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Articles 1 - 30 of 63
Full-Text Articles in Life Sciences
Investigation Of Murine Spleen As A Niche For Hematopoiesis., Jonathan Tan, Helen O'Neill
Investigation Of Murine Spleen As A Niche For Hematopoiesis., Jonathan Tan, Helen O'Neill
Jonathan Tan
Background Spleen as a lymphoid tissue is specialized for monitoring blood and mounting immunity against blood-borne antigens. Antigen-presenting cells present in spleen commonly develop from bone marrow-derived precursors that enter blood circulation. However, a distinct splenic myeloid antigen-presenting cell subset described in this laboratory, namely “dendritic-like cells” (L-DC), has been hypothesized not to share a bone marrow origin. Methods In this study, the presence of endogenous hematopoietic progenitors in spleen was investigated by transplanting intact spleen into allotype-distinct recipients and monitoring development of progeny cells in grafted tissues. Results Successful engraftment of donor spleens was achieved for up to 4 …
Expression Of Acetate Permease-Like (Apl) Genes In Subsurface Communities Of Geobacter Species Under Fluctuating Acetate Concentrations, Derek Lovley, Hila Elifantz, Lucie N'Guessan, Paula Mouser, Kenneth Williams, Michael Wilkins, Carla Risso, Dawn Holmes, Philip Long
Expression Of Acetate Permease-Like (Apl) Genes In Subsurface Communities Of Geobacter Species Under Fluctuating Acetate Concentrations, Derek Lovley, Hila Elifantz, Lucie N'Guessan, Paula Mouser, Kenneth Williams, Michael Wilkins, Carla Risso, Dawn Holmes, Philip Long
Carla Risso
The addition of acetate to uranium-contaminated aquifers in order to stimulate the growth and activity of Geobacter species that reduce uranium is a promising in situ bioremediation option. Optimizing this bioremediation strategy requires that sufficient acetate be added to promote Geobacter species growth. We hypothesized that under acetate-limiting conditions, subsurface Geobacter species would increase the expression of either putative acetate symporters genes (aplI and aplII). Acetate was added to a uranium-contaminated aquifer (Rifle, CO) in two continuous amendments separated by 5 days of groundwater flush to create changing acetate concentrations. While the expression of aplI in monitoring well D04 (high …
Rapid Response Of A Grassland Ecosystem To An Experimental Manipulation Of A Keystone Rodent And Domestic Livestock, Ed Frederickson
Rapid Response Of A Grassland Ecosystem To An Experimental Manipulation Of A Keystone Rodent And Domestic Livestock, Ed Frederickson
Ed L. Frederickson
Megaherbivores and small burrowing mammals commonly coexist and play important functional roles in grassland ecosystems worldwide. The interactive effects of these two functional groups of herbivores in shaping the structure and function of grassland ecosystems are poorly understood. In North America's central grasslands, domestic cattle (Bos taurus) have supplanted bison (Bison bison), and now coexist with prairie dogs (Cynomys spp.), a keystone burrowing rodent. Understanding the ecological relationships between cattle and prairie dogs and their independent and interactive effects is essential to understanding the ecology and important conservation issues affecting North American grassland ecosystems. To address these needs, we established …
Integrating Geographic Information Systems And Multi-Criteria Analysis To Assess Suitable Species And Plantation Sites: A Case Study Assessing Elaeocarpus Grandis And Gevillea Robusta Suitability On The Nsw North Coast, Kristin Den Exter
Dr Kristin den Exter
No abstract provided.
Using Computer Technology To Provide Decision Support For Species And Site Selection, Kristin Den Exter
Using Computer Technology To Provide Decision Support For Species And Site Selection, Kristin Den Exter
Dr Kristin den Exter
No abstract provided.
Using Computer Technology To Provide Decision Support For Species And Site Selection, Kristin Den Exter, Sumith Pathirana, Alison Specht
Using Computer Technology To Provide Decision Support For Species And Site Selection, Kristin Den Exter, Sumith Pathirana, Alison Specht
Dr Kristin den Exter
No abstract provided.
