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Articles 1741 - 1760 of 1760

Full-Text Articles in Life Sciences

Monoclonal Antibodies Reveal The Structural Basis Of Antibody Diversity, Jean-Luc Teillaud, Catherine Desaymard, Angela Giusti, Barbara Haseltine, Roberta Pollock, Dale Yelton, Donald Zach, Matthew Scharff Dec 1982

Monoclonal Antibodies Reveal The Structural Basis Of Antibody Diversity, Jean-Luc Teillaud, Catherine Desaymard, Angela Giusti, Barbara Haseltine, Roberta Pollock, Dale Yelton, Donald Zach, Matthew Scharff

Roberta Pollock

Hybridoma technology has made it possible to introduce into continuous culture normal antibody-forming cells and to obtain large amounts of the immunoglobulin produced by each of these cells. Examination of the structure of a number of monoclonal antibodies that react with a single antigen has provided new information on the structural basis of the specificity and affinity of antibodies. Comparisons of families of monoclonal antibodies derived from a single germ line gene revealed the importance of somatic mutation in generating antibody diversity. Monoclonal antibodies that react with variable regions of other monoclonals allow the further dissection and modulation of the …

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Live Northern Harrier Entrapped In Ice, Given Harper, Thomas C. Dunstan Dec 1982

Live Northern Harrier Entrapped In Ice, Given Harper, Thomas C. Dunstan

Given Harper

No abstract provided.

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Drosophila Alcohol Dehydrogenase: Developmental Studies On Cryptic Variant Lines, Gurbachan Miglani, Franklin Ampy Sep 1981

Drosophila Alcohol Dehydrogenase: Developmental Studies On Cryptic Variant Lines, Gurbachan Miglani, Franklin Ampy

Franklin Ampy

Thirty-five cryptic variant lines were used to examine the mechanisms involved in genetic modulation of alcohol metabolism in Drosophila. Late third-instar larval, preemergence pupal, and adult stages cultured at 18 and 28 C were examined. Spectrophotometric analyses for native alcohol dehydrogenase (ADH) activity and residual ADH activity after treatment with guanidine hydrochloride and heat were performed. Differential response of cryptic variants to treatment with the denaturants during development suggested that this variation may have an adaptive significance.

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Changes In Native Alcohol Dehydrogenase Activity Of Drosophila Upon Treatment With Guanidine Hydrochloride, Urea And Heat, Gurbachan Miglani, Franklin Ampy Aug 1981

Changes In Native Alcohol Dehydrogenase Activity Of Drosophila Upon Treatment With Guanidine Hydrochloride, Urea And Heat, Gurbachan Miglani, Franklin Ampy

Franklin Ampy

Fifty-two isochromosomal lines ofDrosophila melanogaster were examined for the existence of additional genetic variations in ADH activity subsequent to treatment With guanidine hydrochloride, urea and heat. A wealth of hidden variation was discovered among and within the Mexican populations of the insect after treatment with the denaturants.

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Statistical Analysis Of Cryptic Variation In Drosophila Alcohol Dehydrogenase, Gurbachan Miglani, Franklin Ampy Aug 1981

Statistical Analysis Of Cryptic Variation In Drosophila Alcohol Dehydrogenase, Gurbachan Miglani, Franklin Ampy

Franklin Ampy

Statistical analysis indicated that mean alcohol dehydrogenase (ADH) activity levels within ADH1 and ADH11 isochromosomal lines varied significantly among the Mexican populations ofDrosophila melanogaster used. Also as indicated by coefficient of variation values for ADH activity, the relative amount of genetic variation differed among and within the ADH1 and ADH11 strains examined. The quantitative nature of the differences in ADH activity supported the concept of the additive gene action of the alcohol dehydrogenase (Adh) locus. The manner in which our isochromosomal lines were constructed suggested that genes regulating ADH activity inD. melanogaster were located on the second chromosomes.

