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Articles 91 - 120 of 194
Full-Text Articles in Biomedical Engineering and Bioengineering
Three-Dimensional Multimedium Computational Model For Drug Delivery Using Finite Element Analysis, Eduardo Martinez
Three-Dimensional Multimedium Computational Model For Drug Delivery Using Finite Element Analysis, Eduardo Martinez
Bioengineering Theses - Archive
Approximately 2.8% of trauma patients present peripheral nerve injury, which can result in loss of motor function. Current strategies for peripheral nerve repair had focused on the development of synthetic nerve conduits that provide physical guidance. One advantage of the synthetic nerve conduits is that the conduit can be utilize as a delivery system and gain the ability to deliver neurotrophic factors, which have an effect on controlling the survival, migration, proliferation, and differentiation of different neural cell types. Currently there is no method to quantify the concentration of growth factors in the nerve conduit during the implantation time. In …
Magnetic Resonance Spectroscopy Study Of Metabolic Profiles In Brain Tumors, Aditya Manoj Patel
Magnetic Resonance Spectroscopy Study Of Metabolic Profiles In Brain Tumors, Aditya Manoj Patel
Bioengineering Theses - Archive
Metabolic profiles in brain tumors were measured using proton (1H) magnetic resonance spectroscopy (MRS) at 3T. Spectra were obtained from normal tissues and tumor mass regions of 6 low-grade gliomas, 7 anaplastic astrocytomas and 23 glioblastoma (GBM) patients, using PRESS at two echo times (TE = 54 and 112 ms). Glutamate (Glu), glutamine (Gln) and lactate (Lac) were well resolved at TE = 112 ms. The ratio of Gln and Glu concentrations, [Gln]/[Glu], was elevated significantly (p < 0.05) in all the tumor types compared to normal tissue. Elevation of Gln was confirmed through [Gln]/[water]; the ratio was increased in all the three tumor types but the increase was significant only in GBM. Glycine (Gly) was increased significantly in GBM. Alanine was detectable from GBM only, indicating its elevation for most malignant tumor. Other observations included significant increases in choline (Cho) and Lac (p < 0.05) and decrease in NAA (N-acetylaspartate), in consistent with prior studies. The creatine to water ratio was observed to decrease in tumor patients but was not significant. Myo-inositol (mIns) was observed to decrease in low grade patients as compared to normal tissue, but was seen to increase with grade of tumor, but was not significant. [Lac]/[water] was significantly higher and [Cho]/[Lac] significantly lower for GBM patients indicating the increase in Lac as compared to normal tissue.Treatment had a significant impact on tumor cells. After radiation therapy the Lac was observed to be elevated significantly and decrease after bevacizumab treatment. [Cho]/[Cr], [Cho]/[NAA], [Gln]/[Glu] and [Cho]/[Gly] was reduced significantly after the bevacizumab treatment. Gly was not detectable after Bevacizumab treatment. Some of the patients showed no infiltrating tumor cells after successful surgery and therapy with ratios close to that of normal tissue. These observations can help in characterizing the effect of various therapies on brain metabolites and tumor cells.
Post-Operative Renal Function Analysis Using Visible Dlp® Hyperspectral Imaging System, Abhas Thapa
Post-Operative Renal Function Analysis Using Visible Dlp® Hyperspectral Imaging System, Abhas Thapa
Bioengineering Theses - Archive
Surgical and clinical settings in medical hospitals strive to keep up with technological innovations in order to improve the current healthcare scenario. Hyperspectral imaging (HSI) is a novel technology that addresses this problem. HSI is a non-invasive imaging technique that can provide information on both structural and functional conditions of tissue. This information is very useful particularly in live surgical procedures wherein the surgeons can get real-time feedback of the anatomical and functional changes of tissue, as they perform the operation. Currently available HSI systems are extremely slow and thus impractical for time restricted surgical or clinical uses. Hence, DLP® …
Wide Field Of View Imaging Of Premotor And Sensorimotor Cortex Activation Patterns By Functional Near Infrared Spectroscopy, Pankaj Chand
Wide Field Of View Imaging Of Premotor And Sensorimotor Cortex Activation Patterns By Functional Near Infrared Spectroscopy, Pankaj Chand
Bioengineering Theses - Archive
