Biology Commons^™

Understanding The Impact Of Post-Translational Modifications On Nucleosome Positioning, Bronwyn Kennington-Nitz, Steven Johnson, Sophie Lo, Michael Mann, David Bates

Library/Life Sciences Undergraduate Poster Competition 2024

The placement of histones along DNA is known to be a significant factor in determining gene expression in eukaryotic cells, with post-translational modifications (or PTMs) helping modulate gene expression by acting as an intermediate to other factors. Using the Lys>Gln and Acetyl-Lys mutations of H3, our working hypothesis is that acetylation will decrease the overall strength of positioning, and that mutations will have an identical or nearly identical effect on nucleosome positioning.

Theranostic Approaches To Treat Synovial Sarcoma, Machenzie Burr, Jared Barrott, Jeffrey Okojie, Delaney Anderson, Peyton Worley, Jack Davis, Bridger Kearns, Melanie I'Anson-Holton

Library/Life Sciences Undergraduate Poster Competition 2024

Synovial sarcomas (SS) are rare soft tissue cancers that are found beside bone in children and adolescents. Currently, the prognosis for these diseases are low, as diagnostic and treatment options are limited due to the rarity of the disease. With high rates of metastasis, treatment options for these diseases become further limited to primarily radiation and chemotherapies. These therapies have limited specificity in their mechanisms, causing severe side effects in patients. This work examined alternative options for synovial sarcoma theranostic approaches, specifically using immunoconjugates for Oncostatin M Receptors (OSMR). This receptor was chosen due to the high rate of expression …

The Role Of Sirt7 In Beta Cell Function And Insulin Secretion, Trevor C. Kendrick, Jeffrey S. Tessem, Connor Littlefield

Library/Life Sciences Undergraduate Poster Competition 2024

Diabetes is a chronic metabolic disease characterized by an inability of beta cells to produce or secrete insulin due to decreasing beta cell mass, a condition induced by beta cell death or overuse. Current treatment consists of daily administration of insulin to diabetic individuals. We have shown that Sirtuin 7 (Sirt7), a deacetylase located in the nucleus, directly interacts with Nkx6.1, a transcription factor essential for beta cell function and proliferation. We have shown that one of the post translational modifications that impinges on Nkx6.1 activity is acetylation. Given Sirt7’s role as a deacetylase, and published reports demonstrating its impact …

Tardigrade Niche Partitioning, Samantha Hougaard, Byron Adams

Library/Life Sciences Undergraduate Poster Competition 2024

The two types of Tardigrade (also known as Tardigrade), Ramazzottius and Echiniscus, coexist in the same environment. It could be assumed that they partition their resources by food type to avoid competition. To test this theory, I limited the two tardigrade groups to one food source.

Phylogeny Of Hetaerina (Odonata: Calopterygidae): Settling Taxonomic Issues, Reganne Leigh Hales, Seth M. Bybee, Laura N. Sutherland, Melissa Sanchez Herrera, Samantha Standring

Library/Life Sciences Undergraduate Poster Competition 2024

Recent phylogenetic work within Hetaerininae based on Sanger data highlighted classification issues (e.g., non-monophyly between the genera), however no changes were proposed at that time. We explore the phylogeny of Hetaerininae using a targeted enrichment approach (AHE) of 20KB (18.5KB of nuclear and 1.5 of mitochondrial DNA) in an attempt to resolve any discrepancies.

Fish Tattoos: The Evolutionary Cost Of Black Spot Disease, Eric J. Morris, Jerry B. Johnson

Library/Life Sciences Undergraduate Poster Competition 2024

QUESTION

Does Black Spot Disease increase the fitness of male fishes?

HYPOTHESIS

We hypothesize that Black Spot Disease will increase the fitness of male fishes. We predict that female fishes will exhibit an association preference for infected males over healthy males when given the choice between the two. This observed preference would suggest that BSD is advantageous for male fishes

Achievement Goals And Burnout In Pre-Health Profession Undergraduate Students, Hunter Nelson, Jamie Jensen

Library/Life Sciences Undergraduate Poster Competition 2024

Oral Presentation Honorable

Relevant Background

• STEM majors are saturated with Pre-health students

• There is high demand for academic excellence and high competition

• Medical school programs (Dyrbye, 2016) and health careers (Shanafelt et al., 2022) show a high rate of burnout

• Symptoms of burnout are mental fatigue, less selfsatisfaction, and depression (Koutsimani, 2021).

