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- Nuclear Medicine & Medical;; Imaging (5)
- Nuclear Medicine & Medical Imaging (4)
- Life Sciences & Biomedicine (2)
- Science & Technology (2)
- X-Ray Computed (2)
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- 18F-fluorodeoxyglucose;; Bone scintigraphy;; F-18;; Fluoride-positron emission tomography;; Gallium;; Infection;; Labeled leukocytes;; Positron emission tomography;; Prosthetic joint (1)
- 80 and over;; Carotid Stenosis/*diagnosis;; Female;; Humans;; Ischemic Attack (1)
- 99mTc-sestamibi;; Mibi;; Parathyroid;; Spect/ct;; filtered back projection;; iterative reconstruction (1)
- ACUTE ISCHEMIC-STROKE;; TISSUE-PLASMINOGEN-ACTIVATOR;; HYPERACUTE;; INTRACEREBRAL HEMORRHAGE;; DIGITAL-SUBTRACTION-ANGIOGRAPHY;; AMERICAN-HEART-ASSOCIATION;; COOPERATIVE ACUTE STROKE;; ACUTE HEMISPHERIC;; STROKE;; CEREBRAL-ARTERY SIGN;; THROMBOLYTIC THERAPY;; CT-ANGIOGRAPHY;; Clinical Neurology;; Neuroimaging;; Radiology (1)
- ANEURYSMAL SUBARACHNOID HEMORRHAGE;; PERFUSION-CT;; CEREBRAL PERFUSION;; ACUTE STROKE;; ANGIOGRAPHY;; PARAMETERS;; VALUES;; Clinical Neurology;; Neuroimaging;; Radiology (1)
- Adolescent;; Adult;; Anisotropy;; Brain Concussion/ diagnosis/pathology;; Case-Control Studies;; Diffusion Tensor Imaging/ methods;; Female;; Glasgow Coma Scale;; Humans;; Image Interpretation (1)
- Adult;; Aged;; Aged (1)
- Adult;; Aged;; Biopsy;; Chi-Square Distribution;; Contrast Media/diagnostic use;; Gadolinium DTPA/diagnostic use;; Humans;; Magnetic Resonance Imaging/*methods;; Male;; Middle Aged;; Population Surveillance;; Predictive Value of Tests;; Prostate-Specific Antigen/blood;; Prostatic Neoplasms/*pathology;; Retrospective Studies;; Sensitivity and Specificity (1)
- Adult;; Blood-Brain Barrier/*radiography;; Cerebral Infarction/*etiology/*radiography;; Female;; Humans;; Male;; Middle Aged;; Permeability;; Retrospective Studies;; Sensitivity and Specificity;; Subarachnoid Hemorrhage/*complications/*radiography;; Tomography (1)
- Algorithms. Blood-Brain Barrier / *radiography. Humans. Models (1)
- Arterial input function;; case-fatality;; acute stroke;; vasospasm;; epidemiology;; impairment;; predictors;; metabolism;; infarct;; rates;; Neurosciences & Neurology;; Radiology (1)
- Asymptomatic Diseases;; Carotid Artery Diseases/complications/ultrasonography;; Carotid Stenosis/complications/*ultrasonography;; Humans;; Plaque (1)
- Atherectomy;; calcification;; cardiovascular intervention;; clinical trial;; coronary;; ELUTING STENT IMPLANTATION;; SPEED ROTATIONAL ATHERECTOMY;; SINGLE-CENTER;; EXPERIENCE;; ANGIOGRAPHIC FOLLOW-UP;; ARTERY-DISEASE;; INTRAVASCULAR;; ULTRASOUND;; BALLOON ANGIOPLASTY;; CLINICAL-OUTCOMES;; COMPLEX LESIONS;; INTERVENTION;; Cardiac & Cardiovascular Systems (1)
- Atherosclerotic/*diagnosis;; Sensitivity and Specificity;; Stroke/*diagnosis;; Tomography (1)
- Atherosclerotic/complications/*ultrasonography;; Risk Assessment;; Stroke/*etiology;; carotid stenosis;; plaque;; risk factor;; stroke;; ultrasound (1)
- Atp7b;; Wilson’s disease;; diagnosis;; metal complex;; positron emission tomography;; radiocopper;; therapy (1)
- Brachiocephalic vein;; EC-IC bypass;; Infratemporal approach;; Internal;; maxillary artery;; CAROTID-ARTERY;; ANEURYSMS;; REVASCULARIZATION;; SURGERY;; VEIN;; DISEASE;; GRAFTS;; FOSSA;; Clinical Neurology;; Surgery (1)
- CHILDREN (1)
- CLINICAL-VALUE (1)
- COMPUTED-TOMOGRAPHY;; OUTCOME MEASURES;; VASOSPASM;; ANGIOGRAPHY;; DEFINITION;; MANAGEMENT;; SURGERY;; Clinical Neurology;; Neuroimaging;; Radiology (1)
- Clinical Neurology (1)