Functional near infrared spectroscopy (fNIRS) is a non-invasive optical technique which can measure concentration changes of oxygenated (HbO), deoxygenated (HbR), and total hemoglobin (HbT) in brain tissue that are induced by neuronal activation. A major hindrance at present for brain optical imaging research is the limited field of view (FOV) size, which is restricted due to the limited number of source-detector pairs that current fNIRS hardware technology and cost considerations allow. As a result it is challenging to simultaneously capture hemodynamic changes in the premotor, motor and sensory cortex as some of these activations can occur outside the available FOV. …
Investigation Of End-Tidal Carbon Dioxide (Etco₂) And Heart Rate Variations During Sleep Apnea, Aditya Bashaboyina
Investigation Of End-Tidal Carbon Dioxide (Etco₂) And Heart Rate Variations During Sleep Apnea, Aditya Bashaboyina
Bioengineering Theses - Archive
Sleep Apnea is a sleep disorder where limitation or cessation of breathing occurs. It is characterized by abnormalities in the respiratory pattern and quantity of ventilation during sleep. According to a study 4% of men and 2% of women have sleep apnea, which is a sizable sector of the adult population. To analyze end-tidal CO₂ and heart hate variations due to apnea, 8 hr polysomnography (Sleep Consultant. Inc, Fort Worth, Texas) was performed on limited sleep apnea subjects and breath hold maneuvers were performed in awake subjects. In the simulated apnea study, 16 volunteer subjects (age: 29 ± 5 yrs, …
Quantitative Variation Of Blood Pressure Dynamics During Sleep Apnea, Raichel Mary Alex
Quantitative Variation Of Blood Pressure Dynamics During Sleep Apnea, Raichel Mary Alex
Bioengineering Theses - Archive
Sleep Apnea is one of the major sleep disorders characterized by complete cessation or decline in breathing for about 10s or more during sleep, thereby adversely affecting the quality of sleep. Studies show that about 6 % of the US adult population suffers from obstructive sleep apnea, which in turn plays a major role in the development of hypertension, heart failure, stroke and is also responsible for reduced performance in everyday activities due to lack of quality sleep. In this study the physiological response to sleep apnea were determined using beat to beat blood pressure in both healthy subjects and …
Innovations In ¹H Mr Tissue Oximetry: New Probes And Pulses, Ujjawal Rastogi
Innovations In ¹H Mr Tissue Oximetry: New Probes And Pulses, Ujjawal Rastogi
Bioengineering Theses - Archive
Low oxygenation level (hypoxia) of tissue leads to cellular dysfunction, damage and poor response to therapy. Quantitative measurement of tissue oxygenation is critical not only for the study of tissue physiology, but could also help improve efficacy of therapeutic procedures. Our group has previously developed and implemented a novel approach to quantify oxygen tension in tissue using ¹H MRI, known as “PISTOL” (Proton Imaging of Siloxanes to map Tissue Oxygenation Levels). It exploits a linear relationship between the longitudinal relaxation rate (R1) and oxygen tension (pO₂) of a reporter molecule (probe). Due to close proximity of fat (~ 1 ppm) …
A Study Of The Physiological Effects Of Sleep Apnea On Cerebral Blood Flow Velocity, Gauri Bhave
A Study Of The Physiological Effects Of Sleep Apnea On Cerebral Blood Flow Velocity, Gauri Bhave
Bioengineering Theses - Archive
It is estimated that sleep apnea is prevalent in the US in about 18 million people. The prevalence rate is approximately 6% in the US. Sleep apnea reduces the quality of life of patients. Sleep apnea is characterized by repetitive pauses in breathing during sleep. Recent studies also show loss of gray matter in people diagnosed with sleep apnea. To study the physiological effects of sleep apnea on cerebral blood flow velocity (CBFV), CBFV was measured in subjects simulating apnea. Sixteen volunteers (29 ± 5 yr and BMI 24.1±4.8, 9M and 7F) were recruited as control subjects. We measured CBFV …
An Investigation Of Peripheral Blood Volume And Oxygen Saturation Change In Obstructive Sleep Apnea, Swathi Iyer
An Investigation Of Peripheral Blood Volume And Oxygen Saturation Change In Obstructive Sleep Apnea, Swathi Iyer
Bioengineering Theses - Archive
Obstructive sleep apnea (OSA) is a type of sleep disordered breathing in which the airway collapse partially or fully and causes arousal to resume breathing. In a 2009 National sleep foundation poll of 1000 people, 63% of men and 50% of the females showed signs of sleep apnea. It also showed that subjects with sleep apnea have high risk of high blood pressure, stroke and mental disorders such as depression especially in female. Also by another group of researcher it has been shown that the prevalence of OSA is 4% in male and 2% in female. It has been also …
In Vivo Tracking Of Mesenchymal Stem Cell Recruitment To Tissue Scaffolds, Manwu Sun
In Vivo Tracking Of Mesenchymal Stem Cell Recruitment To Tissue Scaffolds, Manwu Sun
Bioengineering Theses - Archive
