Chemical Engineering Commons^™

Characterization Of Free-Radical Solution Polymerizations Of Acrylamide Initiated By Persulfate Initiator Systems, Yashu Chen

Masters Theses

”In order to reduce the water production and improve the oil recovery of mature reservoir, various conformance control technologies have been extensively developed. Preformed particle gel (PPG), a cost-effective plugging agent, has been successfully applied to block the high permeability zone and thus to displace the water to up-swept zone.

A common PPG based on polyacrylamide hydrogel have been wildly used. Identifying the parameters that affect gelation performance and understand how these parameters affect the performance is very useful to predict and manipulate the gelation time and to control the performance of gels.

The objective of this research is to …

Monobore Completion Design: Classification, Applications, Benefits And Limitations, Anwar Khaled Al-Fadhli

Masters Theses

"A monobore completion is a simple completion design that uses the same internal diameter from the bottom of the well to surface. This may be accomplished by cementing a string of casing in a well, or by having tubing stabbed into a polished bore receptacle on a casing liner the same size as the tubing. Monobore completions have been applied extensively in oil and gas fields around the world, both onshore and offshore, from very low reservoir flow to extremely high production rates, since the late 1980s. They have proven beneficial due to their simplicity and cost savings. This study …

New Wellbore-Integrity Classification For Gas Migration Problems And New Cement Formulations Using Graphene Nano Platelets To Prevent Gas Migration Through Cement, Mohammed Mousa M. Alkhamis

Masters Theses

"Gas migration, one of the primary problems related to the integrity of oil wells, is caused by cement failures. Gas migration can result in costly well repairs and may endanger personal, equipment, and result in severe operational difficulties and environmental issues. The ultimate objectives of this research were to provide a comprehensive review of the problem and to provide a solution to the problem using Graphene Nano Platelets (GNPs).

An intensive review was performed to understand the cement failures. The reasons behind these failures were analyzed and classified with respect to their locations in the wellbore. Recommendations and potential solutions …

Data Analysis Of Low-Salinity Waterflooding To Enhance The Oil Recovery In Sandstone Reservoirs, Nadia Ariani

Masters Theses

"The lack of a single reasonable general mechanism to describe how low-salinity waterflooding can improve oil recovery in both laboratory and field pilot projects has increased the interests of many researchers and stakeholders. There has not been observed the relationship of formation brine salinity and injected brine salinity to see how much salinity is reduced to produce the maximum enhanced oil recovery by LSWF. There is no guidance in what EOR stage the LSWF is best implemented. This work collects data from various published literature to develop a comprehensive data set regarding low-salinity waterflooding in sandstone reservoirs. The LSWF mechanisms …

An Integrated Method For Understanding The Fluid Flow Behavior And Forecasting Well Deliverability In Gas Condensate Reservoirs With Water Aquifer Drive, Abdulaziz Mustafa Em. Ellafi

Masters Theses

"Gas condensate reservoirs constitute a significant portion of global hydrocarbon reserves. In these reservoirs, as bottomhole pressure falls below the dew point, liquid develops in the pore space. This results in the formation of a liquid bank near the wellbore region that decreases gas mobility, which then reduces gas inflow. Some gas condensate reservoirs have bottom aquifer drive, which also negatively impacts gas production. This research used a field case study to demonstrate an integrated workflow for forecasting well deliverability in a gas condensate field in Libya. The workflow began with the interpretation of open-hole log data to identify the …

Effect Of Variation Of Parameters On Biogas Production Using Aspen Plus & Dynamic Simulation Using Mimic, Shruti Shrikant Karambelkar

Masters Theses

"Design and management for Biogas production have gained significance in growing dependency on Renewable energy resources. This would need a detailed information on steady state and dynamic behavior of systems. In order to make this process environmentally ecofriendly, its needs a lot of improvisation on process simulation. Anaerobic digestion helps treat this inefficient water to be converted into water fit for effluent purposes.

