Architecture Commons^™

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Psychosine, The Cytotoxic Sphingolipid That Accumulates In Globoid Cell Leukodystrophy, Alters Membrane Architecture, Jacqueline Hawkins-Salsbury, Archana Parameswar, Xuntian Jiang, Paul Schlesinger, Ernesto Bongarzone, Daniel Ory, Alexei Demchenko, Mark Sands

Chemistry & Biochemistry Faculty Works

Globoid cell leukodystrophy (GLD) is a neurological disease caused by deficiency of the lysosomal enzyme galactosylceramidase (GALC). In the absence of GALC, the cytotoxic glycosphingolipid, psychosine (psy), accumulates in the nervous system. Psychosine accumulation preferentially affects oligodendrocytes, leading to progressive demyelination and infiltration of activated monocytes/macrophages into the CNS. GLD is characterized by motor defects, cognitive deficits, seizures, and death by 2–5 years of age. It has been hypothesized that psychosine accumulation, primarily within lipid rafts, results in the pathogenic cascade in GLD. However, the mechanism of psychosine toxicity has yet to be elucidated. Therefore, we synthesized the enantiomer of …

Psychosine, The Cytotoxic Sphingolipid That Accumulates In Globoid Cell Leukodystrophy, Alters Membrane Architecture, Jacqueline A. Hawkins-Salsbury, Archana R. Parameswar, Xuntian Jiang, Paul H. Schlesinger, Ernesto Bongarzone, Daniel S. Ory, Alexei V. Demchenko, Mark S. Sands

Alexei Demchenko

Walking Box Ranch Custodianship Quarterly Progress Report: Period Ending January 10, 2013, Margaret N. Rees

Walking Box Ranch

• UNLV provides stewardship of Walking Box Ranch (WBR) by providing a caretaker who oversees the property, facilitating use of the property by researchers and educators, developing a use and research policy for the property, and coordinating these activities with BLM and in accordance with TNC restrictions.
• UNLV currently addresses security issues for the property through the presence of the caretaker and two Metro Officers who reside on the property in two recreational vehicles.
• UNLV continues to work with BLM, supplying content for interpretation at the future Walking Box Ranch museum.
• BLM and UNLV visited the ranch on December 5th to …

Walking Box Ranch Planning And Design Quarterly Progress Report: Period Ending January 10, 2013, Margaret N. Rees

Walking Box Ranch

• BLM notified UNLV on Nov 7, 2012 that they had cancelled the WBR solicitation for a general contractor and that they were reconsidering the scope of the project. BLM and UNLV met on Nov. 22, 2012 and BLM updated UNLV on their decision to terminate the task agreement for the field and research station, and to modify plans for interpretation at the future WBR Visitor Center. BLM and UNLV will meet Feb. 7, 2013 to discuss the path forward regarding interpretation and the Visitor’s Center.
• UNLV is continuing to work with direction from Carolyn Shelton, BLM interpreter, to collect interpretive …

La Violencia En Colombia, Fernando Carrión Mena Arq.

Fernando Carrión Mena

Las últimas Navidades colombianas fueron mucho más tranquilas que las del año 2011; al menos, eso dicen las cifras divulgadas por la Policía Nacional de Colombia. Pero también hay una tendencia general en el país que va en la línea de la disminución general de los hechos delictivos. Hubo una reducción cercana al 30% de los homicidios producidos en la temporada navideña, respecto al año pasado. En el caso de Bogotá el descenso fue altamente significativo: el 81%. En cuanto a las riñas que generalmente se producen entre conocidos y familiares, la disminución también fue muy significativa: de 840 riñas …

Obat Aborsi Cytotec Samarinda | 082220219966, Roro Klinik

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Umass Amherst Collections 2013, Ludmilla D. Pavlova-Gillham, Elizabeth R. Dumont

Campus Planning Master Plans

During the Campus Master Planning effort the need to better understand and plan for the UMass Amherst collections was identified and an ad-hoc committee was created to help advance a better understanding of the existing collections and how best to plan for the future. The committee was comprised of Directors/ curators of campus academic collections, Campus Planning staff and other related campus professionals. The first task of the committee was to develop a basis for creating a planning framework for the academic collections. The Committee defined existing collections and set a framework and common language that enabled the classification and …

Campus-Wide Parking Vision Plan, Dennis Swinford, Niels P. La Cour, Vhb

Campus Planning Master Plans

The University of Massachusetts Amherst Parking Vision Plan is a key component of the University of Massachusetts Amherst Campus Master Plan 2012. With the campus in the midst of a $1 billion capital improvement program, the Campus Master Plan looks 40 years into the future, matching academic vision with upgraded facilities to strengthen the sense of community and enhance the campus's beauty. The Parking Vision Plan articulates a parking system vision and guiding principles that support the vision of the Master Plan; it institutes a blueprint for parking-related decisions and policies on the UMass Amherst campus. The report discusses …

University Of Massachusetts Amherst 2012-2021 Capital Improvement Projects, Douglas Vigneau, Juanita Holler, University Of Massachusetts Building Authority, John Mathews, Ludmilla Pavlova-Gillham, Ezra Small

Campus Planning Master Plans

In 2013 the University of Massachusetts, on behalf of the University of Massachusetts Building Authority and Massachusetts Division of Capital Asset Management and Maintenance (DCAMM), submitted an Expanded Environmental Notification Form for the University's 2012 - 2021 Capital Improvement Plan to the Executive Office of Energy and Environmental Affairs (EOEEA) Massachusetts Environmental Policy Act Office (MEPA).