Mesquite: A Long View, Ed Frederickson, Curtis Monger, Eduardo Guevara, Dan Fredrickson
Mesquite: A Long View, Ed Frederickson, Curtis Monger, Eduardo Guevara, Dan Fredrickson
Ed L. Frederickson
Mesquite (Prosopis glandulosa) is among the most successful plants in Northern México and America"s arid Southwest. Mesquite optimizes pollinator services and reproductive effort, resulting in seeds that persist in herbivore digestive tracts and soil seed banks for extended periods. An extensive root system fully occupies the soil profile long distances from its base, allowing it to harvest water and nutrients with extraordinary efficiency. Root nodules harbor nitrogen-fixing bacteria allowing mesquite to overcome usual nitrogen limitations. Mesquite survival is determined early, but once established, it is long-lived, often benefiting from hardships killing most plants. So with mesquite"s superior adaptations and competitive …
In Search Of "Organ Iii" Strata-A Sedimentary Record Of The Medieval Warm Period (Ca. Ad 900 To 1300), Ed Frederickson, Curtis Monger, Katie Laney
In Search Of "Organ Iii" Strata-A Sedimentary Record Of The Medieval Warm Period (Ca. Ad 900 To 1300), Ed Frederickson, Curtis Monger, Katie Laney
Ed L. Frederickson
The period AD 900 to 1300, internationally referred to as the Medieval Warm Period, is a critical time for the archaeological record of the Southwestern USA. During the Medieval Warm Period both alluvial and eolian sedimentation increased, but not to the magnitude of the middle Holocene (the Altithermal) or since Historical erosion began in the middle 1850s (the end of the Little Ice Age). Locally, the term "Organ III" has been given to the Medieval Warm Period allostratigraphic unit. It is a subtle unit stratigraphically between Altithermal sediments (Organ I) and Historical sediments. Diagnostic features for identifying these three units …
Diarylheptanoid From Pleuranthodium Racemigerum With In Vitro Prostaglandin E2 Inhibitory And Cytotoxic Activity, Hans Wohlmuth, Myrna Deseo, Don Brushett, Dion Thompson, Graham Macfarlane, Lesley Stevenson, David Leach
Diarylheptanoid From Pleuranthodium Racemigerum With In Vitro Prostaglandin E2 Inhibitory And Cytotoxic Activity, Hans Wohlmuth, Myrna Deseo, Don Brushett, Dion Thompson, Graham Macfarlane, Lesley Stevenson, David Leach
Dr Hans Wohlmuth
Bioactivity-guided fractionation of an ethanolic extract of the rhizome of Pleuranthodium racemigerum, a tropical Zingiberaceae species from North-eastern Australia, resulted in the isolation and structural elucidation of 1-(4″-methoxyphenyl)-7-(4′-hydroxyphenyl)-(E)-hept-2-ene (1), a new diarylheptanoid related to curcumin. Compound 1 was a fairly potent inhibitor of prostaglandin E2 production in 3T3 murine fibroblasts (IC50 ≈ 34 μM) and also displayed moderate cytotoxicity against this cell line (IC50 = 52.8 μM). The compound also demonstrated cytotoxic activity against the P388D1 murine lymphoblast cell line (IC50 = 117.0 μM) and four human cell lines: Caco-2 colonic adenocarcinoma (IC50 = 44.8 μM), PC3 prostate adenocarcinoma (IC50 …
Human Health And Environmental Hazards Of Farmed Fish, Richard B. Philp
Human Health And Environmental Hazards Of Farmed Fish, Richard B. Philp
Richard B. Philp
Aquaculture, or fish farming, now provides a significant portion of the world's supply of fin-fish for human consumption. Since 1985, the production of farmed fish has nearly quadrupled. Associated problems include levels of persistent organic pollutants and heavy metals as compared to wild-caught fish, enviromnental problems from waste food and excrement, disease hazards for fish and humans and depletion of wild forage fish to produce food pellets for farmed fish. The recent introduction of genetically modified salmon has added another potential hazard for the environment and possible for human health. These and other problems are discussed with recommendations for human …
Ellen Tupper, Tammy Horn
On One Hand, On The Other Hand, Jane Shimon
On One Hand, On The Other Hand, Jane Shimon
Jane Shimon
The presentation addressed current brain research pertaining to physical activity/fitness and academic achievement.
