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Articles 1 - 30 of 333

Full-Text Articles in Bioimaging and Biomedical Optics

Egcg Protects Against 6-Ohda-Induced Neurotoxicity In A Cell Culture Model, Dan Chen, Anumantha G. Kanthasamy, Manju B. Reddy Nov 2017

Egcg Protects Against 6-Ohda-Induced Neurotoxicity In A Cell Culture Model, Dan Chen, Anumantha G. Kanthasamy, Manju B. Reddy

Manju B. Reddy

Background. Parkinson’s disease (PD) is a progressive neurodegenerative disease that causes severe brain dopamine depletion. Disruption of iron metabolism may be involved in the PD progression. Objective. To test the protective effect of (−)-epigallocatechin-3-gallate (EGCG) against 6-hydroxydopamine- (6-OHDA-) induced neurotoxicity by regulating iron metabolism in N27 cells. Methods. Protection by EGCG in N27 cells was assessed by SYTOX green assay, MTT, and caspase-3 activity. Iron regulatory gene and protein expression were measured by RT-PCR and Western blotting. Intracellular iron uptake was measured using 55Fe. The EGCG protection was further tested in primary mesencephalic dopaminergic neurons by immunocytochemistry. Results. EGCG ...


Use Of Imaging Biomarkers To Assess Perfusion And Glucose Metabolism In The Skeletal Muscle Of Dystrophic Mice, Nabeel Ahmad, Ian Welch, Robert Grange, Jennifer Hadway, Savita Dhanvantari, David Hill, Ting-Yim Lee, Lisa M Hoffman Aug 2017

Use Of Imaging Biomarkers To Assess Perfusion And Glucose Metabolism In The Skeletal Muscle Of Dystrophic Mice, Nabeel Ahmad, Ian Welch, Robert Grange, Jennifer Hadway, Savita Dhanvantari, David Hill, Ting-Yim Lee, Lisa M Hoffman

Lisa Hoffman

BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe neuromuscular disease that affects 1 in 3500 boys. The disease is characterized by progressive muscle degeneration that results from mutations in or loss of the cytoskeletal protein, dystrophin, from the glycoprotein membrane complex, thus increasing the susceptibility of contractile muscle to injury. To date, disease progression is typically assessed using invasive techniques such as muscle biopsies, and while there are recent reports of the use of magnetic resonance, ultrasound and optical imaging technologies to address the issue of disease progression and monitoring therapeutic intervention in dystrophic mice, our study aims to validate ...


Multi-Color Ultra-High Resolution Imaging, David A. Miller, Michael Mlodzianoski, Sheng Liu, Fang Huang Aug 2017

Multi-Color Ultra-High Resolution Imaging, David A. Miller, Michael Mlodzianoski, Sheng Liu, Fang Huang

The Summer Undergraduate Research Fellowship (SURF) Symposium

Fluorescence microscopy, which allows multiple-color imaging, plays an important role in observing structures inside cells with high specificity. The advent of super-resolution fluorescence microscopy, or nanoscopy techniques such as single-molecule switching nanoscopy (SMSN), has extended the application range of fluorescence microscopy beyond the diffraction limit, achieving up to 10-fold improvement in spatial resolution. At the same time, the recent development of expansion microscopy (ExM) allows samples to be physically expanded by 4-fold in the lateral dimensions providing another independent method to resolve structures beyond the diffraction limit. When combined, ExM-SMSN makes it possible to achieve another significant leap in resolution ...


Gui For Mri-Compatible Neural Stimulator And Recorder, Soo Han Soon, Nishant Babaria, Ranajay Mandal, Zhongming Liu Aug 2017

Gui For Mri-Compatible Neural Stimulator And Recorder, Soo Han Soon, Nishant Babaria, Ranajay Mandal, Zhongming Liu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) are useful tools to analyze brain activities given active stimulation. However, the electromagnetic noise from the MRI distorts the brain signal recording and damages the subject with excessive heat generated on the electrodes attached to the skin. MRI-compatible recording and stimulation systems previously developed at LIBI lab were capable of removing the electromagnetic noise during the imaging process. Previously, the hardware systems had required the integrative software that could control both circuits simultaneously and enable users to easily change recording and stimulation parameters. Graphical user interface (GUI) programmed with computer language informed ...