• Achievement Goal Theory (AGT) may predict burnout (Nadon et al., 2020).

Reducing Food Scarcity: The Benefits Of Urban Farming, S.A. Claudell, Emilio Mejia

Journal of Nonprofit Innovation

Urban farming can enhance the lives of communities and help reduce food scarcity. This paper presents a conceptual prototype of an efficient urban farming community that can be scaled for a single apartment building or an entire community across all global geoeconomics regions, including densely populated cities and rural, developing towns and communities. When deployed in coordination with smart crop choices, local farm support, and efficient transportation then the result isn’t just sustainability, but also increasing fresh produce accessibility, optimizing nutritional value, eliminating the use of ‘forever chemicals’, reducing transportation costs, and fostering global environmental benefits.

Imagine Doris, who is …

Copus Profiles Paper Data, Jamie Jensen, Rebecca L. Sansom, Jennifer B. Nielson, Richard E. West, Geoffrey Wright, Bryn St. Clair

ScholarsArchive Data

COPUS profile data, interview transcripts

Isolating Highly Specific Antibodies Against Cancer Target Hprt, Austin J. Hansen, Christopher J. Haynie, Kiara V. Whitley, Michelle Townsend, Abby Johnson, Hunter Lindsay, Laura Baird, Kim L. O'Neill

Library/Life Sciences Undergraduate Poster Competition 2023

Effective immunotherapeutic targeting of cancer cells requires identification of specific antigenic differences between cancerous and healthy cells. Hypoxanthine-guanine phosphoribosyltransferase (HPRT) is a cytoplasmic enzyme involved in the salvage pathway for DNA synthesis. Certain cancers (e.g., prostate and breast) upregulate and express HPRT on the cell membrane, making HPRT a potential cancer biomarker for cancer immunotherapies. Antibodies specific for unique cancer proteins are critical to develop targeted cancer immunotherapies. Using a yeast display library and cell sorting, we selected for high-affinity human single-chain (scFv) antibodies against HPRT that can be utilized in chimeric antigen receptor (CAR) T cell therapies and antibody-dependent …

Is There A Link Between Male Gonopodium Size And Mating Strategies Amongst Fish In The Family Poeciliidae?, Ryen Hunsaker, Jerald B. Johnson

Library/Life Sciences Undergraduate Poster Competition 2023

Have different male mating strategies led to evolutionary changes in male gonopodium size?

Natural selection should act strongly on any traits that affect successful reproduction. Fish species in the family Poeciliidae (livebearers) have a unique form of reproduction.

Do Regional Dna Barcode Databases Lead To More Efficient Specimen Identification?, Michael Kerr, Steven D. Leavitt

Library/Life Sciences Undergraduate Poster Competition 2023

DNA barcoding is a method for identifying specimens from specific regions of DNA. 1 Metabarcoding focuses on large, multi specimen scales. 2 These approaches rely on DNA databases for sequence identification, 2 but these databases often lack data from many species, 3 especially from poorly studied groups such as fungi 4 and lichens, which can lead to failure in specimen identification.

Sequencing The Guts Out Of Covid-19; The Evolution Behind The Covid-19 Pandemic, Madelyn Purnell

Undergraduate Honors Theses

The global COVID-19 pandemic has led to an urgent need for scalable methods for clinical diagnostics and tracking of virus variants. In this paper, we attempted a novel method of sequencing using Large Reverse Transcriptase-based cloning (LRTC). Although our methodology ended up not working due to high amount and fast degradation of RNA, we were able to sequence multiple variants of COVID-19 Positive samples from the BYU Student Health Center and 4 sewage samples to check for variant outbreaks in corresponding times. We were able to find several corresponding variants and track the progression of mutation in our local population.

