Engineering Commons^™

Optimization Of Spray Droplet Size For Drug Delivery To The Deep Lung, Renee Worden

Electronic Theses and Dissertations

The lower respiratory regions of the lung boast over 900 million alveoli with a combined 85 m2 of surface area of near direct access to the bloodstream. Within the last century the immense potential of the deep lung as a site for the delivery of drugs has begun to be exploited and today pulmonary delivery of aerosolized therapeutic is commonplace. However, the high inter- and intra-patient variability in dosing is almost completely ignored. Currently, no steps are being taken to mitigate the sources of variability beyond injection into the upper airways. This study seeks to prove that a careful selection …

Method For Determination Of Kinematic Sensor Position And Orientation From Magnetic Resonance Images, Caglar Ozturk

ETD Archive

Concussion and mild traumatic brain injury risk remain high for young athletes participating in helmeted and non-helmeted sports. Because of the short and potential long-term effects on young athletes and early onset Alzheimer's and Parkinson's disease, there is a dire need to correlate a relationship between head impact intensity, frequency, duration and athlete brain health. To address this need, the Cleveland Clinic is developing a custom mouthguard embedded with flexible circuitry and sensors, known as the 'Intelligent Mouthguard'(IMG). To accurately quantify peak values of head impacts or concussions, orientation and position of each sensor relative to CG (Center of Gravity) …

Silver Nanoparticle Removal From Drinking Water: Flocculation/Sedimentation Or Filtration?, Desmond F. Lawler, Anne M. Mikelonis, Ijung Kim, Boris L.T. Lau, Sungmin Youn

All Engineering Faculty Research

Silver nanoparticles are used in a wide variety of consumer products and are therefore rapidly becoming ubiquitous in the natural environment; they can be expected to be found in the natural waters used as drinking water supplies. This research investigated whether such particles could be expected to be removed in conventional water treatment plants such as flocculation and filtration. Both flocculation and granular media filtration experiments with citrate-capped silver nanoparticles were performed at different ionic strengths and in the presence and absence of natural organic matter. The results were generally consistent with theories of particle destabilization that have been developed …

Predictive Modeling Of The Virtual Hemi-Fontan Operation For Second Stage Single Ventricle Palliation: Two Patient-Specific Cases, Ethan Kung, Alessia Baretta, Catriona Baker, Gregory Arbia, Giovanni Biglino, Chiara Corsini, Silvia Schievano, Irene E. Vignon-Clementel, Gabriele Dubini, Giancarlo Pennati, Andrew Taylor, Adam Dorfman, Anthony M. Hlavacek, Alison L. Marsden, Tain-Yen Hsia, Francesco Migliavacca

Publications

Single ventricle hearts are congenital cardiovascular defects in which the heart has only one functional pumping chamber. The treatment for these conditions typically requires a three-staged operative process where Stage 1 is typically achieved by a shunt between the systemic and pulmonary arteries, and Stage 2 by connecting the superior venous return to the pulmonary circulation. Surgically, the Stage 2 circulation can be achieved through a procedure called the Hemi-Fontan, which reconstructs the right atrium and pulmonary artery to allow for an enlarged confluence with the superior vena cava.

Based on pre-operative data obtained from two patients prior to Stage …

A Study Of Designer Familiarity With Product And User During Requirement Elicitation, Beshoy Morkos, Joshua D. Summers

All CEDAR Publications

It is important to recognise the effects of a designer's source of information and decision making during requirements elicitation. Requirements are widely recognised as an important step in the design process. Designers may have perspective based on their experience which results in a level of familiarity with the design. This paper reports on a study that explores the effects of designer familiarity with a project and its user on their ability to elicit requirement specifications. Two familiarity constructs, product and user, are measured as low or high and used to study requirement elicitation with varying familiarity. A high familiarity study …

Examining Student Participation In Three Learning Activities Supported By Social Annotation Tools, Tian Luo, Fei Gao, Kathryn S. Hoff