Erythrocyte Aggregation And Neutrophil Function In An Aging Population, Rhys Christy, Oguz Baskurt, Gregory Gass, A. Gray, Sonya Marshall-Gradisnik
Erythrocyte Aggregation And Neutrophil Function In An Aging Population, Rhys Christy, Oguz Baskurt, Gregory Gass, A. Gray, Sonya Marshall-Gradisnik
A. Bon Gray
There are limited investigations which have examined the relationship between neutrophil activation and erythrocyte aggregation in older persons. The purpose of the present study was to investigate the relationship between neutrophil activation and erythrocyte aggregation (EA) in an aging population. Twenty-eight male and female subjects were allocated into one of four groups with 7 participants in each group (group 1, 20–29 years; group 2, 30–39 years; group 3, 40–49 years; group 4, 50–59 years). EA was determined using the Myrenne aggregometer. Neutrophil function (respiratory burst and phagocytic activity) was assessed using flow cytometry. EA was found to increase with age. …
Predictors Of Safety-Related Enquiries About Psychotropic Medication In Young People And Families Accessing A Medicines Information Service, Angela Dean, Merryn Witham, Treasure Mcguire
Predictors Of Safety-Related Enquiries About Psychotropic Medication In Young People And Families Accessing A Medicines Information Service, Angela Dean, Merryn Witham, Treasure Mcguire
Treasure McGuire
Background: Many consumers express concerns about the safety of psychotropic medication for young people. Despite the increased use of psychotropic medication in children and adolescents, few studies have examined information needs of this group and predictors of safety-related concerns.
Methods: This study was conducted within a national, consumer-based medicines information service. Between September, 2002, and December, 2005, all calls relating to use of psychotropic medications in children and adolescents were identified and reviewed. Information extracted included call characteristics, reason for calling, prior information, and medication details. Calls related to safety were compared to calls about non-safety-related issues.
Results: A total …
Blood Kinetics Of Four Intraperitoneally Administered Therapeutic Candidate Bacteriophages In Healthy And Neutropenic Mice, Jumpei Uchiyama, Yoshihiro Maeda, Iyo Takemura, Russ Chess-Williams, Hiroshi Wakiguchi, Shigenobu Matsuzaki
Blood Kinetics Of Four Intraperitoneally Administered Therapeutic Candidate Bacteriophages In Healthy And Neutropenic Mice, Jumpei Uchiyama, Yoshihiro Maeda, Iyo Takemura, Russ Chess-Williams, Hiroshi Wakiguchi, Shigenobu Matsuzaki
Russ Chess-Williams
Due to multiple-drug resistant bacteria, phage therapy is being revisited. Although most animal experiments focus on therapeutic efficacy, the blood clearance kinetics of phages have not been well described. For further development of an efficient therapeutic strategy, information on phage blood kinetics is important. In this study, time-course concentration changes in peripheral blood of healthy and neutropenic mice were measured using four therapeutic phages (φMR11, KPP10, φEF24C, and KEP10). The results showed a two- to three-day rapid phage clearance, which fits a two-compartment model.
