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Full-Text Articles in Biomedical Engineering and Bioengineering

Viscoelastic Properties Of Shock Wave Exposed Brain Tissue Subjected To Unconfined Compression Experiments, Annastacia K. Mccarty, Ling Zhang, Sarah Hansen, William J. Jackson, Sarah A. Bentil Dec 2019

Viscoelastic Properties Of Shock Wave Exposed Brain Tissue Subjected To Unconfined Compression Experiments, Annastacia K. Mccarty, Ling Zhang, Sarah Hansen, William J. Jackson, Sarah A. Bentil

Mechanical Engineering Publications

Traumatic brain injuries (TBI) affect millions of people each year. While research has been dedicated to determining the mechanical properties of the uninjured brain, there has been a lack of investigation on the mechanical properties of the brain after experiencing a primary blast-induced TBI. In this paper, whole porcine brains were exposed to a shock wave to simulate blast-induced TBI. First, ten (10) brains were subjected to unconfined compression experiments immediately following shock wave exposure. In addition, 22 brains exposed to a shock wave were placed in saline solution and refrigerated between 30 minutes and 6.0 hours before undergoing ...


Sheet‐Extruded Films From Blends Of Hydroxypropylated And Native Corn Starches, And Their Characterization, Hee-Young Kim, Buddhi P. Lamsal, Jay-Lin Jane, David A. Grewell Aug 2019

Sheet‐Extruded Films From Blends Of Hydroxypropylated And Native Corn Starches, And Their Characterization, Hee-Young Kim, Buddhi P. Lamsal, Jay-Lin Jane, David A. Grewell

Jay-Lin Jane

Sheet‐extruded films from the blends of hydroxypropylated normal corn starch (HP) and native normal corn starch (NS) at weight ratios of 100:0, 90:10, 70:30, 50:50, 30:70, and 0:100 were prepared and characterized. Glycerol and water were added as plasticizers at 11 and 27% starch weight, respectively. The highest tensile strength (TS) and longest elongation to break (EB) for dry films were observed at 70:30 HP: NS ratio, which was 25.76 MPa, and 3.97%, respectively. However, TS and EB of this 70:30 blend extruded starch film exhibited low resistance upon ...


Sheet‐Extruded Films From Blends Of Hydroxypropylated And Native Corn Starches, And Their Characterization, Hee-Young Kim, Buddhi P. Lamsal, Jay-Lin Jane, David A. Grewell Aug 2019

Sheet‐Extruded Films From Blends Of Hydroxypropylated And Native Corn Starches, And Their Characterization, Hee-Young Kim, Buddhi P. Lamsal, Jay-Lin Jane, David A. Grewell

Food Science and Human Nutrition Publications

Sheet‐extruded films from the blends of hydroxypropylated normal corn starch (HP) and native normal corn starch (NS) at weight ratios of 100:0, 90:10, 70:30, 50:50, 30:70, and 0:100 were prepared and characterized. Glycerol and water were added as plasticizers at 11 and 27% starch weight, respectively. The highest tensile strength (TS) and longest elongation to break (EB) for dry films were observed at 70:30 HP: NS ratio, which was 25.76 MPa, and 3.97%, respectively. However, TS and EB of this 70:30 blend extruded starch film exhibited low resistance upon ...


Viscoelastic Properties Of Shock Wave Exposed Brain Tissue Subjected To Unconfined Compression Experiments, Annastacia K. Mccarty, Ling Zhang, Sarah Hansen, William J. Jackson, Sarah A. Bentil Aug 2019

Viscoelastic Properties Of Shock Wave Exposed Brain Tissue Subjected To Unconfined Compression Experiments, Annastacia K. Mccarty, Ling Zhang, Sarah Hansen, William J. Jackson, Sarah A. Bentil

Sarah A. Bentil

Traumatic brain injuries (TBI) affect millions of people each year. While research has been dedicated to determining the mechanical properties of the uninjured brain, there has been a lack of investigation on the mechanical properties of the brain after experiencing a primary blast-induced TBI. In this paper, whole porcine brains were exposed to a shock wave to simulate blast-induced TBI. First, ten (10) brains were subjected to unconfined compression experiments immediately following shock wave exposure. In addition, 22 brains exposed to a shock wave were placed in saline solution and refrigerated between 30 minutes and 6.0 hours before undergoing ...


