Engineering Commons^™

Evaluation Of The Efficiency Of Muscle-Specific Promoters To Express Non-Endogenous Proteins In Skeletal Muscle, Gabrielle Bulliard, Made Harumi Padmaswari, Christopher E. Nelson

Biomedical Engineering Undergraduate Honors Theses

Gene therapies are emerging as powerful tools for treating genetic diseases and cancers, offering the potential for a permanent cure. Hemophilia B, affecting approximately 6,000 men in the U.S., results from a deficiency in coagulation factor IX protein (FIX), which is crucial for blood clotting. A substantial portion of patients, over 40%, suffer from severe hemophilia B, experiencing spontaneous, prolonged bleeding. Current prophylactic treatments involve frequent coagulation factor infusions, yet a curative approach would alleviate this burden. Gene editing technologies like CRISPR-Cas systems show promise for correcting genetic mutations, but the diverse nature of factor IX gene (F9) …

Safety Analysis In Ap-1000 Nuclear Power Plant Against Primary Loop Coolant Pump And Fuel Failures, Fabiano Gibson Daud Thulu, Hailemichael Guadie Mengsitu, Chifundo Tenthani, Paul Stone Macheso

International Journal of Nuclear Security

This study focused on the best-estimated thermal-hydraulic calculations performed regarding the AP-1000 nuclear power plant (NPP) under primary coolant loop pump and fuel failures. Primary coolant pump and fuel failure transients are important design-basis accidents in NPP safety assessments. This work examined the primary reactor’s safety margins of fuel and cladding peak temperature, primary and secondary loop pressure, hydrogen formation, and primary and secondary flow rates.The Adaptive System Thermal-Hydraulics program was used in the simulation and event progression analysis. The results showed that the peak fuel surface temperature was kept below the licensing design limit. No observation of corium was …

Modeling And Analysis Of Neutron Flux Of A Vver 1200 Reactor Core Using Monte Carlo Code Openmc, K. M. Rakib Al Hasan, Dr. Debashis Datta, Altab Hossain

International Journal of Nuclear Security

Nuclear reactors and their associated facilities are complex systems that require accurate modeling and analysis to ensure safety, security, and efficient operation. This study aims to model and analyze the neutron flux of a generic VVER 1200 reactor core using the Monte Carlo code OpenMC. For the purpose of this analysis, a generic model of the VVER 1200 reactor core was developed using an OpenMC simulation environment. Furthermore, using this model, the neutron flux spectrum inside the reactor core was evaluated, from which neutron fluence was calculated accordingly. This study analyzed the effect of neutron flux on the developed model …

Threat Modeling Based On A Design Basis Threat For Nuclear Security, Abu Zafor Mohammad Salahuddin, Altab Hossain, Mohammad Shawkat Akbar

International Journal of Nuclear Security

Identification of the design basis threat (DBT) of a nuclear facility is an important factor of overall safety, for which the operator is mainly responsible per the guidelines of the International Atomic Energy Agency. As threat levels increase especially threats beyond the DBT-the responsibility of the state also increases. In recent years, only a few studies on nuclear security and DBTs have comprehensively detailed the full spectrum of nuclear facilities in a nation. Thus, this paper presents the correlation between an actual threat and the DBT. The objectives of the study are to assist in establishing physical protection system (PPS) …

Building A Wireless Electronic Control Unit For An Electric Vehicle, Hector S. Sosa

2024 Spring Honors Capstone Projects - Archive

Modern vehicles have a variety of features such remote start systems, advance drive assist systems, smart suspension systems, and a feature rich infotainment system. With all this technology in the car, there exists a complex network of computers working together in conjunction to deliver the modern driving experience that many people have today. To be competitive in the market, auto manufacturers are tasked to add additional features to vehicles by adding additional or modifying electronic control units (ECUs). In this study, an ECU will be designed for a mock electric vehicle which contains an already established network of ECU’s. The …

Navigate The World Of Rfid: Diversity, Capabilities, And Constraints Of Readers And Tags, Rachana Pandey