The Effects Of Curricular Change On Student Learning And Well-Being In Biomedical And Clinical Education, Rachel Jalaire Tomco Novak

Theses and Dissertations

The implementation of curriculum change, and innovative pedagogical theory, can help educators and administrators in higher education further the learning gains of students in the sciences. But the introduction of new methods of teaching, or curricular restructuring, can be interpreted by students differently, potentially affecting students' emotional states as well as their relationships with peers. To support not only the learning of students, but also their emotional and social well-being, pedagogical and curricular theory should be enacted in ways that take into consideration the full scope of the student experience. In this dissertation, the implementation of curriculum and pedagogical theory, …

Species Invasion Vs. Abundance In The Northern And Southern Regions Of Lake Powell, Amanda Lebarge, Mark Belk

Library/Life Sciences Undergraduate Poster Competition 2022

Lake Powell is a dynamic system, evidenced by its yearly fluctuations in water level. In the last 20 years, this reservoir has experienced invasions from two different invasive species: the gizzard shard, and quagga mussel. Due to the unique nature of Lake Powell, our research seeks to understand if there were catastrophic effects of these invasions on fish biomass and abundance patterns, and do these impacts vary based on region? We hypothesize that both species will have a major impact in all regions on the native species in Lake Powell; however, the southern region will be more catastrophic.

The Mrna/Protein Relationship Is Fluid And Changes Across Tissue And Diseased States, Jose Humberto Giraldez Chavez, Sam Payne

Library/Life Sciences Undergraduate Poster Competition 2022

• Cancer is a dysregulated cell
• Molecular typing via DNA/RNA/protein
• Is RNA a proxy for cell?

Does Bathing After Sexual Assault Or Time Elapsed Have A Greater Effect On The Development Of Codis Eligible Dna Profiles?, Emily Black, Sam Payne, Julie Valentine, Leslie Miles

Library/Life Sciences Undergraduate Poster Competition 2022

Which has a greater effect on the development of CODIS eligible DNA profiles from SAKs – bathing/showering status of the victim or time between the assault and examination?

Ancestral State Reconstruction Of Oviposition Techniques In New World Stick Insects, Ellie Mcgregor, Jackson Linde, Michael F. Whiting

Library/Life Sciences Undergraduate Poster Competition 2022

Phasmids, commonly known as stick bugs, are unique and interesting creatures, both phenotypically and genotypically. Their cryptic abilities are what draws most people to them, but their oviposition techniques, or how they disperse eggs, has become a new source of interest. While most phasmids are known to flick or drop their eggs from the canopy, there are several other techniques including inserting the eggs into the soil or gluing them to a substrate. New world phasmids have not been thoroughly studied, especially in understanding which technique was ancestral. The purpose of this paper was to construct a phylogenetic tree to …

Whole-Body Vibration Alleviates Symptoms Of Morphine Withdrawal, Gavin C. Jones, Christina A. Small, Dallin Z. Otteson, Scott C. Steffensen

Library/Life Sciences Undergraduate Poster Competition 2022

Whole body vibration at 80 Hz has been shown to blunt neuropathological markers and behavioral symptoms of alcohol dependence Here, we evaluate its ability to ameliorate symptoms of morphine use and withdrawal.

Comparison Of Tardigrade Extraction Methods, Abigail Andros

Library/Life Sciences Undergraduate Poster Competition 2022

It is a time-consuming process to pick tardigrades for an experiment. The standard method is to add water to the sample, then look through it and pick out tardigrades with a micropipette or small wire loop (Tsujimoto et al. 2015).

Overcoming Detrimental Potato Fungi With The Secondary Metabolites Of Naturally Occurring Streptomyces In A Greenhouse, Hansan Jones, Jacob Anderson, Erik Kemp, Brad Geary, Matthew Madsen, Ryan Stewart

Library/Life Sciences Undergraduate Poster Competition 2022

• Fungal disease Silver scurf can cause 13% water loss and give poor aesthetic appeal, both of which reduce farmers profits (1,2).
• Pythium leak can result in up to 50% total loss of potatoes in storage (3).
• Streptomyces is the right candidate to mitigate or eliminate these losses because of its ability to survive in soil (4) and its history as a proven biocontrol for other plant pathogens (5).

Morphological Changes Of The Asian Shore Crab Across Latitudes, Ainslee Mcmullin, Blaine D. Griffen

Library/Life Sciences Undergraduate Poster Competition 2022

The Asian shore crab, Hemigrapsus sanguineus , is an invasive species that has rapidly spread across the Eastern United States coastline. First observed in North America in 1988, its range currently extends from Maine to North Carolina. H. sanguineus has adapted very well to this region and has displaced several native species as the dominant crab in rocky intertidal habitats. Although the Asian shore crab’s biology and interactions with native species has been well studied, larger scale impacts (economic, potential further spread, community ecology, etc.) are under researched. We collected specimen samples of H. sanguineus throughout its entire East coast …