Dual-Tuned Removable Common-Mode Current Trap For Mri, Angel G. Enriquez, Joseph V. Rispoli Aug 2017

Dual-Tuned Removable Common-Mode Current Trap For Mri, Angel G. Enriquez, Joseph V. Rispoli

The Summer Undergraduate Research Fellowship (SURF) Symposium

Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) are preferred methods of gathering information from the body due to their non-invasive approach of obtaining a diagnosis. MRI can obtain spatial mappings from a region of interest, while MRS can obtain metabolic information from different elements. Dual-tuned radiofrequency (RF) coils are able to capture signals produced by both hydrogen atoms and a second atom of interest. Unwanted shield currents occur in these scans, which can cause image distortion, while the high energy dissipated can create harmful heat, which can injure the patient. These shield currents, also known as common-mode currents ...


Nanostructured Biosensor For Tear Glucose Detection Based On Bioluminescence Resonance Energy Transfer (Bret) Mechanism., Denghuang Zhan Aug 2017

Nanostructured Biosensor For Tear Glucose Detection Based On Bioluminescence Resonance Energy Transfer (Bret) Mechanism., Denghuang Zhan

Electronic Thesis and Dissertation Repository

Bioluminescence Resonance Energy Transfer (BRET), a sensitive, non-destructive and self-illuminated method, has been now commonly used to test protein interactions. Here, we describe a BRET sensor for non-invasively detecting glucose molecules. The sensor is made by the bioconjugation of quantum dots and recombinant protein. The recombinant protein contains the bacterial glucose binding protein (GBP) and a bioluminescent protein, Renilla luciferase (Rluc), used as the donor with the emission peak at 470 nm, which is able to excite the acceptor of BRET sensor made of cadmium tellurium quantum dots ( CdTe QDs) with the emission peak at 570 nm. The distance between ...


Segmentation Of Heart Ventricles Using Skeletal Representations, Hasana Chaudry, Toshiro Kubota Jul 2017

Segmentation Of Heart Ventricles Using Skeletal Representations, Hasana Chaudry, Toshiro Kubota

Landmark Conference Summer Research Symposium

The objective of the project is to develop practical algorithms to segment the human heart’s left and right ventricles from isotropic Magnetic Resonance Imaging (MRI). An advanced algorithm that allows for efficient analysis of the ventricles in 3D or 4D would help diagnose and treat numerous cardiac diseases and illnesses. The left ventricle is a convex-like structure whereas the right ventricle has a relatively more abstract shape. The constant blood flow in and out of the ventricles causes them to look different at any given time. Therefore, our data set is in 4D where the fourth dimension is time ...


Multi-Material Mesh Representation Of Anatomical Structures For Deep Brain Stimulation Planning, Tanweer Rashid Jul 2017

Multi-Material Mesh Representation Of Anatomical Structures For Deep Brain Stimulation Planning, Tanweer Rashid

Modeling, Simulation & Visualization Engineering Theses & Dissertations

The Dual Contouring algorithm (DC) is a grid-based process used to generate surface meshes from volumetric data. However, DC is unable to guarantee 2-manifold and watertight meshes due to the fact that it produces only one vertex for each grid cube. We present a modified Dual Contouring algorithm that is capable of overcoming this limitation. The proposed method decomposes an ambiguous grid cube into a set of tetrahedral cells and uses novel polygon generation rules that produce 2-manifold and watertight surface meshes with good-quality triangles. These meshes, being watertight and 2-manifold, are geometrically correct, and therefore can be used to ...


A Review Of Autoimmune Diseases Associated With Cancer, Patricia Tai, Edward Yu, Kurian Joseph, Thomas Miale Jun 2017

A Review Of Autoimmune Diseases Associated With Cancer, Patricia Tai, Edward Yu, Kurian Joseph, Thomas Miale

Edward Yu

The focus of this review is on the relationships between autoimmune diseases and cancer from two closely related perspectives: 1.Those autoimmune diseases which are often associated with malignancies. 2.Those prevalent cancers which may increase the risks of developing autoimmune disorders. The review concludes with a brief discussion of some selected innovative approaches to cancer immunotherapy.


Robot Assisted Ultrasound Imaged Guided Interstitial Lung Brachytherapy In A Porcine Model, Richard A. Malthaner, Edward Yu, Jerry J. Battista, Chris Blake, Donal Downey, Aaron Fenster Jun 2017

Robot Assisted Ultrasound Imaged Guided Interstitial Lung Brachytherapy In A Porcine Model, Richard A. Malthaner, Edward Yu, Jerry J. Battista, Chris Blake, Donal Downey, Aaron Fenster

Edward Yu

We set out to see if permanent interstitial brachytherapy seeds could be safely and reproducibly inserted thoracoscopicaly with the ZEUS Robotic system and intraoperative ultrasound into in-vivo porcine lungs.