2024 Spring Honors Capstone Projects - Archive

Radio-Frequency Identification (RFID) technology, a method for storing and retrieving data through electromagnetic transmission to an RFID tag, is revolutionizing inventory and asset management in various sectors, including healthcare. This research explores the applications of RFID in a medical setting. It assesses various RFID readers and tags, focusing on their functional capabilities, ranges, and limitations within a medical environment. Employing a comprehensive approach, the study integrates an extensive literature review, comparative analysis, and empirical data from both experimental simulations and real-world healthcare scenarios. The aim is to identify RFID solutions that optimize surgical equipment management, thereby enhancing both operational efficiency …

Establishing Employee Sense Of Belonging In A Busy Work Environment, Zoe A. Rodriguez

2024 Spring Honors Capstone Projects - Archive

This honors thesis capstone project explores the concept of an employee’s sense of belonging within a busy work environment. A department within ABC Company faces operational challenges regarding their daily tasks. The Honors contribution addresses the comparison between the busy work environment at ABC Company and existing literature to provide scholarly-supported recommendations and mitigation strategies for ABC Company. Existing literature underscores the importance of understanding contributing influences on an employee’s sense of belonging within the workplace. The honors contribution adds value by closing the information gap within companies that operate under a busy work environment and strategies of how to …

Review: Implementation Of Video Documentation In Lessons Learned System In Construction, Jainil Patel

2024 Spring Honors Capstone Projects - Archive

Organizations employ Lessons Learned Systems (LLS) to manage knowledge and capture valuable project experiences to improve future performance. However, the construction industry has yet to adopt such systems widely, presumably due to its sluggish tech integration and risk-prone characteristics. Of the numerous fragmented obstacles that impede LLS adoption, one noteworthy obstacle would be the challenge faced during the text documentation of experiences. Traditional text inputs are labor-intensive and time- consuming. Hence, video documentation can be a more efficient replacement with its quick and modern recording features. The technological advancement and the preference shift of younger generations from text to video …

Effectivity Analysis Of Recommendation Algorithm: A Comparative Study Of The Performance Of A Hybrid Model And An Individual Recommendation Algorithm, Saniah Safat

2024 Spring Honors Capstone Projects - Archive

This study explores the effectiveness of a hybrid recommendation system for e-commerce by integrating content-based, collaborative, and popularity-based models. Traditional individual algorithms have inherent limitations, such as handling new users or items data sparsity and ensuring relevance and diversity in suggestions. The hybrid model seeks to overcome these challenges by leveraging the strengths of all three methods, thus potentially offering more precise, personalized product suggestions. The performance of each model and its integration into a hybrid system are evaluated through logistic regression analysis. Initial results indicate that the hybrid system significantly outperforms the individual models in terms of accuracy and …

Investigating Rural Traffic Dynamics: A Traffic Study On E 2nd Street Intersection’S Behavior And Safety, Ma Anjelika Rose T. Pineda

2024 Spring Honors Capstone Projects - Archive

Traffic studies guide engineers in designing road networks to ensure smooth traffic flow and public safety. Such studies assess the need for traffic control devices to manage vehicle flow safely and efficiently. This is crucial at intersections which pose high risks of collision and congestion. A traffic analysis at the intersection of Island Grove and E 2nd Street on the FM-4 roadway in Cleburne, TX was conducted to evaluate the sufficiency of the current traffic control device. TxDOT warrants and standards and a field study were utilized and performed to justify the substitution for a traffic signal at the intersection. …

An Assessment Of Methane Cracking Technologies For Hydrogen Production And Reduction Of Greenhouse Gases, Alisa E. Pjetrovic

2024 Spring Honors Capstone Projects - Archive

Methane reformation and methane pyrolysis involve separating, or cracking, the components of methane, leading to the production of hydrogen gas, and in the case of pyrolysis, solid carbon. Because methane is known as a leading cause of climate change, these technologies are gaining attention as the global community moves to address methane as a greenhouse gas. This study aims to assess, through a systematic literature review, the current state-of-the-art methane cracking technologies based on seven technology criteria: hydrogen production capability, environmental impact, value of carbon produced, reaction stability, operating temperature requirements, energy requirements, and Technology Readiness Level (TRL). This study …

Development And Evaluation Of A Modeling Platform For Evaluating Immunotherapeutic Efficacy In The Tumor Microenvironment., Dylan Andrew Goodin