Genome-Edited Animals Are Not Transgenic Animals: Moving Toward Responsible Research And Innovation With New Biotechnologies, Yvie Yao Aug 2019

Genome-Edited Animals Are Not Transgenic Animals: Moving Toward Responsible Research And Innovation With New Biotechnologies, Yvie Yao

Minnesota Journal of Law, Science & Technology

No abstract provided.


Investigation Of The Electrode Polarization Effect For Biosensor Applications, Anil Koklu Aug 2019

Investigation Of The Electrode Polarization Effect For Biosensor Applications, Anil Koklu

Mechanical Engineering Research Theses and Dissertations

My research focuses on electrokinetic transport. Particularly, in this dissertation, we focus on fabrication and testing of micro electrodes with nanostructured surfaces to minimize the electrode polarization (EP) effects for biosensor applications. In the first study, electrochemical deposition of gold nanoparticles on to planar gold electrodes was used to generate rough surfaces. Dendritic nanostructures that reduced EP up to two orders of magnitude was obtained by optimizing the deposition conditions. These structures also enhanced dielectrophoresis (DEP) response of our bio-chips, making them usable in physiological buffers. In further studies we discovered a universal scaling of EP in the frequency domain ...


Bioengineering Extracellular Matrix Scaffolds For Volumetric Muscle Loss, Kevin Roberts Aug 2019

Bioengineering Extracellular Matrix Scaffolds For Volumetric Muscle Loss, Kevin Roberts

Theses and Dissertations

Volumetric muscle loss overwhelms skeletal muscle’s ordinarily capable regenerative machinery, resulting in fibrosis and severe functional deficits which have defied clinical repair strategies. My work spans the design and preclinical evaluation of implants intended to drive the cell community of injured muscle toward a regenerative state, as well as the development of an understanding of the molecular responses of this cell community to biomaterial interventions. I demonstrate a new class of biomaterial by leveraging the productive capacity of sacrificial hollow fiber membrane cell culture; I show specifically that unique threads of whole extracellular matrix can be isolated by solvent ...


Resolving Intravoxel White Matter Structures In The Human Brain Using Regularized Regression And Clustering, Andrea Hart, Brianna Smith, Sean Smith, Elijah Sales, Jacqueline Hernandez-Camargo, Yarlin Mayor Garcia, Felix Zhan, Lori Griswold, Brian Dunkelberger, Michael R. Schwob, Sharang Chaudhry, Justin Zhan, Laxmi Gewali, Paul Oh Jul 2019

Resolving Intravoxel White Matter Structures In The Human Brain Using Regularized Regression And Clustering, Andrea Hart, Brianna Smith, Sean Smith, Elijah Sales, Jacqueline Hernandez-Camargo, Yarlin Mayor Garcia, Felix Zhan, Lori Griswold, Brian Dunkelberger, Michael R. Schwob, Sharang Chaudhry, Justin Zhan, Laxmi Gewali, Paul Oh

Computer Science Faculty Publications

The human brain is a complex system of neural tissue that varies significantly between individuals. Although the technology that delineates these neural pathways does not currently exist, medical imaging modalities, such as diffusion magnetic resonance imaging (dMRI), can be leveraged for mathematical identification. The purpose of this work is to develop a novel method employing machine learning techniques to determine intravoxel nerve number and direction from dMRI data. The method was tested on multiple synthetic datasets and showed promising estimation accuracy and robustness for multi-nerve systems under a variety of conditions, including highly noisy data and imprecision in parameter assumptions.


A Systems Biology Approach Toward Understanding Seed Composition In Soybean, Ling Li, Manhoi Hur, Joon-Yong Lee, Wenxu Zhou, Zhihong Song, Nick Ransom, Cumhur Yusuf Demirkale, Daniel S. Nettleton, Mark E. Westgate, Zebulun Wayne Arendsee, Vidya Vaancheeswaran Iyer, Jacqueline V. Shanks, Basil Nikolau, Eve Wurtele Jun 2019

A Systems Biology Approach Toward Understanding Seed Composition In Soybean, Ling Li, Manhoi Hur, Joon-Yong Lee, Wenxu Zhou, Zhihong Song, Nick Ransom, Cumhur Yusuf Demirkale, Daniel S. Nettleton, Mark E. Westgate, Zebulun Wayne Arendsee, Vidya Vaancheeswaran Iyer, Jacqueline V. Shanks, Basil Nikolau, Eve Wurtele

Dan Nettleton

Background

The molecular, biochemical, and genetic mechanisms that regulate the complex metabolic network of soybean seed development determine the ultimate balance of protein, lipid, and carbohydrate stored in the mature seed. Many of the genes and metabolites that participate in seed metabolism are unknown or poorly defined; even more remains to be understood about the regulation of their metabolic networks. A global omics analysis can provide insights into the regulation of seed metabolism, even without a priori assumptions about the structure of these networks.

