Engineering Commons^™

Laser-Assisted Printing Of Alginate And Cellular Tubes, Jingyuan Yan

All Theses

Laser-assisted printing such as laser-induced forward transfer (LIFT) has found increasing biofabrication applications as an orifice-free cell/organ printing approach. Unfortunately, there have been very few studies on its efficacy of three-dimensional (3D) printing performance. In addition, the effects of printing parameters on jet/droplet formation during the printing of Newtonian and non-Newtonian fluids are lacking. Therefore, it is important to investigate its printing process and quality. The resulting knowledge will help to better control the resulting printing quality and feature resolution.
The objective of this study is to investigate the feasibility of laser-assisted 3D printing process and its applicability in making …

Highly Sensitive Fiber-Based Devices For Gene And Protein Analysis, Victor Maximov

All Dissertations

Single cell probing has found a number of applications in different areas of research. It can help us to better understand cell-to-cell interactions; it has found numerous applications in immunology, cancer research, detection of pathogenic infections and genetic abnormalities. The single cell analysis is very important in stem cells research and development of cells. The main obstacle in the single cell analysis is the small amount of analyte that a single cell could provide. Another difficulty is connected to the cell-to-cell variability inside the uniform population due to the differences of single cells in size, activity, mitotic stage, and functions. …

Development Of An Ex Vivo Tissue Testing System For Three Dimensional Biomechanical Analysis Of Abdominal Aortic Aneurysm, Bradley Johns

All Theses

Abdominal aortic aneurysms (AAA) are localized, progressive dilations of the aortic wall and are the 13th most common cause of death in the United States (~15,000 per year) and surgery is usually recommended when the aneurysm is 5 cm or larger in diameter. Because of this clinical parameter, previous studies of AAA biomechanics have utilized a one-dimensional analysis that focuses solely on changes in wall diameter and have attempted to model geometric changes with mathematical formulas, generally based on the LaPlace equation. This is not sufficient however, as the mechanical behavior of the tissue at sites of aneurysm have been …

A Regenerative Medicine Approach To Improved Tendon Healing And Repair, Grace Margaret Dion

All Theses

Surgical repair of torn tendons is a common orthopaedic procedure in the United States, with nearly 400,000 repairs occurring annually. Despite improvements in surgical techniques used to re-attach the tendon to its boney insertion, clinically successful outcomes amongst patients are variable and re-tear rates can be exceedingly high. The use of stem cells as an adjunct to surgical repair to aid in improving tendon healing and repair strength has gained much interest amongst the clinical community. Accordingly, many investigators have begun examining the ability of stem cells to differentiate into tenocytes using various methodologies including the application of growth factors …

Characterization Of Potential Wear Sources In Knee Arthroplasty Prostheses After In Vivo Function, Nicole Durig

All Theses

Total joint arthroplasty (TJA) is a common procedure generally performed in patients with osteoarthritis. While TJA continues to be a successful treatment for degenerative joint disease, there are many studies that demonstrate wear and its sequelae as the major limitation of joint replacement longevity. Previous studies have shown that wear debris originates from four main locations: articulating surfaces, modular component surfaces, surfaces of fixation, and adjuvant fixation devices. Each of these possible wear sources can initiate the cascade of failure associated with wear-induced osteolysis and lead to subsequent revision surgery. The objective of this thesis is to characterize the in …

A Model-Free Approach To Vehicle Stability Control, Chinmay Pandit

All Theses

This project explored the feasibility of using measured responses of a passenger car together with a fuzzy logic based control algorithm to sense the onset of under-steer (or loss of steering control) and mitigate or eliminate it. The controller is simple and robust and, unlike existing controllers, instead of comparing the vehicle response to that of an idealized model it makes decisions based solely upon the measured response of the car.
Simulations were conducted (using CarSim) of various vehicles executing the skid pad and the double lane change tests to characterize the vehicle behavior. Consistent and qualitatively similar patterns in …

The Hydraulic Performance Of Perforated Pipe Under-Drains Surrounded By Loose Aggregate, Patrick Murphy

All Theses

Perforated pipes are commonly used in the construction industry for subsurface drains. These subsurface drains are installed to intercept and convey infiltrated runoff or groundwater. One common application of perforated pipe is to provide an under-drain for an infiltration trench or porous pavement best management practice (BMP). Perforated pipe is installed into a trench on a bed of aggregate ranging from 0 to 28 cm thick and, depending on the design objective, is laid flat or on a slope. However, the actual hydraulic performance of these pipes, i.e. the stage storage relationship, is poorly understood. The resulting flow is quite …

Improving R-Value In Brick Systems Using Various Pore-Forming Agents, Graham Shepherd