Electronic Theses and Dissertations

The tumor microenvironment (TME) represents the complex outcome of numerous tumor, stromal, and immune interactions, and whose composition can significantly affect treatment response. Particularly, immunotherapeutic efficacy is subject to multiple tumor-specific TME interactions that may be difficult to evaluate/predict clinically. Mathematical modelling has been formulated to evaluate specific aspects of the TME, including vasculature, ECM deposition, and immune-tumor interactions. However, the computational challenge of simulating multiple TME interactions has led to sacrificing varying degrees of model generalizability and clinical relevance. This work describes increased computational performance of a 3D continuum model that simulates tumor tissue, ECM, and vasculature using a …

Novel Designs Of Soft Tactile Sensor And Robot Finger Manipulator Based On Optical Fibers., Seokyoung Han

Electronic Theses and Dissertations

Robotic manipulation is one of the main types of automated labor that humans want to achieve in order to free ourselves from mundane and hazardous tasks. The range of realizations could be very broad, from massive industrial robots to highly advanced medical devices for human healthcare. Given the critical nature of these application spaces, they require robust, safe, and most of all versatile designs. In that direction, one of the most interesting topics is the anthropomorphic robotic manipulator. Since it is inspired by human hands’ function and structure, it is able to achieve the aforementioned system requirements. However, the perfect …

Electrokinetic Particle Trapping Performance Of Conductive Nanofiber Mats In Microfluidic Wells., Jacob Hunter West

Electronic Theses and Dissertations

The frequency dependence of electrokinetic particle trapping using large-area (>mm²) conductive carbon nanofiber (CNF) mat electrodes is investigated. The fibers provide nanoscale geometric features for the generation of high electric field gradients, which is necessary for particle trapping via dielectrophoresis (DEP). A device was fabricated with an array of microfluidic wells for repeated experiments; each well included a CNF mat electrode opposing an aluminum electrode. Fluorescent microspheres (1 µm) were trapped at various electric field frequencies between 30 kHz – 1 MHz. Digital images of each well were analyzed to quantify particle trapping. DEP trapping by the …

Emergency Vehicle Prioritization In Connected And Autonomous Traffic., Mohamadreza Haghani

Electronic Theses and Dissertations

Reducing the response time of emergency vehicles (EV) is highly important due to the relationship between response time and fatality rate. Emerging technologies can help reduce response time by enhancing EV prioritization. On the other hand, EV prioritization can negatively impact general traffic especially in cross streets of signalized intersections. In this research, three main objectives were followed. Firstly, creation and dissipation of EVP disruption on arterial cross streets was studied to recommend solutions to prevent this disruption. Secondly, lane-changing and stopping behavior of CAVs were studied in EV prioritization to identify the best lane-changing behavior through minimizing delay. Thirdly, …

A Design Science And Implementation Framework For Studying Interruptions And Its Application In A Dental Clinic., Carsten Ziegler

Electronic Theses and Dissertations

Interruptions during dental treatment are frequent, and often have detrimental effects on quality of care, patient safety and processing times, and have an impact on provider satisfaction and performance. Interruptions can significantly increase the cognitive load on dental providers, making it hard for them to concentrate on complex procedures. Frequent interruptions also disrupt the workflow in general, leading to delays in treatment, which can reduce the overall throughput of a clinic. Unfortunately, there is no comprehensive approach to collectively (i) analyze interruptions in dental healthcare, (ii) design an intervention, and (iii) implement and sustain it. This research proposes a comprehensive …

Attention Guided Data Augmentation For Improving The Classification Performance Of Vision Transformers., Nada Baili

Electronic Theses and Dissertations

For over a decade, Deep Neural Networks (DNNs) have been rapidly progressing and achieving great success, forming a robust foundation of state of the art machine learning algorithms that impacted various domains. The advances in data acquisition and processing have undeniably played a major role in these breakthroughs. Data is a crucial component in building successful DNNs, as it enables machine learning models to optimize complex architectures, necessary to perform certain difficult tasks. However, acquiring large-scale data sets is not enough to learn robust models with generalizable features. Instead, an ideal training set should be diverse enough and contain enough …