The term "Stem cells" has been extensively used to describe precursor undifferentiated cells that have the capacity to self-renew and can also give rise to multiple tissue types. Many studies have been shown improved functional outcome after treated with stem cell therapy. However, almost all of these investigations were analyzed based on histological evaluations which are time-consuming, expensive and fail to provide 3 dimensional and real-time information about stem cell responses. Therefore, there is a need for the development of new method to investigate the migration of stem cells in vivo. Recent evidence supports that fluorescence imaging system offer both …
Attenuation Based Quantification Of Interstitial Lung Disease Using High Resolution Computed Tomography And Correlation With Pulmonary Function Tests, Snehal S. Watharkar
Attenuation Based Quantification Of Interstitial Lung Disease Using High Resolution Computed Tomography And Correlation With Pulmonary Function Tests, Snehal S. Watharkar
Bioengineering Theses - Archive
Interstitial lung disease (ILD) is a chronic and progressive pulmonary disease of the lung parenchyma resulting in fibrotic scar formation of the pulmonary alveoli. The pathologic changes in the lung result in restrictive impairment of lung function. High resolution computed tomography (HRCT) of the chest has become an essential technique in diagnosing and assessing the extent of ILD. Clinical evaluation by HRCT is usually qualitative, leading to inter-observer variability particularly in detecting early disease. We propose a quantitative attenuation-based analysis to standardize the assessment of regional lung disease. We hypothesize that early ILD is associated with greater regional heterogeneity than …
Development Of Magnetic-Based Core-Shell Nanoparticles For Drug Delivery Applications In Melanoma Skin Cancer, Zarna A. Bhavsar
Development Of Magnetic-Based Core-Shell Nanoparticles For Drug Delivery Applications In Melanoma Skin Cancer, Zarna A. Bhavsar
Bioengineering Theses - Archive
Melanoma skin cancer is the most dangerous form of skin cancer and the major cause of deaths related to skin cancer worldwide. Conventional chemotherapeutic treatment is not very effective and faces many problems such as low response rate, development of multidrug resistance, and severe side effects. In order to address these limitations and improve melanoma treatment efficacy, development of a multifunctional nanoparticulate drug delivery system is desired. Thus, we aimed towards the development of magnetic-based core-shell nanoparticles (MBCS NPs) for dual drug release and dual targeting of melanoma tumors. The synthesized nanoparticles were composed of Poly (Lactic-co-glycolic acid) (PLGA) particle …
A Novel Injectable Porous Hydrogel Composite Scaffold For Bone Tissue Engineering, Parvathi Nair
A Novel Injectable Porous Hydrogel Composite Scaffold For Bone Tissue Engineering, Parvathi Nair
Bioengineering Theses - Archive
Over the past decade there has been an increasing use of bone grafts for orthopedic applications. With the aging US population, the need for suitable bone grafts substitutes has also increased. The aim of this study was to develop a novel in situ crosslinkable hydrogel composite for tissue-engineering critical-sized bone defects. This system consists of a newly developed water-soluble biodegradable hydrogel Poly ((ethylene glycol) maleate citrate) (PEGMC) and hydroxyapatite (HA). The PEGMC/HA system is completely injectable and can be crosslinked in situ into crosslinked PEGMC/HA (CPEGMC/HA) hydrogel composite with or without poly (ethylene glycol) diacrylate (PEGDA) as a crosslinker. The …
Microfluidic Systems For Studying Cell Motility, Srikanth Vasudevan
Microfluidic Systems For Studying Cell Motility, Srikanth Vasudevan
Bioengineering Theses - Archive
It is very imperative to develop new in vitro platforms that can help in studying the complex interactions that occur between cell-Extracellular Matrix proteins and also during the process of cell migration in vivo. Such tools would facilitate in better understanding of the mechanisms that are employed by the cells during growth and migration. There are two devices that are presented in this study; 1) Multi-biomolecule coated lane device for unbiased cell preferential migration and 2) Novel Microchannel device for real time monitoring of tumor cell migration.The Multi-biomolecule coated lane device is a basic in vitro platform that helps in …
Incorporation Of Vascular Endothelial Growth Factor And Pleiotrophin Into A Multiluminal Biosynthetic Nerve Implant For The Repair Of Peripheral Nerve Long Gap Defects, An Hai Nguyen
Bioengineering Theses - Archive