- Cognitive Infected prosthetic joints;; Gallium-68 labeled leukocytes;; Fluorine-18-fluorodeoxyglucose;; Positron emission tomography/computed;; tomography;; total-hip-arthroplasty;; white blood-cells;; positron-emission-tomography;; in-111 labeled leukocyte;; hexamethylpropylene amine oxime;; sulfur;; colloid scintigraphy;; bone-marrow scintigraphy;; fdg-pet;; musculoskeletal;; infection;; periprosthetic infection;; Radiology (1)
- Computed tomography perfusion;; deconvolution;; low-dose;; radiation dose;; safety;; regularization;; tensor total variation;; cerebral-blood-flow;; high-resolution measurement;; tracer bolus passages;; image quality;; acute stroke;; brain;; tomography;; noise;; quantification;; reconstruction;; Computer Science;; Engineering;; Imaging Science & Photographic;; Technology;; Radiology (1)
- Computer-Assisted / *methods. Signal-To-Noise Ratio. Stroke / *radiography. Tomography (1)
- Computer-Assisted;; Male;; Middle Aged;; Nerve Fibers (1)
Articles 31 - 60 of 64
Full-Text Articles in Radiology
Type Vi Choledochal Cyst—An Unusual Presentation Of Jaundice, L. Nambiar, E. Siskind, A. W. Shen, C. Fan, G. Grimaldi, C. Choy, J. Madariaga, J. Nicastro, E. P. Molmenti, G. Coppa, +1 Additional Author
Type Vi Choledochal Cyst—An Unusual Presentation Of Jaundice, L. Nambiar, E. Siskind, A. W. Shen, C. Fan, G. Grimaldi, C. Choy, J. Madariaga, J. Nicastro, E. P. Molmenti, G. Coppa, +1 Additional Author
Journal Articles
No abstract provided.
Radioresistance Of Brain Tumors, K. Kelley, J. Knisely, M. Symons, R. Ruggieri
Radioresistance Of Brain Tumors, K. Kelley, J. Knisely, M. Symons, R. Ruggieri
Journal Articles
Radiation therapy (RT) is frequently used as part of the standard of care treatment of the majority of brain tumors. The efficacy of RT is limited by radioresistance and by normal tissue radiation tolerance. This is highlighted in pediatric brain tumors where the use of radiation is limited by the excessive toxicity to the developing brain. For these reasons, radiosensitization of tumor cells would be beneficial. In this review, we focus on radioresistance mechanisms intrinsic to tumor cells. We also evaluate existing approaches to induce radiosensitization and explore future avenues of investigation.
Deformable Image Registration And Interobserver Variation In Contour Propagation For Radiation Therapy Planning., A. C. Riegel, J. G. Antone, H. Zhang, P. Jain, J. Raince, A. Rea, A. M. Bergamo, A. Kapur, L. Potters
Deformable Image Registration And Interobserver Variation In Contour Propagation For Radiation Therapy Planning., A. C. Riegel, J. G. Antone, H. Zhang, P. Jain, J. Raince, A. Rea, A. M. Bergamo, A. Kapur, L. Potters
Journal Articles
Deformable image registration (DIR) and interobserver variation inevitably intro-duce uncertainty into the treatment planning process. The purpose of the current work was to measure deformable image registration (DIR) errors and interobserver variability for regions of interest (ROIs) in the head and neck and pelvic regions. Measured uncertainties were combined to examine planning margin adequacy for contours propagated for adaptive therapy and to assess the trade-off of DIR and interobserver uncertainty in atlas-based automatic segmentation. Two experi-enced dosimetrists retrospectively contoured brainstem, spinal cord, anterior oral cavity, larynx, right and left parotids, optic nerves, and eyes on the planning CT (CT1) and …
Presurgical Ct Evaluation Of Congenital Aural Atresia, V. T. Nguyen, G. Paek, J. Hu, L. P. Smith
Presurgical Ct Evaluation Of Congenital Aural Atresia, V. T. Nguyen, G. Paek, J. Hu, L. P. Smith
Journal Articles
