Engineering Commons^™

Process Management And Design Layout Of High Throughput Screening, Anthony Vasquez, Kyle Dupuy

Industrial and Manufacturing Engineering

Calibr is a pharmaceutical company in San Diego and growing very quickly rate and need help redesigning their lab layout and in doing so reducing their cycle times and down times in machines. In addition to this, they do not currently have an accurate measurement of how long their processes take in an overall cycle. The objective of this project is to provide Calibr with a redesigned layout to accommodate new equipment as well as a software tool that can output Gantt charts for their planning of their testing. Our approach to this project first included mapping out the facilities …

The Bridge Newsletter Winter 2017, Missouri University Of Science And Technology

The Bridge Newsletter

-Hands-on experience in concrete materials research and construction practices
-Making ACML progress
-Taos bridge project

Design And Evaluation Of A Cmos Contact-Imaging System For Microfluidics, Andres Moroni Galan Cherrez

Theses and Dissertations

A CMOS contact-imaging system for microfluidics is presented. The microsystem integrates a five-layer PDMS microfluidic network and a CMOS image sensor fabricated in a standard 0.18 µ­m technology. The CMOS image sensor consists of two 10×1-pixel array, an amplifier, and a control logic. The imager is able to achieve a low dark signal of 1.67 mV/s, a maximum integration time of 514 s, and a high dynamic range of 75.2 dB at 1 s integration time. The microfluidic device integrates several actuated valve to achieve a fully automated lab-on-a-chip. This work also presents a quantitative comparison of the photomultiplier tube …

Event And Time-Triggered Control Module Layers For Individual Robot Control Architectures Of Unmanned Agricultural Ground Vehicles, Tyler Troyer

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Automation in the agriculture sector has increased to an extent where the accompanying methods for unmanned field management are becoming more economically viable. This manifests in the industry’s recent presentation of conceptual cab-less machines that perform all field operations under the high-level task control of a single remote operator. A dramatic change in the overall workflow for field tasks that historically assumed the presence of a human in the immediate vicinity of the work is predicted. This shift in the entire approach to farm machinery work provides producers increased control and productivity over high-level tasks and less distraction from operating …

Tuning Properties Of Poly(Ethylene Glycol)-Block-Poly(Simvastatin) Copolymers Synthesized Via Triazabicyclodecene, Theodora A. Asafo-Adjei, Thomas D. Dziubla, David A. Puleo

Biomedical Engineering Faculty Publications

Simvastatin was polymerized into copolymers to better control drug loading and release for therapeutic delivery. When using the conventional stannous octoate catalyst in ring-opening polymerization (ROP), reaction temperatures ≥ 200 °C were required, which promoted uncontrollable and undesirable side reactions. Triazabicyclodecene (TBD), a highly reactive guanidine base organocatalyst, was used as an alternative to polymerize simvastatin. Polymerization was achieved at 150 °C using 5 kDa methyl-terminated poly(ethylene glycol) (mPEG) as the initiator. ROP reactions with 2 kDa or 550 Da mPEG initiators were also successful using TBD at 150 °C instead of stannous octoate, which required a higher reaction temperature. …

Titanium Addition Influences Antibacterial Activity Of Bioactive Glass Coatings On Metallic Implants, Omar Rodriguez, Wendy Stone, Emil H. Schemitsch, Paul Zalzal, Stephen Waldman, Marcello Papini, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

In an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in terms of antibacterial behavior, solubility and cytotoxicity. Borate-based glasses were found to exhibit significantly superior antibacterial properties and increased solubility compared to their silica-based counterparts, with BRT0 and BRT3 (borate-based glasses with 0 and 15 mol% of titanium dioxide incorporated, respectively) outperforming the remainder of the glasses, both borate and silicate based, in these respects. Atomic Absorption Spectroscopy …

Development Of A Performance-Based Procedure For Assessment Of Liquefaction-Induced Lateral Spread Displacements Using The Cone Penetration Test, Tyler Blaine Coutu