Results

With the future goal of predictive biology in mind, we have combined metabolomics, transcriptomics, and ...


Challenges Of Erau’S First Suborbital Flight Aboard Blue Origin’S New Shepard M7 For The Cell Research Experiment In Microgravity (Crexim), Pedro Llanos, Kristina Andrijauskaite, Vijay V. Duraisamy, Francisco F. Pastrana, Erik Seedhouse, Sathya Gangadharan, Leonid Bunegin, Mariel Rico Jun 2019

Challenges Of Erau’S First Suborbital Flight Aboard Blue Origin’S New Shepard M7 For The Cell Research Experiment In Microgravity (Crexim), Pedro Llanos, Kristina Andrijauskaite, Vijay V. Duraisamy, Francisco F. Pastrana, Erik Seedhouse, Sathya Gangadharan, Leonid Bunegin, Mariel Rico

Pedro J. Llanos (www.AstronauticsLlanos.com)

Cell Research Experiment In Microgravity (CRExIM) was launched aboard Blue Origin’s New Shepard suborbital vehicle on Tuesday, December 12, 2017, from the West Texas Launch Site in Van Horn, Texas. One of the aims of this science experiment was to assess the effects of microgravity on murine T-cells during suborbital flight. These cells were placed in a NanoLab with a data logger that sensed the acceleration, temperature, and relative humidity during preflight, flight, and postflight operations. Some discrepancies in sensor measurement were noticed, and these errors were attributed partly to the difference in sampling rates and partly to the ...


Modulation Of Biological Responses To 2 Ns Electrical Stimuli By Field Reversal, Esin B. Sözer, P. Thomas Vernier Jun 2019

Modulation Of Biological Responses To 2 Ns Electrical Stimuli By Field Reversal, Esin B. Sözer, P. Thomas Vernier

Bioelectrics Publications

Nanosecond bipolar pulse cancellation, a recently discovered Phenomenon, is modulation of the effects of a unipolar electric pulse exposure by a second pulse of opposite polarity. This attenuation of biological response by reversal of the electric field direction has been reported with pulse durations from 60 ns to 900 ns for a wide range of endpoints, and it is not observed with conventional electroporation pulses of much longer duration (> 100 mu s) where pulses are additive regardless of polarity. The most plausible proposed mechanisms involve the field-driven migration of ions to and from the membrane interface (accelerated membrane discharge). Here ...


Compositional Optimization Of Amyloid-Graphene Oxide Nanohybrids For Biomaterials, Claire L. Drewery Jun 2019

Compositional Optimization Of Amyloid-Graphene Oxide Nanohybrids For Biomaterials, Claire L. Drewery

Materials Engineering

Amyloid nanofibrils are natural materials capable of self-assembling into precise structures with tunable functionalities, while exhibiting excellent mechanical properties. In combination with highly conductive graphene oxide (GO), the 1-D amyloid nanofibrils and 2-D nanosheets of GO can produce a robust and bio-functional nanohybrid, hypothesized to exhibit multi-domain functional properties useful for enzyme sensing, water purification, drug delivery, and tissue scaffolding applications. Here, we examine the properties of an amyloid-graphene oxide nanohybrid film made with amyloids derived from hen egg white lysozymes in an attempt to explore the diverse toolbox of amyloid derivatives and establish ideal fabrication methods and formulations of ...


Study Of Paper Microbial Fuel Cells For Use In On-Site Wastewater Testing, William A. Tolmasoff, William A. Tolmasoff Jun 2019

Study Of Paper Microbial Fuel Cells For Use In On-Site Wastewater Testing, William A. Tolmasoff, William A. Tolmasoff

Master's Theses and Project Reports

This study demonstrated a technique for fabricating simple, low-cost Paper Microbial fuel cells (PMFC’s) in the model of a previous study to, for the first time, produce voltage from wastewater effluent. The PMFC’s were created by stacking and gluing the main components of an MFC together: reservoir layer; anode; cation exchange membrane (CEM); air cathode. A wax printer was used to create the hydrophobic borders of the PMFC’s on filter paper, and graphite paint was applied to the paper to create the anode. The CEM’s considered were filter paper, wax, and Nafion, with Nafion being the ...


