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Articles 1 - 30 of 763
Full-Text Articles in Life Sciences
Acknowledgment Of Reviewers, Lily Chiu
Acknowledgment Of Reviewers, Lily Chiu
Journal of Food and Drug Analysis
No abstract provided.
The Analytical And Biomedical Applications Of Carbon Dots And Their Future Theranostic Potential: A Review, Sukunya Ross, Ren-Siang Wu, Shih-Chun Wei, Gareth M. Ross, Huan-Tsung Chang
The Analytical And Biomedical Applications Of Carbon Dots And Their Future Theranostic Potential: A Review, Sukunya Ross, Ren-Siang Wu, Shih-Chun Wei, Gareth M. Ross, Huan-Tsung Chang
Journal of Food and Drug Analysis
In recent years, carbon dots (C-dots) have gained appreciable interest owing to their unique optical properties, including tunable fluorescence, stability against photobleaching and photoblinking, and strong fluorescence. Simple and low-cost hydrothermal and electrochemical approaches have been widely used in the preparation of biocompatible and high-quality C-dots. Various C-dots have been used for the quantitation of small analytes, mostly based on analyte induced fluorescence quenching. Depending on the nature of precursors, synthetic conditions (such as reaction temperature and time), and surface conjugation, multi-function C-dots can be prepared and used in diagnostics and therapeutics. Their strong fluorescence and photostability, enables use in …
Nanomaterial-Based Adsorbents And Optical Sensors For Illicit Drug Analysis, Chun-Hsien Chen, Chun-Chi Wang, Po-Yun Ko, Yen-Ling Chen
Nanomaterial-Based Adsorbents And Optical Sensors For Illicit Drug Analysis, Chun-Hsien Chen, Chun-Chi Wang, Po-Yun Ko, Yen-Ling Chen
Journal of Food and Drug Analysis
The abuse of illicit drugs has been prevalent in recent years and is associated with crime and public health issues. To strengthen public security and fortify public health services with respect to the increasing severity of drug abuse, academic and government institutes have been devoted to constructing relative analytical methods for illicit drugs. To date, the development of sensors has been greatly emphasized due to their features of high sensitivity, prompt detection and flexible manipulation; thus, sensors can serve as alternatives to conventional sophisticated instruments. Recently, the use of nanomaterials has inspired the development of a series of innovative sample …
Gold Nanoparticle-Based Colorimetric And Electrochemical Sensors For The Detection Of Illegal Food Additives, Li Li, Ming Zhang, Wei Chen
Gold Nanoparticle-Based Colorimetric And Electrochemical Sensors For The Detection Of Illegal Food Additives, Li Li, Ming Zhang, Wei Chen
Journal of Food and Drug Analysis
Lately, scandals associated with the illegal addition of poisonous chemicals to food for commercial interests have been gradually disclosed to the public. Problems related to food safety do not only harm public health but also affect the stability of economic and social development. Food safety has become a common issue in society, and strengthening the related regulations have become increasingly important. Although conventional techniques are accurate and sensitive in the detection of the vast majority of illegal food additives, they rely on time-consuming, labor-intensive procedures that depend on expensive instruments. Thus, efficient and rapid identification of poisonous, illegal additives in …
Improved Food Additive Analysis By Ever-Increasing Nanotechnology, Jing Zhang, Shui Hu, Yi Du, Ding Cao, Guirong Wang, Zhiqin Yuan
Improved Food Additive Analysis By Ever-Increasing Nanotechnology, Jing Zhang, Shui Hu, Yi Du, Ding Cao, Guirong Wang, Zhiqin Yuan
Journal of Food and Drug Analysis
Improper use of food additives may lead to potential threat to human health, making it important to develop sensitive and selective method for the detection of them. Nanomaterials with unique chemical and electrochemical properties show extensive applications in the design of food additive sensing systems. In this review, we summarize the recently adopted electrochemical and optical analysis of food additives based on nanomaterials. Detection of typical food additives (colorants and preservatives) by using different sensing mechanisms and strategies are provided. In addition, determination of illegal food additives is also briefly introduced. Finally, this review highlights the challenges and future trend …
