Life Sciences Commons^™

Brainstorm: Head Injuries And The Nfl, Part 11: Microglial Cells, John J. Medina Ph.D.

Brainstorm

We are trying to understand the biology of CTE at the most intimate level possible, the level of cells and molecules. The last entry dealt with the tau protein and its role in mediating closed­-head neural damage. In this installment, let’s consider the role of microglial cells, a little wisp of a cell type with a great big job.

Oregon Wine Board Meeting Minutes November 6, 2012, Oregon Wine Board

Oregon Wine Board Documents

These meeting minutes list individuals in attendance and missing at the November 6, 2012 Oregon Wine Board (OWB) meeting, held at the offices of Davis Wright Tremaine in Portland, Oregon. Michael Donovan, who had traveled to Asia along with representatives from other Oregon agricultural industries as part of Governor John Kitzhaber's Asia trade mission, reported on his experiences during that trip. Updates included information on the 2013 Board nominations, an overview of the OWB website launch and social media efforts, details on international marketing activity, and information from the Oregon Wine Research Institute (OWRI) Policy Board. The meeting concluded with …

U.S. Drought Monitor, November 6, 2012, David Miskus

United States Agricultural Commodities in Drought Archive

Drought map of U.S. for November 6, 2012 (11/6/12) plus: U.S. crop areas experiencing drought (map), Approximate percentage of crop located in drought, by state (bar graph), Percent of crop area located in drought, past 52 weeks (line graph) for: Hay, Cattle, Winter wheat.

Smokejumper Obituary: Amstutz, Ivan C. (Mccall 1945), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Patterns Of Genomic Loss Of Heterozygosity Predict Homologous Recombination Repair Defects In Epithelial Ovarian Cancer, V. Abkevich, K. M. Timms, B. T. Hennessey, M. S. Carey, Julie A. Deloia, +15 Additional Authors

Exercise and Nutrition Sciences Faculty Publications

Background:

Defects in BRCA1, BRCA2, and other members of the homologous recombination pathway have potential therapeutic relevance when used to support agents that introduce or exploit double-stranded DNA breaks. This study examines the association between homologous recombination defects and genomic patterns of loss of heterozygosity (LOH).

Methods:

Ovarian tumours from two independent data sets were characterised for defects in BRCA1,BRCA2, and RAD51C, and LOH profiles were generated. Publically available data were downloaded for a third independent data set. The same analyses were performed on 57 cancer cell lines.

Results:

Loss of heterozygosity regions of …

Is Belief Larger Than Fact: Expectations, Optimism And Reality For Translational Stem Cell Research, Tania M. Bubela, Matthew D. Li, Mohamed Hafez, Mark Bieber, Harold Atkins

Office of the Provost

Background: Stem cell (SC) therapies hold remarkable promise for many diseases, but there is a significant gulf between public expectations and the reality of progress toward clinical application. Public expectations are fueled by stakeholder arguments for research and public funding, coupled with intense media coverage in an ethically charged arena. We examine media representations in light of the expanding global landscape of SC clinical trials, asking what patients may realistically expect by way of timelines for the therapeutic and curative potential of regenerative medicine?
Methods: We built 2 international datasets: (1) 3,404 clinical trials (CT) containing 'stem cell*' from ClinicalTrials.gov …

Findings From The Nutrition Challenge Program, Rayleen Earney, Nicole Bungum, Timothy J. Bungum

Nevada Journal of Public Health

Obesity is an epidemic in the United States. Over 61% of U.S. adults and 58% of Nevada adults have Body Mass Index’s (BMI) that classify them as either overweight or obese (Behavioral Risk Factor Surveillance System [BRFSS], 2005). According to a recent article published in the Journal of the American Medical Association, obesity was the second leading cause of preventable death in the United States behind tobacco use (Mokdad, Marks, Stroup & Gerberding, 2004).

While obesity and overweight are complex, multi-factorial health conditions, an important contributor to the overweight and obesity epidemic is poor dietary habits. One of the major …

Smokejumper Obituary: Gillmore, Duane C. "Gil" (Missoula 1946), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Molecular Evolution And Phylogenetics Of Rodent Malaria Parasites, Ricardo S. Ramiro, Sarah E. Reece, Darren J. Obbard

Harold W. Manter Laboratory of Parasitology: Library Materials

Background: Over the last 6 decades, rodent Plasmodium species have become key model systems for understanding the basic biology of malaria parasites. Cell and molecular parasitology have made much progress in identifying genes underpinning interactions between malaria parasites, hosts, and vectors. However, little attention has been paid to the evolutionary genetics of parasites, which provides context for identifying potential therapeutic targets and for understanding the selective forces shaping parasites in natural populations. Additionally, understanding the relationships between species, subspecies, and strains, is necessary to maximize the utility of rodent malaria parasites as medically important infectious disease models, and for …

Wanda Shockey, Wanda Shockey, Institute Of Child Nutrition. Child Nutrition Archives.

