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Articles 91 - 120 of 131
Full-Text Articles in Biomedical Engineering and Bioengineering
Establishing The Method Of Dual-Tensor For Tract Based Analysis (Dtta) And Investigating Human Brain Developmental Connectome With Diffusion Mri, Virendra Radheshyam Mishra
Establishing The Method Of Dual-Tensor For Tract Based Analysis (Dtta) And Investigating Human Brain Developmental Connectome With Diffusion Mri, Virendra Radheshyam Mishra
Bioengineering Dissertations - Archive
Diffusion MRI (dMRI) has the unique ability of studying white matter fiber structure in the human brain in-vivo. The trajectory of the white matter fibers inside the brain can be mapped using the tractography techniques and their structural integrity can be assessed with the help of various metrics such as fractional anisotropy (FA) derived from diffusion tensor imaging (DTI). But with typical dMRI in clinical applications, almost half of human brain white matter (WM) voxels has crossing-fiber regions (CFR) where WM microstructural integrity is significantly underestimated with single tensor FA. A technique adapted to WM tract analysis and correcting the …
Ultrasound-Modulated Fluorescence Techniques, Yuan Liu
Ultrasound-Modulated Fluorescence Techniques, Yuan Liu
Bioengineering Dissertations - Archive
Ultrasound-modulated fluorescence (UMF) imaging has been proposed as a novel imaging modality by combining ultrasound and optical imaging techniques for early cancer detection. In UMF, a focused ultrasound beam is used to modulate the diffused fluorescence photons in the acoustic focal region, and by specifically analyzing the modulated photons, one can isolate and quantify the fluorescence properties within the ultrasonic focal area. Therefore, UMF is able to provide fluorescence contrast while maintaining ultrasound resolution in tissue. The major challenge of UMF is to extract the weakly modulated fluorescence signal from a bright and unmodulated background, i.e. the low modulation efficiency. …
Evaluation And Use Of Regenerative Multi Electrode Interfaces In Peripheral Nerves, Vidhi Desai
Evaluation And Use Of Regenerative Multi Electrode Interfaces In Peripheral Nerves, Vidhi Desai
Bioengineering Dissertations - Archive
Peripheral nerves offer unique accessibility to the innate motor and sensory pathways that can be interfaced with high degree of selectivity for intuitive and bidirectional control of advanced upper extremity prosthetic limbs. Several peripheral nerve interfaces have been proposed and investigated over the last few decades with significant progress made in the area of sensory feedback. However, clinical translation still remains a formidable challenge due to the lack of long term recordings. Prominent causes include signal degradation, eventual interface failures, and lack of specificity in the low amplitude nerve signals. This dissertation evaluates the capabilities of the newly developed Regenerative …
Development Of Trans-Rectal Ultrasound (Trus) Coupled Diffuse Optical Tomography (Dot) For Prostate Cancer Imaging, Venkaiah Chowdary Kavuri
Development Of Trans-Rectal Ultrasound (Trus) Coupled Diffuse Optical Tomography (Dot) For Prostate Cancer Imaging, Venkaiah Chowdary Kavuri
Bioengineering Dissertations - Archive
Prostate cancer is one of the leading causes among cancer deaths in men in the United States. A minimally invasive real time searching tool for cancer need to be developed, which can enhance the odds of cancer detection; Current diagnostic techniques such as Trans-rectal ultrasound (TRUS) suffers from low sensitivity and specificity. The goal of the dissertation is to develop a Trans-Rectal Ultrasound (TRUS) coupled Diffuse Optical Tomography (DOT) probe that can detect and image prostate cancer. To accomplish the task, an optical clip-on probe has been designed that can incorporate the existing ultrasound probe and can pass through the …
Biliary Tract Differentiation Through Use Of Visible To Nir Hyperspectral Reflectance Imaging, Eleanor F. Wehner
Biliary Tract Differentiation Through Use Of Visible To Nir Hyperspectral Reflectance Imaging, Eleanor F. Wehner
Bioengineering Dissertations - Archive
Cholecystectomies are one of the most common surgeries performed in the United States, and most of the complications which arise from these are injuries to the common bile duct (CBD) resulting from a misidentification of anatomy. Reflectance hyperspectral imaging (HSI) offers a low-cost, non-invasive tool to record superficial chemical spectra of a field of view in many surgical applications. A NIR DLP HSI system is assembled and characterized, and used to gather preliminary CBD reflectance HSI data cubes. NIR hyperspectral imaging (760 nm to 1600 nm) with the DLP HSI system proves ineffectual, so CBD reflectance hyperspectral data collection progresses …