Electrowetting-On-Dielectric (Ewod): Current Perspectives And Applications In Ensuring Food Safety, Snigdha Roy Barman, Imran Khan, Subhodeep Chatterjee, Subhajit Saha, Dukhyun Choi, Sangmin Lee, Zong-Hong Lin
Electrowetting-On-Dielectric (Ewod): Current Perspectives And Applications In Ensuring Food Safety, Snigdha Roy Barman, Imran Khan, Subhodeep Chatterjee, Subhajit Saha, Dukhyun Choi, Sangmin Lee, Zong-Hong Lin
Journal of Food and Drug Analysis
Digital microfluidic (DMF) platforms have contributed immensely to the development of multifunctional lab-on-chip systems for performing complete sets of biological and analytical assays. Electrowetting-on-dielectric (EWOD) technology, due to its outstanding flexibility and integrability, has emerged as a promising candidate for such lab-on-chip applications. Triggered by an electrical stimulus, EWOD devices allow precise manipulation of single droplets along the designed electrode arrays without employing external pumps and valves, thereby enhancing the miniaturization and portability of the system towards transcending important laboratory assays in resource-limited settings. In recent years, the simple fabrication process and reprogrammable architecture of EWOD chips have led to …
Nanomaterial-Based Fluorescent Biosensor For Veterinary Drug Detection In Foods, Xiaoqi Tao, Yuanyuan Peng, Juewen Liu
Nanomaterial-Based Fluorescent Biosensor For Veterinary Drug Detection In Foods, Xiaoqi Tao, Yuanyuan Peng, Juewen Liu
Journal of Food and Drug Analysis
Veterinary drugs have been widely used in the food industry. Their residues in food products need to be tightly regulated to ensure food safety. In particular, some veterinary drugs are still used illegally, although they have already been banned. Nanomaterials are playing an increasingly important role in analytical chemistry due to their unique properties. Compared to traditional organic dyes and colloidal gold nanoparticle labels, fluorescent nanomaterials appear particularly attractive for the detection of veterinary drug residues. This review summarizes recent advancements of fluorescent biosensors using nanomaterials for the detection of veterinary drug residues in foods. The useful properties of each …
Carbon Dots As Artificial Peroxidases For Analytical Applications, Shih-Chun Wei, Yang-Wei Lin, Huan-Tsung Chang
Carbon Dots As Artificial Peroxidases For Analytical Applications, Shih-Chun Wei, Yang-Wei Lin, Huan-Tsung Chang
Journal of Food and Drug Analysis
Nanozymes have become attractive in analytical and biomedical fields, mainly because of their low cost, long shelf life, and less environmental sensitivity. Particularly, nanozymes formed from nanomaterials having high surface area and rich active sites are interesting since their activities can be tuned through carefully controlling their size, morphology, and surface properties. This review article focuses on preparation of carbon dots (C dots) possessing peroxidase-like activity and their analytical applications. We highlight the important roles of the oxidation states and surface residues of C dots and their nanocomposites with metal, metal oxides, or metal sulfides playing on determining their specificity …
Carbon Quantum Dots For The Detection Of Antibiotics And Pesticides, Han-Wei Chu, Binesh Unnikrishnan, Anisha Anand, Yang-Wei Lin, Chih-Ching Huang
Carbon Quantum Dots For The Detection Of Antibiotics And Pesticides, Han-Wei Chu, Binesh Unnikrishnan, Anisha Anand, Yang-Wei Lin, Chih-Ching Huang
Journal of Food and Drug Analysis
Carbon quantum dots (CQDs) are novel nanomaterials with interesting physical and chemical properties, which are intensely studied only in the last decade. Unique properties, such as its inherent fluorescent property, high resistance to photobleaching, high surface area, ease of synthesis, flexible choice of precursor, and surface tunability enable CQDs for promising application in biosensing. Therefore, it is highly useful in clinical, forensic, medical, food and drug analyses, disease diagnosis, and various other fields of biosensing. In addition, their fluorescence properties are tunable by the interaction with certain molecules via different mechanisms, which enables their application for sensing of those molecules, …