To repair a fully transected nerve without putting undue tension on the nerve stumps, and too circumvent many of the obvious problems of using harvested nerve grafts synthetic nerve guides have been used in the clinical setting. Thus far this strategy has met with minimal success for the repair of short defects (i.e. 1 - 2.5 cm) while any defect larger than 3 cm have failed. We hypothesize that neurotorphic support, early vascularization, and contact guidance are needed to successfully regenerate a nerve across a long-gap defect. To this end we proposed a biosynthetic nerve implant (BNI) with a multiluminal …
Magnetically Anchored "Reduced Trocar" Laparoscopy: Evolution Of Surgical Robotics, Richard Bergs
Magnetically Anchored "Reduced Trocar" Laparoscopy: Evolution Of Surgical Robotics, Richard Bergs
Bioengineering Theses - Archive
Laparoscopic surgery has become increasingly popular over the last few years due to its benefits; lower morbidity, less perceived pain, better cosmesis results, and less hospital time. For the surgeon however, there are fundamental issues that can make a laparoscopic procedure more difficult than simple open surgery; loss of tactile feel, limited working envelope, high demand for hand-eye coordination, and one trocar-port required for each tool. A revolutionary concept of using magnetics to support tooling across the abdominal wall was conceived by Dr. Jeffrey Cadeddu and his colleagues at the University of Texas Southwestern Medical Center. Collectively referred to as …
Functional Near Infrared Spectroscopy For The Assessment Of Motor Cortex Plasticity In Pediatric Subjects Affected By Cerebral Palsy, Bilal Khan
Bioengineering Theses - Archive
Functional near infrared spectroscopy (fNIRS) is widely used to monitor hemodynamic changes occurring in the cerebral cortex as a result of neuronal activation. One of the current challenges in this field is that activation-related hemodynamic signals are often eclipsed by global hemodynamic fluctuations due to cardiac pulsation, respiration and Mayer waves. In this study, we demonstrate by using a combination of principal component analysis (PCA) and adaptive filtering that the global hemodynamic modulation signals can be effectively removed from the fNIRS measuring cortical hemodynamic response. While pediatric subjects were performing a finger tapping task, we concurrently recorded cardiac pulsation and …
Spatiotemporal Measurement Of Freezing-Induced Deformation Of Engineered Tissues, Ka Yaw Teo
Spatiotemporal Measurement Of Freezing-Induced Deformation Of Engineered Tissues, Ka Yaw Teo
Bioengineering Theses - Archive
In order to cryopreserve functional engineered tissues (ETs), the microstructure of extracellular matrix (ECM) as well as the cellular viability should be maintained given that the functionality of ETs is closely related to the ECM microstructure. Since the post-thaw ECM microstructure is determined by the deformation of ETs during cryopreservation, the freezing-induced deformation of ETs was measured in the present study with a newly developed quantum dot (QD)-mediated cell image deformetry technique using dermal equivalents as a model system. The dermal equivalents were constructed by seeding QD-labeled fibroblasts in type I collagen matrices. After 24 hour incubation, the ETs were …
Development Of Microscope Stage Incubator For Long-Term Monitoring Of Neuronal Cell Culture During Axotomy, Kailash Karthikeyan
Development Of Microscope Stage Incubator For Long-Term Monitoring Of Neuronal Cell Culture During Axotomy, Kailash Karthikeyan
Bioengineering Theses - Archive
It is imperative to understand the patterns in regeneration of the central and peripheral nervous system after injury. This understanding would provide a fundamental cue towards molecules and other factors involved in regeneration, and how they affect the regeneration pattern after injury. In most culturing techniques currently used for neuronal culturing and observing the neuronal regeneration, it is difficult to determine the regeneration pattern (individual axonal level) though the overall regeneration is observed due to the complexity of neuronal network. Thus a model that provides isolation of individual axons and allowing us to monitor continuously upon injury has been developed. …
Controlled Vascular Cellular Growth By Microstructured Patterned Surfaces On Implantable Biodegradable Polymer Scaffold., Nitin Garg
Bioengineering Theses - Archive
The technological advances in the field of MEMS and biodegradable polymers with elastomeric properties have opened new areas of application for engineering of soft tissues such as blood vessel, heart valves, cartilage, tendon, and bladder, which exhibit elastic properties. In this thesis work, Microfabrication technology has successfully been applied to biodegradable polymer films to encourage cell growth in designated area. This work is presented with the final goal of fabricating implantable polymer scaffolds to produce small diameter blood vessels in a controlled manner spatially by using the concept of wettability and contact guidance.There are several methods to control cell growth …