Cloning A Fluorescent Fusion Protein For Detection And Localization Of The Gastrin Receptor, Vinh Le May 2019

Cloning A Fluorescent Fusion Protein For Detection And Localization Of The Gastrin Receptor, Vinh Le

Honors Projects and Presentations: Undergraduate

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death worldwide. It is promoted by multiple cellular signaling events. Gastrin, a hormone that regulates several aspects of gastrointestinal physiology and maintenance of the gastrointestinal mucosa, is abnormally expressed in pancreatic cancer cells and promotes PDAC growth. Its effects are chiefly mediated through the seven membrane-spanning G protein-coupled receptor CCK2R. Upregulation of CCK2R and the cancer-associated splice variant, CCK2i4svR, have been shown to contribute to tumorigenicity, with the latter promoting increased tumor aggressiveness. Our lab has previously reported the development of monoclonal antibodies specific to CCK2R and CCK2i4svR. However ...


Predicting Tgf-Β-Induced Epithelial-Mesenchymal Transition Using Data Assimilation, Mario J. Mendez, Matthew J. Hoffman, Elizabeth M. Cherry, Dr. Christopher Lemmon, Seth Weinberg May 2019

Predicting Tgf-Β-Induced Epithelial-Mesenchymal Transition Using Data Assimilation, Mario J. Mendez, Matthew J. Hoffman, Elizabeth M. Cherry, Dr. Christopher Lemmon, Seth Weinberg

Biology and Medicine Through Mathematics Conference

No abstract provided.


Computations Of Top-Down Attention By Modulating V1 Dynamics, David Berga, Xavier Otazu May 2019

Computations Of Top-Down Attention By Modulating V1 Dynamics, David Berga, Xavier Otazu

MODVIS Workshop

The human visual system processes information defining what is visually conspicuous (saliency) to our perception, guiding eye movements towards certain objects depending on scene context and its feature characteristics. However, attention has been known to be biased by top-down influences (relevance), which define voluntary eye movements driven by goal-directed behavior and memory. We propose a unified model of the visual cortex able to predict, among other effects, top-down visual attention and saccadic eye movements. First, we simulate activations of early mechanisms of the visual system (RGC/LGN), by processing distinct image chromatic opponencies with Gabor-like filters. Second, we use a ...


Age Dependent Regulation Of Cardiac Sodium Channel Gain Of Function, Madison Nowak, David Ryan King, Steven Poelzing, Seth Weinberg May 2019

Age Dependent Regulation Of Cardiac Sodium Channel Gain Of Function, Madison Nowak, David Ryan King, Steven Poelzing, Seth Weinberg

Biology and Medicine Through Mathematics Conference

No abstract provided.


Immunofluorescence Image Feature Analysis And Clustering Pipeline For Distinguishing Epithelial-Mesenchymal Transition, Shreyas Hirway, Nadiah Hassan, Dr. Christopher Lemmon, Dr. Seth Weinberg May 2019

Immunofluorescence Image Feature Analysis And Clustering Pipeline For Distinguishing Epithelial-Mesenchymal Transition, Shreyas Hirway, Nadiah Hassan, Dr. Christopher Lemmon, Dr. Seth Weinberg

Biology and Medicine Through Mathematics Conference

No abstract provided.


Coupled Influence Of Heart Rate Variability And Subcellular Calcium Heterogeneity On Cardiac Electromechanical Dynamics, Vrishti M. Phadumdeo, Seth H. Weinberg Ph.D May 2019

Coupled Influence Of Heart Rate Variability And Subcellular Calcium Heterogeneity On Cardiac Electromechanical Dynamics, Vrishti M. Phadumdeo, Seth H. Weinberg Ph.D

Biology and Medicine Through Mathematics Conference

No abstract provided.


Feedforward And Feedback Signals In The Olfactory System, Srimoy Chakraborty May 2019

Feedforward And Feedback Signals In The Olfactory System, Srimoy Chakraborty

Theses and Dissertations

The conglomeration of myriad activities in neural systems often results in prominent oscillations. The primary goal of the research presented in this thesis was to study effects of sensory stimulus on the olfactory system of rats, focusing on the olfactory bulb (OB) and the anterior piriform cortex (aPC). Extracellular electrophysiological measurements revealed distinct frequency bands of oscillations in OB and aPC. However, how these oscillatory fluctuations help the animal to process sensory input is not clearly understood. Here we show high frequency oscillations in olfactory bulb carry feedforward signals to anterior piriform cortex whereas feedback from the aPC is predominantly ...