Taken individually, the majority of the Projects, comprising of 13 building/space, 7 site/landscape, and 5 facility/ utility scale improvement projects, do not require MEPA review as most of the Project sites are confined to infill areas on campus that are currently or …

Planning For Campus Collections 2013, Ludmilla D. Pavlova-Gillham, Elizabeth R. Dumont, Dennis Swinford

Campus Planning Reports and Plans

During the Campus Master Planning effort the need to better understand and plan for the UMass Amherst collections was identified and an ad-hoc committee was created to help advance a better understanding of the existing collections and how best to plan for the future. The committee was comprised of Directors/ curators of campus academic collections, Campus Planning staff and other related campus professionals. The first task of the committee was to develop a basis for creating a planning framework for the academic collections. The Committee defined existing collections and set a framework and common language that enabled the classification and …

Umass Amherst Green Building Guidelines 2013, Ludmilla Pavlova-Gillham, Ted Mendoza, Ezra Small, Patricia O'Flaherty, Nariman Mostafavi, Mohamed Farzinmoghadam, Somayeh Tabatabaee Pozveh

Campus Planning Reports and Plans

Facilities & Campus Services, Sustainable UMass and Campus Planning support sustainability and energy conservation initiatives by providing in-house resources to campus staff as well as designers and contractors working with the University. The UMass Amherst Green Building Guidelines provide a framework for approaching new construction and major renovation projects at UMass Amherst that are undergoing LEED certification by focusing the conversation on green building aspects that are most important to the campus. They are intended to be the beginning of a dynamic conversation between designers, environmental consultants and constructors, university stakeholders, and users of new high performance buildings.

Core-House: A Proposal For Re-Inhabiting Underused Buildings, Thom P. Barry

Masters Theses 1911 - February 2014

This thesis is an exploration of how small independent residential units added one at a time can offer old buildings and the cities they are in the opportunity to gradually grow and change – in a way that isn’t presented by the typical double-loaded corridor build-out.

The first component of this exploration is a modular unit that can be brought into existing buildings and assembled in a flexible layout. This House acts as a ‘Core’ that provides basic shelter, warmth, and a place to sleep and prepare food; the density of this unit allows the surrounding square footage to be …

Energy Efficiency Programs At All Utilities: An Analysis Of The Factors That Lead Electric Utilities To Invest In Energy Efficiency, Christopher J. Pletcher

Masters Theses 1911 - February 2014

While the utilization of energy efficiency has grown in recent years, it has not been distributed evenly across the country. In some states, over 2% of a utility’s budget is spent on energy efficiency; in other states that number is 0. Much of the growth in energy efficiency has been due to state policies and the development utility-level energy efficiency programs. Yet, all utility programs are not created equal. Because they are often exempt from state regulation (and therefore state energy efficiency policy), publicly-owned utilities have traditionally lagged behind IOUs when it comes to EE programs.

This research quantifies energy …

Negotiating Postwar Landscape Architecture: The Practice Of Sidney Nichols Shurcliff, Jeffrey Scott Fulford M.D., M.P.H., M.L.A.

Masters Theses 1911 - February 2014

While documentation of the work of a select group of modernist landscape architects of the mid-twentieth century is available, little is known about the professional contributions of transitional landscape architects active in the period following World War II. Using selected projects framed by existing literature covering contemporary social, economic, political, and artistic influences, this study examines the career of one such transitional figure, Sidney Nichols Shurcliff (1906-1981). Project descriptions and analysis measure the scope of Shurcliff's work and the degree to which he contributed to the discipline and its transition to modernism, thereby augmenting the history of landscape architecture practice.

Riverside Brewing Facility: The Sustenance Of Water Allocation, Ryan T. Luczkowiak

Masters Theses 1911 - February 2014

Water is the most vital resource on Earth. We are facing a global water crisis and the time has come to investigate how we can cope with this issue at a local basis. We live in a culture that is facing economic recessions and is striving for a developmental change. In the advancement of our technological age we are looking for new innovative means of development. Our existing infrastructural conditions cannot handle the sort of social shift we are striving for. We have to become sustainable but the most important is the allocation of water. The issue I am addressing …

Of Dirt And Decomposition: Proposing A Place For The Urban Dead, Katrina M. Spade

Masters Theses 1911 - February 2014

The intent of this thesis is to challenge our society’s existing options for the care and processing of the deceased, and to design a space and a ritual which are both deeply meaningful and ecologically beneficial. The community for whom this architecture is designed currently lacks the religious or cultural rituals which would otherwise guide them through the process of laying of their loved ones to rest. For this community, both traditional burial and cremation are devoid of meaning and culturally irrelevant ways of dealing with the deceased, in addition to being unnecessarily wasteful processes. Likewise, the community for which …

A Sustainable Urban Village For The "Six Corners" & "Old Hill" Neighborhoods Of Springfield, Massachusetts, Patricia O'Flaherty

Masters Theses 1911 - February 2014

In the United States, traditional urban centers, particularly in the Northeast, have suffered from neglect, dilapidation, and the general decay of their built environments over the last 50-60 years. Corresponding with this on the social side are increased poverty, unemployment, crime, and the disruption of the family unit.

Our current knowledge of the disciplines of architecture and sustainability can be applied to a built solution that will yield a greater public good. Good design can improve the lives of people by creating homes, neighborhoods, and villages that are comfortable, secure, and sustainable for all of the activities that make life …

Wind Power, Public Power: Evaluating Public Participation In New England Land-Based Wind Development, Gwen M. Miller

Masters Theses 1911 - February 2014

Wind energy is a means of energy production without carbon emissions, facilitating regional and national energy security. While there are currently no offshore wind farms in the United States, there has been growing success in building land-based wind capacity. Within the wind industry, there is a call for a streamlined permitting process, as well as an objective evaluation of current stakeholder processes. Within city and regional planning, the stakeholder process and public participation in general have long been subject to research and discourse, as scholars and practitioners alike seek to identify and typify what exactly makes public participation robust or …