Functionalized Gold Nanoparticles For Sensing Of Pesticides: A Review, Wei-Bin Tseng, Ming-Mu Hsieh, Che-Hsie Chen, Tai-Chia Chiu, Wei-Lung Tseng
Functionalized Gold Nanoparticles For Sensing Of Pesticides: A Review, Wei-Bin Tseng, Ming-Mu Hsieh, Che-Hsie Chen, Tai-Chia Chiu, Wei-Lung Tseng
Journal of Food and Drug Analysis
Pesticides are a family of non-biodegradable chemical compounds which widely used in agriculture to control pests and increase yield production. However, overuse or abuse of pesticides and their metabolites may cause potential toxicity for the environment as well as human health and all other living organisms, even at deficient concentrations. Consequently, the development of sensors for monitoring these compounds is significant. Recently, nanoparticles-based sensors have been extensively employed as a potential alternative or complementary analytical tool to conventional detection methods for pesticides. Among them, gold nanoparticles (AuNPs) owing to their unique optical properties have been developed as smart sensors with …
Noble Metal Nanomaterial-Based Aptasensors For Microbial Toxin Detection, Yue He, Cong-Ying Wen, Zhi-Jun Guo, Yu-Fen Huang
Noble Metal Nanomaterial-Based Aptasensors For Microbial Toxin Detection, Yue He, Cong-Ying Wen, Zhi-Jun Guo, Yu-Fen Huang
Journal of Food and Drug Analysis
Microbial toxins generated by bacteria, fungi and algae cause serious food-safety problems due to the frequent contamination of foodstuffs and their poisonous nature. Becoming acquainted with the contamination condition of foodstuffs is highly dependent on developing sensitive, specific, and accurate methods for targeting microbial toxins. Aptamers, obtained from systematic evolution of ligands by exponential enrichment (SELEX), have significant advantages for microbial toxin analysis, such as small size, reproducible chemical synthesis, and modification, as well as high binding affinity, specificity, and stability. Besides, aptamers have a predictable structure and can be tailored using biomolecular tools (e.g., ligase, endonuclease, exonuclease, …
Perspective On Recent Developments Of Nanomaterial Based Fluorescent Sensors: Applications In Safety And Quality Control Of Food And Beverages, Ailing Han, Sijia Hao, Yayu Yang, Xia Li, Xiaoyu Luo, Guozhen Fang, Jifeng Liu, Shuo Wang
Perspective On Recent Developments Of Nanomaterial Based Fluorescent Sensors: Applications In Safety And Quality Control Of Food And Beverages, Ailing Han, Sijia Hao, Yayu Yang, Xia Li, Xiaoyu Luo, Guozhen Fang, Jifeng Liu, Shuo Wang
Journal of Food and Drug Analysis
As the highly toxic pollutants will seriously harm human health, it is particularly important to establish the analysis and detection technology of food pollutants. Compared with the traditional detection methods, fluorescent detection technique based on nanomaterials trigger wide interesting because of reduced detection time, simple operation, high sensitivity and selectivity and economic. In this review, the application of fluorescent sensors in food pollutants detection is presented. Firstly, conventional fluorescent nanomaterials including metal-based quantum dots, carbon-based quantum dots and metal nanoclusters were summarized, with emphasis on the photoluminescence mechanism. Then, the fluorescence sensors based on these nanomaterials for food pollutants detection …
Preface, Huan-Tsung Chang, Yu-Fen Huang
Preface, Huan-Tsung Chang, Yu-Fen Huang
Journal of Food and Drug Analysis
No abstract provided.
Corrigendum To “Physicochemical Analysis And Nonisothermal Kinetic Study Of Sertralineelactose Binary Mixtures”, Farnaz Monajjemzadeh
Corrigendum To “Physicochemical Analysis And Nonisothermal Kinetic Study Of Sertralineelactose Binary Mixtures”, Farnaz Monajjemzadeh
Journal of Food and Drug Analysis
No abstract provided.
Corrigendum To “Shenmai-Yin Decreased The Clearance Of Nifedipine In Rats: The Involvement Of Time-Dependent Inhibition Of Nifedipine Oxidation”, Yune- Fang Ueng
Corrigendum To “Shenmai-Yin Decreased The Clearance Of Nifedipine In Rats: The Involvement Of Time-Dependent Inhibition Of Nifedipine Oxidation”, Yune- Fang Ueng
Journal of Food and Drug Analysis
No abstract provided.