Theses and Dissertations

Liquefaction-induced lateral spread displacements cause severe damage to infrastructure, resulting in large economic losses in affected regions. Predicting lateral spread displacements is an important aspect in any seismic analysis and design, and many different methods have been developed to accurately estimate these displacements. However, the inherent uncertainty in predicting seismic events, including the extent of liquefaction and its effects, makes it difficult to accurately estimate lateral spread displacements. Current conventional methods of predicting lateral spread displacements do not completely account for uncertainty, unlike a performance-based earthquake engineering (PBEE) approach that accounts for the all inherent uncertainty in seismic design. The …

Collapsible Silicone Tubes: An In Vitro Model For Tracheal Traction, Kevin D. Garman

Master's Theses (2009 -)

Obstructive sleep apnea (OSA) is characterized by recurrent episodes of airway collapse and airflow limitation during sleep. Fragmented sleep and reductions in blood oxygen saturation lead to several comorbidities, including hypertension, cardiovascular disease, and cerebrovascular disease. Longitudinal forces (tracheal traction) acting on the soft tissues surrounding the upper airway have been proposed to play a significant role in stabilizing the airway and preventing collapse. However, the relative contribution of longitudinal forces as compared to other factors that affect airway stability (airway geometry, tissue properties, muscle activity) remains unclear. This in-vitro study aimed to investigate to what extent longitudinal forces can …

Performance Analysis Of Constant Speed Local Abstacle Avoidance Controller Using A Mpc Algorithym On Granular Terrain, Nicholas Haraus

Master's Theses (2009 -)

A Model Predictive Control (MPC) LIDAR-based constant speed local obstacle avoidance algorithm has been implemented on rigid terrain and granular terrain in Chrono to examine the robustness of this control method. Provided LIDAR data as well as a target location, a vehicle can route itself around obstacles as it encounters them and arrive at an end goal via an optimal route. This research is one important step towards eventual implementation of autonomous vehicles capable of navigating on all terrains. Using Chrono, a multibody physics API, this controller has been tested on a complex multibody physics HMMWV model representing the plant …

Effects Of Random Oscillations On Balance Control In Healthy Young Adults, Jacob Van Dehy

Master's Theses (2009 -)

In human walking, balance control is managed through proactive changes in spatio-temporal parameters of stepping [1]. It has been suggested that continuous disruptions to healthy young adult balance cause greater changes to overall variability of these parameters than a shift in the mean stepping parameters [2]. This suggests that walking may be occurring in a more reactive manner, modulating to maintain balance without increasing the mean significantly. Work using continuous oscillations to treadmill walking suggest there is an interplay between the predictability of a signal used to disrupt subject balance and the degree to which compensation occurs [3]. To determine …

Construction And Characterization Of A Single Stage Dual Diaphragm Gas Gun, Nathaniel Steven Helminiak

Master's Theses (2009 -)

In the interest of studying the propagation of shock waves, this work sets out to design, construct, and characterize a pneumatic accelerator that performs high-velocity flyer plate impact tests. A single stage gas gun with a dual diaphragm breach allows for a non-volatile, reliable experimental testing platform for shock phenomena. This remotely operated gas gun utilizes compressed nitrogen to launch projectiles down a 14 foot long, 2 inch diameter bore barrel, which subsequently impacts a target material of interest. A dual diaphragm firing mechanism allows the 4.5 liter breech to reach a total pressure differential of 10ksi before accelerating projectiles …

The Effects Of A Reduced Force Aerial Bucket Control On Upper Extremity Muscular Demands As Assessed With Surface Electromyography, Casey D. Garces

Master's Theses (2009 -)

A common control for operating aerial bucket trucks for utility companies in North America is called a pistol grip control. Based upon many anecdotal reports of forearm muscle fatigue from workers using this control, Prof. Richard Marklin began an EPRI-sponsored study in 2016 using EMG to determine muscle fatigue of workers while they used the pistol grip. Muscle activity recorded by EMG is a measure of the magnitude of muscle force under controlled conditions. This study confirmed the reports of muscle fatigue in extensor digitorum communis (EDC) muscle in the right forearm. The next phase of the study was to …