Visual Communications and Technology Education Faculty Publications

Social annotation (SA) allows learners to highlight and comment on Web pages and share annotations with each other online. Despite its potential in promoting collaborative learning, examining how to integrate it into educational settings has not been fully studied. The purpose of the study is to examine student participation in three different SA-based online activities: (1) peer review, (2) annotated discussion, and (3) collaborative reading. Students participated in all three SA-based activities and took a survey at the end reporting the effectiveness of these activities. The analysis of students’ annotations and their survey responses suggested that although participants perceived the …

Combustion Synthesis And Characterization Of Porous Niti Intermetallic For Structural Application, Jessica Vanterpool

Electronic Theses and Dissertations

This thesis describes experimental investigation of thermal and combustion phenomena as well as structure for self- propagating combustion synthesis of porous Ni - Ti intermetallic aimed for structural biomedical application. The control parameters for the porosity distribution have been investigated experimentally through varying the preheat temperature, initial porosity, initial elemental particle size, and applied pressure during the fabrication process. Ni and Ti elemental powders are mixed using a 1:1 ratio. The mixture is compressed using several different compression forces to produce cylindrical samples of 1.1 cm diameter and 2-3cm length, with initial porosity ranging from 30% to 40%. The samples …

Bridging The Gap Between Fun And Fitness: Instructional Techniques And Real-World Applications For Full-Body Dance Games, Emiko Charbonneau

Electronic Theses and Dissertations

Full-body controlled games offer the opportunity for not only entertainment, but education and exercise as well. Refined gameplay mechanics and content can boost intrinsic motivation and keep people playing over a long period of time, which is desirable for individuals who struggle with maintaining a regular exercise program. Within this gameplay genre, dance rhythm games have proven to be popular with game console owners. Yet, while other types of games utilize story mechanics that keep players engaged for dozens of hours, motion-controlled dance games are just beginning to incorporate these elements. In addition, this control scheme is still young, only …

Learning Hierarchical Representations For Video Analysis Using Deep Learning, Yang Yang

Electronic Theses and Dissertations

With the exponential growth of the digital data, video content analysis (e.g., action, event recognition) has been drawing increasing attention from computer vision researchers. Effective modeling of the objects, scenes, and motions is critical for visual understanding. Recently there has been a growing interest in the bio-inspired deep learning models, which has shown impressive results in speech and object recognition. The deep learning models are formed by the composition of multiple non-linear transformations of the data, with the goal of yielding more abstract and ultimately more useful representations. The advantages of the deep models are three fold: 1) They learn …

Tornadoes In Canada: Improving Our Understanding, David Sills

Goderich August 21 2011 F3 Tornado Associated Files

Environment Canada presentation at ICLR

• What is a tornado?

• How do tornadoes form?

• How are tornadoes rated?

• Where / when do tornadoes occur?

• How does EC provide tornado alerts?

• Are tornadoes in Canada increasing in frequency and/or intensity?

Task Interpretation, Cognitive, And Metacognitive Strategies Of Higher And Lower Performers In An Engineering Design Project: An Exploratory Study Of College Freshmen, Oenardi Lawanto, Deborah Butler, Sylvie Cartier, Harry B. Santoso, Wade H. Goodridge

Engineering Education Faculty Publications

This paper examines the task interpretation and strategy use of higher- and lower-performing college freshmen while engaged in an engineering design project using a self-regulated learning (SRL) framework. Our goals were to consider how students’ interpretation of task demands could be associated with their use of planning, cognitive, and monitoring/fix-up strategies, both as part of the design process and when managing their time, resources and teamwork. The main research question that guided the study was: In what ways did higher- vs. lower-performing students differ when engaged in an engineering design project? With regards to this question, we specifically explored how …

Plants As Bio-Indicators Of Subsurface Conditions: Impact Of Groundwater Level On Btex Concentrations In Trees, Jordan Wilson, Rachel Bartz, Matt Limmer, Joel Gerard Burken

