Life Sciences Commons^™

Apigenin Alleviates Autistic-Like Stereotyped Repetitive Behaviors And Mitigates Brain Oxidative Stress In Mice, Petrilla Jayaprakash, Dmytro Isaev, Keun-Hang Susan Yang, Rami Beiram, Murat Oz, Bassem Sadek

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Studying the involvement of nicotinic acetylcholine receptors (nAChRs), specifically α7-nAChRs, in neuropsychiatric brain disorders such as autism spectrum disorder (ASD) has gained a growing interest. The flavonoid apigenin (APG) has been confirmed in its pharmacological action as a positive allosteric modulator of α7-nAChRs. However, there is no research describing the pharmacological potential of APG in ASD. The aim of this study was to evaluate the effects of the subchronic systemic treatment of APG (10–30 mg/kg) on ASD-like repetitive and compulsive-like behaviors and oxidative stress status in the hippocampus and cerebellum in BTBR mice, utilizing the reference drug aripiprazole (ARP, 1 …

Net Farm Income Impacts Net Worth Growth, Glennis Mcclure

Center for Agricultural Profitability

The beginning of the year is busy for businesses in finalizing records and filing annual income taxes. Farm and ranch operations are no exception. Beyond the net income or loss showing on the farm’s Schedule F, analyzing the true picture of the operation’s net farm income, and earned net worth change for the year is important.

Preparing an income statement using accrual adjustments will tell us more about the operation’s profitability and performance beyond what income tax statements provide. The income statement tells the story of revenue, expenses, and depreciation between the beginning of year balance sheet and the end …

Ideas For Estate And Transition Planning: Gifting, Jessica Groskopf

Center for Agricultural Profitability

For many farm and ranch families, bringing children or grandchildren into the operation is the ultimate goal. Successfully bringing additional family members into the operation may require some creativity as all parties need to maintain a viable standard of living. This article is part of a series that will highlight ideas and tactics for bringing another family member into the operation. If this is the first article you are seeing in this series, I would encourage you to go back to the previous article for background and additional guidance.

The second tactic to transfer wealth between generations is gifting. The …

"The Relevant History And Medical And Ethical Future Viability Of Xenotransplantation", Morgan Janes

Augustana Center for the Study of Ethics Essay Contest

Xenotransplantation, the transplantation of organs or tissues from one species to another, presents a complex nexus of medical, ethical, and cultural considerations. In this article, we delve into the multifaceted landscape of xenotransplantation, beginning with a thorough examination of its relevant historical trajectory. From early experiments to recent advancements, we chart the evolution of this field, setting the stage for a nuanced discussion. We then confront the central issue: the true medical viability of xenotransplantation and the looming specter of operative risk. By scrutinizing the ethical dilemmas inherent in xenotransplantation through a multicultural lens, we illuminate the diverse perspectives that …

Native Wetland Plant Seed Collection And Cleaning Guide For The Intermountain West, Rae Robinson, Maddie Houde, Elana Feldman, Samantha R. Kurkowski, Nathan M. Crawford, Stephanie Aristizabal, Karin M. Kettenring

All Current Publications

Collecting and cleaning seeds from wildlands is an essential part of ecosystem restoration, management, and conservation. Here, we summarize best practices for native wetland plant seed collection and cleaning in the Intermountain West.

A companion guide on seed testing, "Seed Viability Testing Guide for Common Wetland Plant Species," is also available (https://digitalcommons.usu.edu/extension_curall/2389/).

First-Time Market Goat, Ashley Longmore, Cheyenne Reid

All Current Publications

This fact sheet is 4-H youth who are thinking about or have recently purchased their first 4-H goat. This fact sheet is a simple outline that provides information on selection, feeding, housing, basic care, and grooming.

First-Time Market Lamb, Ashley Longmore, Cheyenne Reid

All Current Publications

This fact sheet is 4-H youth who are thinking about or have recently purchased their first 4-H lamb. This fact sheet is a simple outline providing more information on selection, feeding, housing, basic care, and grooming.