Pharmacologic Responses Of The Mouse Urinary Bladder, A. Erdem, Christopher Chapple, Russ Chess-Williams
Pharmacologic Responses Of The Mouse Urinary Bladder, A. Erdem, Christopher Chapple, Russ Chess-Williams
Russ Chess-Williams
The aim of the study was to determine pathways involved in contraction and relaxation of the mouse urinary bladder. Mouse bladder strips were set up in gassed Krebs-bicarbonate solution and responses to various drugs and electrical field stimulation were obtained. Isoprenaline (b-receptor agonist) caused a 63% inhibition of carbachol precontracted detrusor (EC50=2nM). Carbachol caused contraction (EC50=0.3µM), responses were antagonised more potently by 4-DAMP (M3-antagonist) than methoctramine (M2-antagonist). Electrical field stimulation caused contraction, which was inhibited by atropine (60%) and less by guanethidine and α,β-methylene-ATP. The neurogenic responses were not potentiated by inhibition of nitric oxide synthase. Presence of an intact …
Pharmacologic Responses Of The Mouse Urinary Bladder, A. Erdem, Christopher Chapple, Russ Chess-Williams
Pharmacologic Responses Of The Mouse Urinary Bladder, A. Erdem, Christopher Chapple, Russ Chess-Williams
Russ Chess-Williams
The aim of the study was to determine pathways involved in contraction and relaxation of the mouse urinary bladder. Mouse bladder strips were set up in gassed Krebs-bicarbonate solution and responses to various drugs and electrical field stimulation were obtained. Isoprenaline (b-receptor agonist) caused a 63% inhibition of carbachol precontracted detrusor (EC50=2nM). Carbachol caused contraction (EC50=0.3µM), responses were antagonised more potently by 4-DAMP (M3-antagonist) than methoctramine (M2-antagonist). Electrical field stimulation caused contraction, which was inhibited by atropine (60%) and less by guanethidine and α,β-methylene-ATP. The neurogenic responses were not potentiated by inhibition of nitric oxide synthase. Presence of an intact …
Blood Kinetics Of Four Intraperitoneally Administered Therapeutic Candidate Bacteriophages In Healthy And Neutropenic Mice, Jumpei Uchiyama, Yoshihiro Maeda, Iyo Takemura, Russ Chess-Williams, Hiroshi Wakiguchi, Shigenobu Matsuzaki
Blood Kinetics Of Four Intraperitoneally Administered Therapeutic Candidate Bacteriophages In Healthy And Neutropenic Mice, Jumpei Uchiyama, Yoshihiro Maeda, Iyo Takemura, Russ Chess-Williams, Hiroshi Wakiguchi, Shigenobu Matsuzaki
Russ Chess-Williams
Due to multiple-drug resistant bacteria, phage therapy is being revisited. Although most animal experiments focus on therapeutic efficacy, the blood clearance kinetics of phages have not been well described. For further development of an efficient therapeutic strategy, information on phage blood kinetics is important. In this study, time-course concentration changes in peripheral blood of healthy and neutropenic mice were measured using four therapeutic phages (φMR11, KPP10, φEF24C, and KEP10). The results showed a two- to three-day rapid phage clearance, which fits a two-compartment model.
Erythrocyte Aggregation And Neutrophil Function In An Aging Population, Rhys Christy, Oguz Baskurt, Gregory Gass, A. Gray, Sonya Marshall-Gradisnik
Erythrocyte Aggregation And Neutrophil Function In An Aging Population, Rhys Christy, Oguz Baskurt, Gregory Gass, A. Gray, Sonya Marshall-Gradisnik
Sonya Marshall-Gradisnik
There are limited investigations which have examined the relationship between neutrophil activation and erythrocyte aggregation in older persons. The purpose of the present study was to investigate the relationship between neutrophil activation and erythrocyte aggregation (EA) in an aging population. Twenty-eight male and female subjects were allocated into one of four groups with 7 participants in each group (group 1, 20–29 years; group 2, 30–39 years; group 3, 40–49 years; group 4, 50–59 years). EA was determined using the Myrenne aggregometer. Neutrophil function (respiratory burst and phagocytic activity) was assessed using flow cytometry. EA was found to increase with age. …
Prognosis Of Acute Myocardial Infarction Complicated By Complete Heart Block (The Worcester Heart Attack Study), Robert Goldberg, Juan Zevallos, Jorge Yarzebski, Joseph Alpert, Joel Gore, Z. Chen, James Dalen