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Numerous Studies Have Demonstrated Trees' Ability to Extract and Translocate Moderately Hydrophobic Contaminants, and Sampling Trees for Compounds Such as BTEX Can Help Delineate Plumes in the Field. However, When BTEX is Detected in the Groundwater, Detection in Nearby Trees is Not as Reliable an Indicator of Subsurface Contamination as Other Compounds Such as Chlorinated Solvents. Aerobic Rhizospheric and Bulk Soil Degradation is a Potential Explanation for the Observed Variability of BTEX in Trees as Compared to Groundwater Concentrations. the Goal of This Study Was to Determine the Effect of Groundwater Level on BTEX Concentrations in Tree Tissue. the Central …

Modeling Of The Resilient Modulus For Recycled Asphalt Pavement Applications In Base Course Layers, Ehab Noureldin, Magdy Abdelrahman

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The resilient modulus (M_R) is an important parameter for the base course layer in the pavement design process. Use of recycled asphalt pavement (RAP) for this layer must take into consideration the effect of various factors that may occur in the field on the M_R. Previous numerical models used for the granular base layer could be used for the RAP. The study reported here examined the suitability of RAP procedures under the effect of different factors (e.g., water content, dry density, freeze-thaw cycles). Various percentages of the RAP (50%, 75%, and 100% by weight) were employed …

Wave Function Solutions By Transformation From The Helmholtz To Laplacian Operator, Jonathan Blackledge, Bazar Babajanov

Articles

The Helmholtz, Schr¨odinger and Klein-Gordon equations all have a similar form (for constant wavelength) and have applications in optics, quantum mechanics and relativistic quantum mechanics, respectively. Central to these applications is the theory of barrier and potential scattering,which, through application of the Green’s function method yields transcendental equations for the scattered wave function thereby requiring approximation methods to be employed. This paper reports on a new approach to solving this problem which is based on transforming the Helmholtz operator to the Laplacian operator and applying a Green’s function solution to the Poisson equation. This approach yields an exact forward and …

Packaged Chalcogenide Microsphere Resonator With High Q-Factor, Pengfei Wang, Ming Ding, Timothy Lee, Ganapathy Senthil Murugan, Lin Bo, Yuliya Semenova, Qiang Wu, Dan Hewak, Gilberto Brambilla, Gerald Farrell

Articles

The fabrication and characterization of a packaged As2S3 microsphere resonator coupled to a tapered fiber using a low refractive index UV-curable polymer are reported. Embedding provides an efficient means to remove the highest order whispering gallery modes in the microsphere resonator, thus cleaning the resonator spectrum. The device photosensitivity, useful for tuning, is still present and useable after the packaging process

The Influence Of Light Beam Convergence On The Stop-Bands Of A One-Dimensional Photonic Crystal, Vladimir A. Tolmachev, Kevin Berwick, Tatiana S. Perova

Articles

The influence of beam convergence on the photonic band-gaps, or stop-bands (SBs), of onedimensional photonic crystals (1D PCs) is investigated. The investigation is based on an analysis of the gap map obtained from reflection spectra, calculated by the transfer matrix method for various angles of light incidence, φ, The calculated data is compared with reflection spectra taken using Fourier Transform Infrared microspectroscopy. It was found that the introduction of the parameter, Δφ to account for the focused light beam, for angles up to 20°, has little effect on the first, or lowest SB and the SBs adjacent to it. However, …

Biomechanics Of Prosthetic Knee Systems : Role Of Dampening And Energy Storage Systems, Hande Argunsah Bayram

ETD Archive

One significant drawback of the commercial passive and microprocessored prosthetic devices, the inability of delivering positive energy when needed, is due to the absence of the knee flexion during stance phase. Moreover, consequences such as circumduction and disturbed gait pattern take place due to the improper energy flow at the knee and the absence of the positive energy delivery during the swing phase. Current generation powered design has solved these problems by delivering the needed energy with heavy battery demanding motors, which increase the mass of the device significantly. Hence, the gait quality of transfemoral amputees has not improved significantly …

