Life Sciences Commons^™

New Record For Halophila Decipiens Ostenfeld In Kenya Based On Morphological And Molecular Evidence, Kathryn Mcmahon, Michelle Waycott

Kathryn McMahon

No abstract provided.

Feeding Ecology Of Green Turtles (Chelonia Mydas) From Shoalwater Bay, Australia, Karen Arthur, Kathryn Mcmahon, Col Limpus, William Dennison

Kathryn McMahon

No abstract provided.

Anti-Cancer Activity Of An Acid-Labile N-Alkylisatin Conjugate Targeting The Transferrin Receptor, Vineesh Indira Chandran, Lidia Matesic, Julie Locke, Danielle Skropeta, Marie Ranson, Kara Vine

Danielle Skropeta

We have previously reported a series of pH-sensitive imine-linked N-alkylisatin prodrugs that are stable at pH 7.4, but readily cleaved at pH 4.5. Herein, one of the most potent prodrugs, 5,7-dibromo-N-(pmethoxybenzyl) isatin (NAI), was functionalized with a para-phenylpropionic acid linker, and the resulting NAI–imine prodrug conjugated to transferrin (Tf) to form a NAI–imine–Tf conjugate. Cytotoxicity assays revealed the conjugate was equipotent to the free drug against MCF-7 breast cancer cells, with clear selectivity patterns based on TfR levels. These results suggest that this novel isatin-based cytotoxin conjugated to a tumor targeting protein via an acid-labile linker warrants further preclinical testing.

The Effect Of Individual N-Glycans On Enzyme Activity, Danielle Skropeta

Danielle Skropeta

No abstract provided.

Domino Pericyclic Reactions Of Acyclic Conjugated (E,Z,E,E)-Tetraenes, Danielle Skropeta, Rodney Rickards

Danielle Skropeta

No abstract provided.

N-Phenethyl And N-Naphthylmethyl Isatins And Analogues As In Vitro Cytotoxic Agents, John Bremner, Stephen Pyne, Marie Ranson, Danielle Skropeta, Julie Locke, Lidia Matesic, Kara Perrow

Danielle Skropeta

Arange of N-phenethyl,N-phenacyl, and N-(1- and 2-naphthylmethyl) derivatives of 5,7-dibromoisatin 2 were prepared byN-alkylation reactions. Their activity against human monocyte-like histiocytic lymphoma (U937), leukemia (Jurkat), and breast carcinoma (MDA-MB-231) cell lines was assessed. The results allowed further development of structureactivity relationships. The compound 5,7-dibromo-N-(1-naphthylmethyl)-1H-indole-2,3-dione 5a was the most potent against U937 cells with an IC50 value of 0.19 microM.

Complete Assignment Of The 1h And 13c Nmr Spectra Of Antimicrobial 4-Arylamino- 3-Nitrocoumarin Derivatives, Vidoslav Dekic, Niko Radulovic, Rastko Vukicevic, Biljana Dekic, Danielle Skropeta, Radosav Palic

Danielle Skropeta

No abstract provided.

Synthesis And Hydrolytic Evaluation Of Acid-Labile Imine-Linked Cytoxic Isatin Model Systems, Lidia Matesic, Julie Locke, Kara Perrow, Marie Ranson, John Bremner, Danielle Skropeta

Danielle Skropeta

In this study a series of isatin-based, pH-sensitive aryl imine derivatives with differing aromatic substituents and substitution patterns were synthesised and their acid-catalysed hydrolysis evaluated. These derivatives were functionalised at the C3 carbonyl group of a potent N-substituted isatin cytotoxin and were stable at physiological pH but readily cleaved at pH 4.5. Observed rates of hydrolysis for the embedded imine-acid moiety were in the order para-phenylpropionic acid>phenylacetic acid (para>meta)>benzoic acid (meta>para). The ability to fine-tune hydrolysis rates in this way has potential implications for optimising imine linked, tumour targeting cytotoxin-protein conjugates

N-Glycolisation Regulates Endothelial Lipase-Mediated Phospholipid Hydrolysis In Apoe- And Apoa-I-Containing High Density Lipoproteins, Danielle Skropeta, Daniel Rader, Weijun Jin, Monica Mcmahon, Kate Shearston, Philip Barter, Kristine Mcgrath, Kerry-Anne Rye, Chatri Settasatian, Daniela Caiazza

Danielle Skropeta

No abstract provided.