Byproducts contain consists of organic, inorganic and wastes which lead to a high COD content and thus, cannot be discarded into the outlets. The anaerobic digestion process. A study of these effects with simulation need to be …

Cellular Hitchhiking Via Injectable Microparticles, Daniel Smith

Masters Theses

"Tissue engineering is a process of developing new tissues in a host. Tissue engineering draws upon revitalizing damaged tissues that otherwise would not heal completely from the body's natural response. To augment the body's natural response to impairment, cells can be transplanted to the afflicted area to boost the healing response. Implementing these cells onto scaffolds and transplanting them into the body improves the healing response dramatically. Tissue regeneration improves when a biodegradable scaffold is used in conjunction with cells to augment the body's healing response. Microparticles provide a surface that can mimic the environment cells perceive in vivo, …

Proppant Transport With Varying Injection Points And Its Impact On Proppant Development Inside A Fracture, Shail Janakbhai Soni

Masters Theses

"This study presents experimental work which examines the effect of perforation placement and density on proppant placement within a hydraulic fracture. The study also investigates the effect of proppant angularity.

Experiments were conducted with ceramic proppant injected in a fracture slot model consisting of three injection points at the bottom, middle and top of the fracture slot, and two outlets, at the bottom and top of the fracture model. The effect of single point injection height was investigated by injecting solely at the bottom, middle or top of the apparatus, for both bottom and top outlet conditions. Multiple injection points …

The Role Of Flexural Slip In The Development Of Chevron Folds, Yuxing Wu

Masters Theses

"Chevron folds are characterized by straight limbs and narrow hinge zones. One of the conceptual models to initiate and develop chevron folds involves flexural slip during folding. While some kinematical models show the necessity for slip to initiate during chevron folding, recent numerical modeling studies of visco-elastic effective single layer buckle folding have shown that flexural slip does not result in chevron folds. In this study, several 2D finite element analysis models are run, distinguished by 1) geometry of the initial perturbation (sinusoidal and white noise), 2) varying thewavelength of the initial perturbation (10%, 50%, and 100% of the dominant …

The Development Of A New Formulation Of Fly Ash Class C Based Geopolymer And Assessing Its Performance In Presence Of Drilling Fluid Contamination, Mohamed Saad Ahdaya

Masters Theses

"Cementing is one of the most critical steps in the drilling and completion of oil wells. Traditionally, Portland cement is used for oil cementing operations; however, geopolymer materials have recently attracted much attention because they are more cost-effective and have less environmental impacts.

An intensive laboratory work was conducted to obtain a new formulation of fly ash class C based geopolymer cement to be used as a potential alternative cementing material to Portland cement in oil and gas cementing. Twenty-four variations of fly ash class C based geopolymers were prepared, and by comparing several of their properties using API standard …

New Nanoparticle Water-Based Drilling Fluid Formulation With Enhanced Thermal Stability And Inhibition Capabilities In The Woodford Shale, Jose Aramendiz Pacheco

Masters Theses

"Drilling fluid design for unconventional reservoirs aims at preventing formation instability problems associated with fluid invasion, shale swelling, and cuttings dispersion. Although oil-based mud (OBM) can be used to achieve these goals, environmental and economic concerns limit its application. This experimental study evaluated the potential use of nanoparticles (NP) to improve water-based mud (WBM) inhibition capabilities and its ability to enhance the overall drilling fluid thermal stability while providing a cleaner technology to the industry.

Characterization of Woodford shale was completed with X-ray diffraction, cation exchange capacity, and scanning electron microscopy, silica, and graphene NP were characterized with aqueous stability …

Conical Folds -- An Artifact Of Using Simple Geometric Shapes To Describe A Complex Geologic Structure, Avery Joseph Welker

Masters Theses

"Accurate representation of the 3D shapes of natural folds is essential to characterization of the dynamic models for fold formation. Geometrical analysis of folds commonly relies upon analyzing patterns defined by the variation in the orientation of poles to planar surfaces deformed by a shortening event when plotted using graphical calculators (e.g., stereogram, polar tangent diagrams) to interpret the shape of folds. Stereograms for which orientation data define small circles are classified as non-cylindrical regular folds and are interpreted as "conical folds," where the shape of the fold is represented by a cone that terminates at a point. Utilizing similar …

Carbon Black Production, Analyzing And Characterization, Shadha Khalid Jebur

Masters Theses

"Carbon black (CB) plays a significant function in the development of the electrical and mechanical properties of high performance for a tough elastic polymeric substance such as rubber materials. Thus, CB is widely used to manufacture a massive number of products such as reinforcing and pigment phase in automobile tires due to its high ability to increase tire life by reducing the thermal damage. This material is also used in belts, hoses, and other non-tire rubber goods. Before use in valuable materials. CB should first be analyzed and characterized by different instruments to obtain its mechanical properties. A new thermal …