Design Of A Passive Ankle Prosthesis With Energy Return That Increases With Increasing Walking Velocity, Alexander J. Folz

Master's Theses (2009 -)

Patients who undergo a transtibial (below the knee) amputation are often met with a difficult decision: selection of a prosthesis. Limitations of currently available prostheses motivate work on a new solution, the EaSY Walk, a passive device that mimics two key aspects of the natural ankle: non-linear rotational stiffness through implementation of a stiffening flexure mechanism and rotational work output that varies as a function of walking velocity to propel the user forward. To achieve the latter, a strategy to convert the maximum available translational energy acquired from deflection along the leg into rotational energy about the ankle joint through …

Elucidating The Mechanical, Structural, Functional, And Molecular Mechanisms Involved In Irreversible Vascular Changes In Aortic Coarctation, Brandon Wegter

Master's Theses (2009 -)

Coarctation of the aorta (CoA) is a constriction of the thoracic aorta and is one of the most common congenital cardiovascular defects. Treatment by surgical correction has saved the lives of thousands of children, but many still have a reduced lifespan due to hypertension. Previous results using our novel rabbit model showed that the current treatment guideline of a 20 mmHg blood pressure gradient (BPG) induces irreversible vascular changes, which persisted despite correction. Preliminary data of the downregulation of natriuretic peptide receptor C (NPR-C) in proximal aortic tissue of human patients with CoA serves as the possible underlying mechanism for …

An Investigation Into Isogeometric Blended Shells, David Scott Willoughby

Theses and Dissertations

Improvements to isogeometric blended shells are introduced which blend traditional Reissner-Mindlin shells, and Kirchhoff-Love shells, with an exact interpolation of the shell director increment. A gradient extraction operator is introduced which allows derivatives of basis functions to be exactly expressed as a linear combination of the basis functions themselves. Several benchmarks are investigated and the new blended shell is compared with different shell elements in ABAQUS and NASTRAN. In addition, the effect of different quadrature schemes is included in the comparisons. The new isogeometric blended shell performs comparably in some benchmarks, and even outperforms commercial shell finite elements in some …

Considering Manufacturing In The Design Of Thick-Panel Origami Mechanisms, Erica Brunson Crampton

Theses and Dissertations

Origami has been investigated and demonstrated for engineering applications in recent years. Many techniques for accommodating the thickness of most engineering materials have been developed. In this work, tables comparing performance and manufacturing characteristics are presented. These tables can serve as useful design tools for engineers when selecting an appropriate thickness-accommodation technique for their application. The use of bent sheet metal for panels in thick-origami mechanisms shows promise as a panel design approach that mitigates several trade-offs between performance and manufacturing characteristics. A process is described and demonstrated that can be employed to use sheet metal in designs of origami-adapted …

Engineering Cyber Physical Systems: Preface, Cihan H. Dagli

Engineering Management and Systems Engineering Faculty Research & Creative Works

Multi-faceted systems of the future will entail complex logic with many levels of reasoning in intricate arrangement. The organization of these systems involves a web of connections and demonstrates self-driven adaptability. They are designed for autonomy and may exhibit emergent behavior that can be visualized.

Complex Adaptive Systems have dynamically changing meta-architectures. Finding an optimal architecture for these systems is a multi-criteria decision making problem often involving many objectives in the order of 20 or more. This creates "Pareto Breakdown" which prevents ordinary multi-objective optimization approaches from effectively searching for an optimal solution; saturating the decision maker with large sets …

Instance Selection Using Genetic Algorithms For An Intelligent Ensemble Trading System, Youngmin Kim, David Lee Enke