Cytotoxic And Anticancer Activities Of Isatin And Its Derivatives: A Comprehensive Review From 2000-2008, Marie Ranson, Danielle Skropeta, Julie Locke, Lidia Matesic, Kara Perrow

Danielle Skropeta

No abstract provided.

Chemotaxonomy Of The Peppergrass Lepidium Coronopus (L.) Al-Shehbaz (Syn. Coronopus Squamatus) Based On Its Volatile Glucosinolate Autolysis Products, Niko Radulovic, Bojan Zlatkovic, Danielle Skropeta, Radosav Palic´

Danielle Skropeta

The genus Lepidium comprises approximately 175 different plant species commonly referred to as peppergrasses or pepperworts ( Al-Shehbaz, 1997 and Mummenhoff et al., 2001), which occur worldwide apart from the polar regions where they are considered rare in the Arctic and are absent from Antarctica. Lepidium is a comparatively large genus belonging to the mustard family Brassicaceae. Lepidium coronopus (L.) Al-Shehbaz, a representative of the genus, is a herbaceous annual to biennial plant that belongs to the tribe Lepidieae and has previously been described by the following synonymous species: Coronopus squamatus (Forsskal) Ascherson; C. squamatus subsp. conradi (Muschler) Maire; C. …

Effects Of Natural Flooding And Manual Trapping On The Facilitation Of Invasive Crayfish-Native Amphibian Coexistence In A Semi-Arid Perennial Stream, Lee Kats, Gary Bucciarelli, Thomas Vandergon, Rodney Honeycutt, Evan Mattiasen, Arthur Sanders, Seth Riley, Jacob Kerby, Robert Fisher

Lee Kats

Aquatic amphibians are known to be vulnerable to a myriad of invasive predators. Invasive crayfish are thought to have eliminated native populations of amphibians in some streams in the semi-arid Santa Monica Mountains of southern California. Despite their toxic skin secretions that defend them from native predators, newts are vulnerable to crayfish attacks, and crayfish have been observed attacking adult newts, and eating newt egg masses and larvae. For 15 years, we have observed invasive crayfish and native California newts coexisting in one stream in the Santa Monica Mountains. During that period, we monitored the densities of both crayfish and …

Phytochemical And Pharmacological Aspects Of Australian Bloodroots (Haemodora Spp.), Lei Liu, Myrna Deseo, D Thompson, Hans Wohlmuth, David Leach

Dr Hans Wohlmuth

No abstract provided.

Phytochemistry And Pharmacology Of Volatile Components Of Plectranthus Graveolens R. Br., L Cyril, Myrna Deseo, G Buchbauer, P Forster, David Leach

Dr Myrna A Deseo

No abstract provided.

Phytochemical And Pharmacological Aspects Of Australian Bloodroots (Haemodora Spp.), Lei Liu, Myrna Deseo, D Thompson, Hans Wohlmuth, David Leach

Dr Myrna A Deseo

No abstract provided.

Compounds From Saccharum Officinarum L. As Leads For Anti-Diabetes Treatment, D Payne, David Leach, C Morris, M O'Shea, Lei Liu, Kellie Shepherd, Myrna Deseo

Dr Myrna A Deseo

No abstract provided.

Seed Biology Research And Conservation Of Eastern Australian Rainforest Diversity, K Hamilton, C Offord, P Cuneo, S Ashmore, Myrna Deseo

Dr Myrna A Deseo

No abstract provided.

Gc Analysis Of Aqueous Plant Extracts, K Shepherd, V Westbrooke, Myrna Deseo

Dr Myrna A Deseo

No abstract provided.

Modulation Of Natural Killer Cell Activity By Water Soluble Polysaccharides From The Roots Of Asparagus Racemosus Linn, M Thakur, P Connellan, Myrna Deseo, Carol Morris, V Dixit

Dr Myrna A Deseo

Asparagus racemosus L. (Fam. Liliaceae) is an ethno-pharmacologically acclaimed Ayurvedic medicinal plant [1]. The plant belongs to the category of 'Rasayana' i.e., plants possessing immunomodulatory and adaptogenic activity [2]. Although there have been claims on immune system potentiation by aqueous extracts of A. racemosus, there is a lack of information specifying the exact molecular mechanism and phytochemical components responsible for the immuno-stimulatory activity.