A Review Of Autoimmune Diseases Associated With Cancer, Patricia Tai, Edward Yu, Kurian Joseph, Thomas Miale Jun 2017

A Review Of Autoimmune Diseases Associated With Cancer, Patricia Tai, Edward Yu, Kurian Joseph, Thomas Miale

Edward Yu

The focus of this review is on the relationships between autoimmune diseases and cancer from two closely related perspectives: 1.Those autoimmune diseases which are often associated with malignancies. 2.Those prevalent cancers which may increase the risks of developing autoimmune disorders. The review concludes with a brief discussion of some selected innovative approaches to cancer immunotherapy.


A Novel Mra-Based Framework For The Detection Of Changes In Cerebrovascular Blood Pressure., Yitzhak Atakilt Gebru May 2017

A Novel Mra-Based Framework For The Detection Of Changes In Cerebrovascular Blood Pressure., Yitzhak Atakilt Gebru

Electronic Theses and Dissertations

Background: High blood pressure (HBP) affects 75 million adults and is the primary or contributing cause of mortality in 410,000 adults each year in the United States. Chronic HBP leads to cerebrovascular changes and is a significant contributor for strokes, dementia, and cognitive impairment. Non-invasive measurement of changes in cerebral vasculature and blood pressure (BP) may enable physicians to optimally treat HBP patients. This manuscript describes a method to non-invasively quantify changes in cerebral vasculature and BP using Magnetic Resonance Angiography (MRA) imaging.

Methods: MRA images and BP measurements were obtained from patients (n=15, M=8, F=7 ...


Metabolic Response To Stress Differentiates Heterogeneous Cancer Cells With Varying Metastatic Potential, Kinan Alhallak May 2017

Metabolic Response To Stress Differentiates Heterogeneous Cancer Cells With Varying Metastatic Potential, Kinan Alhallak

Biomedical Engineering Undergraduate Honors Theses

Intratumoral heterogeneity is ubiquitously present within primary tumors and contributes to intractable behaviors such as metastasis and mutability spatiotemporally. Mounting evidence has shown that heterogeneous cell populations can adversely affect cell metabolism and metastatic potential. The cell’s only fluorescent molecules within the electron transport chain, flavin adenine dinucleotide (FAD) and nicotinamide adenine dinucleotide (NADH), can allow the quantitation of cell metabolism. We demonstrate the use of the optical redox ratio (FAD/(NADH+FAD)) to determine the metabolic behaviors of a heterogeneous panel of cells with varying metastatic programs at normal conditions and following acute hypoxia. At normal conditions, we ...


In Vivo Multi-Parametric Imaging Of Metastatic And Non-Metastatic Breast Cancer, Raisa B. Rasul May 2017

In Vivo Multi-Parametric Imaging Of Metastatic And Non-Metastatic Breast Cancer, Raisa B. Rasul

Biomedical Engineering Undergraduate Honors Theses

A current issue in cancer therapy is the characterization of metastatic tumors, which can increase ease of treatment and patient trials. We present an in vivo study of metastatic (4T1) and non-metastatic (4T1-TWIST KO) breast tumor sister cell lines to understand their metabolic behavior, determine differences in two modes of imaging (reflection & transmission), and observe effect of breathing higher oxygen percentage on vascular hemoglobin oxygen saturation. After injection of 10,000 cells into mice dorsal window chambers, the glucose intake and hemoglobin oxygen saturation was measured using a fluorescent glucose analog (2-NBDG) and hyperspectral trans-illumination imaging from 520-620 nm at ...


Low-Cost Optics For Field-Based Optical Biosensors, Viktoriia Kriuchkovskaia Apr 2017

Low-Cost Optics For Field-Based Optical Biosensors, Viktoriia Kriuchkovskaia

Symposium on Undergraduate Research and Creative Expression

One of the main reasons of failures to ensure safe food production, especially in developing countries, is the lack of effective, low-cost detectors for toxic molecules. The manufacture of low-cost, easy-touse optical biosensors is expected to provide the means to detect toxic chemical and biological molecules in agricultural industry. Thus, such technologies are highly beneficial for in-field applications. The proposed approach integrates fairly sophisticated engineering concepts and low-cost parts and materials. Indeed, we employ low-cost light-emitting diode and single-board Raspberry Pi computer in order to build a fifty-dollar optical reader that can be applied to Nanotube-based biosensors. Previous research and ...