Molecular Modelling Of Dna Translocation In Bio-Functionalized Nanopores With Applications In Gene Sequencing, Abhijit Ramachandran
Molecular Modelling Of Dna Translocation In Bio-Functionalized Nanopores With Applications In Gene Sequencing, Abhijit Ramachandran
Bioengineering Theses - Archive
The human genome project which was completed in 2003 took more than 12 years to complete at a cost of $2.7 billion. The advancement in technologies in the next five years led to the same feat being achieved in 5 months with a total cost of $1.5 million. Micro-fabrication technology has now made it possible miniaturize to micro- and nanofluidic devices for biochemical analysis. Solid-state nanopore based molecular analysis provides the potential to characterize and sequence DNA, based on the signature of the ionic current measured. A major challenge in using solid-state nanopores for DNA detection and sequencing is the …
Dlp Hyperspectral Imaging For Surgical And Clinical Utility, Robert Paul Francis
Dlp Hyperspectral Imaging For Surgical And Clinical Utility, Robert Paul Francis
Bioengineering Theses - Archive
Surgeons want technology to help them see differences in tissue chemistry. If they know how oxygenated tissues and organs are during medical procedures, they are more able to eliminate dangerous tissues and maintain viable organs. Hyperspectral imaging non-invasively measures the optical absorbance spectrum of each pixel in a spatial field of view and, with chemometric image processing, can visualize the spatial distribution of tissue oxygenation. Current hyperspectral imaging systems are too slow to monitor real-time physiological changes in live tissue. Therefore, a novel DLP Hyperspectral Imaging (DLP HSI) system is developed for real-time, non-invasive, in-vivo imaging of tissue chemistry in …
A Novel Device For The Establishment Of An Animal Model Mimicking Spinal Deformity Surgery For Neurological Deficit Risk Mitigation, Bradley Elmer
A Novel Device For The Establishment Of An Animal Model Mimicking Spinal Deformity Surgery For Neurological Deficit Risk Mitigation, Bradley Elmer
Bioengineering Theses - Archive
Correction forces during spine deformity surgery impart significant multidirectional stress forces to the spinal cord, which in some cases result in severe damage to the spinal cord and permanent paralysis, the most feared complication. Animal models are critical for the development of neuroprotective strategies. However, those currently available are limited to contusion, transection, or unidirectional distraction injuries, which fail to replicate the multidirectional forces that occur during spine corrective surgery. In order to develop an improved model of distraction spinal cord injury we designed a device based on intervertebral grip fixation and linear actuators, capable of inducing controllable bidirectional distraction …
In Situ Crosslinkable Polyesters For Tissue Engineering And Drug Delivery, Dipendra Raj Gyawali
In Situ Crosslinkable Polyesters For Tissue Engineering And Drug Delivery, Dipendra Raj Gyawali
Bioengineering Theses - Archive
In situ crosslinkable elastic materials are increasingly being explored for various biomedical applications such as drug delivery and tissue engineering due to their site specific nature. The creation of an in situ crosslinkable elastomer rich in pendant chemistry has been a challenge in the field of biomaterials. Herein, we have developed two new in situ biodegradable materials: poly(octamethylene maleate citrates) (POMC) and poly(poly(ethylene glycol) maleate citrate) (PPEGMC). These materials are all low molecular weight in their pre-polymeric form, which shows their potential to be used as an injectable biomaterial. The preservation of pendant carboxylic and hydroxyl groups in these polymeric …
Development Of An Optical Spectroscopic Method To Detect Neurohemodynamic Changes Induced By Pain In Rats, Sweta Narvenkar
Development Of An Optical Spectroscopic Method To Detect Neurohemodynamic Changes Induced By Pain In Rats, Sweta Narvenkar
Bioengineering Theses - Archive
In my optical spectroscopy study, multi-channel, thin optical probes with short source-detector separation have been implemented, calibrated, and used along with a multi-channel spectrometer as a quantitative technique to observe changes in vascular hemoglobin concentration and hemoglobin oxygen saturation as well as light scattering of tissues. Each of the four needle probes used in my study consists of two bifurcated fibers; one fiber is connected to a halogen light source and the other fiber to a CCD-array spectrometer having a spectral window from 450 nm to 900 nm. Each fiber is 100 micron in diameter. As we utilized the four …