Congenital aural atresia occurs in approximately 1 in 10,000‐20,000 births and may be surgically repaired if the middle ear malformation is limited in character. External auditory canal atresia is difficult to repair surgically, with significant risks and complications. Surgical candidacy in congenital aural atresia is based on multiple factors, central to which are the anatomy of the temporal bone and audiometric findings. High-resolution multidetector CT is the imaging technique of choice for anatomy delineation, although there are some specific indications for MR imaging in presurgical assessment. Various CT grading systems have been developed to determine surgical candidacy and are described …
Fdg-Pet-Positive Lower-Extremity Sebaceous-Gland Carcinoma In A Patient With Muir-Torre Syndrome, B. Kviatkovsky, E. Landau, M. Siddique, S. Hossri, A. Ebaee, J.P. Attalah, A. Picon, A. Brenner
Fdg-Pet-Positive Lower-Extremity Sebaceous-Gland Carcinoma In A Patient With Muir-Torre Syndrome, B. Kviatkovsky, E. Landau, M. Siddique, S. Hossri, A. Ebaee, J.P. Attalah, A. Picon, A. Brenner
Journal Articles
Sebaceous-gland carcinoma can occur alone or as one of the defining features of the Muir-Torre syndrome. Cases occurring below the head and neck are extremely rare. Here we describe the case of a 70-year-old male with Muir-Torre syndrome who had a recurrent sebaceous-gland carcinoma in the left lower extremity that demonstrated 18F-FDG avidity. An 18F-FDG-avid lower-extremity sebaceous-gland carcinoma has not been previously reported.
Evaluating Ct Perfusion Deficits In Global Cerebral Edema After Aneurysmal Subarachnoid Hemorrhage, H. Baradaran, V. Fodera, D. Mir, K. Kesavobhotla, J. Ivanidze, U. Ozbek, A. Gupta, J. Claassen, P. C. Sanelli
Evaluating Ct Perfusion Deficits In Global Cerebral Edema After Aneurysmal Subarachnoid Hemorrhage, H. Baradaran, V. Fodera, D. Mir, K. Kesavobhotla, J. Ivanidze, U. Ozbek, A. Gupta, J. Claassen, P. C. Sanelli
Journal Articles
BACKGROUND AND PURPOSE: Global cerebral edema is an independent predictor of mortality and poor outcomes after aneurysmal SAH. Global cerebral edema, a complex disease process, is thought to be associated with an altered cerebral autoregulatory response. We studied the association between cerebral hemodynamics and early global cerebral edema by using CTP. MATERIALS AND METHODS: We retrospectively studied consecutive patients with aneurysmal SAH with admission CTP performed at days 0-3. Two neuroradiologists classified global cerebral edema and hydrocephalus on NCCT performed concurrently with CTP. Global cerebral edema was defined as diffuse effacement of the sulci and/or basal cisterns or diffuse disruption …
Robust Low-Dose Ct Perfusion Deconvolution Via Tensor Total-Variation Regularization, R. G. Fang, S. T. Zhang, T. H. Chen, P. C. Sanelli
Robust Low-Dose Ct Perfusion Deconvolution Via Tensor Total-Variation Regularization, R. G. Fang, S. T. Zhang, T. H. Chen, P. C. Sanelli
Journal Articles
Acute brain diseases such as acute strokes and transit ischemic attacks are the leading causes of mortality and morbidity worldwide, responsible for 9% of total death every year. "Time is brain" is a widely accepted concept in acute cerebrovascular disease treatment. Efficient and accurate computational framework for hemodynamic parameters estimation can save critical time for thrombolytic therapy. Meanwhile the high level of accumulated radiation dosage due to continuous image acquisition in CT perfusion (CTP) raised concerns on patient safety and public health. However, low-radiation leads to increased noise and artifacts which require more sophisticated and time-consuming algorithms for robust estimation. …
Sparsity Techniques In Medical Imaging, R. Fang, T. Chen, D. Metaxas, P. Sanelli, S. Zhang
Sparsity Techniques In Medical Imaging, R. Fang, T. Chen, D. Metaxas, P. Sanelli, S. Zhang
Journal Articles
No abstract provided.