Bifunctional Porous Polymeric Fiber As A Catalyst For N-Phenylglycine Synthesis And Carbonation Of Propylene Oxide To Propylene Carbonate, Ahmed Abdulghani Almuslem

Masters Theses

"In this study, development of a polymeric bi-functional porous catalyst that can be used in various applications such as batch, packed-bed, and continuous flow reactors and the formation of highly important chemicals that have many applications in the industry. With this material many homogenous reactions can be conducted in heterogeneous environment which is more efficient and profitable. The catalyst was formed by grafting hollow fiber with APS then immobilized with Br using 1,2-dibromoprobane (Br/APS/PAI-HFs). The formed catalyst was tested with BET and FTIR to confirm the immobilization of Br. A porous polymeric material Br/APS/PAI-HFs provides the ability for ring opining …

Ceria Nanostructured Catalysts For Conversion Of Methanol And Carbon Dioxide To Dimethyl Carbonate, Jawad Hassan A Al Drwish

Masters Theses

"In this study, three different shapes of ceria (CeO₂) nanostructures (e.g., nanooctahedra, nanocubes and nanorods) were synthesized via the hydrothermal method and screened for carbonylation reaction. Of these three shapes of nanostructures, the nanorod was doped with metals such as Ca, Ni, Cu, and Co by wet impregnation method. All materials were characterized by XRD, NH₃/CO₂-TPD, XRF, FTIR and N₂ physorption to determine the crystal size and phases, acid-base properties, metal loading, and surface properties. The obtained materials were employed as catalysts for the activation of Carbon Dioxide (CO₂) and methanol …

Fluid Flow In A Krogh Cylinder: A Model For A Single Capillary And Surrounding Tissue, Xianjie Qiu

Masters Theses

"A model describing the flow of plasma from the capillaries to the interstitial space in the extravascular tissue and back into the capillaries is constructed and solved. The flow through the tissue or the interstitial spaces is described by the Brinkman equation for porous medium, modified to account for the presence of cells considered as spheres. The flow of blood through the capillaries is considered to be that of a Newtonian fluid. The flow between capillary and tissue is coupled by the permeability of the capillary wall. The nature of flow and its magnitude was found to be highly dependent …

Surface Engineering And Monomer Design For Light-Mediated Ring Opening Metathesis Polymerization, Ishan A. Fursule

Theses and Dissertations--Chemical and Materials Engineering

Stimuli-responsive materials are changing the landscape of actuated materials, optoelectronics, molecular machines, solar cells, temporary memory storage, and biomedical materials. Specifically, photo-responsive polymers have gained acceleration in research and application since the last two decades in the form of a surface coating and micro-patterns. Light as a stimulus can be coherent, mono or polychromatic, tunable for power (intensity) and energy (wavelength), and has precise spatiotemporal control. Conventional surface coating techniques such as spin coating are unable to impart properties to the coatings in terms of sturdiness, homogeneity, uniformity over the complex surface, post deposition modification, and process efficiency. Also, in …

Understanding Carbohydrate Recognition Mechanisms In Non-Catalytic Proteins Through Molecular Simulations, Abhishek A. Kognole

Theses and Dissertations--Chemical and Materials Engineering

Non-catalytic protein-carbohydrate interactions are an essential element of various biological events. This dissertation presents the work on understanding carbohydrate recognition mechanisms and their physical significance in two groups of non-catalytic proteins, also called lectins, which play key roles in major applications such as cellulosic biofuel production and drug delivery pathways. A computational approach using molecular modeling, molecular dynamic simulations and free energy calculations was used to study molecular-level protein-carbohydrate and protein-protein interactions. Various microorganisms like bacteria and fungi secret multi-modular enzymes to deconstruct cellulosic biomass into fermentable sugars. The carbohydrate binding modules (CBM) are non-catalytic domains of such enzymes that …

Application Of Process Systems Engineering Tools And Methods To Fermentation-Based Biorefineries, Kwabena Darkwah