Corrigendum To “The Time-Dependent Effects Of St John's Wort On Cytochrome P450, Uridine Diphosphate-Glucuronosyltransferase, Glutathione S-Transferase, And Nad(P)H-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng
Journal of Food and Drug Analysis
No abstract provided.
Corrigendum To “Effects Of Aqueous Extract Of Ruta Graveolens And Its Ingredients On Cytochrome P450, Uridine Diphosphate (Udp)-Glucuronosyltransferase, And Reduced Nicotinamide Adenine Dinucleotide (Phosphate) (Nad(P)H)-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng
Journal of Food and Drug Analysis
No abstract provided.
Detection Of Melamine Based On The Suppressed Anodic Response Of Uric Acid By A Au-Ag Nanoparticles Modified Glassy Carbon Electrode, Yu-Hui Peng, Tsunghsueh Wu, Yang-Wei Lin
Detection Of Melamine Based On The Suppressed Anodic Response Of Uric Acid By A Au-Ag Nanoparticles Modified Glassy Carbon Electrode, Yu-Hui Peng, Tsunghsueh Wu, Yang-Wei Lin
Journal of Food and Drug Analysis
We demonstrated a sensitive electrochemical method for the determination of non-electroactive melamine (Mel) using a modified glassy carbon electrode (GCE), with uric acid (UA) as the signal reporter. To increase the anodic response of UA, GCE was coated with Au–Ag nanoparticles and a Nafion thin film (Au–Ag/Nafion/GCE). The sensing mechanism was based on the competitive adsorption behavior of Mel on the Au–Ag/Nafion/GCE, which reduces the electroactive surface area of nanoparticles and thus hinders anodic response of UA. Under optimal conditions and the use of an analytical method of differential pulse voltammetry, this modified electrode detected Mel concentrations ranging from 2.5 …
Acarbose Attenuates Migration/Proliferation Via Targeting Microrna-143 In Vascular Smooth Muscle Cells Under Diabetic Conditions, Wei-Yuan Chuang, Meng-Hsun Yu, Tsung-Yuan Yang, Kuei-Chuan Chan, Chau-Jong Wang
Acarbose Attenuates Migration/Proliferation Via Targeting Microrna-143 In Vascular Smooth Muscle Cells Under Diabetic Conditions, Wei-Yuan Chuang, Meng-Hsun Yu, Tsung-Yuan Yang, Kuei-Chuan Chan, Chau-Jong Wang
Journal of Food and Drug Analysis
Acarbose (an a-glucosidase inhibitor) has been demonstrated to reduce the progression of atherosclerosis without affecting serum levels of glucose in rabbits fed a high cholesterol diet. The main focus of recent atherosclerosis studies has been microRNA targets. However, the mechanism by which acarbose targets miRNA-mediated atherosclerosis remains unclear. This study aimed to evaluate the effect of acarbose on microRNA-related regulation of rat aortic vascular smooth cell line (A7r5 cell) migration and proliferation induced by diabetic conditions. We reported that acabose exhibit significantly inhibits proliferative and cell migration abilities in A7r5 cells. The expression of protein and levels of mRNA were …
Effect Of 6,7-Dimethoxy-2,2-Dimethyl-2h-Chromene (Agerarin) On The Recovery Of Filaggrin Expression Through Targeting Of Janus Kinases In The Inflammatory Skin, Sung Shin Ahn, Young Han Lee, Hyunjin Yeo, Youngshim Lee, Do Sik Min, Yoongho Lim, Soon Young Shin
Effect Of 6,7-Dimethoxy-2,2-Dimethyl-2h-Chromene (Agerarin) On The Recovery Of Filaggrin Expression Through Targeting Of Janus Kinases In The Inflammatory Skin, Sung Shin Ahn, Young Han Lee, Hyunjin Yeo, Youngshim Lee, Do Sik Min, Yoongho Lim, Soon Young Shin
Journal of Food and Drug Analysis
Filaggrin (FLG) is a structural component of the stratum corneum that is essential for maintaining the barrier function of the skin and for the formation of natural moisturizing factors. 6,7-Dimethoxy-2,2-dimethyl-2H-chromene (Agerarin) is a bioactive compound derived from Ageratum houstonianum, a plant that is used as a traditional medicine to treat skin diseases. This study aimed to evaluate the effect of agerarin on skin inflammation in a dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model. We found that the topical administration of agerarin ameliorates atopic dermatitis-like skin lesions. We also showed that agerarin restores the reduced filaggrin (FLG) expression in …
