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Articles 241 - 253 of 253
Full-Text Articles in Medicine and Health Sciences
Urinary Phytate Concentration And Risk Of Fracture Determined By The Frax Index In A Group Of Postmenopausal Women, Angel Arturo Lopez Gonzalez, Felix Grases, Bartolome Mari, Matias Tomas-Salva, Adrian Rodriguez
Urinary Phytate Concentration And Risk Of Fracture Determined By The Frax Index In A Group Of Postmenopausal Women, Angel Arturo Lopez Gonzalez, Felix Grases, Bartolome Mari, Matias Tomas-Salva, Adrian Rodriguez
Turkish Journal of Medical Sciences
Background/aim: This study was designed to evaluate the relationship between urinary phytate concentration and risk of fracture at 10 years, determined by using the FRAX model, in women who had undergone menopause within 5 years of the time of enrollment. Materials and methods: Of the 212 postmenopausal women evaluated, 69 were excluded because they had urinary phytate concentrations between 0.51 and 0.99 mg/L. Of the remaining 143 women, 91 had low (≤0.50 mg/L) and 52 had high (≥1.0 mg/L) urinary phytate concentrations. The 10-year risk of fracture was calculated by using the FRAX model.Results: The risks of major osteoporotic fracture …
Long-Term Monitoring Of Graves' Disease In Children And Adolescents: A Single-Center Experience, Selma Tunç, Özge Köprülü, Hati̇ce Ortaç, Özlem Nalbantoğlu, Ceyhun Di̇zdarer, Korcan Demi̇r, Behzat Özkan
Long-Term Monitoring Of Graves' Disease In Children And Adolescents: A Single-Center Experience, Selma Tunç, Özge Köprülü, Hati̇ce Ortaç, Özlem Nalbantoğlu, Ceyhun Di̇zdarer, Korcan Demi̇r, Behzat Özkan
Turkish Journal of Medical Sciences
Background/aim: Graves' disease (GD) is more severe, requires a more complex treatment, and has a lower probability of achieving remission in children than in adults. There is no consensus on the appropriate duration of antithyroid drug (ATD) treatment. Surgical or radioactive iodine (RAI) treatments are not definitive and generally result in permanent hypothyroidism.This study's goal was examining the effectiveness of ATD treatment in children and adolescents withGD and determining the risk factors of remission and relapse.Materials and methods: This retrospective study included 45 patients (36 females and 9 males, median age 12.5 years) aged 4-18 who were diagnosed with GD …
The Distribution Of Mefv Mutations In Turkish Fmf Patients: Multicenter Study Representing Results Of Anatolia, Nazi̇fe Şule Yaşar Bi̇lge, İsmai̇l Sari, Di̇lek Solmaz, Abdurrahman Soner Şenel, Hakan Emmungi̇l, Levent Kiliç, Si̇bel Yilmaz Öner, Fati̇h Yildiz, Sedat Yilmaz, Emi̇ne Duygu Ersözlü, Müge Aydin Tufan, Sema Yilmaz, Veli̇ Yazisiz, Yavuz Pehli̇van, Cemal Bes
The Distribution Of Mefv Mutations In Turkish Fmf Patients: Multicenter Study Representing Results Of Anatolia, Nazi̇fe Şule Yaşar Bi̇lge, İsmai̇l Sari, Di̇lek Solmaz, Abdurrahman Soner Şenel, Hakan Emmungi̇l, Levent Kiliç, Si̇bel Yilmaz Öner, Fati̇h Yildiz, Sedat Yilmaz, Emi̇ne Duygu Ersözlü, Müge Aydin Tufan, Sema Yilmaz, Veli̇ Yazisiz, Yavuz Pehli̇van, Cemal Bes
Turkish Journal of Medical Sciences
Background/aim: The distribution of Mediterranean fever (MEFV) gene mutations in Turkish familial Mediterranean fever (FMF) patients varies according to geographic area of Turkey. There is a need for highly representative data for Turkish FMF patients. The aim of our study was to investigate the distribution of the common MEFV mutations in Turkish FMF patients in a nationwide, multicenter stu dy.Materials and methods: Data of the 2246 FMF patients, from 15 adult rheumatology clinics located in different parts of the country, were evaluated retrospectively. The following mutations have been tested in all patients: M694V, M680I, M694I, V726A, and E148Q.Results: There were …
Irak-4 Rs4251481 Gene Variant: As A Risk Factor On Inflammatory Bowel Disease, Gonca Candan, Resul Kahraman, Hayri̇ye Arzu Ergen