Theses and Dissertations--Chemical and Materials Engineering

Biofuels produced from lignocellulosic biomass via the fermentation platform are sustainable energy alternatives to fossil fuels. Process Systems Engineering (PSE) uses computer-based tools and methods to design, simulate and optimize processes. Application of PSE tools to the design of economic biorefinery processes requires the development of simulation approaches that can be integrated with existing, mature PSE tools used to optimize traditional refineries, such as Aspen Plus. Current unit operation models lack the ability to describe unsteady state fermentation processes, link unsteady state fermentation with in situ separations, and optimize these processes for competing factors (e.g., yield and productivity). This work …

Design And Analysis Of Curcumin Conjugated Poly(Beta-Amino Ester) Networks For Controlled Release In Oxidative Stress Environments, Carolyn T. Jordan

Theses and Dissertations--Chemical and Materials Engineering

Oxidative stress, the imbalance of free radical generation with antioxidant defenses, leads to cellular inflammation, apoptosis and cell death. This compromised environment results in debilitating diseases, such as oral mucositis (OM), atherosclerosis, and ischemia/reperfusion injury. Antioxidant therapeutics has been a proposed strategy to ameliorate these imbalances and maintain homeostatic environments. However, the success of these approaches, specifically curcumin, has been limited due to characteristics such as hydrophobicity and high reactivity when released as bolus doses to contest to oxidative stress induced diseases. The development of a controlled release system to aid in protection of the antioxidant capacity of curcumin, as …

The Development Of Microfluidic Devices For The Production Of Safe And Effective Non-Viral Gene Delivery Vectors, Jason Matthew Absher

Theses and Dissertations--Chemical and Materials Engineering

Including inherited genetic diseases, like lipoprotein lipase deficiency, and acquired diseases, such as cancer and HIV, gene therapy has the potential to treat or cure afflicted people by driving an affected cell to produce a therapeutic protein. Using primarily viral vectors, gene therapies are involved in a number of ongoing clinical trials and have already been approved by multiple international regulatory drug administrations for several diseases. However, viral vectors suffer from serious disadvantages including poor transduction of many cell types, immunogenicity, direct tissue toxicity and lack of targetability. Non-viral polymeric gene delivery vectors (polyplexes) provide an alternative solution but are …

Mixed Matrix Flat Sheet And Hollow Fiber Membranes For Gas Separation Applications, Nicholas W. Linck

Theses and Dissertations--Chemical and Materials Engineering

Mixed matrix membranes (MMM) offer one potential path toward exceeding the Robeson upper bound of selectivity versus permeability for gas separation performance while maintaining the benefits of solution processing. Many inorganic materials, such as zeolites, metal-organic frameworks, or carbon nanotubes, can function as molecular sieves, but as stand-alone membranes are brittle and difficult to manufacture. Incorporating them into a more robust polymeric membrane matrix has the potential to mitigate this issue.

In this work, phase inversion polymer solution processing for the fabrication and testing of asymmetric flat sheet mixed matrix membranes was employed with CVD-derived multiwall carbon nanotubes (MWCNTs) dispersed …

Synthesis Of Biologically-Inspired Nanofiltration Membranes Using Protected, Mutated, And Simulated Aquaporins, Priyesh Ashokrao Wagh

Theses and Dissertations--Chemical and Materials Engineering

Gram-negative bacterial cells are surrounded by a cell membrane which protects the cell and controls the transport of nutrients and waste products in and out of the cells at a fast rate. This rapid transport of nutrients and wastes through the cell membrane is made possible by channel proteins called porins. Various types of porins present in the cell membrane have specific functions depending on their selectivity towards different nutrients, and channel proteins selective towards water are called aquaporins. These proteins restrict the passage of all entities except water molecules and they provide a fast transport rate of water molecules …

Surface Functionalization Via Photoinitiated Radical Polymerization For Rare Cell Isolation And Mechanical Protection, Calvin Frank Cahall

Theses and Dissertations--Chemical and Materials Engineering

Surface functionalization of living cells for cell therapeutics has gained substantial momentum in the last two decades. From encapsulating islets of Langerhans, to cell laden gels for tissue scaffolds, to individual cell encapsulation in thin hydrogels, to surface adhesives and inert surface camouflage, modification of living cell surfaces has a wide array of important applications. Here we use hydrogel encapsulation of individual cells as a mode of protection from mechanical forces for high throughput cell printing, and chemical stimuli for the isolation of rare cells in blood.