Engineering Management and Systems Engineering Faculty Research & Creative Works

Instance selection is a way to remove unnecessary data that can adversely affect the prediction model, thereby selecting representative and relevant data from the original data set that is expected to improve predictive performance. Instance selection plays an important role in improving the scalability of data mining algorithms and has also proven to be successful over a wide range of classification problems. However, instance selection using an evolutionary approach, as proposed in this study, is different from previous methods that have focused on improving accuracy performance in the stock market (i.e., Up or Down forecast). In fact, we propose a …

Establishing Rules For Self-Organizing Systems-Of-Systems, David M. Curry, Cihan H. Dagli

Engineering Management and Systems Engineering Faculty Research & Creative Works

Self-organizing systems-of-systems offer the possibility of autonomously adapting to new circumstances and tasking. This could significantly benefit large endeavors such as smart cities and national defense by increasing the probability that new situations are expediently handled. Complex self-organizing behaviors can be produced by a large set of individual agents all following the same simple set of rules. While biological rule sets have application in achieving human goals, other rules sets may be necessary as these goals are not necessarily mirrored in nature. To this end, a set of system, rather than biologically, inspired rules is introduced and an agent-based model …

Development And Validation Of A Hybrid Virtual/Physical Nuss Procedure Surgical Trainer, Mohammad F. Obeid

Computational Modeling & Simulation Engineering Theses & Dissertations

With continuous advancements and adoption of minimally invasive surgery, proficiency with nontrivial surgical skills involved is becoming a greater concern. Consequently, the use of surgical simulation has been increasingly embraced by many for training and skill transfer purposes. Some systems utilize haptic feedback within a high-fidelity anatomically-correct virtual environment whereas others use manikins, synthetic components, or box trainers to mimic primary components of a corresponding procedure.

Surgical simulation development for some minimally invasive procedures is still, however, suboptimal or otherwise embryonic. This is true for the Nuss procedure, which is a minimally invasive surgery for correcting pectus excavatum (PE) – …

Computational Methods For Nonlinear Systems Analysis With Applications In Mathematics And Engineering, Geoffrey Kenneth Rose

Mechanical & Aerospace Engineering Theses & Dissertations

An investigation into current methods and new approaches for solving systems of nonlinear equations was performed. Nontraditional methods for implementing arc-length type solvers were developed in search of a more robust capability for solving general systems of nonlinear algebraic equations. Processes for construction of parameterized curves representing the many possible solutions to systems of equations versus finding single or point solutions were established. A procedure based on these methods was then developed to identify static equilibrium states for solutions to multi-body-dynamic systems. This methodology provided for a pictorial of the overall solution to a given system, which demonstrated the possibility …

Emergency Diesel-Electric Generator Set Maintenance And Test Periodicity, Stephen John Fehr

Engineering Management & Systems Engineering Theses & Dissertations

Manufacturer and industry recommendations vary considerably for maintenance and tests of emergency diesel-electric generator sets in emergency standby duty. There is little consistency among generator sets of similar technology, and manufacturers and their representatives often provide contradictory guidance. As a result, periodicity of emergency diesel-electric generator set maintenance and tests varies considerably in practice. Utilizing the framework proposed and tested by Fehr (2014), this research developed a parametric regression survival model of the reliability of modern diesel-electric generator sets in emergency standby duty as a function of maintenance, age, and cumulative run hours. A survival regression technique leveraging Cox’s (1972) …

Quantifying Pollutant Removal Rates Of Bioretention Basins As A Stormwater Best Management Practice, Evan Nathanial Waagen

Civil & Environmental Engineering Theses & Dissertations

Water pollution is an ongoing problem that can be attributed to human activities. As world population increases and countries become more developed, this problem intensifies. Fortunately, the causes and solutions of water pollution are documented and have been implemented with various levels of success. These solutions, or Best Management Practices (BMPs), vary in type and function and remove pollutants from runoff prior to it reaching rivers, lakes, and other bodies of water. This study investigates bioretention basins, a specific group of BMPs, and presents analysis and prediction of their performance, of which our knowledge is incomplete in the existing literature. …

Development Of A Data Acquisition System For Unmanned Aerial Vehicle (Uav) System Identification, Donald Joseph Lear

Mechanical & Aerospace Engineering Theses & Dissertations

Aircraft system identification techniques are developed for fixed wing Unmanned Aerial Vehicles (UAV). The use of a designed flight experiment with measured system inputs/outputs can be used to derive aircraft stability derivatives. This project set out to develop a methodology to support an experiment to model pitch damping in the longitudinal short-period mode of a UAV. A Central Composite Response Surface Design was formed using angle of attack and power levels as factors to test for the pitching moment coefficient response induced by a multistep pitching maneuver.

