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Obstructive Lung Disease Models: What Is Valid, Jill M. Ferdinands, David M. Mannino

David M. Mannino

Use of disease simulation models has led to scrutiny of model methods and demand for evidence that models credibly simulate health outcomes. We sought to describe recent obstructive lung disease simulation models and their validation. Medline and EMBASE were used to identify obstructive lung disease simulation models published from January 2000 to June 2006. Publications were reviewed to assess model attributes and four types of validation: first-order (verification/debugging), second-order (comparison with studies used in model development), third-order (comparison with studies not used in model development), and predictive validity. Six asthma and seven chronic obstructive pulmonary disease models were identified. Seven …

Epidemiology Of Copd Exacerbations, Andrea K. Johnston, David M. Mannino

David M. Mannino

Chapter Opening

Chronic obstructive pulmonary disease (COPD) is expected to be the third cause of death worldwide by the year 2020, behind only cardiovascular disease and cerebrovascular disease (1), and the fifth leading cause of disability-adjusted life years lost (2). In the United States, COPD accounted for 8 million outpatient visits, 1.5 millions emergency department (ED) visits, 726,000 hospitalizations, and 119,000 deaths in 2000, with the number of women dying from COPD surpassing the number of men for the first time (3). In the United Kingdom, COPD exacerbations are now the most common cause of hospital admission (4). Acute exacerbations …

Rationale And Design Of The Prsm Study: Pulmonary Rehabilitation Of Self Management For Chronic Obstructive Pulmonary Disease (Copd), What Is The Best Approach?, Angela Chang, Terry Haines, Claire Jackson, Ian Yang, Jennifer Nitz, Nancy Low Choy, Bill Vicenzino

Nancy Low Choy

Background:
Pulmonary rehabilitation is only accessible by a small proportion of individuals with COPD. For the vast majority who are not able to access these programs, self management approaches may be an alternative to improve health care outcomes.

Methods:
The PRSM study is a three group randomised controlled trial with individual randomisation, blinded outcome assessment, 3 monthly follow-up assessments across a 12-month period and concurrent economic evaluation. The inclusion criteria are adults with COPD. The primary outcome measure is the St George Respiratory Disease Questionnaire. Secondary outcome measures include a series of questionnaires (Frenchay Activities Index, International Physical Activity Questionnaire, …

Chronic Obstructive Pulmonary Disease And The Role Of Spirometry, T. L. Petty, David M. Mannino

David M. Mannino

No abstract provided.