Scalp Eeg And Tms Based Electrophysiological Study Of Brain Function Of Motor Control In Aging, Mehmed Satuk Bayram

ETD Archive

Voluntary movements of human body are controlled by the brain through corticomuscular pathways. Although neuromuscular control mechanisms of voluntary movements have been studied extensively, many remain to be learned, especially neuromuscular adaptations related to clinical conditions such as neurological disorders and aging. This research aims at a better understanding of functional connection between the brain and muscle during voluntary motor activities in aging and the extent to which this connection can be changed by training the neuromuscular system. Three research projects were conducted to achieve this aim. The analyses in the first two projects are based on comparisons of non-invasive …

Electrochemical/Electroflotation Process For Dye Wastewater Treatment, Erick Benjamin Butler

ETD Archive

The use of dyes has become very significant across various industries such as textiles, paper, and clothing. The organic chemical composition of dyes is a major concern when discharging wastewater not only into the environment, but also within wastewater treatment plants. Dye effluent consists of high chemical oxygen demand (COD) and also color, components that require treatment before discharge. As a result, federal legislation has required industries that discharge high components in wastewater to undergo treatment within the plants. Within literature, authors have considered various biological, physical, and chemical methods of treating dye wastewater. Recently, electrocoagulation/electroflotation (ECF) has been an …

An In Silico Liver: Model Of Gluconeogenesis, Elie R. Chalhoub

ETD Archive

An in silico liver was developed in attempt to represent the in vivo state of the fasted liver. It featured two conceptual models. The first one represented carbohydrate metabolism of the human liver, which included the heterogeneous nature of the liver by incorporating spatial variation of key enzyme activities. This model was able to predict the overall fluxes in tissue and the effect of high intensity exercise on the various hepatic fluxes. A second model of hepatic metabolism was developed to represent the complex interplay between gluconeogenesis, lipid metabolism, and alcohol metabolism in the fasted rat liver. Biochemical pathways are …

A Robotic Neuro-Musculoskeletal Simulator For Spine Research, Robb W. Colbrunn

ETD Archive

An influential conceptual framework advanced by Panjabi represents the living spine as a complex neuromusculoskeletal system whose biomechanical functioning is rather finely dependent upon the interactions among and between three principal subsystems: the passive musculoskeletal subsystem (osteoligamentous spine plus passive mechanical contributions of the muscles), the active musculoskeletal subsystem (muscles and tendons), and the neural and feedback subsystem (neural control centers and feedback elements such as mechanoreceptors located in the soft tissues) [1]. The interplay between subsystems readily encourages "thought experiments" of how pathologic changes in one subsystem might influence another--for example, prompting one to speculate how painful arthritic changes …

Radial Diffusion Of Florescein Molecules (376 Da) In Canine Bone Tissue, Daniel O'Conor

ETD Archive

No abstract provided.

Lipid Production By Scenedesmus Dimorphus: Comparison Of Extraction Techniques And Effect Of Sodium Nitrate Concentration, Bahareh Kanani

ETD Archive

No abstract provided.

Synthesis And Characterization Of Ph-Responsive Elastin-Like Polypeptides With Different Configurations, Mingjie Tang

ETD Archive

Elastin-like polypeptides (ELP) are environmentally responsive polymers that exhibit phase transition behavior in response to various stimuli such as temperature, pH and irradiation. In this work, we focused on pH-responsive ELPs. It has been shown that pH value, configurations of ELPs, ELP concentration, and salt concentration can impact the phase transition behavior of pH-responsive ELPs. Quantitative models have been developed to engineer various linear ELPs, but there has not been any detailed study for engineering ionizable ELP with non-linear configurations. In this study, we designed, synthesized, and characterized pH-responsive ELPs with two different configurations. One is linear ELP, (GVGVPGEGVPGVGVP)12, and …