Barocaloric Heat Pumps Based On Soft Materials., Naveen Weerasekera

Electronic Theses and Dissertations

Solid-state refrigeration offers a promising alternative to traditional vapor compression systems that are relatively inefficient, unreliable, and have a high global warming potential. Various solid-state cooling technologies, including those based on electrocaloric, magnetocaloric, and elastocaloric effects have been investigated in the recent past. However, concerns regarding their efficiency, scalability and cost remain. Refrigeration and heat pump technologies based on the barocaloric effect (temperature/entropy change due to hydrostatic pressure) hold great promise but have received comparatively less attention. Barocaloric heating/cooling based on low cost, compressible soft materials with large barocaloric response have the potential to pave the way for efficient, scalable, …

Context Dependent Training Data Selection For Automatic Target Detection., Tylman Michael

Electronic Theses and Dissertations

An Automatic Target Detection (ATD) algorithm is capable of identifying the location of targets of interest captured by Infra-Red imagery in vastly different contexts. ATD is often a precursor in a 2-stage methodology in order to ascertain the location and nature of a target in both military and civilian applications. In order to train an ATD algorithm, a large amount of data from varied sources is required. One drawback of this requirement is that some sources of data may harm the performance of the method in different contexts. This thesis explores utilizing an unsupervised method to identify a subset of …

Rockin’ Rehab: Novel Rocking Chair For Children With Spinal Cord Injury To Enable Trunk Muscle Activation And Detect Muscle Activation Patterns., Johnathan Jay George

Electronic Theses and Dissertations

Introduction: Activity-based locomotor training improves trunk control in children with spinal cord injury (SCI), and there is need for additional activities to allow these children to activate trunk muscles. The purpose of this research was to design, fabricate, and evaluate a rocking chair for children with SCI, and to investigate the activation of muscles during use. Sensorization of the chair to confirm muscle activation is also explored. Methods: Quality Function Deployment (QFD) design methodologies identified and ranked needs and features for the rocking chair. A design was developed and evaluated via finite element analysis. The chair was fabricated and tested …

Multithreaded Applications On The Heterogeneous Research Computing Environment., Sungbo Jung

Electronic Theses and Dissertations

Bioinformatics is a domain that has experienced rapid research growth in recent years, as evidenced by the increasing number of articles in biomedical databases such as PubMed, which adds over a million publications every year. However, this also poses a challenge for researchers who need to find relevant citations for their work. Therefore, developing efficient indexing and searching methods for text data is crucial for Bioinformatics. One key technique for information retrieval is document inversion, which involves creating an inverted index to enable efficient searching through vast collections of text or documents. This Ph.D. research aims to design the research …

Effect Of Swirl Ratio On Simulated Vortech Chamber Vortex Parameters, Samuel Kolar

Civil Engineering Undergraduate Honors Theses

A numerical simulator can use computational fluid dynamics (CFD) to model an experimental tornado-simulating chamber at Texas Tech University (known as VorTECH). Previous studies evaluating this particular CFD model have produced results that compare the touchdown swirl ratio (S_TD), core radius (r_c), maximum tangential velocity at touchdown (V_tmax @ S_TD), and height of the maximum tangential velocity (z_c) reasonably well with experimental data from the VorTECH facility. The effects of swirl ratio beyond S_TD on important vortex parameters including r_c, V_tmax, z …

Modeling Of Multi-Period Disaster Logistics Planning In The State Of South Carolina, Emma Simon

All Theses

South Carolina is one of the most vulnerable states in the United States to the impact of hurricanes. Currently, when threatened with a natural disaster such as a hurricane, the state government makes many vital decisions based on knowledge and experience. In this study, the distribution of disaster relief commodities to meet immediate needs is analyzed through two models for the case of South Carolina to generate an optimal logistics strategy that considers the social vulnerability of affected populations. The first model is a multi-objective pre-disaster logistics model that uses a four-index formulation for the multiple trip vehicle routing problem. …

Release Of Small Molecules From Rubber: Effects Of Materials Properties, Mechanical Loading And Molecular Interactions, Yongcan Du

All Dissertations

Release of small molecules from polymeric materials has wide applications in the delivery systems of active molecules such as drug, fragrance, and semiochemical. Rubber materials are good candidates for the excipients of those systems due to properties such as good flexibility, permeability, and biocompatibility. Factors like material properties, mechanical loading, and molecular interactions may affect the release of small molecules in those systems. Therefore, understanding how those factors affect the release is key to the formulation, design, and evaluation of those systems.