Development Of Spectroscopic Methods For Dynamic Cellular Level Study Of Biochemical Kinetics And Disease Progression, Anna M. Sitarski Mar 2017

Development Of Spectroscopic Methods For Dynamic Cellular Level Study Of Biochemical Kinetics And Disease Progression, Anna M. Sitarski

Electronic Theses and Dissertations

One of the current fundamental objectives in biomedical research is understanding molecular and cellular mechanisms of disease progression. Recent work in genetics support the stochastic nature of disease progression on the single cell level. For example, recent work has demonstrated that cancer as a disease state is reached after the accumulation of damages that result in genetic errors. Other diseases like Huntingtons, Parkinsons, Alzheimers, cardiovascular disease are developed over time and their cellular mechanisms of disease transition are largely unknown. Modern techniques of disease characterization are perturbative, invasive and fully destructive to biological samples. Many methods need a probe or ...


Computer-Assisted Characterization Of Prostate Cancer On Magnetic Resonance Imaging, Derek J. Soetemans Mar 2017

Computer-Assisted Characterization Of Prostate Cancer On Magnetic Resonance Imaging, Derek J. Soetemans

Electronic Thesis and Dissertation Repository

Prostate cancer (PCa) is one of the most prevalent cancers among men. Early diagnosis can improve survival and reduce treatment costs. Current inter-radiologist variability for detection of PCa is high. The use of multi-parametric magnetic resonance imaging (mpMRI) with machine learning algorithms has been investigated both for improving PCa detection and for PCa diagnosis. Widespread clinical implementation of computer-assisted PCa lesion characterization remains elusive; critically needed is a model that is validated against a histologic reference standard that is densely sampled in an unbiased fashion. We address this using our technique for highly accurate fusion of mpMRI with whole-mount digitized ...


A Novel Hybrid Imaging System To Aid In Surgical Decision Making, Lawrence Yip, Madeleine Van De Kleut, Ivan Kosik, Astrid Chamson-Reig, Jeffrey Jl Carson Mar 2017

A Novel Hybrid Imaging System To Aid In Surgical Decision Making, Lawrence Yip, Madeleine Van De Kleut, Ivan Kosik, Astrid Chamson-Reig, Jeffrey Jl Carson

Western Research Forum

Background:

Breast cancer accounts for 25% of all cancer cases among women. In breast-conserving surgery, a common treatment, the tumour is excised with a healthy tissue margin. However, detection of the margin can be difficult. Current techniques to guide excision are often insufficient, and re-excision can occur up to 25% of the time.

Methods:

Photoacoustic imaging is a hybrid imaging modality that combines the advantages of optical imaging and ultrasound while using safe non-ionizing light. This project involves the development of a novel imaging system with a new scanner design to overcome common limitations and provide images to aid in ...


Using A Respiratory Navigator Significantly Reduces Variability When Quantifying Left Ventricular Torsion With Cardiovascular Magnetic Resonance, Sean M. Hamlet, Christopher M. Haggerty, Jonathan D. Suever, Gregory J. Wehner, Kristin N. Andres, David K. Powell, Richard J. Charnigo, Brandon K. Fornwalt Mar 2017

Using A Respiratory Navigator Significantly Reduces Variability When Quantifying Left Ventricular Torsion With Cardiovascular Magnetic Resonance, Sean M. Hamlet, Christopher M. Haggerty, Jonathan D. Suever, Gregory J. Wehner, Kristin N. Andres, David K. Powell, Richard J. Charnigo, Brandon K. Fornwalt

Electrical and Computer Engineering Faculty Publications

Background: Left ventricular (LV) torsion is an important indicator of cardiac function that is limited by high inter-test variability (50% of the mean value). We hypothesized that this high inter-test variability is partly due to inconsistent breath-hold positions during serial image acquisitions, which could be significantly improved by using a respiratory navigator for cardiovascular magnetic resonance (CMR) based quantification of LV torsion.

Methods: We assessed respiratory-related variability in measured LV torsion with two distinct experimental protocols. First, 17 volunteers were recruited for CMR with cine displacement encoding with stimulated echoes (DENSE) in which a respiratory navigator was used to measure ...