Plaque Echolucency And Stroke Risk In Asymptomatic Carotid Stenosis: A Systematic Review And Meta-Analysis, A. Gupta, K. Kesavabhotla, H. Baradaran, H. Kamel, A. Pandya, A. E. Giambrone, E. E. Mtui, J. S. Suri, P. C. Sanelli, A. I. Mushlin, +2 Additional Authors
Plaque Echolucency And Stroke Risk In Asymptomatic Carotid Stenosis: A Systematic Review And Meta-Analysis, A. Gupta, K. Kesavabhotla, H. Baradaran, H. Kamel, A. Pandya, A. E. Giambrone, E. E. Mtui, J. S. Suri, P. C. Sanelli, A. I. Mushlin, +2 Additional Authors
Journal Articles
BACKGROUND AND PURPOSE: Ultrasonographic plaque echolucency has been studied as a stroke risk marker in carotid atherosclerotic disease. We performed a systematic review and meta-analysis to summarize the association between ultrasound-determined carotid plaque echolucency and future ipsilateral stroke risk. METHODS: We searched the medical literature for studies evaluating the association between carotid plaque echolucency and future stroke in asymptomatic patients. We included prospective observational studies with stroke outcome ascertainment after baseline carotid plaque echolucency assessment. We performed a meta-analysis and assessed study heterogeneity and publication bias. We also performed subgroup analyses limited to patients with stenosis >/=50%, studies in which …
Neutrophil Trafficking In Pulmonary Inflammation: Monitoring Migration And Blockade With 111in-Labeled Leukocytes, C. Palestro, H. M. Linge, K. J. Nichols, K. Ochani, K. Bhargava, E. J. Miller
Neutrophil Trafficking In Pulmonary Inflammation: Monitoring Migration And Blockade With 111in-Labeled Leukocytes, C. Palestro, H. M. Linge, K. J. Nichols, K. Ochani, K. Bhargava, E. J. Miller
Journal Articles
No abstract provided.
Effect Of Reconstruction Algorithms On The Accuracy Of (99m)Tc Sestamibi Spect/Ct Parathyroid Imaging, K. J. Nichols, G. G. Tronco, C. J. Palestro
Effect Of Reconstruction Algorithms On The Accuracy Of (99m)Tc Sestamibi Spect/Ct Parathyroid Imaging, K. J. Nichols, G. G. Tronco, C. J. Palestro
Journal Articles
The superiority of SPECT/CT over SPECT for (99m)Tc-sestamibi parathyroid imaging often is assumed to be due to improved lesion localization provided by the anatomic component (computed tomography) of the examination. It also is possible that this superiority may be related to the algorithms used for SPECT data reconstruction. The objective of this investigation was to determine the effect of SPECT reconstruction algorithms on the accuracy of MIBI SPECT/CT parathyroid imaging. We retrospectively analyzed preoperative MIBI SPECT/CT parathyroid imaging studies performed on 106 patients. SPECT data were reconstructed by filtered back projection (FBP) and by iterative reconstruction with corrections for collimator …
Carotid Artery Stenosis: Cost-Effectiveness Of Assessment Of Cerebrovascular Reserve To Guide Treatment Of Asymptomatic Patients, A. Pandya, A. Gupta, H. Kamel, B. B. Navi, P. C. Sanelli, B. R. Schackman
Carotid Artery Stenosis: Cost-Effectiveness Of Assessment Of Cerebrovascular Reserve To Guide Treatment Of Asymptomatic Patients, A. Pandya, A. Gupta, H. Kamel, B. B. Navi, P. C. Sanelli, B. R. Schackman
Journal Articles
PURPOSE: To project and compare the lifetime health benefits, health care costs, and incremental cost-effectiveness of a decision rule based on assessment of cerebrovascular reserve (CVR) compared with medical therapy and immediate revascularization in asymptomatic patients with carotid artery stenosis for prevention of stroke. MATERIALS AND METHODS: The three strategies compared included immediate revascularization (carotid endarterectomy) and ongoing medical therapy (with antiplatelet, statin, and antihypertensive agents plus lifestyle modification), medical therapy-based treatment with revascularization only for patients who progressed, and use of a CVR-based decision rule for treatment in which patients with CVR impairment undergo immediate revascularization and all others …
Radionuclide Imaging: Past, Present And Future Outlook In The Diagnosis Of Infected Prosthetic Joints, L. Brammen, C. Palestro, H. Sinzinger
Radionuclide Imaging: Past, Present And Future Outlook In The Diagnosis Of Infected Prosthetic Joints, L. Brammen, C. Palestro, H. Sinzinger
Journal Articles