Quantitative Evaluation Of Geared Manual Wheelchair Mobility In Individuals With Spinal Cord Injury: An Integrative Approach, Omid Jahanian May 2019

Quantitative Evaluation Of Geared Manual Wheelchair Mobility In Individuals With Spinal Cord Injury: An Integrative Approach, Omid Jahanian

Theses and Dissertations

The purpose of this dissertation is to quantify the effects of using geared wheelchair wheels on upper extremity biomechanics and energy expenditure during functional mobility tasks in individuals with spinal cord injury (SCI). The effects of using geared wheels on hand-rim biomechanics, glenohumeral joint dynamics, and shoulder muscle activity were investigated during manual wheelchair propulsion over tiled and carpeted level-floors and up a ramp in low gear (1.5:1) and standard gear (1:1) conditions. The results for the hand-rim biomechanics indicated that regardless of the terrain, using the geared wheels in the low gear condition significantly decreased the ...


Diffuse Reflectance Spectroscopy To Quantify In Vivo Tissue Optical Properties: Applications In Human Epithelium And Subcutaneous Murine Colon Cancer, Gage Joseph Greening May 2019

Diffuse Reflectance Spectroscopy To Quantify In Vivo Tissue Optical Properties: Applications In Human Epithelium And Subcutaneous Murine Colon Cancer, Gage Joseph Greening

Theses and Dissertations

Colorectal cancer is the 4th most common and 2nd deadliest cancer. Problems exist with predicting which patients will respond best to certain therapy regimens. Diffuse reflectance spectroscopy has been suggested as a candidate to optically monitor a patient’s early response to therapy and has been received favorably in experimentally managing other cancers such as breast and skin. In this dissertation, two diffuse reflectance spectroscopy probes were designed: one with a combined high-resolution microendoscopy modality, and one that was optimized for acquiring data from subcutaneous murine tumors. For both probes, percent errors for estimating tissue optical properties (reduced scattering coefficient ...


Volumetric Muscle Loss: The Role Of Physical Activity And Autologous Repair On Force Recovery And Signaling Pathways, Richard Perry May 2019

Volumetric Muscle Loss: The Role Of Physical Activity And Autologous Repair On Force Recovery And Signaling Pathways, Richard Perry

Theses and Dissertations

Volumetric muscle loss affects both military and civilian persons. The hallmark of this injury is incomplete muscle regeneration, excessive fibrosis, and chronic inflammatory signaling resulting in permanent functional loss. Since permanent functional loss drastically reduces quality of life, many studies have been conducted to improve force recovery. Current scientific literature considers a repair strategy of either devitalized scaffolds infused with growth factors or viable tissue plus activating factors to be the more promising interventions for optimal force recovery. PURPOSE The purpose of this study is to incorporate autologous repair and physical activity and observe the effects of muscle force recovery ...


Incorporation Of Egfr And Ron Receptors Into Nanodiscs, Cristina Flores-Cadengo Apr 2019

Incorporation Of Egfr And Ron Receptors Into Nanodiscs, Cristina Flores-Cadengo

Biomedical Engineering ETDs

Understanding the structure-function relationship of membrane receptors is essential to comprehend the crosstalk between key signaling pathways. Aberrant trans-activation between receptors can lead to tumorigenesis. Two of these receptors known to be involved in cancer development are receptor tyrosine kinases (RTKs), RON (Recepteur d'Origine Nantais) and EGFR (Epidermal Growth Factor Receptor). There has been evidence of heterodimerization and crosstalk between these two receptors based on co-immunoprecipitation, however the structural requirements behind these interactions remain unknown. Structural studies could provide insights into these RTKs’ modes of dimerization and structure-function relationship. However, structural studies of full-length membrane proteins are often difficult ...


Establishment Of 3-D Human Colorectal Cancer Spheroids, India Barnett Apr 2019

Establishment Of 3-D Human Colorectal Cancer Spheroids, India Barnett

Kansas State University Undergraduate Research Conference

Three-Dimensional (3D) cell culture plays an important role in cancer biology by providing a life-like microenvironment as a model for drug discovery and treatment. Hydrogels, like many other 3D scaffolds, demonstrate a unique property as matrices for 3D cell culture. The goal of this project is to establish a 3D cell culture for colorectal cancer and apply this 3D model to drug testing. Colorectal cancer is one of the most common cancers in the United States with an early detection rate of 39%. Previously, 2D cell culture of human colorectal cancer cells, SW480, was used to determine the efficacy of ...