All Theses

Energy efficiency and energy savings are two topics that have continued to gain momentum over the last decade. This topic is extremely important when it comes to the construction of buildings and homes. Efforts have been ongoing to increase the insulation value of brick systems to hinder the conductive heat transfer through the material. The use of pore-forming agents (PFA’s) have been studied to increase the porosity within a ceramic system, through sacrificial burnout or place–holder method, which leave a residual, defined pore size distribution. This increase in porosity leads to better insulating capabilities and inherently lower conductivity values. In …

Parallex File System (Pxfs): Bridging The Gap Between Exascale Processing Capabilities And I/O Performance, Shane Snyder

All Theses

Due to processors reaching the maximum performance allowable by current technology, architectural trends for computer systems continue to increase the number of cores per processing chip to maximize system performance. Most estimates suggest massively parallel systems will be available within the decade, containing millions of cores and capable of exaFlops of performance. New models of execution are necessary to maximize processor utilization and minimize power costs for these exascale systems. ParalleX is one such execution model, which attempts to address inefficiencies of current execution models by exposing fine-grained parallelism, increasing system utilization using asynchronous workflow, and resolving resource contention through …

Post-Market Surveillance Of Total Knee Replacement Combining Clinical Outcomes And Quantitative Image Processing Techniques, Leah Nunez

All Theses

Total knee replacement (TKR) is a successful procedure for the relief of pain, correction of deformity, and restoration of function in patients with knee arthritis.1-3 In the United States, the number of primary TKR surgeries performed in 2030 is projected to be between 2,938,000 to 4,136,000 and revision surgeries between 193,000 to 381,000.4 Osteolysis, pain, and aseptic loosening are the most common causes of revision TKR surgery.5 The purpose of this thesis is to complete assessments for post-market surveillance of total knee replacement (TKR) targeting areas for improving polymer bearings through evaluation of clinical outcomes and analysis of prosthesis retrieved …

A Methodology For Designing Pervious Bicycle Lanes For Stormwater Management, Donald West Iii

All Theses

Bicycles have proven to be an efficient and reliable form of transportation in urban settings. Therefore, the addition of bicycle lanes into the transportation network could significantly impact and improve the sustainability of our infrastructure by reducing greenhouse emissions and improving the health of individuals who cycle on a regular basis. Pervious pavements are an approved (LID) strategy that could potentially be used to construct these new facilities thereby reducing the quantity of stormwater runoff and improving the water quality. Practicing engineers need both a design aid and research supported methods for designing these improvements before they can be fully …

Three-Dimensional Finite Element Analysis Of Sound Transmission Performance Of Honeycomb Sandwich Structures, Xin Wang

All Theses

Due to the lighter weight of honeycomb structures compared with a cuboid of similar material, honeycomb is widely used in applications requiring a high stiffness to weight ratio. One important honeycomb meta-structure is sandwich composites designed with a honeycomb core between two thin panel layers. The geometry of the honeycomb is formed from periodically spaced, non-overlapping unit cells. An important advantage of cellular materials such as honeycomb is that vibration and acoustic properties can be changed simply by changing the unit cell geometry variables such as included angle, cell wall thickness and length, while keeping the overall dimensions of the …

Numerical Study Of The Structural Performance Of Large Panelized All-Wood Roof Diaphragms, Sami Pant

All Theses

The use of flexible roof diaphragms is very common in the United States, both for multi-family residential buildings and large-scale commercial buildings. Due to its simplicity, the traditional diaphragm design method is commonly used in diaphragm design, in particular for the design of diaphragms with relatively small dimensions. The traditional diaphragm design method assumes the axial forces developed in framing members under in-plane loading carried only by the perimeter chords. The traditional diaphragm design method has always been thought to be a conservative design method, especially when applied to large diaphragms. In recent years, the engineering community began to question …

Dynamic Transcriptional Response Of Escherichia Coli To Inclusion Body Formation, Faraz Baig

All Theses

Escherichia coli is used intensively for recombinant protein production due to its many unique advantages, but one key challenge with the use of E. coli is the tendency of recombinant proteins to misfold and aggregate into insoluble inclusion bodies (IBs). The presence of IBs stresses cells and can hinder overall growth. Additionally, IBs contain high concentrations of recombinant protein in an inactive form and thus require recovery steps to salvage functional recombinant protein. Currently, no universally effective method exists to prevent IB formation in recombinant E. coli. Further research into the gene expression response to insoluble recombinant protein may …

Quantifying Annual Bridge Cost By Overweight Trucks In South Carolina, Linbo Chen