Biologically-Guided Isolation Of Natural Lead Antithyroid Drug From Medicago Sativa L. Sprouts And Its Toxic Profile In Comparison With Propylthiouracil, Reham S. Ibrahim, Nesrine S. El-Mezayen, Asmaa Khairy, Hala H. Zaatout, Hala M. Hammoda, Aly M. Metwally
Biologically-Guided Isolation Of Natural Lead Antithyroid Drug From Medicago Sativa L. Sprouts And Its Toxic Profile In Comparison With Propylthiouracil, Reham S. Ibrahim, Nesrine S. El-Mezayen, Asmaa Khairy, Hala H. Zaatout, Hala M. Hammoda, Aly M. Metwally
Journal of Food and Drug Analysis
Hyperthyroidism is a common endocrine disorder associated with increased risk of cardiovascular complications and mortality. Although antithyroid drugs (ATDs) are approved as first line option for many hyperthyroidism cases, including pregnancy and childhood, they exert significant toxic profile. Medicago sativa L. (alfalfa) also called “The father of all food” was among the diet consumed by mares that gave birth to foals with congenital hypothyroidism. Since, greenfeed was accused for the development of such condition, alfalfa may possess constituents with promising antithyroid potential that could be a valuable substitute for the conventional ATDs. The current work was designed to identify the …
Establishment Of Indirect Competitive Enzyme Linked Immunosorbent Assay For The Detection Of Platycodin D In Radix Platycodonis, Shuai Luo, Yanfei He, Hongxiang Sun
Establishment Of Indirect Competitive Enzyme Linked Immunosorbent Assay For The Detection Of Platycodin D In Radix Platycodonis, Shuai Luo, Yanfei He, Hongxiang Sun
Journal of Food and Drug Analysis
Platycodin D (PD) has been used as the quality control marker of Radix Platycodonis for its high content and various pharmacological properties. In this study, a specific polyclonal antibody against PD (PD–pAb) was developed, and PD–pAb-based indirect competitive enzyme-linked immunosorbent assay (icELISA) was established for the detection of PD in Radix Platycodonis. The 50% inhibition concentration (IC50) of PD was 2.70 μg/mL and the linearity range for PD was from 0.064 μg/mL to 100 μg/mL. No cross reactivity with PD–pAb was found in five PD analogs except for PD2 (0.93%). The average recovery of PD by icELISA was …
Spatiotemporal Patterns Of Polychlorinated Dibenzo-P-Dioxins And Dibenzofurans And Dioxin-Like Polychlorinated Biphenyls In Foodstuffs In Air Quality Regions In Taiwan, Ching-Chang Lee, Wei-Hsiang Chang, Hsin-Tang Lin, Jung-Wei Chang
Spatiotemporal Patterns Of Polychlorinated Dibenzo-P-Dioxins And Dibenzofurans And Dioxin-Like Polychlorinated Biphenyls In Foodstuffs In Air Quality Regions In Taiwan, Ching-Chang Lee, Wei-Hsiang Chang, Hsin-Tang Lin, Jung-Wei Chang
Journal of Food and Drug Analysis
High-fat food intake is the main source of dioxin-like compounds for humans, such as consumption of meat, dairy and eggs, and seafood products. Fruits, vegetables, and cereals have relatively low levels of dioxin-like compounds, but because of high consumption they also contribute to the food-borne intake. It is necessary to clarify dietary dioxin exposure affected by different food contamination levels and dietary habits among different geographic areas. We aimed to evaluate chronic dietary PCDD/Fs and DL-PCBs exposure in 725 individual foods in 14 categories in 6 Taiwan air quality regions (AQRs) and a total of 2,441 foods from 2004 and …
Quantification Of Adenosine Mono-, Di- And Triphosphate From Royal Jelly Using Liquid Chromatography - Tandem Mass Spectrometry, Wan-Rou Liao, Jen-Pang Huang, Sung-Fang Chen