Oral History Project (all interviews)

Wanda Shockey, a native of Monroe, Louisiana, began her child nutrition career in Bastrop, Louisiana, first as the home economics teacher and then becoming the child nutrition director. After moving to Arkansas, Shockey was child nutrition director for Little Rock School District for nine years and had fifty schools. Later she moved to the Arkansas Department of Education where she has been director of child nutrition for the past fifteen years.

11/03/2012 University Of Arkansas Monticello Vs Swosu (Wide Angle), Southwestern Oklahoma State University

Football Videos

Football video of the University of Arkansas Monticello vs SWOSU game on November 3, 2012 in Weatherford, OK. Footage is compiled from individual clips and has no audio.

Also attached is a PDF of the stats from the game, collected from: https://static.swosuathletics.com/custompages/stats/football/foot2012/12-11-03.htm

11/03/2012 University Of Arkansas Monticello Vs Swosu (Tight Angle), Southwestern Oklahoma State University

Football Videos

Football video of the University of Arkansas Monticello vs SWOSU game on November 3, 2012 in Weatherford, OK. Footage is compiled from individual clips and has no audio.

Also attached is a PDF of the stats from the game, collected from: https://static.swosuathletics.com/custompages/stats/football/foot2012/12-11-03.htm

A Study To Determine If University Athletic Teams In Desert Environments Experience Risky Diet-Related Behaviours, Susan Meacham, Christine Bergman, Marcia M. Ditmyer, Kyle Wilson, Connie Mobley

Nevada Journal of Public Health

Training and competing in desert environments may exacerbate concerns related to disordered eating, supplement use, and hydration in some student athlete populations. A survey administered equitably to both genders solicited self-reported responses from members of 18 different teams over four years from a southwestern United States university athletic program. More than 1,700 athletes responded to 42 items on the questionnaire. Teams, not individual student athletes, were the units of measure for statistical analyses. Initial analysis of results indicated that there were no overt concerns regarding dietary behaviors due to training and competing in the desert environment. Further analysis subjected the …

The Effects Of Television Food Advertising On Childhood Obesity, Aleathia Cezar

Nevada Journal of Public Health

Children’s food choices are influenced by the media, television advertising, focusing directly at infants and toddlers. This literature review presents multiple studies that explain how TV advertising of fast food, sugary cereals and other foods high in calories, fat, sugar, sodium and low in nutrients are contributing to the increase rates of childhood obesity. It is concluded that children are exposed to high amounts of food advertisements which affect young children’s food choices and poor food consumption. Due to the growing numbers of hours that children sit in front of the television, less physical activity and the epidemic of childhood …

Environews #1: Nov 2/12, Richard Philp

Data and Test Instruments

Environews #1 is, hopefuly, the first of a series dealing with current issues of environmental concern. This issue discusses the possible role of climate change in the massive floods that followed hurricane sandy, depletion of the world's fish stocks, the possible role, bothe positive and negative, of aquaculture, and the trend to seek oil in increasingly environmentally dangerous venues.

Mechanism Of Action Studies On A New Class Of Anticancer Nucleosides, Megan E. Browning

Theses and Dissertations

We have completed mechanism of action studies on a new class of anticancer nucleosides typified by a novel nucleoside discovered in our lab, MAP-870. In order to study the mechanism of MAP-870, several experiments were completed on a colorectal adenocarcinoma cell line, HT-29, including trypan blue cell count, sulforhodamine B assays, flow cytometry of cell cycle, propidium iodide incorporation, and phosphatidylserine externalization, Caspase-Glo3/7 assays, DNA fragmentation gel, cyclophilin A release gel, PAMPA, and confocal imaging. Sulforhodamine B assays show that MAP-870 does indeed cause growth inhibition and cell death in the model tested. PAMPA assays show that MAP-870 does not …

Tug-Of-War In Motor Protein Ensembles Revealed With A Programmable Dna Origami Scaffold, N. D. Derr, B. S. Goodman, R. Jungmann, A. E. Leschziner, W. M. Shih, S. L. Reck-Peterson

Biological Sciences: Faculty Publications

Cytoplasmic dynein and kinesin-1 are microtubule-based motors with opposite polarity that transport a wide variety of cargo in eukaryotic cells. Many cellular cargos demonstrate bidirectional movement due to the presence of ensembles of dynein and kinesin, but are ultimately sorted with spatial and temporal precision. To investigate the mechanisms that coordinate motor ensemble behavior, we built a programmable synthetic cargo using three-dimensional DNA origami to which varying numbers of DNA oligonucleotide-linked motors could be attached, allowing for control of motor type, number, spacing, and orientation in vitro. In ensembles of one to seven identical-polarity motors, motor number had minimal affect …