Continuous Mowing Differentially Affects Floral Defenses In The Noxious And Invasive Weed Solanum Elaeagnifolium In Its Native Range, Alejandro Vasquez, Alexa Alaniz, Robert K. Dearth, Rupesh R. Kariyat

Biology Faculty Publications and Presentations

In weeds, disturbance has been found to affect life history traits and mediate trophic interactions. In urban landscapes, mowing is an important disturbance, and we previously showed that continuous mowing leads to enhanced fitness and defense traits in Solanum elaeagnifolium, Silverleaf Nightshade (SLN). However, most studies have been focused on foliar defenses, ignoring floral defenses. In this study we examined whether continuous mowing affected floral defenses in SLN using mowed and unmowed populations in South Texas, their native range. We found flowers of mowed SLN plants larger but lighter than unmowed plants. Additionally, flowers on plants that were mowed …

Unsupervised Deep Representation Learning Enables Phenotype Discovery For Genetic Association Studies Of Brain Imaging, Khush Patel, Ziqian Xie, Hao Yuan, Sheikh Muhammad Saiful Islam, Yaochen Xie, Wei He, Wanheng Zhang, Assaf Gottlieb, Han Chen, Luca Giancardo, Alexander Knaack, Evan Fletcher, Myriam Fornage, Shuiwang Ji, Degui Zhi

Journal Articles

Understanding the genetic architecture of brain structure is challenging, partly due to difficulties in designing robust, non-biased descriptors of brain morphology. Until recently, brain measures for genome-wide association studies (GWAS) consisted of traditionally expert-defined or software-derived image-derived phenotypes (IDPs) that are often based on theoretical preconceptions or computed from limited amounts of data. Here, we present an approach to derive brain imaging phenotypes using unsupervised deep representation learning. We train a 3-D convolutional autoencoder model with reconstruction loss on 6130 UK Biobank (UKBB) participants' T1 or T2-FLAIR (T2) brain MRIs to create a 128-dimensional representation known as Unsupervised Deep learning …

Changes In Reef Tourism’S Adaptive Capacity After Severe Climate Disturbances, Henry Bartelet, Michele Barnes, Lalu Bakti, Graeme S. Cumming

Quantitative Methods and Information Technology Faculty Publications

Knowledge about adaptive capacity and its determinants has increased significantly over the last decade. However, most research on adaptive capacity has been static, not considering how adaptive capacity might change over time, particularly after severe disturbances. We studied the adaptive capacity dynamics of Asian-Pacific reef tourism operators affected by coral bleaching and tropical cyclones compared with a control group with non-affected operators. We found that impacts from tropical cyclones were associated with frequent changes in adaptive capacity. Notably, we found a reduction in tangible attributes (assets and flexibility) of adaptive capacity, whereas intangible attributes (agency and social organization) increased. Our …

Discovery Of A Small-Molecule Inhibitor That Traps Polθ On Dna And Synergizes With Parp Inhibitors, William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John Krais, Yifan Wang, Umeshkumar Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang Chen, Richard Pomerantz

Department of Biochemistry and Molecular Biology Faculty Papers

The DNA damage response (DDR) protein DNA Polymerase θ (Polθ) is synthetic lethal with homologous recombination (HR) factors and is therefore a promising drug target in BRCA1/2 mutant cancers. We discover an allosteric Polθ inhibitor (Polθi) class with 4-6 nM IC₅₀ that selectively kills HR-deficient cells and acts synergistically with PARP inhibitors (PARPi) in multiple genetic backgrounds. X-ray crystallography and biochemistry reveal that Polθi selectively inhibits Polθ polymerase (Polθ-pol) in the closed conformation on B-form DNA/DNA via an induced fit mechanism. In contrast, Polθi fails to inhibit Polθ-pol catalytic activity on A-form DNA/RNA in which the enzyme binds in …

Evaluation Of Yield And Physicochemical Quality Of Pentadesma Butyracea Butter Obtained By Different Traditional Extraction Methods In Ghana, Josephine Akuba Timtey, Francis Alemawor, William Otoo Ellis, Jacob K. Agbenorhevi, Nana Baah Pepra-Ameyaw