Increased Capacity For Vdl Mode 2 Aeronautical Data Communication, Sanjin Đerić

ETD Archive

VDL Mode 2 is the principal data communication technology for aeronautical communications implemented in the NextGen project for the National Airspace System (NAS), with potentially worldwide service. Aeronautical communications have strict transmission delay standards for safety considerations. Meeting the strict standards significantly drops the capacity of the number of aircraft that can communicate using the Very High Frequency (VHF) Data Radio (VDR). In this thesis, three methods of increasing the capacity while maintaining the strict standards are evaluated: transmit power control, load regulation and ground station placement. A simulation model using OPNET software is used for testing. Load regulation shows …

External Control Interface, Dynamic Modeling And Parameter Estimation Of A Research Treadmill, Omer Sirin

ETD Archive

Treadmills providing linear continuous movement are used for robotic testing of prostheses in order to study their operating characteristics. However, traditional exercise treadmills are not able to simulate various conditions such as avoiding an obstacle, climbing, descending, reversing direction, or stopping instantly. The focus of this thesis is to examine control algorithms (position, speed and force) for the drive mechanism of a research treadmill to fulll the gap in the situations described above. The system consists of a power supply, a computer with Matlab, and the treadmill that includes a DC motor, a pulley and belt. Also, an external encoder …

Path Planning And Evolutionary Optimization Of Wheeled Robots, Daljeet Singh

ETD Archive

Probabilistic roadmap methods (PRM) have been a well-known solution for solving motion planning problems where we have a fixed set of start and goal configurations in a workspace. We define a configuration space with static obstacles. We implement PRM to find a feasible path between start and goal for car-like robots. We further extend the concept of path planning by incorporating evolutionary optimization algorithms to tune the PRM parameters. The theory is demonstrated with simulations and experiments. Our results show that there is a significant improvement in the performance metrics of PRM after optimizing the PRM parameters using biogeography-based optimization, …

Physical Layer Watermarking Of Direct Sequence Spread Spectrum Signals, Xiang Li

ETD Archive

Security services and mechanisms in wireless networks have long been studied and developed. However, compared to upper network layers, physical layer security did not play a signicant role in the OSI security model. Thanks to the easier implementation and verication methods brought by the development of software dened radio (SDR) techniques, physical layer security mechanisms have recently drawn increasing interest from researchers. Digital watermarking is one of the popular security techniques that can fully utilize various exclusive characteristics of the physical layer. This thesis proposes a physical layer watermarking technique named Water-marked Direct Sequence Spread Spectrum (DSSS) or WDSSS technique, …

Bench-Top Validation Of "Intelligent" Mouth Guard, Alper Aksu

ETD Archive

Concussion is the signature athletics injury of the 21st Century. Scientists are hard at work monitoring effects of hard impacts on the human brain. However, existing tools and devices are inadequate to screen the effects. Hence, a new approach is required to accurately quantify peak values of head impacts or concussions and relate these values to clinical brain health outcomes. A new head impact dosimeter, the "Intelligent Mouth Guard" (IMG) has been developed and can be conveniently located inside the mouth. In this study, the IMG printed circuit board (PCB) including four (4) high-quality shock resistant sensors has been developed …

Scaffold Composition And Architecture Critically Regulate Extracellular Matrix Synthesis By Cardiomyocytes, Arsela Gishto

ETD Archive

Heart failure accounts for over 5 million cases in the U.S. A major onset of this is myocardial infarction, which causes the myocardium to loose cardiomyocytes and transform into a scar tissue. Given that the adult infarcted cardiac tissue has a limited ability to regenerate, alternative methods to restore the damaged area need to be developed. The goal of these approaches is to design an optimal scaffold that can retain and deliver cardiomyocytes at the site of damaged myocardium. This tissue engineering approach would allow cardiac reconstruction by replacing the lost cardiomyocytes, delivering the required biomolecules, as well as remodeling …