Prognosis Of Acute Myocardial Infarction Complicated By Complete Heart Block (The Worcester Heart Attack Study), Robert Goldberg, Juan Zevallos, Jorge Yarzebski, Joseph Alpert, Joel Gore, Z. Chen, James Dalen
Jorge L. Yarzebski
As part of a community-based study of patients hospitalized with acute myocardial infarction (AMI) in the Worcester, Massachusetts, metropolitan area, changes over time in the incidence rates of complete heart block (CHB) complicating AMI, and the prognostic impact of CHB on the in-hospital and long-term survival of these patients were examined. In all, 4,762 patients with validated AMI hospitalized at 16 hospitals in the Worcester metropolitan area during 1975, 1978, 1981, 1984, 1986 and 1988 constituted the study sample. The incidence rates of CHB complicating AMI remained relatively stable at 5.8% over the 13-year (1975 to 1988) period studied. The …
Narrowing Gender Differences In Procedure Use For Acute Myocardial Infarction: Insights From The Worcester Heart Attack Study, Leslie Harrold, Julian Esteban, Darleen Lessard, Jorge Yarzebski, Jerry Gurwitz, Joel Gore, Robert Goldberg
Narrowing Gender Differences In Procedure Use For Acute Myocardial Infarction: Insights From The Worcester Heart Attack Study, Leslie Harrold, Julian Esteban, Darleen Lessard, Jorge Yarzebski, Jerry Gurwitz, Joel Gore, Robert Goldberg
Jorge L. Yarzebski
OBJECTIVE: To examine age-specific gender differences and trends over time in the management of patients with acute myocardial infarction (AMI). DESIGN: Cross-sectional study of patients admitted with AMI from a community-wide perspective over a 10-year period (1990-1999). SETTING: All hospitals in the Worcester (Mass) metropolitan area (1990 census = 437000). PATIENTS/PARTICIPANTS: We identified 2037 women and 2645 men who were hospitalized in the Worcester metropolitan area with confirmed AMI during six 1-year periods between 1990 and 1999. Four age groups (<55, 55 to 64, 65 to 74 and >or=75 years) of men and women were studied. MEASUREMENTS AND MAIN RESULTS: Use of echocardiography, exercise treadmill testing (ETT), …
Long-Term Trends (1986-2003) In The Use Of Coronary Reperfusion Strategies In Patients Hospitalized With Acute Myocardial Infarction In Central Massachusetts, Robert J. Goldberg, Frederick A. Spencer, Joseph Okolo, Darleen M. Lessard, Jorge L. Yarzebski, Joel M. Gore
Long-Term Trends (1986-2003) In The Use Of Coronary Reperfusion Strategies In Patients Hospitalized With Acute Myocardial Infarction In Central Massachusetts, Robert J. Goldberg, Frederick A. Spencer, Joseph Okolo, Darleen M. Lessard, Jorge L. Yarzebski, Joel M. Gore
Jorge L. Yarzebski
BACKGROUND: The objectives of our study were to examine long-term (1986-2003) trends in the use of percutaneous coronary interventions (PCI) and thrombolytic therapy in the management of patients hospitalized at all Central Massachusetts medical centers with acute myocardial infarction (AMI). Our secondary study goal was to examine factors associated with use of these coronary reperfusion strategies. Limited contemporary data are available about changing trends in the use of coronary reperfusion strategies, particularly from a population-based perspective. METHODS: The sample consisted of 9422 greater Worcester (MA) residents hospitalized with AMI at all metropolitan Worcester medical centers in 10 annual periods between …
A Community-Wide Perspective Of Gender Differences And Temporal Trends In The Use Of Diagnostic And Revascularization Procedures For Acute Myocardial Infarction, David Chiriboga, Jorge Yarzebski, Robert Goldberg, Z. Chen, Jerry Gurwitz, Joel Gore, Joseph Alpert, James Dalen
A Community-Wide Perspective Of Gender Differences And Temporal Trends In The Use Of Diagnostic And Revascularization Procedures For Acute Myocardial Infarction, David Chiriboga, Jorge Yarzebski, Robert Goldberg, Z. Chen, Jerry Gurwitz, Joel Gore, Joseph Alpert, James Dalen
Jorge L. Yarzebski