Nanoscale Approaches For Biomolecule Separation And Detection, Swati Goyal
Nanoscale Approaches For Biomolecule Separation And Detection, Swati Goyal
Bioengineering Theses - Archive
Nanotechnology has the potential to contact and impact the biological interactions at the most basic chemical and physical levels. New approaches to nanodevices allow high sensitivity and specificity with low sample requirement. Such devices are potential candidates for early disease detection at molecular levels and have important implications in associated therapeutics.This research work focuses on two different areas: developing devices for DNA detection, protein enrichment and exploring material properties to fabricate microscale/nanoscale structures. In one approach, hairpin probe DNA was used to detect fmol of ss-DNA from k-ras oncogene. In another approach, nanochannel based device was developed to selectively increase …
A Study On The Effect Of Mechanical Stretch And Aligned Scaffold Architecture On Morphology Of Rat Ventricular Cells, Shruti Kanakia
A Study On The Effect Of Mechanical Stretch And Aligned Scaffold Architecture On Morphology Of Rat Ventricular Cells, Shruti Kanakia
Bioengineering Theses - Archive
Heart disease is one of the major causes of death in developing and industrialized countries. Myocardial infarction leads to remodeling of the left ventricle, which severely affects the pumping efficiency of the heart. In order to provide mechanical support to left ventricle the scaffold material should be elastic and mechanically strong. For the success of cardiac graft in vivo one of the important factor is ability of cardiac myocyte morphology to resemble that in vivo. The goal of this study is to build thick, prevascularized cardiac graft for myocardial infarction repair. Mechanical stress has been recognized as one of the …
An Evaluation Of The Biomechanical Properties Of The Superficial Musculoaponeurotic System, Matthew David Ruff
An Evaluation Of The Biomechanical Properties Of The Superficial Musculoaponeurotic System, Matthew David Ruff
Bioengineering Theses - Archive
The Superficial Musculoaponeurotic System (SMAS) is a well defined tissue layer of the face commonly utilized in facial surgery, including facelifts. There are several reasons for the utilization of this tissue, including aesthetic results and reliability. Basic to the outcomes for these procedures are the inherent biomechanical properties of the SMAS. Most important for the surgeon in this regard are tissue burst pressure, elasticity, stress-relaxation under load, and creep. This study experimentally determines the biomechanical properties for human cadaveric tissue specimens. As well as defining the cited biomechanical properties, the study examines how they change, as sampled from different regions …
Signal Processing Techniques For Artifact Removal In Electroencephalogram (Eeg), Jyoti Bhat
Signal Processing Techniques For Artifact Removal In Electroencephalogram (Eeg), Jyoti Bhat
Bioengineering Theses - Archive
The electroencephalographic recordings measure the electric impulses generated in the brain, in response to a given stimulus. The spontaneous EEG data is used for diagnosis and treatment of some brain diseases. For the data to be used for clinical applications, it needs to be free of the various artifacts like the eye blinks, movement, head movements and muscle activity. These artifacts need to be corrected or the affected parts need to be removed in the preprocessing of the EEG dataset. This pre-processing is normally done manually, which tends to be not only time-consuming but also subjective. With large number of …
Diffuse Optical Imaging Of Brain Function Under Repetitive Transcranial Magnetic Stimulation And In Children With Cerebral Palsy, Sameer C. Dhamne
Diffuse Optical Imaging Of Brain Function Under Repetitive Transcranial Magnetic Stimulation And In Children With Cerebral Palsy, Sameer C. Dhamne
Bioengineering Theses - Archive
Diffuse Optical Imaging (DOI) is a non-invasive neuroimaging technique which measures the changes in oxy- and deoxy-hemoglobin concentrations at a high temporal resolution based on the principle of Near-Infrared Spectroscopy.DOI was combined with repetitive Transcranial Magnetic Stimulation (rTMS) to assess the neuronal changes induced in the cortical regions, which are directly under rTMS and the connected areas, by applying 1Hz rTMS to the left hemisphere of the motor cortex followed by the stimulation to the prefrontal cortex for two visits. The DOI signals were simultaneously acquired from both ipsilateral and contralateral brain regions before, during, and after rTMS. We observed …