Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Down-Regulation Of Circular Rnaitch And Circhipk3 In Gastric Cancer Tissues, Sara Ghasemi, Modjtaba Emadi-Baygi, Parvaneh Nikpour
Down-Regulation Of Circular Rnaitch And Circhipk3 In Gastric Cancer Tissues, Sara Ghasemi, Modjtaba Emadi-Baygi, Parvaneh Nikpour
Turkish Journal of Medical Sciences
Background/aim: Gastric cancer (GC) is one of the major causes of cancer mortality worldwide. As a novel type of endogenous noncoding RNAs, circular RNAs (circRNAs) are formed by a covalent link between 5' and 3' ends. They are very stable and abundant in eukaryotes. As there were no reported studies on the expression profiles of circular RNA ITCH (cir-ITCH) and circHIPK3 in GC, in the current study, we aimed to delineate the expression profiles and clinicopathological relevance of these two circRNAs in GC tissues compared to their paired adjacent noncancerous tissues.Materials and methods: Quantitative real-time polymerase chain reaction was performed …
Contribution Of Dect In Detecting Serosal Invasion Of Gastric Cancer, Ali̇ Küpeli̇, Eser Bulut, Ayşegül Cansu, Ali̇ Güner, Mehmet Soytürk, Gürkan Danişan
Contribution Of Dect In Detecting Serosal Invasion Of Gastric Cancer, Ali̇ Küpeli̇, Eser Bulut, Ayşegül Cansu, Ali̇ Güner, Mehmet Soytürk, Gürkan Danişan
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the relationship between the iodine concentration (IC) of perigastric fat tissue as assessed by dual-energy computed tomography (DECT) and serosal invasion of gastric cancer.Materials and methods: A total of 41 patients underwent preoperative staging evaluation for gastric cancer using DECT between July 2015 and March 2018. Patients were divided into 2 groups based on pathology results: serosal invasion (stage T4a) and intact serosa (stages T1-T3). Cutoff values, the diagnostic efficacy of IC in the perigastric fat tissue, and the perigastric fat tissue/tumor (P/T) ratio were determined.Results: Among the 41 patients, 22 had stage T4a …
Prognostic Importance Of Pten, Egfr, Her-2, And Igf-1r In Gastric Cancer Patients Treated With Postoperative Chemoradiation, Berri̇n Benli̇ Yavuz, Mehmet Koç, Sümeyye Kozacioğlu, Gül Kanyilmaz, Meryem Aktan
Prognostic Importance Of Pten, Egfr, Her-2, And Igf-1r In Gastric Cancer Patients Treated With Postoperative Chemoradiation, Berri̇n Benli̇ Yavuz, Mehmet Koç, Sümeyye Kozacioğlu, Gül Kanyilmaz, Meryem Aktan
Turkish Journal of Medical Sciences
Background/aim: This study aimed to describe the prognostic importance of epidermal growth factor (EGFR), phosphatase and tensin homolog (PTEN), human EGF receptor-2 (HER-2), and insulin-like growth factor 1 receptor (IGF-1R) in gastric cancer patients treated with postoperative chemoradiation therapy. Materials and methods: Sixty-nine patients treated with adjuvant chemoradiation therapy were retrospectively evaluated. Tumor samples were stained immunohistochemically. Results: All patients were treated with 3D conformal radiation therapy with concomitant and adjuvant chemotherapy. Perineural invasion (PNI) (P = 0.042), prechemoradiation therapy albumin levels below 3.5 mg/dL (P = 0.011), and EGFR positivity (P = 0.008) had negative effects on overall survival …