Mri Assessment Of Brain Vascular Reactivity To Physiological Challenges, Binu Panjikattil Thomas
Mri Assessment Of Brain Vascular Reactivity To Physiological Challenges, Binu Panjikattil Thomas
Bioengineering Dissertations - Archive
With a growing need for specific biomarkers in vascular diseases, the past decade has seen a surging interest in mapping brain vascular reactivity. There is great potential that this CVR mapping can be added to standard clinical MRI protocol, but before this is achieved, we need to better understand the mechanism of BOLD signal change to physiological challenges. A signal increase in the BOLD image is usually seen to CO₂ inhalation, but there are reports of negative CVR as well, i.e. decrease in BOLD signal during inhalation of CO₂ gas. Negative CVR is usually seen in patients with vascular occlusions, …
Long Gap Peripheral Nerve Reconstruction Using Decellularized Nerve Grafts, Srikanth Vasudevan
Long Gap Peripheral Nerve Reconstruction Using Decellularized Nerve Grafts, Srikanth Vasudevan
Bioengineering Dissertations - Archive
Peripheral nerve injuries that arise as a result of trauma, tumor excision or birth can adversely affect the quality of patient life, leading to lifelong disabilities in some cases. Autologous nerve grafts are the clinical "gold standard" for long gap nerve repair, and allogeneic nerve grafts are considered the next best treatment option. Despite having numerous benefits, autologous nerve grafts are associated with limited supply, longer operation time, risk of infection, painful neuroma formation and most importantly, loss of function at the donor site. Allogeneic nerve grafts require transient immunosuppression, which exposes the patients to risks of infection, toxicity and …
Protoporphyrin Ix (Ppix)-Conjugated Self-Lighting Nanoparticles For Photodynamic Therapy: Synthesis And Characterization, Homa Homayoni
Protoporphyrin Ix (Ppix)-Conjugated Self-Lighting Nanoparticles For Photodynamic Therapy: Synthesis And Characterization, Homa Homayoni
Bioengineering Dissertations - Archive
In Photodynamic therapy (PDT) PDT, cancer destruction relies on applying a photosensitizing drug (PS) followed by light. Absorbed light can activate the PS to transfer energy to existing molecules and substrates or to oxygen to generate singlet oxygen which are highly toxic to cells. Protophorphyrin IX (PpIX) is a photosensitizers (PSs) which has FDA approval and an absorbance near the Soret band which is 10 times stronger than the absorbance in Q-band (600nm). Our goal was to design a modality to eliminate of external blue light in addition to increasing the drug's water dispersion which finally may result in enhancing …
Establishment And Characterization Of An Animal Model Of Distraction Spinal Cord Injury, Jennifer Elisabeth Stearns Bell
Establishment And Characterization Of An Animal Model Of Distraction Spinal Cord Injury, Jennifer Elisabeth Stearns Bell
Bioengineering Dissertations - Archive
Scoliosis corrective surgery requires the application of multidirectional stress forces to the spinal cord, including those of distraction, in addition to the application of fixation rods for correction of the curved spine deformity. If excessive, spine distraction may result in the development of new neurologic deficits, some as severe as permanent paralysis. Intraoperative monitoring is used to alert the surgeon to possible complications; however, the complex nature of spinal cord injury (SCI) involves a primary mechanical insult to the tissue and/or vasculature that may go undetected by monitoring. This is followed by the activation of widespread secondary injury mechanisms. The …
Diffuse Optical Tomography To Study The Ischemic Stroke In Rat Models, Zi-Jing Lin
Diffuse Optical Tomography To Study The Ischemic Stroke In Rat Models, Zi-Jing Lin
Bioengineering Dissertations - Archive
Stroke, including ischemic stroke and hemorrhagic stroke, is the major leading cause of death in the United States. More than 80 percent of stroke patients are diagnosed with ischemic stroke, which usually results from blockage of artery in the brain by thrombosis or arterial embolism. Animal Models, which permit powerful genetic and molecular approaches, provide an essential tool to study and understand the basic processes and potential therapeutic interventions for this disease. Significant efforts have been made to closely mimic the changes that occur in humans during and after stroke using animal models. Recent development on near infrared (NIR) diffuse …
The Pivotal Role Of Fibrocytes On Foreign Body Reactions, David William Baker
The Pivotal Role Of Fibrocytes On Foreign Body Reactions, David William Baker