Reviewing The Effects Of Human-Induced Limb Damage In Crabs, Jacob B. Spencer, Blaine D. Griffen

Library/Life Sciences Undergraduate Poster Competition 2022

Limb damage in crabs comes in various forms, each with unique consequences. Brachyuran crabs shed limbs as a defensive reflex, with natural breakage occurring along a plane, otherwise known as autotomy. In addition to autotomy, crabs commonly lose limbs due to fishing practices such as declawing. In many areas, taking the limbs and releasing the crab is a common practice. The logic is that the populations won’t decline if the crab is put back. Other practices such as nicking, or cutting the main claw tendon, are used to restrict claw movement. Various effects of these fishery practices have been documented …

Male And Female Victims Experience Different Types Of Sexual Assault, Carolyn Allen, Samuel Payne, Julie Valentine

Library/Life Sciences Undergraduate Poster Competition 2022

Intro:

• Sexual assault kits (SAKs) contain forensic evidence and are collected following an assault
• Most research on SAK processing has been done with combined male and female assaults
• 10% of victims are male
• There is lots of research on female victims, but very little research on male victims

In-Class Evolution Discussions Change Bible Interpretation, Jessica Abele

Library/Life Sciences Undergraduate Poster Competition 2022

Conflict between religion and evolution is a major barrier for religious biology students. Educators have been working to increase evolution acceptance by using a variety of methods (e.g., increasing evolution knowledge, addressing creationism in class, etc.) with little success. However, recent research shows using a reconciliatory approach to evolution and religion increases evolution acceptance while overall religiosity is unaffected (Lindsay et al., 2019).

Dietary And Energetic Trends Of The Invasive Asian Shore Crab, Tanner Reese, Blaine D. Griffen

Library/Life Sciences Undergraduate Poster Competition 2022

The Asian shore crab, Hemigrapsus sanguineus , is an invasive crab species that lives on the East Coast of the United States. It has become an important part of its invaded ecosystems and their energetic interactions. We studied this species’ energetics to better understand how they vary across season and latitude.

• The ratio of gut width to carapace width (“standardized gut size”) is indicative of long term diet quality in crabs (a larger gut corresponds to a lower average diet quality) (Griffen & Mosblack 2011)
• We measured standardized gut size and gut energy content to examine how this species’ diet …

Eeg As Successful Diagnostic Tool For Immune Effector Cell Associated Neurotoxicity Syndrome, Daniel Jones, Christine Eckhardt, Haoqi Sun, Ryan Tesh, Brandon Westover

Library/Life Sciences Undergraduate Poster Competition 2022

CAR T cell therapy was first proven effective in 2013¹ for the treatment of certain cancer s . However, its widespread adoption is still hindered by side effects like immune effector cell associated neurotoxicity syndrome (ICANS). Current research aims to better predict, diagnose, and treat ICANS so that CAR T cell therapy can be more widely applied. Although prior studies have attempted to identify an objective biomarker of ICANS² , current practice relies on clinical assessment to diagnose ICANS. We hypothesize that qualitative features of the EEG may be utilized to develop a physiological grading system of the …

Introducing Xanthoria Parietina: Invasive, Naturalized, Or Opportunistic?, Mikele Baugh, Steve Leavitt

Library/Life Sciences Undergraduate Poster Competition 2022

Lichens are one of the world’s ubiquitous group of organisms. They have been documented from frigid tundras to arid deserts. While some species are known to be particularly hardy and flexible in their habitats, many species are linked to specific growing conditions. As the global climate changes, the geographical range for different growing conditions shifts. Economic trade and human travel provide new opportunities for species to access new locations that are beginning to develop habitable conditions. Xanthoria parietina has been observed in the Great Basin (a region outside of its typical coastal distribution) found in newly built horticultural landscapes. Individuals …

Teach And Question Data, Rachel Tomco Novak

ScholarsArchive Data

Data collected from a Teach-and-Question assignment in 11 sections of an introductory science course, during Winter semester 2021.

Testing The Effect Of Aquarium-Based Learning On Patron Acceptance Of Evolutionary Theory, Jamie Jensen, Ethan R. Tolman, Spencer G. Shumway, Liam S. Williams

ScholarsArchive Data

This is data collected prior to and directly following an intervention at a public aquarium in Idaho surrounding the reconciliation of evolution with religious audiences.