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Full-Text Articles in Biomedical Engineering and Bioengineering

Detection Of Sk2 Channels On Hippocampal Neurons, Jamie L. Maciaszek Apr 2012

Detection Of Sk2 Channels On Hippocampal Neurons, Jamie L. Maciaszek

Master's Theses

Calcium-activated small conductance potassium channels (SK) are crucial for synaptic plasticity, sleep, and learning and memory (Hammond, Bond et al. 2006; Cueni, Canepari et al. 2008; Lin, Lujan et al. 2008). Despite the recent progress on SK channel physiology, the precise spatial organization of SK channels in neurons has remained unknown. Such knowledge is critical as the subcellular distribution of SK channels is an important determinant of neuronal excitability. Currently, there are no techniques to image ion channel distribution quantitatively at the nanometer scale in living cells. Here, it is demonstrated that integration of natural toxins with single molecule atomic ...


Automation Of Orthodontic Wire Tester For Performing Three Point Bending Tests, Adithya Venkatesan Aug 2011

Automation Of Orthodontic Wire Tester For Performing Three Point Bending Tests, Adithya Venkatesan

Master's Theses

Abstract

Understanding the biomechanical factors in orthodontics is important in order to improve the overall effectiveness of actual clinical treatment. An accurate method to study the threedimensional (3D) force systems and the resulting movements of teeth during orthodontic treatment is needed along with the understanding of the material properties of any orthodontic wire. Until recently, most of the orthodontic biomechanics literature was limited to twodimensional experimental studies. Recent advances in threedimensional computer modeling have also been developed but have been limited to the manual control of tooth movement. Overall, there is very little published evidence in the literature on the ...


Effect Of Prostaglandin E2 On Mechanical Stresses Applied By Mc3t3-E1 Osteoblast-Like Cells On A Soft Hydrogel Substrate, Abhijit Deb Roy Aug 2011

Effect Of Prostaglandin E2 On Mechanical Stresses Applied By Mc3t3-E1 Osteoblast-Like Cells On A Soft Hydrogel Substrate, Abhijit Deb Roy

Master's Theses

Osteoblasts are sensitive to mechanical stimuli and release Prostaglandin E2 (PGE2) when exposed to a fluid shear stress. The exact mechanism by which these cells sense mechanical stress is not well established. A study of the stresses applied by the osteoblasts, under the influence of PGE2, on a hydrogel provided information regarding intercellular-communication via changes in the substrate surface pattern.

A digital image correlation program was developed using the Levenberg-Marquardt optimization algorithm to analyze images and compare the deformations between pairs of images. Comparisons of images before and after the addition of PE2 to the media showed differences in the ...


1-Nitronaphthalene Causes Ultrastructural Changes Primarily In Nonciliated Bronchiolar Epithelium Followed By Ciliated Epithelium In The Rat, John-Michael Sauer Jun 1991

1-Nitronaphthalene Causes Ultrastructural Changes Primarily In Nonciliated Bronchiolar Epithelium Followed By Ciliated Epithelium In The Rat, John-Michael Sauer

Master's Theses

This study describes morphological changes in the lung at several time intervals following a single injection of 1-Nitronaphthalene (100 mg/kg intraperitoneal) in male Sprague-Dawley rats using transmission and scanning electron microscopy. Dilation of the smooth endoplasmic reticulum and mitochondrial distension in the nonciliated bronchiolar (Clara) cells was apparent as early as 1 hour after injection, while adjacent ciliated cell showed minimal changes. At 6 hours, when respiratory distress was apparent in the animals, Clara and ciliated cells exhibited chromatin clumping, loss of mitochondrial cristae and cytoplasmic vacuolization. Also at 6 hours, the interstitial area around the terminal bronchioles was ...