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Fungal Metabolite From Members Of The Genus Rhizopus, D P. Thompson, A W. Smalley, Broderick Eribo Apr 1981

Fungal Metabolite From Members Of The Genus Rhizopus, D P. Thompson, A W. Smalley, Broderick Eribo

Broderick Eribo

A fluorescent metabolite present in seven members of the genus Rhizopus was isolated. This compound appeared green before spray treatment and purple after spray treatment with p-anisaldehyde in visible light. Subsequent purification and structural elucidation of the isolated compound yielded 1-[2,6,10,14-tetramethyl-17-carbomethyl heptadecyl]-1-[2,6,10,14-tetramethyl-17-methanoyl heptadecyl]-benzene.

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Immunobiology Of Schistosomiasis, Clarence Lee, Mohamed A. Elhelu, Georgiana Aboko-Cole Feb 1980

Immunobiology Of Schistosomiasis, Clarence Lee, Mohamed A. Elhelu, Georgiana Aboko-Cole

Clarence Lee

Although malaria and hookworm disease appear to be on the decline, another dreaded parasitic disease-schistosomiasis-is on the increase. Presently, the number of infected individuals with schistosomes is estimated to be 250 million, and even though only a small proportion of them become sick and die, schistosomiasis remains a medical problem of great significance. The high incidence of infection of man with Schistosoma mansoni, Schistosoma japonicum or Schistosoma haematobium, as well as the chronic debilitating diseases produced, places these organisms among the world's most important infectious agents. This paper discusses the nature of immunity to schistosomiasis.

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Genetic Control Of Murine Igd Structural Heterogeneity, Roberta R. Pollock, Martin E. Dorf, Matthew F. Mescher Dec 1979

Genetic Control Of Murine Igd Structural Heterogeneity, Roberta R. Pollock, Martin E. Dorf, Matthew F. Mescher

Roberta Pollock

Murine B lymphocytes express two native forms of surface IgD: IgDI consists of two delta heavy chains and two light chains; IgDII consists of one heavy chain and one light chain. The relative amounts of IgDI and IgDII present on spleen cells were found to vary significantly among different strains of mice. Genetic evidence demonstrated that the IgDI/IgDII ratio is linked to the Igh-5 allotype. (The delta heavy chain is the product of the Igh-5 locus). Mice bearing the Igh-5e allotype have a low ratio, and mice bearing the Igh-5a or Igh-5b allotype have a high ratio. The Igh-5 locus …

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Immunobiology Of Malaria, Clarence Lee, Yvonne Hogan, Georgiana Aboko-Cole Mar 1979

Immunobiology Of Malaria, Clarence Lee, Yvonne Hogan, Georgiana Aboko-Cole

Clarence Lee

Malaria, the number one disease in the world, is caused by intracellular protozoans belonging to the Subphylum, Sporozoa; Suborder, Haemosphoridia; and Family, Plasmodiidae. The four classical organisms producing disease in man are Plasmodium vivax, P. falciparum, P. malariae, and P. ovale. Although malaria has been known to man for centuries, attempts are still being made to control and eliminate its devastating effects in tropical and subtropical areas of the world. Current active interest in malarial immunology and immunopathology derives from two main facts: (1) that human malaria is still one of the chief health problems in a broad tropical and …

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Rna Sequencing Provides Evidence For Allelism Of Determinants Of The N-, B-, Or Nb- Tropism Of Murine Leukemia Viruses, Jean Rommelaere, Helen Donis-Keller, Nancy Hopkins Dec 1978

Rna Sequencing Provides Evidence For Allelism Of Determinants Of The N-, B-, Or Nb- Tropism Of Murine Leukemia Viruses, Jean Rommelaere, Helen Donis-Keller, Nancy Hopkins

Helen Donis-Keller

Previous genetic and biochemical studies identified three large RNAase T1-resistant oligonucleotides, each associated with either the N-, B- or NB-tropism of murine C-type viruses of BALB/c origin. These oligonucleotides were shown to lie in the 5′ third of the oligonucleotide maps of their respective viruses. We sequenced the three oligonucleotides and found that they share a 10 base sequence. Together these observations provide good evidence that the determinants of N-, B- or NB-tropism monitored by the three oligonucleotides are allelic.The oligonucleotides associated with N- and B-tropism differ in sequence at four of sixteen nucleotides, while the B- and NB-tropism-associated oligonucleotides …