Bioengineering Dissertations - Archive
Fibrocytes are circulating connective tissue precursor cells that were first described in 1994 by Bucala et al. as mediators of the innate immune response [1]. Recently the notion of a fibrocyte has not only gained widespread acceptance, but these cells have been identified to participate in a number of disease and pathologic states including aberrant wound repair, fibrosis of organs, cardiovascular disease, and even normal aging. Despite these advancements, little was known about the response of these dynamic cells to biomaterial implants and foreign body reactions. The main focus of my thesis work has therefore focused on investigating fibrocyte-mediate responses, …
Development Of Non-Invasive Methods For Imaging Inflammatory Response, Yi-Ting Tsai
Development Of Non-Invasive Methods For Imaging Inflammatory Response, Yi-Ting Tsai
Bioengineering Dissertations - Archive
Persistent inflammatory cell reactions are responsible for the pathogenesis of a variety of inflammatory diseases. Although many non-invasive imaging methods have been used in the clinics to monitor the extent of inflammatory responses, almost all of them are based on indirect detection of inflammation-associated anatomical or structure changes of tissues and organs. To fill the gap, our laboratory has focused research efforts on detecting different processes of inflammatory responses. Our results can be summarized in the sequence of inflammatory responses - edema formation, inflammatory cell recruitment, inflammatory product release, and cell death. Shortly after medical device implantation or injury, edema …
Kinetics Analyses Of Interactions Between Oncogenic And Tumor Suppressor Proteins By Quantitative High Resolution Microscopy Methods, Shu-Fen Tseng
Kinetics Analyses Of Interactions Between Oncogenic And Tumor Suppressor Proteins By Quantitative High Resolution Microscopy Methods, Shu-Fen Tseng
Bioengineering Dissertations - Archive
DAB2IP is correlated to the risk of aggressive prostate cancer and loss of DAB2IP not only leads to epithelial-to-mesenchymal transition (EMT), but also makes cells radioresistant. These observations support the notion that improved knowledge of DAB2IP involvement in cellular pathways could be of help to cancer therapy. The goal of this work was to enable the study of how DAB2IP and some of its known key molecular partners interact in the cell by a combination of molecular biology techniques and recently reported quantitative fluorescence microscopy methods. The first part of this work was dedicated on investigating the interaction of DAB2IP …
Investigations Into Causes Of Failure Of Regenerative Peripheral Nerve Interfaces, R. Collins Watson
Investigations Into Causes Of Failure Of Regenerative Peripheral Nerve Interfaces, R. Collins Watson
Bioengineering Dissertations - Archive
All highly selective methods of neural interfacing for mental control of a robotic prosthesis tested to date have exhibited high rates of failure over time. Regenerative peripheral nerve interfaces (RPNIs) may offer the greatest potential among the proposed technologies for providing the number of degrees of freedom necessary to control a robotic limb, but are unacceptable for clinical use due to several shortcomings of current technology: (1) all RPNIs tested to date have exhibited signal loss over time due to biological mechanisms of rejection of implanted electrodes; (2) all chronically tested interfaces have suffered from high rates of device failure …
Pleiotrophin Enhance Nerve Regeneration Across Long Gap Peripheral Nerve Defects, Swarup Narayan Dash
Pleiotrophin Enhance Nerve Regeneration Across Long Gap Peripheral Nerve Defects, Swarup Narayan Dash
Bioengineering Dissertations - Archive
Peripheral nerve injuries resulting in extensive loss in nerve continuity pose a challenge in reconstructive surgery. Autografts still remain the treatment of choice for nerve defects despite the need of donor nerve harvest and the associated morbidity of this procedure. In contrast to short gap injuries, isografts achieve sub normal functional recovery for gaps longer than a critical 30 mm length, and simple tubularization methods fail completely. The regenerative failure of peripheral nerves through long gaps can be postulated to the lack of appropriate growth substrate and trophic support. We hypothesize that for successful nerve regeneration across long-gap nerve defects, …
Magnetic-Based Theranostic Nanoparticles For Prostate Cancer Management, Aniket Sharadrao Wadajkar
Magnetic-Based Theranostic Nanoparticles For Prostate Cancer Management, Aniket Sharadrao Wadajkar
Bioengineering Dissertations - Archive