In the first study, we review methods of surface functionalization and establish a …

The Role Of Microenvironment Reagent Solubility On Reaction Kinetics Of 4-Nitrophenol Reduction, Michael P. Zeevi, Andrew Harrison, Christina Tang

UROP Posters

The Role of Microenvironment Reagent Solubility on Reaction Kinetics of 4-Nitrophenol Reduction

Michael Zeevi¹ with Andrew Harrison¹ and Christina Tang, PhD¹

¹Department of Chemical and Life Science Engineering, VCU School of Engineering

Introduction: Nanoparticles are of increasing interest due to their high surface area to volume ratio, as well as that they enable fine-tuning of the reaction microenvironment. Through flash nanoprecipitation, core-shell polymer nanoreactors were formed by directed self-assembly. Using the reduction of 4-nitrophenol as a model reduction reaction, we investigated the effect of reagent solubility in the nanoreactor microenvironment’s on nanoreactor kinetics.

Methods: The standard …

Effects Of Predation On The Biochemical Constituents Of The Bleached Soft Coral Sinularia Polydactyla, Carley Elizabeth Cole

Honors Theses

Climate change can indirectly affect the level of predation on soft corals. As sea temperatures rise, more and more bleaching events are occurring, which can affect the production of chemical defenses and the concentrations of the biochemical constituents that make up the soft corals. These changes may make the soft corals more attractive to predators. This phenomenon is suggested by the environmental stress theory (EST), which states that under stressful conditions, more of an organism's energy is allocated to survival rather than to other factors, such as reproduction or predator deterrence. To test the effect of predation on already bleached …

Technique For The Synthesis Of Difluorinated Organic Molecules Using Magnesium Bases, Cassidy S. Baldwin

Honors Theses

The presence of fluorine in organic molecules can confer biological advantages which are often exploited in drug development. For example, fluorine has been shown to limit drug metabolism and enhance drug distribution. However, the development of fluorinated pharmaceutics poses synthetic challenges. These challenges are especially pronounced when developing molecules with a difluoromethyl group. One difluoromethyl functional group of particular interest is the α,α-difluoro-β-amino carbonyl group, which has been seen in potential drug leads. The previous methods of accessing this group are inefficient and complex. The goal of this project was to develop a new technique to access this group by …

Inhibition Of Blood Coagulation Factor Xii: Evaluation Of Flavonoids As A Drug Candidate, Betsy Crosswhite

Honors Theses

This study investigated natural product inhibitors of blood coagulation Factor XII (FXII). FXII initiates the Kallikrein Kinin-System (KKS) within the intrinsic coagulation pathway. Increased expression of this system leads to proinflammatory and procoagulant activities. Inflammation occurs through downstream activation in the KKS. Following the activation of FXII-dependent pathway, bradykinin (BK) binds to the BK receptor 2 (B2) and produces inflammatory signaling. Abnormally increased BK can result in life threatening Hereditary Angioedema (HAE), characterized by severe reoccurring swelling. FXII is critical for pathogenic thrombosis, but is dispensable for hemostasis. This unique property of FXII makes it an attractive drug target. We …

Perceptions Regarding Concussions In Collegiate Football At The University Of Mississippi, Madison Frerker

Honors Theses

Concussions are a form of mild traumatic brain injury (mTBI) that can occur from any force to the head or body that causes the brain to move within the skull. Concussions are common in the sport of football due to the highly physical nature of the sport, and injured athletes can experience a wide array of symptoms. Like other players participating with powerhouse football programs, those at the University of Mississippi are at risk of concussion throughout their collegiate career. Whether players and fans perceive the risks of concussion equally has not been previously studied. Considering the passionate history of …

Development Of A Scn1a Null Zebrafish Model For Screening Potential Anti-Epileptic Natural Products, Patricia Ann Lipson

Honors Theses

Epilepsy affects around 50 million people in the world. Thus, it is imperative that new more effective and safe treatments be found. This study was designed to use zebrafish to screen potential anti-epileptic natural products. We utilized two scn1Lab null zebrafish models (morpholino-injected fish where scn1Lab was transiently knocked down and a transgenic scn1Lab -/- fish line). Alternatively, we used AB wildtype fish to test compounds in a chemically-induced seizure model. Natural compounds including cannabidiol, CBD, and Tapinanthus globiferous, TG, extracts were screened for their anti-seizure activity. When scn1Lab -/- fish were treated with CBD (0.075 and 0.3 mg/L) from …