Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Circulating Levels Of Cytokines During Pregnancy; Thrombopoietin Is Elevated In Miscarriage, Brian W. Whitcomb, Enrique F. Schisterman, Mark A. Klebanoff, Mona Baumgarten, Xiaoping Luo, Nasser Chegini
Circulating Levels Of Cytokines During Pregnancy; Thrombopoietin Is Elevated In Miscarriage, Brian W. Whitcomb, Enrique F. Schisterman, Mark A. Klebanoff, Mona Baumgarten, Xiaoping Luo, Nasser Chegini
Brian W. Whitcomb
Objective To evaluate the hypothesis that cytokine levels are associated with miscarriage risk using serum samples collected prior to report of miscarriage. Design A nested case-control study. Setting Biospecimens from the multi-site Collaborative Perinatal Project, University of Florida laboratory assessment of IL-1ra, IL-1β, IL-4, IL-6, IFN-γ, TNF-α, TPO and G-CSF. Patients were obtained from cases of miscarriage (N=439) matched to controls (N=373) by gestational age (GA) at sample collection. Intervention None. Main outcome measures Miscarriage. Results Increased risk of miscarriage was associated with elevated TPO (AOR: 1.16, 95% confidence interval (CI):1.00 – 1.36) and decreased G-CSF (AOR: 0.78, 95% CI …
Blastocyst Development Rate Impacts Outcome In Cryopreserved Blastocyst Transfer Cycles, Eric D. Levens, Brian W. Whitcomb, Sasha Hennessy, Aidita N. James, Belinda J. Yauger, Frederick W. Larsena
Blastocyst Development Rate Impacts Outcome In Cryopreserved Blastocyst Transfer Cycles, Eric D. Levens, Brian W. Whitcomb, Sasha Hennessy, Aidita N. James, Belinda J. Yauger, Frederick W. Larsena
Brian W. Whitcomb
Objective To assess cycle outcome among day 5 and day 6 cryopreserved frozen-thawed blastocyst embryo transfers (FBET). Design Retrospective cohort study. Setting Military-based ART center. Patients One hundred seventy-two non-donor, programmed cryopreserved embryo cycles. Interventions Fully expanded blastocysts on day 5 were cryopreserved on day 5 and those achieving this state on day 6 were cryopreserved on day 6. Leuprolide acetate was given for ovulation inhibition and endometrial supplementation was by oral and vaginal estradiol. Progesterone in oil was administered and blastocyst transfer occurred in the morning of the 6th day of progesterone. Main Outcome Measures Implantation, pregnancy and live …
Evidence Of Absence Or Absence Of Evidence? A Re-Analysis Of The Effects Of Low-Dose Aspirin In Ivf, Marcus D. Ruopp, Tara C. Collins, Brian W. Whitcomb, Enrique F. Schisterman
Evidence Of Absence Or Absence Of Evidence? A Re-Analysis Of The Effects Of Low-Dose Aspirin In Ivf, Marcus D. Ruopp, Tara C. Collins, Brian W. Whitcomb, Enrique F. Schisterman
Brian W. Whitcomb
Objective—To assess the conflicting evidence whether low-dose aspirin (LDA) is beneficial in invitro fertilization (IVF), and evaluate the meta-analysis performed by Gelbaya et al. in the March 2007 issue of Human Reproduction Update, in which they found no effects of LDA and recommended discontinuing its use in IVF. We present a re-analysis of the effects of LDA in IVF and raise methodological questions regarding the analysis by Gelbaya et al. Design—A meta-analysis of prospective randomized trials evaluating the effects of low-dose aspirin in IVF. Patients—Women undergoing in-vitro fertilization/intracytoplasmic sperm injection Interventions—Low-dose acetylsalicylic acid (aspirin) Main Outcome Measure(s)—Pregnancy rates, implantation rates, …
Assays With Lower Detection Limits: Implications For Epidemiological Investigations, Brian W. Whitcomb, Enrique F. Schisterman
Assays With Lower Detection Limits: Implications For Epidemiological Investigations, Brian W. Whitcomb, Enrique F. Schisterman
Brian W. Whitcomb
No abstract provided.