Food Science Faculty Articles and Research

Pentadesma butyracea seed butter or fat (PBSB) is a vegetable fat extracted from the seeds of the P. butyracea plant. The butter has potential use in the food, pharmaceutical, and cosmetic industries. The study investigated traditional PBSB processing methods in Ghana and evaluated their effects on yield, physicochemical parameters, and fatty acid composition. Four traditional extraction methods were identified and evaluated, and these methods are direct wet extraction of PBSB from a fresh mixture of the seed paste and water (DEW); wet extraction of PBSB from a 12-hour fermented mixture of the seed paste and water (FWO); direct wet extraction …

Historical And Morphological Review Of The Subgenus Indonthophagus Kabakov, 2006 Of Onthophagus Latreille, 1802 (Coleoptera: Scarabaeidae: Scarabaeinae: Onthophagini), Stefano Ziani

Insecta Mundi

The subgenus Indonthophagus Kabakov, 2006 of Onthophagus Latreille, 1802 (Coleoptera: Scarabaeidae: Scarabaeinae: Onthophagini) is reviewed. A morphological definition of it is provided. A diagnosis, based both on external and internal characters, of the seven species deemed to belong to the group according to literature, is supplied. As a result, Onthophagus spinifex (Fabricius, 1781), previously placed with some uncertainty in the subgenus, is definitively excluded. A key to Indonthophagus species is also provided, as well as images of male, aedeagus and endophallus for each species. New country records of Onthophagus turbatus Walker, 1858 for Pakistan, Nepal, and Bhutan are given.

ZooBank …

The Identification Of The Flower Thrips, Frankliniella Karny (Thysanoptera: Thripidae) Intercepted At U. S. Ports Of Entry, Thomas L. Skarlinsky Ii

Insecta Mundi

United States port of entry interception data revealed that Frankliniella Karny (Thysanoptera: Thripidae) was the most frequently intercepted genus of Thripidae. No published identification resource for intercepted Frankliniella is available to United States Department of Agriculture (USDA) port of entry entomology identifiers. A morphological review of intercepted species was conducted. A dichotomous key for the identification of intercepted slide mounted adult females was created. Morphological diagnosis, description of each species with their geographic region(s) of origin and frequency of interception is provided.

ZooBank registration. urn:lsid:zoobank.org:pub:403B362E-9A7F-4385-A0F1-9DB87FE09AD2

Predicting The Potential Distribution Of Pseudococcus Longispinus (Targioni-Tozzetti) (Hemiptera: Pseudococcidae) In South Korea Using A Climex Model, Su Bin Kim, Soo-Jung Suh

Insecta Mundi

Pseudococcus longispinus (Targioni-Tozzetti) (Hemiptera: Pseudococcidae) is a widely-distributed pest that feeds on many economically important hosts, particularly tropical fruits and ornamentals. The potential distribution of this mealybug pest in South Korea remains a primary concern because of its high incidence of interceptions screened during inspection. Hence, this species prompted a modelling effort to assess its potential risk of introduction. Potential risk maps were developed for this pest with a CLIMEX model based on occurrence records under environmental data. The potential distribution of these pests in South Korea in the 2020s, 2050s and 2090s was projected based on the RCP 8.5 …

The Genus Centris Fabricius In Cuba, With A New Record And The Description Of A New Species (Hymenoptera: Apoidea: Anthophila), Julio A. Genaro, Dayron Breto

Insecta Mundi

Members of the genus Centris Fabricius (Hymenoptera: Apoidea: Anthophila) constitute a significant component of the Neotropical (including insular) bee fauna, exhibiting high species richness, a moderate to large body size, and extensive interactions with various important plant groups. Females of most species possess specialized morphology adapted for collecting oils from flowers. This study documents the presence of the genus in Cuba, recognizing six species: C. aethiops Cresson, C. cornuta Cresson, C. fulviventris Cresson, C. poecila Lepeletier, C. taina Genaro and Breto new species, and C. tarsata F. Smith. Detailed information is provided for …

Notes On The Tribe Chlorocorini With The Description Of A New Species Of Chlorocoris Spinola (Hemiptera: Heteroptera: Pentatomidae) From Panama, Donald B. Thomas

Insecta Mundi

A new species, Chlorocoris charluzae Thomas (Hemiptera: Heteroptera: Pentatomidae), is described from Panama. Eludocoris grandis Thomas is reported from Panama for the first time. The distribution of Chlorocoris rufispinus Dallas to include Panama is confirmed. Arawacoris Thomas, described as a subgenus of Chlorocoris Spinola, is elevated to full genus.

