Medicine and Health Sciences Commons^™

Characterization Of Secreted Recombinant Toxoplasma Gondii Surface Antigen 2 (Sag2) Heterologously Expressed By The Yeast Pichia Pastoris, Lau Yee Ling

lau yee ling

The surface antigen 2 (SAG2) gene of the protozoan parasite, Toxoplasma gondii, was cloned and extracellularly expressed in the yeast Pichia pastoris. The effectiveness of the secreted recombinant SAG2 (rSAG2-S) as a serodiagnosis reagent was assessed by western blots and ELISA. In the western blot assay, rSAG2-S reacted with all Toxoplasma-antibody positive human serum samples but not with Toxoplasma-negative samples. In the ELISA, rSAG2-S yielded sensitivity rates ranging from 80% (IgG negative, IgM positive) to 100% (IgG positive, IgM negative). In vivo experiments showed that serum from mice immunized with rSAG2-S reacted specifically with the native SAG2 of T. gondii. …

Long-Term Consequences Of The Delay Between Virologic Failure Of Highly Active Antiretroviral Therapy And Regimen Modification, Maya L. Petersen, Mark J. Van Der Laan, Napravnik Sonia, Joseph J. Eron, Richard G. Moore, Steven G. Deeks

Maya Petersen

Objectives: Current treatment guidelines recommend immediate modification of antiretroviral therapy in HIV-infected individuals with incomplete viral suppression. These recommendations have not been tested in observational studies or large randomized trials. We evaluated the consequences of delayed modification following virologic failure. Design/methods: We used prospective data from two clinical cohorts to estimate the effect of time until regimen modification following first regimen failure on all-cause mortality. The impact of regimen type was also assessed. As the effect of delayed switching can be confounded if patients with a poor prognosis modify therapy earlier than those with a good prognosis, we used a …

Spinal Cord Injury And Co-Occuring Traumatic Brain Injury: Assessment And Incidence, Nicole Thompson

Nicole Thompson

Egészségpolitika És Etika (Health Policy And Ethics), Attila Tanyi, Zsofia Kollanyi

Attila Tanyi

This book provides a survey of the ethical aspects of health care resources distribution. It first distinguishes health from health care in an effort to clear up the ethical landscape. After this, still with the same purpose, it makes a distinction between problems of macro-allocation and micro-allocation. In the rest of the book two questions of macro-allocation are treated in some detail. First, several approaches – in particular: utilitarian, egalitarian, communitarian, and libertarian – to the question whether we have a right to health care are assessed. Second, it is discussed how best, if we have such a right, health …

Challenges To Preschool Teachers In Learner’S Acquisition Of English As Language Of Learning And Teaching, Sandra Du Plessis, Brenda Louw

Brenda Louw

Use Of Psychometric-Function Slopes For Forward-Masked Tones To Investigate Cochlear Nonlinearity, Kim Schairer, Jessica Messersmith, Walt Jesteadt

Kim S. Schairer

Functional Generalized Linear Models With Applications To Neuroimaging, Philip T. Reiss, R. Todd Ogden

Philip T. Reiss

No abstract provided.

The Hazards Of Starting The Cigarette Smoking Habit, Nisha Malhotra, Brahim Boudarbat

Nisha Malhotra

In order to develop effective policies and programs that reduce the number of smokers a necessary first step is to understand the determinants of starting to smoke. In this paper, we present a split-sample duration model of the decision to start smoking. We use data from the 2002 Canadian tobacco use monitoring survey. The hazard rate of starting smoking peaks sharply at age 15 and quickly declines thereafter. Our parametric estimates provide evidence that gender, education, marital status and household size are important determinants of the smoking habit. We also find that higher cigarettes prices have an impact on picking …

What Is Good About Feeling Bad: Finding Purpose And A Path Through Your Suffering, John Charles Thomas

John C. Thomas

When you’re tightly clenched in the grip of suffering, it doesn’t always help to hear that God has a plan and a purpose. In fact, it may feel like adding salt to a raw wound. Why would a loving God put you through this? How can you be sure there is a greater good to be gained? In What’s Good about Feeling Bad? counselor John C. Thomas and renowned philosopher Gary Habermas and will help you find the answers you need. No strangers to personal tragedy themselves, the authors thoughtfully explore the impact of pain on our lives, explain fifteen …

From Convenience To Hazard: A Short History Of The Emergence Of The Menstrual Activism Movement, 1971-1992, Chris Bobel

Chris Bobel

No abstract provided.