Irak-4 Rs4251481 Gene Variant: As A Risk Factor On Inflammatory Bowel Disease, Gonca Candan, Resul Kahraman, Hayri̇ye Arzu Ergen
Turkish Journal of Medical Sciences
Background/aim: Abnormal immune response occurs in individuals who have alleles associated with innate and adaptive immune mechanisms that predispose to inflammatory bowel disease (IBD). Interleukin-1 receptor-associated kinase 4 (IRAK-4) involved in the pathway produces cytokines that initiate and maintain inflammation through Toll-like receptors and interleukin-1 receptors on the membranes of innate immune cells are stimulated with antigens. It was aimed to investigate whether IRAK-4 rs3794262 and rs4251481 polymorphisms predispose to IBD and the possible effects of these polymorphisms by examining these gene polymorphisms with the clinic and prognostic parameters of IBD.Material and methods: Real-time PCR technique was used to detect …
Seroprevalence Of Hantavirus And Borreliaburgdorferi In Düzce (Turkey) Forest Villages And The Relationship With Sociodemographic Features, Ni̇da Akar, Emel Çalişkan, Ci̇hadi̇ye Eli̇f Öztürk, Handan Ankarali, Özge Kilinçel, Şükrü Öksüz, İdri̇s Şahi̇n
Seroprevalence Of Hantavirus And Borreliaburgdorferi In Düzce (Turkey) Forest Villages And The Relationship With Sociodemographic Features, Ni̇da Akar, Emel Çalişkan, Ci̇hadi̇ye Eli̇f Öztürk, Handan Ankarali, Özge Kilinçel, Şükrü Öksüz, İdri̇s Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: Hantavirus and Borrelia burgdorferi are two zoonotic agents that pose a great risk especially for people living in forest areas. This study aimed to investigate the seroprevalence of hantavirus and B. burgdorferi in forest villages of Düzce and its relationship with sociodemographic features.Materials and methods: The presence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against hantavirus and B. burgdorferi in serum samples was investigated via enzyme-linked immunosorbent assay (ELISA). Hantavirus IgG and B. burgdorferiIgM and IgG positivity was then validated by western blot (WB) method. Results: During the analyses,193 serum samples were tested. Eleven (6%) cases of …
Influence Of Lrp5 (Rs556442) Polymorphism On Insulin Resistance In Healthy Iranian Children And Adolescents, Nima Montazeri Najafabady, Mohammad Hossein Dabbaghmanesh, Rajeeh Mohamadian-Amiri, Marzieh Bakhshayeshkaram, Gholamhossein Ranjbar Omrani
Influence Of Lrp5 (Rs556442) Polymorphism On Insulin Resistance In Healthy Iranian Children And Adolescents, Nima Montazeri Najafabady, Mohammad Hossein Dabbaghmanesh, Rajeeh Mohamadian-Amiri, Marzieh Bakhshayeshkaram, Gholamhossein Ranjbar Omrani
Turkish Journal of Medical Sciences
Background/aim: Genetic aspects play a role in insulin resistance in children. In this study, for the first time, the association of LRP5 (rs556442) polymorphism and insulin resistance in Iranian children and adolescents was investigated.Materials and methods: The study population comprises children and adolescents aged 9-18 years. Anthropometric and biochemical parameters were assessed. Insulin resistance/sensitivity was determined by the quantitative insulin sensitivity check index (QUICKI), homeostasis model assessment-insulin resistance (HOMA-IR), insulin-to-glucose ratio, McAuley index, revised McAuley index, fasting insulin resistance index (FIRI), and Bennett's index. LRP5 (rs566442) single nucleotide polymorphism (SNP) was identified using restriction fragment length polymorphism (RFLP). Linear regression …
Reference Ranges For Serum Immunoglobulin (Igg, Iga, And Igm) And Igg Subclass Levels In Healthy Children, Rumeysa Olcay Bayram, Hülya Özdemi̇r, Ayça Emsen, Hati̇ce Türk Daği, Hasi̇be Artaç
Reference Ranges For Serum Immunoglobulin (Igg, Iga, And Igm) And Igg Subclass Levels In Healthy Children, Rumeysa Olcay Bayram, Hülya Özdemi̇r, Ayça Emsen, Hati̇ce Türk Daği, Hasi̇be Artaç