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Mapping Adenines, Guanines, And Pyrimidines In Rna, Helen Donis-Keller, Allan Maxam, Walter Gilbert Jul 1977

Mapping Adenines, Guanines, And Pyrimidines In Rna, Helen Donis-Keller, Allan Maxam, Walter Gilbert

Helen Donis-Keller

The positions of adenines, guanines, and pyrimidines can be determined by partial nuclease digestion of a terminally labeled RNA molecule. In urea, at elevated temperatures, RNase T1 generates a pattern reflecting cleavage at guanines while RNase U2 cleaves only at adenine. A limited alkaline hydrolysis provides a continuum of fragments derived from breaks at every phosphodiester bond. The reaction products are electrophoretically fractionated by size in adjacent lanes of a polyacrylamide gel. An autoradiograph of the gel displays the sequence up to 100 nucleotides from the end of the molecule, although uracil cannot as yet be distinguished from cytosine. These …

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Algae-Grazer Interactions, Warren Abrahamson Dec 1976

Algae-Grazer Interactions, Warren Abrahamson

Warren G. Abrahamson, II

No abstract provided.

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Solidago Canadensis Galls: A Study Of Interacting Natural Populations, Warren Abrahamson Dec 1976

Solidago Canadensis Galls: A Study Of Interacting Natural Populations, Warren Abrahamson

Warren G. Abrahamson, II

No abstract provided.

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Niche Analysis Of Marine Algae, Warren Abrahamson Dec 1976

Niche Analysis Of Marine Algae, Warren Abrahamson

Warren G. Abrahamson, II

No abstract provided.

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The Effects Of Grazing On Vegetation, Warren Abrahamson Dec 1976

The Effects Of Grazing On Vegetation, Warren Abrahamson

Warren G. Abrahamson, II

No abstract provided.

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Growth Forms Of Opuntia Compressa (Cactaceae) In Florida Sandridge Habitats, Warren Abrahamson, J. Rubinstein Dec 1975

Growth Forms Of Opuntia Compressa (Cactaceae) In Florida Sandridge Habitats, Warren Abrahamson, J. Rubinstein

Warren G. Abrahamson, II

No abstract provided.

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Reproductive Strategies Of Dewberries, Warren Abrahamson Dec 1974

Reproductive Strategies Of Dewberries, Warren Abrahamson

Warren G. Abrahamson, II

No abstract provided.

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Reproduction Of Rubus Hispidus L. In Different Habitats, Warren Abrahamson Dec 1974

Reproduction Of Rubus Hispidus L. In Different Habitats, Warren Abrahamson

Warren G. Abrahamson, II

No abstract provided.

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Growth Form And Reproductive Effort In Goldenrods, Warren Abrahamson, M. Gadgil Dec 1972

Growth Form And Reproductive Effort In Goldenrods, Warren Abrahamson, M. Gadgil

Warren G. Abrahamson, II

No abstract provided.

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Logical And Persuasive Structures In Charles Darwin's Prose Style, Charles Kay Smith Dec 1969

Logical And Persuasive Structures In Charles Darwin's Prose Style, Charles Kay Smith

Charles Kay Smith

This paper analyzes Charles Darwin's characteristic writing behavior. Darwin was a more interesting and dedicated writer than he is commonly credited for being. This essay will reassess the importance of his writing. The surface characteristics of Darwin's prose (conventionally referred to as his "style") seem at first glance so plain and ordinary that Darwin's writing rarely interests students of style. Exceptions such as Theodore Baird in an essay entitled "Darwin and the Tangled Bank"1 and Stanley Edgar Hyman in a longer study of Darwin's writing, The Tangled Bank,2 both make a point of the current general disregard of Darwin as …

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