Objective: A serious complication of joint replacement surgery is infection, which results in prolonged invalidity as well as removal and subsequent re-implantation after lengthy antibiotic therapy. In terms of diagnostic imaging, nuclear medicine has presented several tracers and imaging modalities over the years to be used in prosthetic joint infection. The PubMed/MEDLINE literature database was systematically examined for publications on infection, arthroplasty, joint replacement, prosthetic joint, gallium, labeled leukocytes, sulfur colloid, antimicrobial peptides, Fluorine-18-fluorodeoxyglucose (F-18-FDG), positron emission tomography/computed tomography (PET-CT), and single-photon emission (SPET-CT). This was determined to be a comprehensive review, not a meta-analysis of prosthetic joint infection and …
Detection Of Symptomatic Carotid Plaque Using Source Data From Mr And Ct Angiography: A Correlative Study, A. Gupta, H. Baradaran, E. E. Mtui, H. Kamel, A. Pandya, A. Giambrone, C. Iadecola, P. C. Sanelli
Detection Of Symptomatic Carotid Plaque Using Source Data From Mr And Ct Angiography: A Correlative Study, A. Gupta, H. Baradaran, E. E. Mtui, H. Kamel, A. Pandya, A. Giambrone, C. Iadecola, P. C. Sanelli
Journal Articles
BACKGROUND: Carotid plaque MRI has been a useful method to characterize vulnerable atherosclerotic plaque elements. Recent investigations have suggested that source images from CT angiography (CTA) and MR angiography (MRA) can identify the simple high-risk features of symptom-producing carotid artery plaque. We studied the correlation and relative diagnostic accuracies of CTA and MRA source images in detecting symptomatic carotid artery plaque. METHODS: Subjects were eligible if they had carotid stenosis between 50 and 99% and had MRA and CTA exams performed within 10 days of one another. We measured the soft (non-calcified) plaque and hard (calcified) plaque thickness on CTA …
Evaluating Blood-Brain Barrier Permeability In Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage, J. Ivanidze, K. Kesavabhotla, O. N. Kallas, D. Mir, H. Baradaran, A. Gupta, A. Z. Segal, J. Claassen, P. C. Sanelli
Evaluating Blood-Brain Barrier Permeability In Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage, J. Ivanidze, K. Kesavabhotla, O. N. Kallas, D. Mir, H. Baradaran, A. Gupta, A. Z. Segal, J. Claassen, P. C. Sanelli
Journal Articles
BACKGROUND AND PURPOSE: Patients with SAH are at increased risk of delayed infarction. Early detection and treatment of delayed infarction remain challenging. We assessed blood-brain barrier permeability, measured as permeability surface area product, by using CTP in patients with SAH with delayed infarction. MATERIALS AND METHODS: We performed a retrospective study of patients with SAH with delayed infarction on follow-up NCCT. CTP was performed before the development of delayed infarction. CTP data were postprocessed into permeability surface area product, CBF, and MTT maps. Coregistration was performed to align the infarcted region on the follow-up NCCT with the corresponding location on …
Emphysematous Pyelonephritis, N. Kim, S. Machnicki
Emphysematous Pyelonephritis, N. Kim, S. Machnicki
Journal Articles
No abstract provided.
Comparison Of Multiparametric Mri Scoring Systems And The Impact On Cancer Detection In Patients Undergoing Mr Us Fusion Guided Prostate Biopsies, A. R. Rastinehad, N. Waingankar, B. Turkbey, O. Yaskiv, A. M. Sonstegard, M. Fakhoury, C. A. Olsson, D. N. Siegel, P. L. Choyke, E. Ben-Levi, R. Villani
Comparison Of Multiparametric Mri Scoring Systems And The Impact On Cancer Detection In Patients Undergoing Mr Us Fusion Guided Prostate Biopsies, A. R. Rastinehad, N. Waingankar, B. Turkbey, O. Yaskiv, A. M. Sonstegard, M. Fakhoury, C. A. Olsson, D. N. Siegel, P. L. Choyke, E. Ben-Levi, R. Villani
Journal Articles
INTRODUCTION: Multiple scoring systems have been proposed for prostate MRI reporting. We sought to review the clinical impact of the new Prostate Imaging Reporting and Data System v2 (PI-RADS) and compare those results to our proposed Simplified Qualitative System (SQS) score with respect to detection of prostate cancers and clinically significant prostate cancers. METHODS: All patients who underwent multiparametric prostate MRI (mpMRI) had their images interpreted using PI-RADS v1 and SQS score. PI-RADS v2 was calculated from prospectively collected data points. Patients with positive mpMRIs were then referred by their urologists for enrollment in an IRB-approved prospective phase III trial …
Internal Maxillary Artery-Middle Cerebral Artery Bypass: Infratemporal Approach For Subcranial-Intracranial (Sc-Ic) Bypass, E. Nossek, P. Costantino, M. Eisenberg, A. R. Dehdashti, A. Setton, D. J. Chalif, R. A. Ortiz, D. J. Langer