Turkish Journal of Medical Sciences
Background/aim: The serum immunoglobulin levels are used routinely in clinical practice because they provide key information on the humoral immune status. This study aimed to determine the age-related reference values of serum immunoglobulin levels in healthy children.Materials and methods: A total of 330 healthy children, aged between 0 and 18 years, were included in this study. The serum immunoglobulin levels were measured using a nephelometric method in a total of 11 groups, each group consisting of 30 individuals, and IgG subclasses in 6 groups of children aged more than 2 years. Results: The serum IgG levels were high during the …
Mortality Predictors Of Patients Suffering Of Acute Pancreatitis And Development Of Intraabdominal Hypertension, Maja Stojanovic, Petar Svorcan, Aleksandar Karamarkovic, Nebojsa Ladjevic, Radmilo Jankovic, Predrag Stevanovic
Mortality Predictors Of Patients Suffering Of Acute Pancreatitis And Development Of Intraabdominal Hypertension, Maja Stojanovic, Petar Svorcan, Aleksandar Karamarkovic, Nebojsa Ladjevic, Radmilo Jankovic, Predrag Stevanovic
Turkish Journal of Medical Sciences
Background/aim: Intraabdominal hypertension (IAH) occurs frequently in patients with acute pancreatitis and adds to their morbidity and mortality. The main aim of the study was to identify the determination of the predictive factors connected to IAH that influence the evolution of acute pancreatitis. Materials and methods: The prospective cohort study was conducted on 100 patients who had acute pancreatitis. According to obtained intraabdominal pressure (IAP) values, the patients were divided into two groups: one group (n = 40) with normal IAP values and the other (IAH group, n = 60) with increased IAP values. Deceased patients were specially analyzed within …
Audiometric Threshold Shifts After Total Knee Arthroplasty By Using Gentamicin-Loaded Bone Cement, Adem Çöbden, İsmet Yalkin Çamurcu, Serap Bulut Çöbden, Hakan Sofu, Hani̇fi̇ Üçpunar, Ahmet Sevencan, Hüseyi̇n Demi̇rel
Audiometric Threshold Shifts After Total Knee Arthroplasty By Using Gentamicin-Loaded Bone Cement, Adem Çöbden, İsmet Yalkin Çamurcu, Serap Bulut Çöbden, Hakan Sofu, Hani̇fi̇ Üçpunar, Ahmet Sevencan, Hüseyi̇n Demi̇rel
Turkish Journal of Medical Sciences
Background/aim:The aim of this study was to investigate postoperative audiometric threshold shifts in patients who underwent primary total knee arthroplasty (TKA) using gentamicin-loaded bone cement (GLBC) in comparison with the ones who underwent TKA without GLBC.Materials and methods: Forty patients (gentamicin group) who underwent primary TKA usingGLBC and 29 patients (control group) who underwent primary TKA using standard bone cement were included in this prospective case-control study. Baseline pure-tone audiometric evaluation was performed preoperatively and repeated at the postoperative third day for all patients. Control audiometric evaluation was performed weekly for patients who were diagnosed with ototoxicity according to audiometric …
Percutaneous Navigable Intradiscal Decompression In Treatment Of Lumbar Disc Herniation: A Single-Center Experience, Ayşegül Ceylan, Ibrahim Asik
Percutaneous Navigable Intradiscal Decompression In Treatment Of Lumbar Disc Herniation: A Single-Center Experience, Ayşegül Ceylan, Ibrahim Asik
Turkish Journal of Medical Sciences
Background/aim: Minimally invasive procedures have been increasingly used for the treatment of herniated discs. Nonsurgical interventions minimize the secondary damage to other tissues and shorten the length of hospital stay by avoiding general anesthesia. Possible complications are thermal injuries, root injury, discitis, endplate damage, dural injury, meningitis, infection, increase in pain, and muscle spasm. We aimed to evaluate the efficacy of percutaneous decompression therapy by using intradiscal navigable electrodes on pain and functional movement index in patients with herniated nucleus pulposus (HNP).Materials and methods: A total of 209 patients with protrusive lumbar disc herniation underwent percutaneous ablation decompression treatment using …