With an increasing rate of cancers, the need for effective cancer management has led to the development of theranostic systems for diagnosis and therapy. Conventional techniques for cancer management have limited success due to inaccurate diagnosis and treatment side effects. Development of magnetic-based theranostic nanoparticles (MBTN) may overcome these limitations with the advantages of magnetic nanoparticles (MNPs) such as magnetic targeting, hyperthermia, and magnetic resonance imaging (MRI) contrast agents; and advantages of polymer coatings for carrying payloads and allowing bioconjugation for active targeting applications. Aim of this research was to develop multifunctional MBTNs for prostate cancer management. First, biodegradable photoluminescent …
A Novel Minimally Invasive Dual-Modality Fiber Optic Probe For Prostate Cancer Detection, Vikrant Sharma
A Novel Minimally Invasive Dual-Modality Fiber Optic Probe For Prostate Cancer Detection, Vikrant Sharma
Bioengineering Dissertations - Archive
Prostate cancer is the most common form of cancer in males, and is the second leading cause of cancer related deaths in United States. In prostate cancer diagnostics and theapy, there is a critical need for a minimally invasive tool for in vivo evaluation of prostate tissue. Such a tool finds its niche in improving TRUS (trans-rectal ultrasound) guided biopsy procedure, surgical margin assessment during radical prostatectomy, and active surveillance of patients with a certain risk levels. This work is focused on development of a fiber-based dual-modality optical device (dMOD), to differentiate prostate cancer from benign tissue, in vivo. dMOD …
Methodology Of Citric Acid Based Functional Biomaterial Development And Application, Yi Leaf Zhang
Methodology Of Citric Acid Based Functional Biomaterial Development And Application, Yi Leaf Zhang
Bioengineering Dissertations - Archive
Biomaterials play critical roles in modern strategies of biomedical applications, such as tissue engineering, and theranostic therapy. Attempts to design ideal biomaterials for each specific application have led to an enormous increase in the number of polymeric biomaterials. Different biomedical applications require specific functionality of biomaterials. Unfortunately, the limited versatility of currently available biodegradable polymers fails to meet the wide range of requirement for biomedical applications. Therefore, a methodology of functional biomaterials development would be beneficial to the biomaterial field. It has been proved that citric acid can be utilized as a key element in the development of novel biodegradable …
Phase Sensitive Spectral Domain Interferometry For Label Free Biomolecular Interaction Analysis And Biosensing Applications, Sajal Chirvi
Phase Sensitive Spectral Domain Interferometry For Label Free Biomolecular Interaction Analysis And Biosensing Applications, Sajal Chirvi
Bioengineering Dissertations - Archive
Biomolecular interaction analysis (BIA) plays vital role in wide variety of fields, which include biomedical research, pharmaceutical industry, medical diagnostics, and biotechnology industry. Study and quantification of interactions between natural biomolecules (proteins, enzymes, DNA) and artificially synthesized molecules (drugs) is routinely done using various labeled and label-free BIA techniques. Labeled BIA (Chemiluminescence, Fluorescence, Radioactive) techniques suffer from steric hindrance of labels on interaction site, difficulty of attaching labels to molecules, higher cost and time of assay development. Label free techniques with real time detection capabilities have demonstrated advantages over traditional labeled techniques. The gold standard for label free BIA is …
Application Of Scanning Correlation Spectroscopy Techniques To Quantify Dna Double Strand Break Repair Kinetics In The Living Cell After Exposure To Γ-Rays And Radiomimetic Chemicals, Salim Abdisalaam
Bioengineering Dissertations - Archive
The kinetics of most proteins involved in DNA damage sensing, signaling and repair following ionizing radiation exposure cannot be quantified by current live cell fluorescence microscopy methods. This is because most of these proteins, with only few notable exceptions, do not attach in large numbers at DNA damage sites to form easily detectable foci in microscopy images. As a result a high fluorescence background from freely moving and immobile fluorescent proteins in the nucleus masks the aggregation of proteins at sparse DNA damage sites. Currently, the kinetics of these repair proteins are studied by laser-induced damage and Fluorescence Recovery After …
Development Of Sers Nanoprobes For Multiplexed And Multi-Modality Molecular Diagnosis Of Cancer, James Otieno Nyagilo