Internal Maxillary Artery-Middle Cerebral Artery Bypass: Infratemporal Approach For Subcranial-Intracranial (Sc-Ic) Bypass, E. Nossek, P. Costantino, M. Eisenberg, A. R. Dehdashti, A. Setton, D. J. Chalif, R. A. Ortiz, D. J. Langer
Journal Articles
BACKGROUND:Internal maxillary artery (IMax)-middle cerebral artery (MCA) bypass has been recently described as an alternative to cervical extracranial-intracranial bypass. This technique uses a keyhole craniectomy in the temporal fossa that requires a technically challenging end-to-side anastomosis.OBJECTIVE:To describe a lateral subtemporal craniectomy of the middle cranial fossa floor to facilitate wide exposure of the IMax to facilitate bypass.METHODS:Orbitozygomatic osteotomy is used followed by frontotemporal craniotomy and subsequently laterotemporal fossa craniectomy, reaching its medial border at a virtual line connecting the foramen rotundum and foramen ovale. The IMax was identified by using established anatomic landmarks, neuronavigation, and micro Doppler probe (Mizuho Inc. …
Pivotal Trial To Evaluate The Safety And Efficacy Of The Orbital Atherectomy System In Treating De Novo, Severely Calcified Coronary Lesions (Orbit Ii), J. W. Chambers, R. L. Feldman, S. I. Himmelstein, R. Bhatheja, A. E. Villa, K. C. Patel, J. A. Puma, P. Makam, B. D. Bertolet, G. Y. Nseir, +10 Additional Authors
Pivotal Trial To Evaluate The Safety And Efficacy Of The Orbital Atherectomy System In Treating De Novo, Severely Calcified Coronary Lesions (Orbit Ii), J. W. Chambers, R. L. Feldman, S. I. Himmelstein, R. Bhatheja, A. E. Villa, K. C. Patel, J. A. Puma, P. Makam, B. D. Bertolet, G. Y. Nseir, +10 Additional Authors
Journal Articles
Objectives The ORBIT II (Evaluate the Safety and Efficacy of OAS in Treating Severely Calcified Coronary Lesions) trial evaluated the safety and efficacy of the coronary Orbital Atherectomy System (OAS) to prepare de novo, severely calcified coronary lesions for stent placement. Background Despite advances in interventional techniques, treatment of calcified coronary lesions remains a challenge. Stent placement in these lesions may result in stent underexpansion, malapposition, and procedural complications. Methods ORBIT II is a prospective, multicenter, nonblinded clinical trial that enrolled 443 consecutive patients with severely calcified coronary lesions at 49 U.S. sites from May 25, 2010, to November 26, …
Diagnosis Of Abnormal Biliary Copper Excretion By Positron Emission Tomography With Targeting Of (64)Copper-Asialofetuin Complex In Lec Rat Model Of Wilson's Disease, R. Bahde, S. Kapoor, K. K. Bhargava, C. J. Palestro, S. Gupta
Diagnosis Of Abnormal Biliary Copper Excretion By Positron Emission Tomography With Targeting Of (64)Copper-Asialofetuin Complex In Lec Rat Model Of Wilson's Disease, R. Bahde, S. Kapoor, K. K. Bhargava, C. J. Palestro, S. Gupta
Journal Articles
Identification by molecular imaging of key processes in handling of transition state metals, such as copper (Cu), will be of considerable clinical value. For instance, the ability to diagnose Wilson's disease with molecular imaging by identifying copper excretion in an ATP7B-dependent manner will be very significant. To develop highly effective diagnostic approaches, we hypothesized that targeting of radiocopper via the asialoglycoprotein receptor will be appropriate for positron emission tomography, and examined this approach in a rat model of Wilson's disease. After complexing (64)Cu to asialofetuin we studied handling of this complex compared with (64)Cu in healthy LEA rats and diseased …
Improving Low-Dose Blood-Brain Barrier Permeability Quantification Using Sparse High-Dose Induced Prior For Patlak Model, R. Fang, K. Karlsson, T. Chen, P. C. Sanelli
Improving Low-Dose Blood-Brain Barrier Permeability Quantification Using Sparse High-Dose Induced Prior For Patlak Model, R. Fang, K. Karlsson, T. Chen, P. C. Sanelli
Journal Articles
Blood-brain barrier permeability (BBBP) measurements extracted from the perfusion computed tomography (PCT) using the Patlak model can be a valuable indicator to predict hemorrhagic transformation in patients with acute stroke. Unfortunately, the standard Patlak model based PCT requires excessive radiation exposure, which raised attention on radiation safety. Minimizing radiation dose is of high value in clinical practice but can degrade the image quality due to the introduced severe noise. The purpose of this work is to construct high quality BBBP maps from low-dose PCT data by using the brain structural similarity between different individuals and the relations between the high- …