This study compares the overall use, as well as temporal trends, of various diagnostic and revascularization procedures for acute myocardial infarction (AMI) in men and women. The study sample comprised a total of 2,924 men and 1,838 women with validated AMI admitted to any of the 16 teaching and community hospitals in the Worcester, Massachusetts, metropolitan area during 1975, 1978, 1981, 1984, 1986 and 1988. During the period under study there was a significant increase in use of each of the examined procedures during hospitalization for AMI in both men and women. Increasing use of multiple procedures was also seen …
Decade-Long Trends And Factors Associated With Time To Hospital Presentation In Patients With Acute Myocardial Infarction: The Worcester Heart Attack Study, Robert Goldberg, Jorge Yarzebski, Darleen Lessard, Joel Gore
Decade-Long Trends And Factors Associated With Time To Hospital Presentation In Patients With Acute Myocardial Infarction: The Worcester Heart Attack Study, Robert Goldberg, Jorge Yarzebski, Darleen Lessard, Joel Gore
Jorge L. Yarzebski
BACKGROUND: Duration of prehospital delay in patients with acute myocardial infarction (AMI) is receiving increasing attention given the time-dependent benefits associated with prompt use of coronary reperfusion strategies. OBJECTIVE: To examine trends (1986-1997) in time to hospital presentation and factors associated with prolonged delay in a community-wide study of patients with AMI. METHODS: Longitudinal study of 3837 residents of the Worcester, Mass, metropolitan area hospitalized with AMI in 7 one-year periods between 1986 and 1997 in whom information about prehospital delay was available. RESULTS: The mean, median, and distribution of delay times exhibited either inconsistent or no changes over time. …
Use Of Aspirin, Beta-Blockers, And Lipid-Lowering Medications Before Recurrent Acute Myocardial Infarction: Missed Opportunities For Prevention, Danny Mccormick, Jerry Gurwitz, Darleen Lessard, Jorge Yarzebski, Joel Gore, Robert Goldberg
Use Of Aspirin, Beta-Blockers, And Lipid-Lowering Medications Before Recurrent Acute Myocardial Infarction: Missed Opportunities For Prevention, Danny Mccormick, Jerry Gurwitz, Darleen Lessard, Jorge Yarzebski, Joel Gore, Robert Goldberg
Jorge L. Yarzebski
BACKGROUND: For patients who have had a previous myocardial infarction (MI), the use of aspirin, beta-blockers, and lipid-lowering agents reduces the risk of recurrent MI and death. OBJECTIVE: To examine trends in and determinants of receipt of these 3 medications before hospitalization for recurrent acute MI (AMI). METHODS: The study population consisted of 1710 patients with a previous history of MI hospitalized with a validated recurrent AMI in all hospitals in Worcester, Mass, during 1986, 1988, 1990, 1991, 1993, and 1995. Logistic regression analyses were used to assess the effect of demographic, clinical, and temporal factors on the receipt of …
Temporal Trends And Factors Associated With Extent Of Delay To Hospital Arrival In Patients With Acute Myocardial Infarction: The Worcester Heart Attack Study, Jorge Yarzebski, Robert Goldberg, Joel Gore, Joseph Alpert
Temporal Trends And Factors Associated With Extent Of Delay To Hospital Arrival In Patients With Acute Myocardial Infarction: The Worcester Heart Attack Study, Jorge Yarzebski, Robert Goldberg, Joel Gore, Joseph Alpert
Jorge L. Yarzebski
Factors associated with delay to hospital arrival after the onset of symptoms suggestive of acute myocardial infarction (AMI) were examined in the late 1960s and 1970s, but recent data concerning these characteristics are limited. The purpose of the present study was to examine overall and temporal distributions of the extent of patients' delay from the time of onset of AMI symptoms to hospital arrival and factors associated with delay in seeking medical care from a multihospital, population-based perspective. Review of medical records was undertaken of patients hospitalized with a discharge diagnosis of AMI in 16 teaching and community hospitals in …
A Community-Wide Survey Of Physician Practices And Attitudes Toward Cholesterol Management In Patients With Recent Acute Myocardial Infarction, Jorge Yarzebski, Carmen Bujor, Robert Goldberg, Frederick Spencer, Darleen Lessard, Joel Gore
A Community-Wide Survey Of Physician Practices And Attitudes Toward Cholesterol Management In Patients With Recent Acute Myocardial Infarction, Jorge Yarzebski, Carmen Bujor, Robert Goldberg, Frederick Spencer, Darleen Lessard, Joel Gore