To study the effects of materials properties, vulcanized natural rubber sheets with different crosslink densities, loaded with small …

Free And Forced Vibrations Of Elastically Restrained Cantilever With Lumped Oscillator, Alireza Babaei, Johné Parker, Paria Moshaver

Earth and Environmental Sciences Faculty Publications

The efficiency assessment of cantilever-based energy harvesters relies on vibrational analysis, which necessitates modi- fications aimed at enhancing efficiency. These modifications involve manipulating the fundamental frequency to lower values and encompassing a wider range of resonances within a specified bandwidth. Consequently, this paper introduces an original analytical-numerical exploration into the vibratory response of a cantilever with a novel boundary condi- tion involving an elastically restrained oscillator-spring arrangement. At the microbeam’s tip, an oscillator is elastically confined by a linear spring, resulting in a novel set of coupled governing equations and a distinct shearing boundary condition. Microbeam equations is derived from …

Transcriptomic Profiling Of Engineered Human Gene Integration In The Mouse Genome Following In Vitro Gene Editing, Ethan Potts, Made Harumi Padmaswari, Christopher Nelson

Biomedical Engineering Undergraduate Honors Theses

Gene replacement is a promising method of therapy for genetic diseases. However, safety and efficacy are areas that need more research. This experiment aims to use RNA sequencing and bioinformatic techniques to provide answers to these questions and provide direction to future studies to develop a gene replacement therapeutic. C2C12 mouse myoblast cells were transfected with a vector containing a CRISPR-Cas9 system and the Human Factor IX (hF9) gene in order to hijack target genes and integrate the hF9 gene. The two target genes, myoglobin (Mb) and creatine kinase (Ckm), were chosen for their high rate of expression and low …

Real-Time Measurements From Wearable Sensors To Enhance Stability On Uneven Terrain, Sophie Copelin

Biomedical Engineering Undergraduate Honors Theses

The presented thesis is a study of sensation associated with inversion/eversion movement about the anterior/posterior axis. The long-term goal is to create a system that provides feedback to a prosthesis user, so their chances of falling is decreased. This feedback system would use wearable sensors to detect certain angles, so that sensory feedback could be provided. The study aimed to determine if Xsens Movella DOT sensors could be used in a system like this, so the accuracy of the Xsens Movella DOT sensors was assessed and the difference in angles that could be determined by them when compared to that …

A Comprehensive Materials Approach To Thermal Management In Fiber Lasers, Bailey Meehan

All Dissertations

Optical fiber-based amplifiers and lasers enable a great many useful devices and conveniences. Unfortunately, however, they can generate considerable heat during operation that drives the need for complex cooling solutions, thus reducing many of the size, weight, and power (SWAP) benefits for which fiber lasers are known. Additionally, at elevated temperatures, thermally-driven phenomena, such as Transverse Mode Instability (TMI), can be induced that limit the power-scaling of fiber lasers. The focus of this Dissertation is to explore novel approaches to thermal management in fiber lasers through judicious materials science and engineering to obviate the aforementioned limitations. Fibers studied in this …

The Development Of A Convenient And Consistent Methodology For Flight Proficiency To Certify Multi-Rotor Uas Pilots For State Departments Of Transportation, Colin Dees

All Dissertations

To fly an unmanned aircraft system (UAS), commonly referred to as a “drone,” the Federal Aviation Administration (FAA) requires pilots to pass a knowledge test. There is no requirement at the state or federal level for drone operators to demonstrate the ability to operate a UAS. The National Institute of Science and Technology (NIST) has created an exam for public and private entities to assess basic UAS flight proficiency. It is the only nationally recognized flight proficiency protocol. NIST does not provide a scoring recommendation and leaves it to the user to determine the minimum criteria to pass. There is …

Female Students’ Sense Of Belonging Influence On Engineering Technology Degree Retention: A Phenomenological Study, Edith Wittenmyer

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this qualitative study is to identify and understand the phenomenon of sense of belonging regarding female students’ lived experiences that may impact retention rates for female students in engineering technology majors at this particular major midwestern university. Delving deeper into the lived experiences of engineering technology female students is the focus of this research. The study’s outcome may support academic policy changes which will increase retention and graduation of female students in pursuit of engineering technology degrees.