Development Of Sers Nanoprobes For Multiplexed And Multi-Modality Molecular Diagnosis Of Cancer, James Otieno Nyagilo
Bioengineering Dissertations - Archive
Importance of cancer diagnosis and staging through molecular biomarker detection is evident in the increasing number of molecular biomarkers being discovered that are associated with specific cancers types with their role in disease severity and progression being elucidated. Development of molecular imaging modalities capable of simultaneously detecting multiple molecular biomarkers will have a major impact on research, detection, diagnosis, treatment and monitoring of cancer. Combining molecular imaging with high resolution structural imaging can potentially deliver a cancer diagnostic imaging platform with superior resolution and sensitivity. Nanotechnology, specifically in the form of functionalized metal nanoparticles exhibit unique chemical and electromagnetic properties …
Micro-Device For Selective Isolation And Cytology Of Cancer Cells, Yuan Wan
Micro-Device For Selective Isolation And Cytology Of Cancer Cells, Yuan Wan
Bioengineering Dissertations - Archive
Early detection and isolation of circulating tumor cells (CTCs) can enable early cancer diagnosis and more effective therapeutics. Aptamers have emerged as probe molecules that have binding affinities comparable to antibodies but specificities better than those of antibodies. Epidermal Growth Factor Receptor (EGFR) is the most frequently overexpressed receptor in all human malignancies. The expression levels of EGFR in cancer cells can be over 100 times higher than those in normal cells. It is an attractive target for cancer therapy and cancer cell isolation.This dissertation focuses on two different areas: developing strategies for anti-EGFR aptamer based cancer cell isolation, and …
Methodology Of Citrate-Based Biomaterial Development And Application, M. Richard Tran
Methodology Of Citrate-Based Biomaterial Development And Application, M. Richard Tran
Bioengineering Dissertations - Archive
Biomaterials play central roles in modern strategies of regenerative medicine and tissue engineering. Attempts to find tissue-engineered solutions to cure various injuries or diseases have led to an enormous increase in the number of polymeric biomaterials over the past decade. The breadth of new materials arises from the multiplicity of anatomical locations, cell types, and mode of application, which all place application-specific requirements on the biomaterial. Unfortunately, many of the currently available biodegradable polymers are limited in their versatility to meet the wide range of requirements for tissue engineering. Therefore, a methodology of biomaterial development, which is able to address …
Investigation Of Neural Correlates Between Perception Of Pain And Hemodynamic Response Measured In The Pre-Frontal Cortex Using Functional Near Infra-Red Spectroscopy, Venkatagiri Krishnamurthy
Investigation Of Neural Correlates Between Perception Of Pain And Hemodynamic Response Measured In The Pre-Frontal Cortex Using Functional Near Infra-Red Spectroscopy, Venkatagiri Krishnamurthy
Bioengineering Dissertations - Archive
Perception of pain is multi-dimensional, comprising three major psychological dimensions: sensory-discriminative, motivational-affective and cognitive-evaluative. This dissertation study investigates the cognitive evaluation of pain, by acquiring functional Near Infra-Red Spectroscopic (fNIRS) measurements from the prefrontal cortex (PFC) areas, during mechanical and thermal pain stimulation induced on the subject's volar forearm. Clustered-wise analysis on the oxy-hemoglobin (HbO) response from specific PFC areas was followed by categorizing the resulting HbO response into early (0.1-12sec) and late (12.1-25sec) phases. For each respective phase, regression analysis was carried between the HbO-derived parameters and behaviorally measured pain rating. The major findings of this study include: (1) …
Novel Applications Of Compressed Sensing To Magnetic Resonance Imaging And Spectroscopy, Sairam Geethanath
Novel Applications Of Compressed Sensing To Magnetic Resonance Imaging And Spectroscopy, Sairam Geethanath
Bioengineering Dissertations - Archive
In this work, three novel applications of compressed sensing to MRI have been developed and implemented which accomplish reduction in acquisition time, thereby also enabling increased spatial and/or temporal resolution. The first application is for reducing the acquisition time of conventional 1H magnetic resonance spectroscopic imaging (MRSI), which requires alongeracquisition time than conventional MRI. The implementation involved exploiting the inherent sparsity of the MRSI data in the wavelet domain by the use of Daubechies wavelet. This was demonstrated on an in vitro phantom, 6 healthy human brain MRSI data sets, 2 brain and prostate cancer data sets. The reconstructions were …