Quantification Of Adenosine Mono-, Di- And Triphosphate From Royal Jelly Using Liquid Chromatography - Tandem Mass Spectrometry, Wan-Rou Liao, Jen-Pang Huang, Sung-Fang Chen
Journal of Food and Drug Analysis
Nucleotides are composed of nitrogen bases, ribose units and phosphate groups. Adenine (Ade), adenosine monophosphate (AMP), adenosine diphosphate (ADP) and adenosine triphosphate (ATP) all play important roles in physiological metabolism. Royal jelly, a secretion produced by worker bees, contains a variety of natural ingredients and several studies have shown that royal jelly can serve as a source of nutrition for humans. In this study, a rapid and effective LC/MS method coupled with pre-processing methods was developed and validated for the accurate quantification of Ade, AMP, ADP and ATP in royal jelly. To achieve the best extraction efficiency, two pretreatment methods, …
Lipophilized Epigallocatechin (Egc) And Its Derivatives: Inhibition Of Oxidation Of Β-Carotene–Linoleate Oil-In-Water Emulsion And Dna Strand Scission, Priyatharini Ambigaipalan, Won Young Oh, Fereidoon Shahidi
Lipophilized Epigallocatechin (Egc) And Its Derivatives: Inhibition Of Oxidation Of Β-Carotene–Linoleate Oil-In-Water Emulsion And Dna Strand Scission, Priyatharini Ambigaipalan, Won Young Oh, Fereidoon Shahidi
Journal of Food and Drug Analysis
Tea epigallocatechin (EGC) was acylated with selected fatty acids, namely propionic acid [C3:0], caprylic acid [C8:0], lauric acid [C12:0], stearic acid [C18:0] and docosahexaenoic acid (DHA; C22:6 n-3). Antioxidant activity of EGC and its lipophilized derivatives were examined in various food (β-carotene–linoleate oil-in-water emulsion and bulk oil) and biological (supercoiled DNA and LDL) systems in vitro in order to evaluate the effect of increased lipophilicity on their antioxidant capacity. Lipophilized EGC derivatives were more effective in β-carotene–linoleate oil-in-water emulsion and bulk oil than their parent EGC molecule. Meanwhile, EGC and its derivatives showed more than 60 …
Introduction To Dr. Jerzy Leszczynski, P. Fu
Introduction To Dr. Jerzy Leszczynski, P. Fu
Journal of Food and Drug Analysis
[No abstract available]
Codonopsis Javanica Root Extracts Attenuate Hyperinsulinemia And Lipid Peroxidation In Fructose-Fed Insulin Resistant Rats, K.-N. Chen, W.-H. Peng, C.-W. Hou, C.-Y. Chen, H.-H. Chen, C.-H. Kuo, M. Korivi
Codonopsis Javanica Root Extracts Attenuate Hyperinsulinemia And Lipid Peroxidation In Fructose-Fed Insulin Resistant Rats, K.-N. Chen, W.-H. Peng, C.-W. Hou, C.-Y. Chen, H.-H. Chen, C.-H. Kuo, M. Korivi
Journal of Food and Drug Analysis
From ancient times, Dǎngshēn (Codonopsis javanica) has been used in Chinese traditional medicine. In this study we investigated the anti-hyperinsulinemia and antioxidant properties of C. javanica root extracts in a rat model of insulin resistance (IR), induced by chronic fructose feeding. Twenty-four Sprague–Dawley rats were randomized into control, fructose-treated (10%, w/v), and fructose then C. javanica (Fru + Cod)-treated groups. After 8 weeks fructose feeding, increased fasting serum insulin levels (2.6 ± 0.45 μg/L) and insulin area under the curve confirmed the IR (p < 0.001). However, C. javanica treatment to fructose-fed rats significantly attenuated the hyperinsulinemia with correspondingly improved glucose tolerance. Weight gain in Fru + Cod group was comparably (p < 0.01) lower than in the fructose-fed group. Furthermore, IR-induced increased hepatic lipid peroxidation, as demonstrated by elevated malondialdehyde levels, were significantly (p < 0.001) alleviated by C. javanica treatment. These findings reveal that chronic fructose intake may facilitate IR and oxidative damage, which could be eradicated by improved antioxidant status. Accordingly, we found that C. javanica treatment significantly improved the antioxidant enzyme activities, including superoxide dismutase, glutathione peroxidase and glutathione reductase in the liver. These findings that fructose-induced hyperinsulinemia and associated oxidative stress could be attenuated by C. javanica root extracts. © 2013