White Matter Involvement In Chronic Musculoskeletal Pain, G. Lieberman, M. Shpaner, R. Watts, T. Andrews, C. G. Filippi, M. Davis, M. R. Naylor
White Matter Involvement In Chronic Musculoskeletal Pain, G. Lieberman, M. Shpaner, R. Watts, T. Andrews, C. G. Filippi, M. Davis, M. R. Naylor
Journal Articles
There is emerging evidence that chronic musculoskeletal pain is associated with anatomic and functional abnormalities in gray matter. However, little research has investigated the relationship between chronic musculoskeletal pain and white matter. In this study, we used whole-brain tract-based spatial statistics and region-of-interest analyses of diffusion tensor imaging data to demonstrate that patients with chronic musculoskeletal pain exhibit several abnormal metrics of white matter integrity compared with healthy controls. Chronic musculoskeletal pain was associated with lower fractional anisotropy in the splenium of the corpus callosum and the left cingulum adjacent to the hippocampus. Patients also had higher radial diffusivity in …
Combined Pulmonary Venous Thromboembolism And Renal Artery Thrombosis In A Patient With Non-Small Cell Lung Cancer, G. Mavani, S. Machnicki, R. Lavie
Combined Pulmonary Venous Thromboembolism And Renal Artery Thrombosis In A Patient With Non-Small Cell Lung Cancer, G. Mavani, S. Machnicki, R. Lavie
Journal Articles
No abstract provided.
Ct Perfusion For Detection Of Delayed Cerebral Ischemia In Aneurysmal Subarachnoid Hemorrhage: A Systematic Review And Meta-Analysis, D. I. A. Mir, A. Gupta, A. Dunning, L. Puchi, C. L. Robinson, H. A. B. Epstein, P. C. Sanelli
Ct Perfusion For Detection Of Delayed Cerebral Ischemia In Aneurysmal Subarachnoid Hemorrhage: A Systematic Review And Meta-Analysis, D. I. A. Mir, A. Gupta, A. Dunning, L. Puchi, C. L. Robinson, H. A. B. Epstein, P. C. Sanelli
Journal Articles
BACKGROUND AND PURPOSE: Delayed cerebral ischemia is a significant cause of morbidity and mortality after aneurysmal SAH, leading to poor outcomes. The purpose of this study was to evaluate the usefulness of CTP in determining delayed cerebral ischemia in patients with aneurysmal SAH. MATERIALS AND METHODS: We conducted a systematic review evaluating studies that assessed CTP in patients with aneurysmal SAH for determining delayed cerebral ischemia. Studies using any of the following definitions of delayed cerebral ischemia were included in the systematic review: 1) new onset of clinical deterioration, 2) cerebral infarction identified on follow-up CT or MR imaging, and …
Does The Location Of The Arterial Input Function Affect Quantitative Ctp In Patients With Vasospasm?, B. J. Shin, N. Anumula, S. Hurtado-Rua, P. Masi, R. Campbell, R. Spandorfer, A. Ferrone, T. Caruso, A. Gupta, P. C. Sanelli, +2 Additional Authors
Does The Location Of The Arterial Input Function Affect Quantitative Ctp In Patients With Vasospasm?, B. J. Shin, N. Anumula, S. Hurtado-Rua, P. Masi, R. Campbell, R. Spandorfer, A. Ferrone, T. Caruso, A. Gupta, P. C. Sanelli, +2 Additional Authors
Journal Articles
BACKGROUND AND PURPOSE: In recent years, there has been increasing use of CTP imaging in patients with aneurysmal SAH to evaluate for vasospasm. Given the critical role of the arterial input function for generation of accurate CTP data, several studies have evaluated the effect of varying the arterial input function location in patients with acute stroke. Our aim was to determine the effect on quantitative CTP data when the arterial input function location is distal to significant vasospasm in patients with aneurysmal SAH. MATERIALS AND METHODS: A retrospective study was conducted of patients with aneurysmal SAH admitted from 2005 to …
Nuclear Medicine And The Failed Joint Replacement: Past, Present, And Future, C. J. Palestro
Nuclear Medicine And The Failed Joint Replacement: Past, Present, And Future, C. J. Palestro
Journal Articles
Soon after the introduction of the modern prosthetic joint, it was recognized that radionuclide imaging provides useful information about these devices. The bone scan was used extensively to identify causes of prosthetic joint failure. It became apparent, however, that although sensitive, regardless of how the images were analyzed or how it was performed, the test was not specific and could not distinguish among the causes of prosthetic failure. Advances in anatomic imaging, notably cross sectional modalities, have facilitated the diagnosis of many, if not most, causes of prosthetic failure, with the important exception of infection. This has led to a …
