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Articles 1 - 8 of 8

Full-Text Articles in Life Sciences

The Saccharomyces Cerevisiae Ubiquitin-Proteasome System, Mark Hochstrasser, Phoebe Johnson, Cassandra Arendt, Alexander Amerik, Sowmya Swaminathan, Rob Swanson, Shyr-Jiann Li, Jeffrey Laney, Robin Pals-Rylaarsdam, Jonathan Nowak, Pamela Connerly, M. Yanagida, K. Nasmyth, M. Tyers, R. Hunt, J. Diffley Sep 1999

The Saccharomyces Cerevisiae Ubiquitin-Proteasome System, Mark Hochstrasser, Phoebe Johnson, Cassandra Arendt, Alexander Amerik, Sowmya Swaminathan, Rob Swanson, Shyr-Jiann Li, Jeffrey Laney, Robin Pals-Rylaarsdam, Jonathan Nowak, Pamela Connerly, M. Yanagida, K. Nasmyth, M. Tyers, R. Hunt, J. Diffley

Rob Swanson

Our studies of the yeast ubiquitin-proteasome pathway have uncovered a number of general principles that govern substrate selectivity and proteolysis in this complex system. Much of the work has focused on the destruction of a yeast transcription factor, MAT alpha 2. The alpha 2 protein is polyubiquitinated and rapidly degraded in alpha-haploid cells. One pathway of proteolytic targeting, which depends on two distinct endoplasmic reticulum-localized ubiquitin-conjugating enzymes, recognizes the hydrophobic face of an amphipathic helix in alpha 2. Interestingly, degradation of alpha 2 is blocked in a/alpha-diploid cells by heterodimer formation between the alpha 2 and a1 homeodomain proteins. The …


The Use Of Multimedia In Large Classrooms, Don Morrow May 1999

The Use Of Multimedia In Large Classrooms, Don Morrow

Donald Morrow

No abstract provided.


The New Technologies And The University Classroom: The Changing Roles Of Faculty And Instructional Developers, Don Morrow May 1999

The New Technologies And The University Classroom: The Changing Roles Of Faculty And Instructional Developers, Don Morrow

Donald Morrow

No abstract provided.


Changes In Movement Parameters Occur At Different Rates When Learning A Wrist Movement, T. Kempf, D. Corcos, D. Flament Apr 1999

Changes In Movement Parameters Occur At Different Rates When Learning A Wrist Movement, T. Kempf, D. Corcos, D. Flament

Timothy Kempf

No abstract provided.


Difficile, William Thomas Dec 1998

Difficile, William Thomas

William D Thomas Jr

No abstract provided.


Physical Fitness & Wellness, Donald Morrow, Jennifer Irwin Dec 1998

Physical Fitness & Wellness, Donald Morrow, Jennifer Irwin

Donald Morrow

No abstract provided.


Characterization Of A Mutant T Cell Hybridoma Line With Defects In Tcr-Mediated Apoptotic Pathway, Sallie Smith Schneider, G. Morgan, S.W. Smith, L. Pak, A. Marshak-Rothstein, R. Fissore, B.A. Osborne Dec 1998

Characterization Of A Mutant T Cell Hybridoma Line With Defects In Tcr-Mediated Apoptotic Pathway, Sallie Smith Schneider, G. Morgan, S.W. Smith, L. Pak, A. Marshak-Rothstein, R. Fissore, B.A. Osborne

Sallie W Smith Schneider

No abstract provided.


Swan Canning Estuary, Western Australia, Kathryn Mcmahon, L Kalnejais, M Robb Dec 1998

Swan Canning Estuary, Western Australia, Kathryn Mcmahon, L Kalnejais, M Robb

Kathryn McMahon

No abstract provided.