Regulation Of Sensory Neurogenesis In The Trigeminal Placode: Notch Pathway Genes, Pax3 Isoforms, And Wnt Ligands, Jason Samuel Adams

Theses and Dissertations

This dissertation is divided into three chapters, each discussing the study of different regulatory molecules involved in sensory neurogenesis occurring in the trigeminal placode. Chapter one is a spatiotemporal description of Notch pathway genes in chick opV placode by stage-specific expression analysis, showing expression of many Notch pathway genes and effectors in the opV placode. Notch pathway gene expression is primarily confined to the ectoderm with highest expression of these genes at the beginning stages of peak neuronal differentiation. This information preceded studies of the functional roles that Notch signaling has in the opV placode and how it may affect …

Physical Activity Among Mexicans And Mexican Americans In An Ecologic Systems Framework, Rebecca E. Lee, Lorna Mcneill, Lucie Levesque, Cynthia M. Castro, Edtna Jauregui

International Journal of Exercise Science: Conference Proceedings

Purpose: To operationalize the Ecologic Model of Physical Activity (EMPA) in an environmental and cultural context born in Mexico, but broadly adopted by Mexican Americans in the USA. Methods: Participant observation occurred over an immersive, ten month period in Jalisco, Baja California South, and the Distrito Federal, Mexico. Numerous meetings with researchers, school personnel, state health departments, and residents helped define environmental factors, cultural values, and the political context of Mexico. The EMPA was adapted to include examples from physical activity resources, health care settings and behavioral interventions. Results: Mexico is a middle income country leapfrogging from traditional physical activities …

Gender Difference In Obesity And Preventive Health Behaviors In A Us-Mexico Border Hispanic Cohort, Jing Wang, Belinda M. Reininger, Stanley Cron, Deidra Carroll, Susan P. Fisher-Hoch

International Journal of Exercise Science: Conference Proceedings

Purpose: Overweight and obesity is a prevalent chronic disorder in Mexican Americans, however, obesity-related behaviors and the role of gender remain unclear. This study examined gender difference in obesity-related health behaviors among Mexican Americans. Methods: A sample (n=1439) was drawn from the Cameron County Hispanic Cohort, a prospective cohort sample of Mexican American adults aged 18 years and older living in a large and poor city along the Texas / Mexico border. The participants’ baseline demographic, behavioral, and clinical measures were used for this analysis. Descriptive statistics and chi-square tests were conducted to analyze the data. Results: The sample had …

Healthy Bites: A Challenge-Based Worksite Wellness Nutrition Program, Mary E. Herndon, Adelina J. Espat, Laura R. Nathan-Garner

International Journal of Exercise Science: Conference Proceedings

Purpose: The worksite health promotion literature has shown that successful nutrition communication programs call for making small changes to diet, one at a time. The use of observational learning (role models) and a “challenge” scenario for behavior change is supported by Social Cognitive Theory. The significance of these small changes in worksites is underscored by a recent Harvard Business Review article suggesting workplace wellness programs can return up $2.71 on every $1.00 invested. The purpose of the proposed program, Healthy Bites, is to increase knowledge of employees regarding the impact of specific nutrition behaviors related to reducing cancer risk and …

Physical Activity Among Asian American Adults: Data From The 2010 Health Of Houston Survey, Dennis Kao, Amy Carvalho, Rebecca E. Lee

International Journal of Exercise Science: Conference Proceedings

Purpose: The Asian American population represents the fastest growing minority groups in the US; yet, little is still known about physical activity (PA) among Asian Americans. This study examines PA among Asian American adults living in the Houston, TX area. Methods: Data on adults aged 18 and over were drawn from the Health of Houston Survey 2010—a population-based survey focused in the city of Houston and Harris County. PA was operationalized in two ways: number of moderate leisure-time PA days in the past week; and meeting CDC recommendations for aerobic exercise. Multivariate regression models (negative binomial and logistic) were used …

Using Housing Market Information To Improve Evaluation Of Physical Activity., Michael C. Farmer, Michael S. Shiroya

International Journal of Exercise Science: Conference Proceedings

Purpose: Heterogeneity exists in urban neighborhoods. Factors that affect home choice can differ even though socio-demographics are quite similar. It is possible residents’ tastes for environment features in home location also predict how well they respond to built-environment changes by increasing physical activity. Observing factors that affect location can contribute to physical activity success in public health. A study area in West Texas appears very homogeneous: 89% Caucasian; 72% registered Republican; 81% families with children; 68% college educated - 87% ‘some college;’ yet two distinct submarkets exist based on subtle differences in home purchase choices. The area has a high …