Imaging And Treatment Of Patients With Acute Stroke: An Evidence-Based Review, P. C. Sanelli, J. B. Sykes, A. L. Ford, J. M. Lee, K. D. Vo, D. K. Hallam
Imaging And Treatment Of Patients With Acute Stroke: An Evidence-Based Review, P. C. Sanelli, J. B. Sykes, A. L. Ford, J. M. Lee, K. D. Vo, D. K. Hallam
Journal Articles
Evidence-based medicine has emerged as a valuable tool to guide clinical decision-making, by summarizing the best possible evidence for both diagnostic and treatment strategies. Imaging plays a critical role in the evaluation and treatment of patients with acute ischemic stroke, especially those who are being considered for thrombolytic or endovascular therapy. Time from stroke-symptom onset to treatment is a strong predictor of long-term functional outcome after stroke. Therefore, imaging and treatment decisions must occur rapidly in this setting, while minimizing unnecessary delays in treatment. The aim of this review was to summarize the best available evidence for the diagnostic and …
Delayed Cerebral Ischemia In Aneurysmal Subarachnoid Hemorrhage: Proposal Of An Evidence-Based Combined Clinical And Imaging Reference Standard, P. C. Sanelli, S. Kishore, A. Gupta, H. Mangat, A. Rosengart, H. Kamel, A. Segal
Delayed Cerebral Ischemia In Aneurysmal Subarachnoid Hemorrhage: Proposal Of An Evidence-Based Combined Clinical And Imaging Reference Standard, P. C. Sanelli, S. Kishore, A. Gupta, H. Mangat, A. Rosengart, H. Kamel, A. Segal
Journal Articles
Aneurysmal subarachnoid hemorrhage is associated with high morbidity and mortality, with delayed neurologic deficits from delayed cerebral ischemia contributing to a large portion of the adverse outcomes in this patient population. There is currently no consensus reference standard for establishing the diagnosis of delayed cerebral ischemia either in the research or clinical settings, ultimately limiting strategies for preventing delayed infarction and permanent neurologic deficits. There are currently both clinical and imaging-based criteria for the diagnosis of delayed neurologic deficits and vasospasm, respectively, however, neither clinical nor angiographic assessment alone has been shown to identify patients who develop adverse outcomes from …
Mirror Image Artifact Mimicking Heterotopic Pregnancy On Transvaginal Ultrasound: Case Series, R. Malhotra, R. M. Bramante, M. Radomski, M. Nelson
Mirror Image Artifact Mimicking Heterotopic Pregnancy On Transvaginal Ultrasound: Case Series, R. Malhotra, R. M. Bramante, M. Radomski, M. Nelson
Journal Articles
Vaginal bleeding in early pregnancy is a common emergency department complaint. Point-of-care ultrasound is a useful tool to evaluate for intrauterine ectopic pregnancy. Emergency physicians performing these studies need to be cognizant of artifacts produced by ultrasound technology, as they can lead to misdiagnosis. We present two cases where mirror-image artifacts initially led to a concern for heterotopic pregnancies but were excluded on further imaging.
Appropriate Use Of Ct Perfusion Following Aneurysmal Subarachnoid Hemorrhage: A Bayesian Analysis Approach, R. P. Killeen, A. Gupta, H. Delaney, C. E. Johnson, A. J. Tsiouris, M. E. Fink, H. S. Mangat, A. Z. Segal, A. I. Mushlin, P. C. Sanelli, +1 Additional Author
Appropriate Use Of Ct Perfusion Following Aneurysmal Subarachnoid Hemorrhage: A Bayesian Analysis Approach, R. P. Killeen, A. Gupta, H. Delaney, C. E. Johnson, A. J. Tsiouris, M. E. Fink, H. S. Mangat, A. Z. Segal, A. I. Mushlin, P. C. Sanelli, +1 Additional Author
Journal Articles
These investigators evaluated the test characteristics of CTP in patients with SAH for detection of delayed cerebral ischemia. Ninety-seven patients were assessed with CTP for ischemia and with DSA for vasospasm. The authors concluded that positive CTP findings identified patients who should be carefully considered for induced hypertension, hypervolemia, and hemodilution and/or intra-arterial therapy while negative CTP findings are useful in guiding a no-treatment decision. BACKGROUND AND PURPOSE: In recent years CTP has been used as a complementary diagnostic tool in the evaluation of delayed cerebral ischemia and vasospasm. Our aim was to determine the test characteristics of CTP for …