ZooBank registration. urn:lsid:zoobank.org:pub:F4E45B6C-5BD8-4B3E-B599-3BB61855B392

Review Of Pharaxonotha Reitter (Coleoptera: Erotylidae: Pharaxonothinae) Inhabiting Cones Of The Cycad Zamia L. (Cycadales) In Panama, With Descriptions Of Five New Species, William Tang, Paul E. Skelley, Alberto S. Taylor R., Shayla Salzman

Insecta Mundi

The beetle genus Pharaxonotha Reitter (Coleoptera: Erotylidae: Pharaxonothinae) is found in the cones of cycad genera in the New World, including species of Ceratozamia Brongn., Dioon Lindl., Microcycas (Miq.) A.DC, and Zamia L. Its presence and diversity are analyzed for the 17 species of Zamia known to occur in Panama. Nine species are recognized, and five new species are described: Pharaxonotha clarkorum Pakaluk, P. confusa Pakaluk, P. fortunensis Tang, Skelley and Taylor new species, P. holzmani Tang, Skelley and Taylor new species, P. kirschii Reitter, P. manicatae Tang, Skelley and Taylor new species …

Diagnosis Of Spilococcus Pacificus (Borchsenius, 1949) And An Updated List Of Scale Insects (Hemiptera: Coccomorpha) On Pears (Pyrus L.: Rosaceae) In South Korea, Jungyoun Ji, Soo-Jung Suh

Insecta Mundi

Pears, Pyrus pyrifolia (Burm.f.) Nak. (Rosaceae) are one of the most widely grown fruit trees in South Korea. Approximately 11% of the total pear production in 2022 was exported to countries such as the United States and Vietnam. Exported pears must be free of pest species that are considered of quarantine importance by the importing countries. Herein, a list of scale insects (Hemiptera: Coccomorpha) associated with pear trees is updated. Additionally, Spilococcus pacificus (Borchsenius) is added to the list of mealybugs affecting pears in South Korea and is briefly diagnosed based on non-type specimens and illustrated using photographs. Information on …

A Taxonomic Review Of The Genus Psephenops Grouvelle Of The Lesser Antilles With Description Of New Species Psephenops Trini, And Reassignment Of Peruvian Species Psephenus Robacki Spangler (Coleoptera: Psephenidae: Psepheninae), Cheryl B. Barr, William D. Shepard

Insecta Mundi

An overview of the genus Psephenops Grouvelle (Coleoptera: Psephenidae: Psepheninae) is provided with geographic distributions of the species. The taxonomic history of Psephenops smithi Grouvelle, the type species from Grenada and St. Vincent, and junior synonym Xexanchorinus latus Grouvelle from Grenada, is discussed, and lectotypes and paralectotypes are designated for both. Photographs of the type series and a non-type specimen with illustrated male genitalia, along with new distributional information for the species, are provided. The male, female, and associated larva of Psephenops trini Barr and Shepard, new species, are described and illustrated, as is the habitat of this species …

Acalyptomerus Asiaticus Crowson (Coleoptera: Clambidae: Acalyptomerinae) New To The Faunae Of The United States, Dominican Republic And Vietnam, Michael A. Ivie, Susan E. Halbert

Insecta Mundi

Acalyptomerus asiaticus Crowson (Coleoptera: Clambidae: Acalyptomerinae) is recorded for the first time from the United States (Florida), Dominican Republic, and Vietnam.