Kinematics During Knee Extension, Lunge, And Chair Rise, Center For Orthopaedic Biomechanics, Kevin Shelburne, Phd, Michael D. Harris, Phd, Vasiliki Kefala, Donald R. Hume, Bradley S. Davidson, A. J. Cyr, R. H. Kim, A. A. Ali, E. M. Mannen Apr 2019

Kinematics During Knee Extension, Lunge, And Chair Rise, Center For Orthopaedic Biomechanics, Kevin Shelburne, Phd, Michael D. Harris, Phd, Vasiliki Kefala, Donald R. Hume, Bradley S. Davidson, A. J. Cyr, R. H. Kim, A. A. Ali, E. M. Mannen

Living Kinematics of the Knee

No abstract provided.


Visual Contributions To Balance Control During Gait, Kyle Brozek Mar 2019

Visual Contributions To Balance Control During Gait, Kyle Brozek

Student Research and Creative Activity Fair

We propose to isolate the contributions of continuous OF to the orthogonal relationship between balance and gait control during treadmill walking using a series of conditions. Manipulating the direction of OF using a CAREN (Motek Medical, Amsterdam, Netherlands) virtual reality treadmill environment will isolate these visual contributions in human subjects as they walk. We plan to tease out the effect of OF direction on the relationship between gait and balance control by having healthy young adults perform a series of treadmill walking trials while immersed in a VR environment. This will be done by manipulating the direction of walking and ...


The Time Of Slip Onset During Stance Influences The Characteristics Of The Unconstrained Perturbation, Corbin Rasmussen, Nathaniel Hunt Mar 2019

The Time Of Slip Onset During Stance Influences The Characteristics Of The Unconstrained Perturbation, Corbin Rasmussen, Nathaniel Hunt

Student Research and Creative Activity Fair

Falls pose a significant health hazard, resulting in devastating injuries like broken wrists, fractured hips, and traumatic brain injuries that exceed $50 billion in U.S. medical costs. To address these risks, biomechanists have subjected individuals to simulated slips in order to study the factors that lead to falls. These studies have focused on slips that happen immediately after heel-strike and are unnaturally restricted by the methods used to cause the slip. Therefore, the effects of unconstrained slips that occur throughout stance phase are unknown. To address this knowledge gap, we examined the relationship between the timing of slip onset ...


Long-Term, Super-Resolution Imaging Of Amyloid Structures Using Transient Amyloid Binding Microscopy, Tianben Ding, Kevin Spehar, Jan Bieschke, Matthew D. Lew Feb 2019

Long-Term, Super-Resolution Imaging Of Amyloid Structures Using Transient Amyloid Binding Microscopy, Tianben Ding, Kevin Spehar, Jan Bieschke, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Amyloid fibrils and tangles are signatures of Alzheimer disease, but nanometer-sized aggregation intermediates are hypothesized to be the structures most toxic to neurons. The structures of these oligomers are too small to be resolved by conventional light microscopy. We have developed a simple and versatile method, called transient amyloid binding (TAB), to image amyloid structures with nanoscale resolution using amyloidophilic dyes, such as Thioflavin T, without the need for covalent labeling or immunostaining of the amyloid protein. Transient binding of ThT molecules to amyloid structures over time generates photon bursts that are used to localize single fluorophores with nanometer precision ...


Analyzing Drug Release Kinetics From Water-Soluble Polymers, Sean M. Kelly, Arun K. Upadhyay, Akash Mitra, Balaji Narasimhan Feb 2019

Analyzing Drug Release Kinetics From Water-Soluble Polymers, Sean M. Kelly, Arun K. Upadhyay, Akash Mitra, Balaji Narasimhan

Chemical and Biological Engineering Publications

The ability to develop predictive mathematical models of therapeutic release from pharmaceutical formulations has enormous potential to enhance our understanding of such systems and improve the controlled release of the payload. The current work describes the development and testing of a one-dimensional model of drug transport from amorphous, swelling/dissolving polymers. Model parameters such as the diffusivities of water and drug, the initial loading of the drug, the polymer dissolution rate, drug-polymer interactions, and the tablet thickness were varied, demonstrating the ability to tune the release to be controlled by either drug diffusion or polymer chain disentanglement. In addition, predictions ...