In the present study, an aqueous extract of A. racemosus (ARC) was further fractionated to isolate the polysaccharide fraction (ARP). The isolated polysaccharides (ARP) were characterized by enzymatic, size exclusion, GC-FID, and thin layer chromatographic analyses. …

Preliminary Investigation Into Milk Flavour, V Westbooke, H Smyth, K Shepherd, Carol Morris, B Granzin, Myrna Deseo

Dr Myrna A Deseo

No abstract provided.

Preliminary Investigation Into The Phytochemical And Pharmacological Aspects Of Plectranthus Species, E Pasoski, L Marangattil, Myrna Deseo, David Leach, P Forster

Dr Myrna A Deseo

No abstract provided.

Rainforest Seed Project, K Hamilton, C Offord, P Cuneo, S Ashmore, Myrna Deseo, K Shepherd

Dr Myrna A Deseo

No abstract provided.

Preliminary Investigation Into The Phytochemical And Pharmacological Aspects Of Plecthrantus Sp. 'Hann Tableland', E Pasoski, Myrna Deseo, G Buchbauer, Lei Liu, P Forster, David Leach

Dr Myrna A Deseo

No abstract provided.

Chemical Composition And Biological Activity Of The Essential Oils From Native Australian Callitris Species, Angela Oprava, David Leach, Karren Beattie, Paul Connellan, Paul Forster, Greg Leach, Gerhard Buchbauer, Kellie Shepherd, Myrna Deseo

Dr Myrna A Deseo

The chemical composition of the essential oil of the wood of the Australian native cypress Callitris endlicheri, C. intratropica and C. columellaris were determined by GCMS. The colour of the oils from C. endlicheri were yellow, yellow green and light green, whilst the distinct blue colour of the oil from C. intratropica was in keeping with its generic name ‘blue cypress oil'. The sesquiterpene alcohol guaiol (1) comprised >50% of the C. endlicheri oil. Significant differences were observed in components between the three accessions. In contrast, the oils of C. intratropica showed more subtle variations between collection …

Sugarcane Molasses – A Potential Source Of Anti-Diabetic Compounds, D Payne, R Taylor, Myrna Deseo, M O'Shea, N Masel, David Leach

Dr Myrna A Deseo

No abstract provided.

Chemical Variation In The Leaf Essential Oils Of Australian Corymbia Spp., Myrna Deseo, K Shepherd, M Abasolo, Mervyn Shepherd, D Lee

Dr Myrna A Deseo

No abstract provided.

Isolation And Identification Of Antioxidant Compounds From Carica Papaya L, E Jensen, A Larsen, David Leach, Myrna Deseo

Dr Myrna A Deseo

No abstract provided.

Genomics And Metabolomics For New Plant Products, Daniel Waters, Peter Bundock, Hans Wohlmuth, Myrna Deseo, Lei Liu, Frances Shapter, Agnelo Furtado

Dr Myrna A Deseo

No abstract provided.

Alterg Anti-Gravity Treadmill Walking Program On An Extremely Obese Female, Jane Shimon, Shawn Simonson, Elaine Long, Brooke Lester

Elaine M. Long

No abstract provided.

Identifying Links In The Chain: The Dynamic Coupling Of Catecholamines, Peptide Synthesis, And Peptide Release In Hypothalamic Neuroendocrine Neurons, Alan Watts, Arshad Khan

Arshad M. Khan, Ph.D.

Compared to conventional neurons that use synaptic mechanisms to communicate with closely apposed targets, peptidergic neuroendocrine neurons release relatively large quantities of peptide into the vasculature to control neuroendocrine function at more distal sites. This means that maintaining adequate amounts of peptide for release through controlled biosynthesis is critical for their function. But the flexible and adaptive responses these neurons generate to many different challenges require synthesis and release must be coordinated in some way. How neuroendocrine—or in fact, any neuropeptide—neurons link appropriate levels of peptide biosynthesis with the patterns of action potentials that drive peptide release is unknown. Here …