ZooBank registration. urn:lsid:zoobank.org:pub:F05EE9D0-7305-4C6B-BE7F-8D9E86C66AA7

Harnessing Exosomes As A Platform For Drug Delivery In Breast Cancer: A Systematic Review For In Vivo And In Vitro Studies, Abdulwahab Teflischi Gharavi, Saeed Irian, Azadeh Niknejad, Keykavous Parang, Mona Salimi

Pharmacy Faculty Articles and Research

Breast cancer remains a significant global health concern, emphasizing the critical need for effective treatment strategies, especially targeted therapies. This systematic review summarizes the findings from in vitro and in vivo studies regarding the therapeutic potential of exosomes as drug delivery platforms in the field of breast cancer treatment. A comprehensive search was conducted across bibliographic datasets, including Web of Science, PubMed, and Scopus, using relevant queries from several related published articles and the Medical Subject Headings Database. Then, all morphological, biomechanical, histopathological, and cellular-molecular outcomes were systematically collected. A total of 30 studies were identified based on the Preferred …

Research Day 2024 Program, Western Michigan University Homer Stryker M.D. School Of Medicine

Research Day

No abstract provided.

First-Time Market Steer, Ashley T. Longmore, Cheyenne A. Reid

All Current Publications

The target audience for this fact sheet is 4-H youth who are thinking about or have recently purchased their first 4-H steer. This fact sheet is a simple outline that will give them more information on selection, feeding, housing, basic care, and grooming.

First-Time Market Hog, Ashley T. Longmore, Cheyenne A. Reid

All Current Publications

This fact sheet is for 4-H youth who are thinking about or have recently purchased their first 4-H hog. This fact sheet is a simple outline that will give them more information on selection, feeding, housing, basic care, and grooming.

Maintaining And Improving Irrigation Application Uniformity In Sprinkler And Drip Systems, Burdette Barker, Sheridan Stewart, Mark Nelson

All Current Publications

The goal of most irrigation system design and management is to provide all plants in an irrigated area with equal access to water. Ideally, each plant should receive the exact amount of water it needs. If a field needs 1 inch of water for irrigation, all parts of the field should receive exactly that. The reality is not so perfect. It is practically impossible to apply the same quantity of water to all plants in an irrigated area, plot, or field. In other words, all irrigation systems have some nonuniformities in the water delivered. Instead of designing and managing irrigation …

Social Media Does Not Elicit A Physiological Stress Response As Measured By Heart Rate And Salivary Cortisol Over 20-Minute Sessions Of Cell Phone Use, Suzanne Oppenheimer, Laura Bond, Charity Smith

Biomolecular Research Center Publications and Presentations

The pervasive use of social media has raised concerns about its potential detrimental effects on physical and mental health. Others have demonstrated a relationship between social media use and anxiety, depression, and psychosocial stress. In light of these studies, we examined physiological indicators of stress (heart rate to measure autonomic nervous system activation and cortisol to assess activity of the hypothalamic-pituitary-adrenal axis) associated with social media use and investigated possible moderating influences of sex, age, and psychological parameters. We collected physiological data from 59 subjects ranging in age from 13 to 55 across two cell phone treatments: social media use …

Employing Ai To Enhance In-Class Role Playing Scenarios, Eric Fournier

Generative AI Teaching Activities

Role playing can deepen student’s engagement with course content and help them develop skills while learning course material. Students will use AI to develop their characters and help them craft compelling arguments in the role-play scenarios

Teaching Evolutionary Principles With Ai Image Generators, Jacqueline Garnett

Generative AI Teaching Activities

The purpose of this assignment is for students to practice constructing phylogenies using the principle of parsimony. In this activity, students will use an AI Image Generator to create a grid of images of the same organism and identify a series of traits that vary to build a possible phylogenetic tree.

Classification Of Lakebed Geologic Substrate In Autonomously Collected Benthic Imagery Using Machine Learning, Joseph K. Geisz, Phillipe A. Wernette, Peter C. Esselman

Michigan Tech Publications, Part 2

Mapping benthic habitats with bathymetric, acoustic, and spectral data requires georeferenced ground-truth information about habitat types and characteristics. New technologies like autonomous underwater vehicles (AUVs) collect tens of thousands of images per mission making image-based ground truthing particularly attractive. Two types of machine learning (ML) models, random forest (RF) and deep neural network (DNN), were tested to determine whether ML models could serve as an accurate substitute for manual classification of AUV images for substrate type interpretation. RF models were trained to predict substrate class as a function of texture, edge, and intensity metrics (i.e., features) calculated for each image. …