Jorge L. Yarzebski
BACKGROUND: Physicians' current attitudes and practices toward the management of high cholesterol levels in patients with recent acute myocardial infarction are not well defined. OBJECTIVE: To examine threshold levels of serum cholesterol and other factors that influence physicians' decision to prescribe lipid-lowering drugs and initiate dietary therapy in patients with recent acute myocardial infarction. METHODS: Community-wide questionnaire survey of general internists, cardiologists, and family physicians practicing in the Worcester, Mass, metropolitan area. RESULTS: Among the 257 responding physicians, lipid-lowering drug therapy was more likely to be initiated in younger patients at lower total serum and low-density lipoprotein (LDL) cholesterol levels …
Patient Delay And Receipt Of Thrombolytic Therapy Among Patients With Acute Myocardial Infarction From A Community-Wide Perspective, Robert Goldberg, Jerry Gurwitz, Jorge Yarzebski, J. Landon, Joel Gore, Joseph Alpert, P. Dalen, James Dalen
Patient Delay And Receipt Of Thrombolytic Therapy Among Patients With Acute Myocardial Infarction From A Community-Wide Perspective, Robert Goldberg, Jerry Gurwitz, Jorge Yarzebski, J. Landon, Joel Gore, Joseph Alpert, P. Dalen, James Dalen
Jorge L. Yarzebski
The duration of patient delay from the time of onset of symptoms of acute myocardial infarction (AMI) to hospital presentation, and the relation of delay time and various patient characteristics to receipt of thrombolytic therapy were examined as part of a community-based study of patients hospitalized with AMI in the Worcester, Massachusetts, metropolitan area. In all, 800 patients with validated AMI hospitalized at 16 hospitals in the Worcester metropolitan area in 1986 and 1988 constituted the study sample. Patients delayed on average 4 hours between noting symptoms suggestive of AMI and presenting to area-wide emergency departments with no significant change …
Temporal Trends (1986-1997) In Cholesterol Level Assessment And Management Practices In Patients With Acute Myocardial Infarction: A Population-Based Perspective, Jorge Yarzebski, Frederick Spencer, Robert Goldberg, Darleen Lessard, Joel Gore
Temporal Trends (1986-1997) In Cholesterol Level Assessment And Management Practices In Patients With Acute Myocardial Infarction: A Population-Based Perspective, Jorge Yarzebski, Frederick Spencer, Robert Goldberg, Darleen Lessard, Joel Gore
Jorge L. Yarzebski
BACKGROUND: Elevated serum cholesterol levels are associated with increased risk for acute myocardial infarction (AMI) and adverse patient outcomes. It is unclear what proportion of patients have their serum cholesterol levels measured during hospitalization for AMI and are given hypolipidemic therapy. OBJECTIVE: To examine decade-long trends in measurement of serum cholesterol levels during hospitalization for AMI and use of hypolipidemic therapy. METHODS: Observational study of 5204 residents of the Worcester, Mass, metropolitan area hospitalized with validated AMI in all greater Worcester hospitals in seven 1-year periods from 1986 through 1997. RESULTS: Increases in the measurement of serum cholesterol levels during …
Temporal Trends And Factors Associated With Pulmonary Artery Catheterization In Patients With Acute Myocardial Infarction, Jorge Yarzebski, Robert Goldberg, Joel Gore, Joseph Alpert
Temporal Trends And Factors Associated With Pulmonary Artery Catheterization In Patients With Acute Myocardial Infarction, Jorge Yarzebski, Robert Goldberg, Joel Gore, Joseph Alpert
Jorge L. Yarzebski
STUDY OBJECTIVE: To examine changes over time in the utilization of and factors associated with pulmonary artery (PA) catheterization in patients hospitalized with acute myocardial infarction (AMI). DESIGN: Nonconcurrent prospective study carried out in 16 teaching and community hospitals in Worcester, Mass, in seven time periods between 1975 and 1990. A total of 5,480 patients hospitalized with validated AMI comprised the study sample. RESULTS: Use of PA catheterization increased from 1975 to 1984 with a consistent decline thereafter in all patients with AMI studied. Among the 2,441 patients with complicated AMI, use of PA catheterization increased from 1975 through 1988 …