Directed Acyclic Graph Continuous Max-Flow Image Segmentation For Unconstrained Label Orderings, John Sh Baxter, Martin Rajchl, A. Jonathan Mcleod, Jing Yuan, Terry M. Peters Feb 2017

Directed Acyclic Graph Continuous Max-Flow Image Segmentation For Unconstrained Label Orderings, John Sh Baxter, Martin Rajchl, A. Jonathan Mcleod, Jing Yuan, Terry M. Peters

Robarts Imaging Publications

Label ordering, the specification of subset–superset relationships for segmentation labels, has been of increasing interest in image segmentation as they allow for complex regions to be represented as a collection of simple parts. Recent advances in continuous max-flow segmentation have widely expanded the possible label orderings from binary background/foreground problems to extendable frameworks in which the label ordering can be specified. This article presents Directed Acyclic Graph Max-Flow image segmentation which is flexible enough to incorporate any label ordering without constraints. This framework uses augmented Lagrangian multipliers and primal–dual optimization to develop a highly parallelized solver implemented ...


Estimation Of The Centre Of Mass From Motion Capture And Force Plate Recordings: A Study On The Elderly, Sebastien Cotton, Michele Vanoncini, Philippe Fraisse, Nacim Ramdani, Emel Demircan, Andrew P. Murray, Thierry Keller Feb 2017

Estimation Of The Centre Of Mass From Motion Capture And Force Plate Recordings: A Study On The Elderly, Sebastien Cotton, Michele Vanoncini, Philippe Fraisse, Nacim Ramdani, Emel Demircan, Andrew P. Murray, Thierry Keller

Andrew P. Murray

The estimation of the centre of mass position in humans is usually based on biomechanical models developed from anthropometric tables. This method can potentially introduce errors in studies involving elderly people, since the ageing process is typically associated with a modification of the distribution of the body mass. In this paper, an alternative technique is proposed, and evaluated with an experimental study on 9 elderly volunteers. The technique is based on a virtual chain, identified from experimental data and locating the subject's centre of mass. Its configuration defines the location of the centre of mass, and is a function ...


Ex Vivo Bio-Orthogonal Mri Imaging – A Novel Method Proposed For Metastatic Cancer Detection, Tanner Ravsten, William G. Pitt, Neal K. Bangerter, Randy Hartley, Forrest Howell, Jessica Doud Feb 2017

Ex Vivo Bio-Orthogonal Mri Imaging – A Novel Method Proposed For Metastatic Cancer Detection, Tanner Ravsten, William G. Pitt, Neal K. Bangerter, Randy Hartley, Forrest Howell, Jessica Doud

Biomedical Engineering Western Regional Conference

Bio-orthogonal detection of metastatic cancer using MRI, Gd Iron-oxide contrast agents using T1 T2* scans


Mri Field Mapping Using Bssfp Elliptical Signal Model, Joseph Valentine, Meredith Taylor, Steven Whitaker, Michael Hoff, Neal Bangerter Feb 2017

Mri Field Mapping Using Bssfp Elliptical Signal Model, Joseph Valentine, Meredith Taylor, Steven Whitaker, Michael Hoff, Neal Bangerter

Biomedical Engineering Western Regional Conference

MRI, Field Mapping, bSSFP, ssfp, Elliptical Signal model, ellipse, phase unwrapping


Engineering Fret Biosensors For Microrna Presence/Absence Analysis, Nicholas E. Larkey, Sean M. Burrows Feb 2017

Engineering Fret Biosensors For Microrna Presence/Absence Analysis, Nicholas E. Larkey, Sean M. Burrows

Biomedical Engineering Western Regional Conference

No abstract provided.


Validation, Optimization, And Image Processing Of Spiral Cine Dense Magnetic Resonance Imaging For The Quantification Of Left And Right Ventricular Mechanics, Gregory J. Wehner Jan 2017

Validation, Optimization, And Image Processing Of Spiral Cine Dense Magnetic Resonance Imaging For The Quantification Of Left And Right Ventricular Mechanics, Gregory J. Wehner

Theses and Dissertations--Biomedical Engineering

Recent evidence suggests that cardiac mechanics (e.g. cardiac strains) are better measures of heart function compared to common clinical metrics like ejection fraction. However, commonly-used parameters of cardiac mechanics remain limited to just a few measurements averaged over the whole left ventricle. We hypothesized that recent advances in cardiac magnetic resonance imaging (MRI) could be extended to provide measures of cardiac mechanics throughout the left and right ventricles (LV and RV, respectively).

Displacement Encoding with Stimulated Echoes (DENSE) is a cardiac MRI technique that has been validated for measuring LV mechanics at a magnetic field strength of 1.5 ...


