populated by cyanobacterial algal blooms, mainly formed by Planktothrix. Fertilizers containing nitrogen and phosphorus run from agricultural lands into the bay, building up excess nutrients forming eutrophic waters. The Planktothrix feed off these nutrients and grow into algal blooms. To determine a potential solution to the growth of these blooms, I implemented a hydroponics system involving Lactuca Sativa for analysis of Planktothrix growth and productivity. Four different nutrient conditions were added to a Planktothrix-only solution and a solution growing Planktothrix with the lettuce in the hydroponics system. The four conditions consisted of no nutrient …

Identification Of Genes That Determine Fitness, Virulence, And Disease Outcomes In Mastitis Associated Eschericia Coli, Michael Andrew Olson

Theses and Dissertations

Escherichia coli is an incredibly diverse group of bacteria that consist of both commensal and pathogenic strains that cause disease in a wide variety of tissues in many different animals. The current dogma, based on years of extensive molecular and genetic studies, is that individual strains have adapted to specific environments through acquisition of specific genes or come from lineages that are particularly suited to a unique tissue or host. However, mastitis-associated E. coli (MAEC) have thus far resisted such descriptions. The fitness and virulence factors of MAEC are poorly understood and molecular tools are rarely applied. This dissertation reports …

Comparison Of Threatened Neosho Madtom Densities Between Riverscapes Differing In Anthropogenic Stressors, With A Particular Focus On Recovery From Mining-Derived Metal Pollution, Kali Boroughs

Electronic Theses & Dissertations

Water pollution imperils the Neosho Madtom (Noturus placidus), which is threatened in Kansas and federally. Within Kansas madtom densities were historically lower in the Spring River compared to the Cottonwood and Neosho Rivers, especially within the Spring River below tributary inputs that delivered cadmium, lead, and zinc pollution from the Tri-State Mining District. Studies suggest that madtoms are less numerous in waters containing elevated metal concentrations because of direct toxicity and lower benthic macroinvertebrate availability, which is also depressed by elevated metal concentrations. However, long-term reductions in metal concentrations in the Spring River have occurred, but to date …

Chamaecyparis Obtusa (False Cypress-Hinoki), Id #982, Margaret O. Kimball

BIO 140 Arboretum Project

Location: West of Misto Gatehouse, on Bellevue Avenue.

Taxonomic Review Of South American Butter Frogs: Phylogeny, Geographic Patterns, And Species Delimitation In The Leptodactylus Latrans Species Group (Anura: Leptodactylidae), Felipe De M. Magalhães, Mariana L. Lyra, Thiago R. De Carvalho, Diego Baldo, Francisco Brusquetti, Pamela Burella, Guarino R. Colli, Marcelo C. Gehara, Rafael O. De Sá, Et Al.

Biology Faculty Publications

The Leptodactylus latrans species group currently comprises eight medium- to large-sized frog species with a convoluted taxonomic history, particularly related to the specific limits of the L. latrans complex, and the species pair Leptodactylus chaquensis–Leptodactylus macrosternum. Their homogeneous external morphology and continental geographic distribution in South America have posed severe limitations to a comprehensive review, such that taxonomic consensus and species limits remain uncertain. This is further worsened by the presence of chromatic polymorphism among coexisting species that can hardly be distinguished by external morphology. Based on a large-scale geographic sampling including multilocus DNA analyses, and acoustic …

Characterizing Patterns In Texas Gulf Coast Beach Dune Plant Species Composition, Cody Foster

Electronic Theses and Dissertations

Regional vegetation patterns of Texas beach plant communities were analyzed using cluster analysis, ANOSIM, SIMPER, NMDS, and ISA for fives zones representing the foredune complex of twenty Gulf Coast beaches. ANOVA revealed that zones differ in terms of percent bare sand, percent vegetative cover, and species richness. Cluster Analysis, ANOSIM, and SIMPER results indicate that Texas beaches can be divided into northern and southern regions based on differences in species composition of plant communities. Indicator Species Analysis (ISA) indicates that northern beaches are characterized by the presence of Rayjacksonia phyllocephala, Ambrosia Strophostyles, Ambrosia psilostachya, and Panicum amarum …