All Theses

With the economic development in recent decades, more trucks including overweight trucks are operating on the highways. As a result, many bridges are expected to carry more loads than they did in previous years. The impact of overweight trucks on existing bridges has been an urgent concern for the South Carolina Department of Transportation (SCDOT). There is a pressing need to quantify the annual bridge cost in South Carolina caused by trucks and, in particular, overweight trucks so that the SCDOT and the state legislators can determine the appropriate fee structure for operating overweight trucks. This research focused on quantifying …

Engineering A Biomimetic Structure For Human Long Bone Regeneration, Eleni Katsanevakis

All Dissertations

Bone tissue serves many functions, including structural support, protection of internal organs, and mineral and growth factor storage, to name a few. Moreover, human bone exhibits excellent mechanical properties, demonstrating superb compressive strength as well as significant elasticity, due to its collagen content. However, defects still occur at a relatively high rate in this tissue. Critical sized defects in bone are defined as defects that cannot form a union and heal on their own. These types of defects occur often, and typically require surgical intervention. The current gold standard treatment for critical sized defects in bone is the use of …

Adaptive Model Based Combustion Phasing Control For Multi Fuel Spark Ignition Engines, Baitao Xiao

All Dissertations

This research describes a physics-based control-oriented feed-forward model, combined with cylinder pressure feedback, to regulate combustion phasing in a spark-ignition engine operating on an unknown mix of fuels. This research may help enable internal combustion engines that are capable of on-the-fly adaptation to a wide range of fuels. These engines could; (1) facilitate a reduction in bio-fuel processing, (2) encourage locally-appropriate bio-fuels to reduce transportation, (3) allow new fuel formulations to enter the market with minimal infrastructure, and (4) enable engine adaptation to pump-to-pump fuel variations. These outcomes will help make bio-fuels cost-competitive with other transportation fuels, lessen dependence on …

Design Of An Apparatus To Detect Small Changes In The Mass Of Rotational Machine Components, Jonathan R.A. Maier, M. Laine Mears, Joshua D. Summers

Publications

In this study, an apparatus was designed to detect changes on the order of grams in the mass of test samples subject to accelerations approaching 275g. The apparatus incorporated a surface speedometer, displacement transducer and on-board data-logging device in order to correlate mass loss events with changes in rotational speed and acceleration. An accessory was also designed to allow for on-board video recording to validate the findings and to better understand the mechanics of mass loss events. Such mass loss events are of interest for high-speed rotating machinery (e.g., manufacturing equipment, turbine rotors and automotive drivetrains), where material can build …

The Sustainability Generation: Why Young People Hold The Key To A Better Future, Leidy Klotz

Publications

In a standard test of reasoning, you are given a candle, a box of thumbtacks, and a book of matches. Your task is to attach the candle to the wall so that it does not drip onto the table below.

I thought about how to melt the wax and use it to stick the candle to the wall. What would you do?

This challenge is designed to reveal functional fixedness, mental blocks against using objects in a new way. The experience that comes with age is a disadvantage here because it leads to thinking of the normal use of the …

A Study Of Designer Familiarity With Product And User During Requirement Elicitation, Beshoy Morkos, Joshua D. Summers

All CEDAR Publications

It is important to recognise the effects of a designer's source of information and decision making during requirements elicitation. Requirements are widely recognised as an important step in the design process. Designers may have perspective based on their experience which results in a level of familiarity with the design. This paper reports on a study that explores the effects of designer familiarity with a project and its user on their ability to elicit requirement specifications. Two familiarity constructs, product and user, are measured as low or high and used to study requirement elicitation with varying familiarity. A high familiarity study …

Predictive Modeling Of The Virtual Hemi-Fontan Operation For Second Stage Single Ventricle Palliation: Two Patient-Specific Cases, Ethan Kung, Alessia Baretta, Catriona Baker, Gregory Arbia, Giovanni Biglino, Chiara Corsini, Silvia Schievano, Irene E. Vignon-Clementel, Gabriele Dubini, Giancarlo Pennati, Andrew Taylor, Adam Dorfman, Anthony M. Hlavacek, Alison L. Marsden, Tain-Yen Hsia, Francesco Migliavacca

Publications

Single ventricle hearts are congenital cardiovascular defects in which the heart has only one functional pumping chamber. The treatment for these conditions typically requires a three-staged operative process where Stage 1 is typically achieved by a shunt between the systemic and pulmonary arteries, and Stage 2 by connecting the superior venous return to the pulmonary circulation. Surgically, the Stage 2 circulation can be achieved through a procedure called the Hemi-Fontan, which reconstructs the right atrium and pulmonary artery to allow for an enlarged confluence with the superior vena cava.

Based on pre-operative data obtained from two patients prior to Stage …