The Viability Of Advantg Deterministic Method For Synthetic Radiography Generation, Andrew Albert Bingham Jan 2017

The Viability Of Advantg Deterministic Method For Synthetic Radiography Generation, Andrew Albert Bingham

Masters Theses

"Time sensitive and high resolution image simulations are needed for synthetic radiography generation. The standard stochastic approach requires lengthy run times with poor statistics at higher resolutions. The investigation of the viability of a deterministic approach to synthetic radiography image generation was explored. The aim was to analyze a computational time decrease over the stochastic method. ADVANTG was compared to MCNP in multiple scenarios including a Benchtop CT prototype, to simulate high resolution radiography images. By using ADVANTG deterministic code to simulate radiography images the computational time was found to decrease over 10 times compared to the MCNP stochastic approach ...


Automatic Optimum Atlas Selection For Multi-Atlas Image Segmentation Using Joint Label Fusion, Kofi Agyeman Jan 2017

Automatic Optimum Atlas Selection For Multi-Atlas Image Segmentation Using Joint Label Fusion, Kofi Agyeman

Master's Theses

Multi-atlas image segmentation using label fusion is one of the most accurate state of the art image segmentation techniques available for biomedical imaging applications. Motivated to achieve higher image segmentation accuracy, reduce computational costs and a continuously increasing atlas data size, a robust framework for optimum selection of atlases for label fusion is vital. Although believed not to be critical for weighted label fusion techniques by some works (Sabuncu, M. R. et al., 2010, [1]), others have shown that appropriate atlas selection has several merits and can improve multi-atlas image segmentation accuracy (Aljabar et al., 2009, [2], Van de Velde ...


Characterization Of The Properties Of Photopatterned Hydrogels For Use In Regenerative Medicine, Callie Irene Fiedler Jan 2017

Characterization Of The Properties Of Photopatterned Hydrogels For Use In Regenerative Medicine, Callie Irene Fiedler

Electrical, Computer & Energy Engineering Graduate Theses & Dissertations

The goal of this thesis was to locally photopattern cytocompatible hydrogels to exhibit a wide range of mechanical properties and to probe the fundamental parameters governing these materials printed via stereolithography (SLA). Fabricating cell-laden structures with locally defined mechanical properties is non-trivial because the use of multiple precursor materials is wasteful, slow, and can lead to cell-death. To investigate the range of mechanical properties a single precursor solution can produce, I initially formed a single-network hydrogel and cyclically in- swelled fresh precursor solution followed by photo-exposure of the swollen gel (“swelling + exposure” or SE cycle). Because transport (i.e., diffusion ...


Neuroconductor: An R Platform For Medical Imaging Analysis, John Muschelli Iii, Jean-Philippe Fortin, Adrian Gherman, Brian Avants, Brandon Whitcher, Jonathan D. Clayden, Brian S. Caffo Phd, Ciprian Crainiceanu Phd Dec 2016

Neuroconductor: An R Platform For Medical Imaging Analysis, John Muschelli Iii, Jean-Philippe Fortin, Adrian Gherman, Brian Avants, Brandon Whitcher, Jonathan D. Clayden, Brian S. Caffo Phd, Ciprian Crainiceanu Phd

John Muschelli III

Neuroconductor (https://neuroconductor.org) is an open-source platform for rapid testing and dissemination of reproducible computational imaging software. The goals of the project are to: 1) provide a centralized repository of R software dedicated to image analysis, 2) disseminate software updates quickly, 3) train a large, diverse community of scientists using detailed tutorials and short courses, 4) increase software quality via automatic and manual quality controls, and 5) promote reproducibility of image data analysis. Based on the programming language R (https://www.r-project.org/), Neuroconductor starts with 51 inter-operable packages that cover multiple areas of imaging including visualization, data processing ...


Sensitivity Analysis Of Geometry Changes In The Simulation Of Basilar Aneurysms, Paul Eserkaln Dec 2016

Sensitivity Analysis Of Geometry Changes In The Simulation Of Basilar Aneurysms, Paul Eserkaln

Theses and Dissertations

Computer simulation is a useful tool in the research and treatment of basilar aneurysms. Current technology allows researchers to create 3D models from cerebral vasculature in-vivo, allowing for the investigation of surgical options with minimal risk to the patient. The method used to construct these models overlooks smaller lateral arterial branches which are difficult to discern due to resolution limits of the imaging process. These lateral branches have minimal impact on the overall blood flow through the basilar artery, but they play a significant role in the health of the patient, so it is important to ensure sufficient blood will ...