Evaluating The Urate-Lowering Effects Of Different Microbial Fermented Extracts In Hyperuricemic Models Accompanied With A Safety Study, R.-J. Chen, M.-H. Chen, Y.-L. Chen, C.-M. Hsiao, H.-M. Chen, S.-J. Chen, M.-D. Wu, Y.-J. Yech, G.-F. Yuan, Y.-J. Wang
Evaluating The Urate-Lowering Effects Of Different Microbial Fermented Extracts In Hyperuricemic Models Accompanied With A Safety Study, R.-J. Chen, M.-H. Chen, Y.-L. Chen, C.-M. Hsiao, H.-M. Chen, S.-J. Chen, M.-D. Wu, Y.-J. Yech, G.-F. Yuan, Y.-J. Wang
Journal of Food and Drug Analysis
Uric acid (UA) is an end product of purine metabolism by the enzyme xanthine oxidase (XOD). Hyperuricemia is characterized by the accumulation of serum UA and is an important risk factor for gout and many chronic disorders. XOD inhibitors or uricase (catalyzes UA to the more soluble end product) can prevent these chronic diseases. However, currently available hypouricemic agents induce severe side effects. Therefore, we developed new microbial fermented extracts (MFEs) with substantial XOD inhibition activity from Lactobacillus (MFE-21) and Acetobacter (MFE-25), and MFE-120 with high uricase activity from Aspergillus. The urate-lowering effects and safety of these MFEs were evaluated. …
Lactobacillus Pentosus Gmnl-77 Inhibits Skin Lesions In Imiquimod-Induced Psoriasis-Like Mice, Y.-H. Chen, C.-S. Wu, Y.-H. Chao, C.-C. Lin, H.-Y. Tsai, Y.-R. Li, Y.-Z. Chen, W.-H. Tsai, Y.-K. Chen
Lactobacillus Pentosus Gmnl-77 Inhibits Skin Lesions In Imiquimod-Induced Psoriasis-Like Mice, Y.-H. Chen, C.-S. Wu, Y.-H. Chao, C.-C. Lin, H.-Y. Tsai, Y.-R. Li, Y.-Z. Chen, W.-H. Tsai, Y.-K. Chen
Journal of Food and Drug Analysis
Psoriasis, which is regarded as a T-cell-mediated chronic inflammatory skin disease, is characterized by hyperproliferation and poor differentiation of epidermal keratinocytes. In this study, we aimed to determine the in vivo effect of a potentially probiotic strain, Lactobacillus pentosus GMNL-77, in imiquimod-induced epidermal hyperplasia and psoriasis-like skin inflammation in BALB/c mice. Oral administration of L. pentosus GMNL-77 significantly decreased erythematous scaling lesions. Real-time polymerase chain reaction showed that treatment with L. pentosus GMNL-77 significantly decreased the mRNA levels of proinflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-6, and the IL-23/IL-17A axis-associated cytokines (IL-23, IL-17A/F, and IL-22) in the skin of …
Long-Term Feeding Of Red Algae (Gelidium Amansii) Ameliorates Glucose And Lipid Metabolism In A High Fructose Diet-Impaired Glucose Tolerance Rat Model, H.-C. Liu, C.-J. Chang, T.-H. Yang, M.-T. Chiang
Long-Term Feeding Of Red Algae (Gelidium Amansii) Ameliorates Glucose And Lipid Metabolism In A High Fructose Diet-Impaired Glucose Tolerance Rat Model, H.-C. Liu, C.-J. Chang, T.-H. Yang, M.-T. Chiang
Journal of Food and Drug Analysis
This study was designed to investigate the effect of Gelidium amansii (GA) on carbohydrate and lipid metabolism in rats with high fructose (HF) diet (57.1% w/w). Five-week-old male Sprague-Dawley rats were fed a HF diet to induce glucose intolerance and hyperlipidemia. The experiment was divided into three groups: (1) control diet group (Con); (2) HF diet group (HF); and (3) HF with GA diet group (HF + 5% GA). The rats were fed the experimental diets and drinking water ad libitum for 23 weeks. The results showed that GA significantly decreased retroperitoneal fat mass weight of HF diet-fed rats. Supplementation …