Glutamate Transporter Slc1a1 Is Associated With Clear Cell Renal Cell Carcinoma, Sercan Ergün, Sezgi̇n Güneş, Recep Büyükalpelli̇, Oğuz Aydin
Glutamate Transporter Slc1a1 Is Associated With Clear Cell Renal Cell Carcinoma, Sercan Ergün, Sezgi̇n Güneş, Recep Büyükalpelli̇, Oğuz Aydin
Turkish Journal of Medical Sciences
Background/aim: This study aimed to comparatively analyze the expression levels of the SLC1A1 gene in renal specimens from tumors and adjacent healthy kidney tissues of patients with clear cell renal cell carcinoma (ccRCC).Material and methods: Nineteen patients diagnosed with ccRCC were included in the study. The expression levels of the SLC1A1 and GAPDH genes were measured in tumor and formalin-fixed paraffin-embedded (FFPE) tissue specimens from the adjacent healthy kidney of each subject. Via the GEPIA database, the distribution of SLC1A1 gene expressions in ccRCC and healthy kidney tissues was obtained. The relative expression of SLC1A1 was evaluated for the association …
High Neutrophil-To-Lymphocyte Ratio Predicts Acute Allograft Rejection In Kidney Transplantation: A Retrospective Study, Gi̇ray Ergi̇n, Serpi̇l Müge Değer, Burak Köprü, Ülver Deri̇ci̇, Seli̇m Turgay Arinsoy
High Neutrophil-To-Lymphocyte Ratio Predicts Acute Allograft Rejection In Kidney Transplantation: A Retrospective Study, Gi̇ray Ergi̇n, Serpi̇l Müge Değer, Burak Köprü, Ülver Deri̇ci̇, Seli̇m Turgay Arinsoy
Turkish Journal of Medical Sciences
Background/aim: Our research focused on the identification of easily available and sensitive markers for early prediction of acute kidney allograft rejection (AR). We aimed to investigate the association between neutrophil-to-lymphocyte ratio (NLR) and AR in kidney transplant patients. Materials and methods: The medical records of 51 kidney transplant patients [12 female/39 male; median age of 32 (IQR: 24-44) years] were evaluated retrospectively. We considered a cut-off value of >2.5 as high NLR. Results: A total of 22 biopsy-proven AR patients and 29 controls were evaluated. The AR group had a higher NLR compared to the controls (P < 0.001). NLR levels over 2.5 [95% CI: 54.88 (9.96-302.3), P < 0.001] were significantly associated with AR in univariate analysis. The NLR levels were the only significant factor associated with AR in multivariate models, in model 1 (adjusted by age and sex) [95% CI: 114 (11.1-1175), P < 0.001], and in model 2 (adjusted by steroid dosage, uric acid, and NLR) [95% CI: 4.60 (1.59-29.3), P = 0.004]. Conclusion: Our data showed that higher NLR values (>2.5) are associated …
The Association Of Reduced Bone Density With Paraspinal Muscle Atrophy And Adipose Tissue In Geriatric Patients: A Cross-Sectional Ct Study, Eli̇f Evri̇m Eki̇n, Muhi̇tti̇n Emre Altunrende
The Association Of Reduced Bone Density With Paraspinal Muscle Atrophy And Adipose Tissue In Geriatric Patients: A Cross-Sectional Ct Study, Eli̇f Evri̇m Eki̇n, Muhi̇tti̇n Emre Altunrende
Turkish Journal of Medical Sciences
Background/aim: The aim of the study is to examine the relationship among bone density, adipose tissue, and muscle mass with abdominal CT in geriatric patients.Materials and methods: The study is a retrospective cohort study of patients 65 years and over who underwent abdominal CT for any reason between October 2017 and July 2018. Third lumbar vertebra density, fatty degeneration of the paraspinal muscle, subcutaneous adipose tissue, and mesenteric adipose tissue ratio were evaluated. Results: A total of 312 patients, 144 females and 168 males, were included in the study. Reduced bone density was found in 237 (76%) patients. Reduced bone …