Selecting a high-quality data acquisition platform was critical to the success of the …

Using Optimality Theory And Reference Points To Improve The Diversity And Convergence Of A Fuzzy-Adaptive Multi-Objective Particle Swarm Optimizer, Amit A. Kulkarni

Mechanical & Aerospace Engineering Theses & Dissertations

Particle Swarm Optimization (PSO) has received increasing attention from the evolutionary optimization research community in the last twenty years. PSO is a metaheuristic approach based on collective intelligence obtained by emulating the swarming behavior of bees. A number of multi-objective variants of the original PSO algorithm that extend its applicability to optimization problems with conflicting objectives have also been developed; these multi-objective PSO (MOPSO) algorithms demonstrate comparable performance to other state-of-the-art metaheuristics. The existence of multiple optimal solutions (Pareto-optimal set) in optimization problems with conflicting objectives is not the only challenge posed to an optimizer, as the latter needs to …

2017 (Fall) Ensi Informer Magazine, Morehead State University. Engineering Sciences Department

ENSI Informer Magazine Archive

The ENSI Informer Magazine published in the fall of 2017.

Understanding The Determinants Affecting The Continuance Intention To Use Cloud Computing, Shailja Tripathi Dr.

Journal of International Technology and Information Management

Cloud computing has been progressively implemented in the organizations. The purpose of the paper is to understand the fundamental factors influencing the senior manager’s continuance intention to use cloud computing in organizations. A conceptual framework was developed by using the Technology Acceptance Model (TAM) as a base theoretical model. A questionnaire was used to collect the data from several companies in IT, manufacturing, finance, pharmaceutical and retail sectors in India. The data analysis was done using structural equation modeling technique. Perceived usefulness and perceived ubiquity are identified as important factors that affect continuance intention to use cloud computing. In addition, …

Table Of Contents Jitim Vol 26 Issue 3, 2017

Journal of International Technology and Information Management

Table of Contents

Eulerian-Based Virtual Visual Sensors To Measure Dynamic Displacements Of Structures, Ali Shariati, Thomas Schumacher

Civil and Environmental Engineering Faculty Publications and Presentations

Vibration measurements provide useful information about a structural system's dynamic characteristics and are used in many fields of science and engineering. Here, we present an alternative noncontact approach to measure dynamic displacements of structural systems using digital videos. The concept is that intensity measured at a pixel with a fixed (or Eulerian) coordinate in a digital video can be regarded as a virtual visual sensor. The pixels in the vicinity of the boundary of a vibrating structural element contain useful frequency information, which we have been able to demonstrate in earlier studies. Our ultimate goal, however, is to be able …

Impact Of Electrospun Conduit Composition And Peritoneal Pre-Conditioning On Patency And Remodeling Of Tissue Engineered Vascular Grafts, Mozhgan Shojaee

Theses and Dissertations

Overall goal of this project was to develop a tissue engineered vascular graft by implanting an electrospun tubular conduit into the peritoneal cavity to recruit autologous cells to it and provide the cells with the components of the hysiological environment prior to grafting the conduit into the artery. This was accomplished through three complimentary studies: finding the best ratio of poly(ε-caprolactone) (PCL) and collagen that improves inflammatory response within the peritoneal cavity; determining the effect of peritoneal pre-implantation and the amount of incorporated collagen on graft functionality; and reducing the potential side effect of peritoneal adhesion formation. In the first …