Novel ¹H Mr Probes To Interrogate The Tumor Microenvironment, Praveen Kumar Gulaka
Novel ¹H Mr Probes To Interrogate The Tumor Microenvironment, Praveen Kumar Gulaka
Bioengineering Dissertations - Archive
The term "tumor microenvironment" usually refers to the description of the physiological and metabolic conditions within solid tumors (primary or metastatic), and is significantly different from that of normal tissues. Assessment of factors like pH, tissue oxygen tension (pO2) and gene expression in the tumor microenvironment and the ability to image them in vivo can provide useful prognostic information. For example, hypoxia (low pO2), typically distributed heterogeneously in solid tumors, is known to affect both radiation sensitivity and the development of metastases thereby influencing the response to treatment. This dissertation research focuses on the evaluation of novel probes to interrogate …
Wireless Closed-Loop Feedback Systems For Automatic Detection And Suppression Of Nociceptive Signals, Aydin Farajidavar
Wireless Closed-Loop Feedback Systems For Automatic Detection And Suppression Of Nociceptive Signals, Aydin Farajidavar
Bioengineering Dissertations - Archive
Chronic pain is an important public health issue. Several approaches have been implemented for management of chronic pain, including surgical implantation of neurostimulators. Neurostimulators have been used in clinics for spinal cord implantation and they have been suitable for relieving certain types of pains, such as neuropathic pain in leg or arm, complex regional pain, and refractory angina. The stimulation at spinal cord has little relieving effects on syndromes such as facial pain, cluster headache, phantom limb pain, and post stroke pain. For treating such syndromes, electrical stimulation of deep brain structures such as thalamic nuclei (e.g. ventroposterolateral (VPL) or …
Cell Specific Guidance Of Nerve And Vascular Regeneration Through Sustained Growth Factor Release, Parisa Lotfi
Cell Specific Guidance Of Nerve And Vascular Regeneration Through Sustained Growth Factor Release, Parisa Lotfi
Bioengineering Dissertations - Archive
Regenerative peripheral nerve interfaces have been proposed as viable alternatives for the natural control of robotic prosthetic devices. However, sensory and motor axons at the neural interface are of mixed submodality types, which difficult the specific recording from motor axons and the eliciting of precise sensory modalities through selective stimulation. Here we evaluated the possibility of using type-specific neurotrophins to preferentially entice the regeneration of defined axonal populations from injured peripheral nerves. Segregation of mixed sensory fibers from dorsal root ganglion neurons was evaluated in vivo by compartmentalized diffusion delivery of nerve growth factor (NGF) and neurotrophin-3 (NT-3), to preferentially …
Targeted Delivery Of Carbon Nanotubes To Cancer Cells, Pavitra Chakravarty
Targeted Delivery Of Carbon Nanotubes To Cancer Cells, Pavitra Chakravarty
Bioengineering Dissertations - Archive
CD22 is broadly expressed on human B cell lymphomas. Monoclonal anti-CD22 antibodies (MAbs) alone, or coupled to toxins, have been used to selectively target these tumors both in severe combined immunodeficient (SCID) mice with xenografted human lymphomas and in patients. Single-walled carbon nanotubes (CNTs) attached to antibodies or peptides represent another approach to targeting cancer cells. CNTs convert absorbed near-infrared (NIR) light into heat, which can thermally ablate cells in the vicinity of the CNTs. We have made MAb-CNT constructs where the MAb was either noncovalently or covalently coupled to CNTs, and investigated their ability to bind specifically to cells …
Enhanced Endothelialization On Surface Modified Poly(L-Lactic Acid), Hao Xu
Enhanced Endothelialization On Surface Modified Poly(L-Lactic Acid), Hao Xu
Bioengineering Dissertations - Archive
Current synthetic vascular grafts and polymer-coated drug-eluting stents (DES) have certain limitations, such as thrombosis and restenosis due to the incomplete recovery of vascular endothelial cells on their luminal sides. Surface modification of these materials is a viable method to enhance the endothelialization on them. In this study, we proposed several way to modify poly(L-lactic acid) (PLLA), a promising material for vascular prostheses to enhance the endothelialization on its surface. In the first method, we modified the material surface with deposition of poly(vinylacetic acid) (PVAA) using plasma polymerization. PVAA having different surface densities of -COOH group or film thickness were …