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Zucker School of Medicine at Hofstra/Northwell
Atp7b;; Wilson’s disease;; diagnosis;; metal complex;; positron emission tomography;; radiocopper;; therapy
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Full-Text Articles in Radiology
Diagnosis Of Abnormal Biliary Copper Excretion By Positron Emission Tomography With Targeting Of (64)Copper-Asialofetuin Complex In Lec Rat Model Of Wilson's Disease, R. Bahde, S. Kapoor, K. K. Bhargava, C. J. Palestro, S. Gupta
Diagnosis Of Abnormal Biliary Copper Excretion By Positron Emission Tomography With Targeting Of (64)Copper-Asialofetuin Complex In Lec Rat Model Of Wilson's Disease, R. Bahde, S. Kapoor, K. K. Bhargava, C. J. Palestro, S. Gupta
Journal Articles
Identification by molecular imaging of key processes in handling of transition state metals, such as copper (Cu), will be of considerable clinical value. For instance, the ability to diagnose Wilson's disease with molecular imaging by identifying copper excretion in an ATP7B-dependent manner will be very significant. To develop highly effective diagnostic approaches, we hypothesized that targeting of radiocopper via the asialoglycoprotein receptor will be appropriate for positron emission tomography, and examined this approach in a rat model of Wilson's disease. After complexing (64)Cu to asialofetuin we studied handling of this complex compared with (64)Cu in healthy LEA rats and diseased …