The Impact Of Home Availability Of The Relationship Between Neighborhood Availability And Fruit And Vegetable Conumption In Low-Income Ethnic Minorities, Erica Soltero, Scherezade K. Mama, Rebecca E. Lee

International Journal of Exercise Science: Conference Proceedings

Purpose: High availability of grocery stores and supermarkets has been positively associated with increased fruit and vegetable consumption, yet some studies have reported that the relationship between availability and consumption is equivocal or inconclusive indicating that availability does not directly translate to increased consumption. The purpose of this study was to investigate the mediating effect of home availability of fruits and vegetables on the relationship between neighborhood availability of supermarkets and grocery stores and fruit and vegetable consumption in low-income, ethnic minority neighborhoods. Methods: Data used in this study was taken from the Healthful Options Using Streets and Transportation in …

The Physical Activity Promotion Environment In Mexican Health Care Settings, Karla I. Galaviz, Lucie Lévesque, Rebecca Lee, Kim Bergeron

International Journal of Exercise Science: Conference Proceedings

Purpose: The health care environment is recognized as a promising setting in which to promote physical activity (PA). Nearly 40% of Mexican adults are inactive and whether Mexican health care environments are promoting PA is unknown. The purpose of this study was to describe and compare the PA promotion environment in Guadalajara, Mexico. Methods: Forty primary care clinics and hospitals from the three health care systems in Guadalajara were sampled: 15 from the Secretary of Health, 14 from the Social Security Institutes and 11 from the private sector. A tool for measuring the PA environment of health care settings, including …

A Quantitative Simulation Study Of Obesity Development Among A Young Population, Grant Zhao, Kevin Hall

International Journal of Exercise Science: Conference Proceedings

Purpose: Studying the process of obesity development among a real human population is difficult due to its impracticalities and ethical limitations. Our study aims to discover quantitative relationships and patterns in body weight change and obesity development via a novel approach - mathematical modeling of human metabolism and body weight simulation. Methods: Using publicly available data from the CDC, 1000 male and 1000 female individuals 18 years of age were randomly generated as a virtual population following a normal distribution in body weight and height. Three sample groups, each consisting of 100 male and 100 female individuals, were randomly selected …

A Snapshot: Concepts Of Healthy Eating And Fitness Held By K-8 Pre-Service Teachers, Jon M. Aoki

International Journal of Exercise Science: Conference Proceedings

Purpose: The purpose of this study was to describe the concepts of healthy eating and fitness held by K-8 pre-service teachers at a four-year urban university located in southeast Texas. Methods: A questionnaire that described the participants’ concept of healthy eating and fitness was distributed on the first day of class. A phenomenological approach using a constant comparative method was used to describe the responses from the teacher candidates. Results: Ninety-five percent of the participants lived with someone and were responsible for 75% of the grocery shopping solely or with someone else. In addition, 66% of the students indicated …

Childhood Obesity: Epidemiology - A Social And Cultural Perspective, Thu Huong T. Vu

International Journal of Exercise Science: Conference Proceedings

Purpose: The purpose of this study was to explore the social and cultural aspects of the epidemiology of childhood obesity among local populations in Houston, TX. Methods: Review of recent journal articles, studies, and surveys regarding the relationship between childhood obesity and other social factors, including race, ethnicity, culture, socioeconomic status, and parental behaviors. Literatures should contain not just quantitative data or listing of social and cultural factors affecting childhood obesity, but also discuss how these factors accomplish that. Literatures are analyzed and compared for consistencies and inconsistencies. Results: The findings are divided into three sections: socioeconomic factors, ethno-cultural factors, …

Logic Modeling And The Ridiculome Under The Rug, Michael L. Blinov, Ion I. Moraru

UCHC Articles - Research

Logic-derived modeling has been used to map biological networks and to study arbitrary functional interactions, and fine-grained kinetic modeling can accurately predict the detailed behavior of well-characterized molecular systems; at present, however, neither approach comes close to unraveling the full complexity of a cell. The current data revolution offers significant promises and challenges to both approaches - and could bring them together as it has spurred the development of new methods and tools that may help to bridge the many gaps between data, models, and mechanistic understanding.

Have you used logic modeling in your research? It would not be surprising …

How I Would Like Semantic Web To Be, For My Children., Raghava Mutharaju

Kno.e.sis Publications

Semantic Web, since its inception, has gone through lot of developments in its relatively nascent existence; right from people's perception, to the standards and to its adoption by the industry and more importantly by the scientific community. This impressive growth only seems to increase. In this paper, we project this growth to the next 10 years and highlight some of the facets on which Semantic Web could have a major impact on. We also present the challenges that Semantic Web and its community has to deal with in order to get there.