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Examining The Urban Heat Island Effect In Albany, Ny Using Remote Sensing And Gis Techniques, Zhaoxin Ma
Examining The Urban Heat Island Effect In Albany, Ny Using Remote Sensing And Gis Techniques, Zhaoxin Ma
Undergraduate Honors Theses
This research delves into the complex dynamics of the Urban Heat Island (UHI) effect within the urban landscape of Albany, New York, employing advanced remote sensing and Geographic Information Systems (GIS) methodologies. With a primary focus on two interconnected objectives, this study attempts to unravel the spatial patterns of temperature extremes and assess associated vulnerabilities within communities, while also exploring the influence of green space distribution on the intensity of urban heat islands. The first objective examines temperature extremes' spatial distribution and vulnerability among demographic groups such as race/ethnicity, age, and income. It examines whether marginalized communities bear a disproportionate …
Investigating The Role Of Tryptophan In The Native Photo-Crosslinking Of A Cys-Containing Transmembrane Helix To A Membrane Lipid Double Bond, Michael Jay Telehany
Investigating The Role Of Tryptophan In The Native Photo-Crosslinking Of A Cys-Containing Transmembrane Helix To A Membrane Lipid Double Bond, Michael Jay Telehany
Undergraduate Honors Theses
Our research group has previously discovered that a Cys residue within a transmembrane (TM) helix can directly photo-crosslink to a membrane lipid via an oxythiolation addition reaction to the double bond within the lipid, with a reaction yield of 10-20%. The pH-low Insertion Peptide (pHLIP) serves as our model TM helix, while the POPC lipid bilayer is our model membrane. We had long believed that the Trp residues within the sequence of pHLIP served as the key chromophore for this reaction, and thus they were essential for the formation of the TM helix-lipid adduct. To test this hypothesis, I synthesized …
Ethanol-Induced Alterations To Astrocytic Glutamate Transporter Mrna Expression In The Mpfc Of Adult Mice, Zachary Evans
Ethanol-Induced Alterations To Astrocytic Glutamate Transporter Mrna Expression In The Mpfc Of Adult Mice, Zachary Evans
Undergraduate Honors Theses
The medial prefrontal cortex (mPFC) is one of several brain structures that is contained in the mesolimbocortical pathway and controls many processes involved in alcohol use disorder (AUD). There is vast glutamatergic output from the mPFC to other mesolimbocortical regions; neuroplastic changes to this system are believed to be closely tied to the development and maintenance of AUD. Astrocytes are key regulators of glutamatergic transmission through their uptake of excess glutamate from the synapse and recycling back into neurons. Ethanol (EtOH) alters the expression of astrocytic genes that encode for transporters that control glutamate homeostasis; these include the glutamate transporter-1 …
A Compendium Of Cross-Culturally Valid Intimate Partner Violence Assessment Items For North American Spanish Speakers, Alberto D. Torres-Aragón
A Compendium Of Cross-Culturally Valid Intimate Partner Violence Assessment Items For North American Spanish Speakers, Alberto D. Torres-Aragón
Undergraduate Honors Theses
Intimate partner violence (IPV) is physical, psychological, or sexual abuse by a current or former romantic partner. The long- and short-term consequences can lead to severe repercussions. To prevent these consequences of IPV, we need to screen for it and assess it. Across cultures, IPV is present and should be assessed regardless of linguistic boundaries. Spanish is the most widely used language in the U.S. other than English; therefore, assessment instruments that can reliably capture IPV in Spanish are necessary. Although Spanish-language IPV instruments are available, they may be challenging to understand for Spanish speakers because of linguistic differences. In …
Behavioral Economic Demand: Investigation Of Sex Differences In Four Core Genotype Model Of Oral Oxycodone Self-Administration, Michelle Elsmore, David Jentsch, Joshua Peck, Anushree Karkhanis
Behavioral Economic Demand: Investigation Of Sex Differences In Four Core Genotype Model Of Oral Oxycodone Self-Administration, Michelle Elsmore, David Jentsch, Joshua Peck, Anushree Karkhanis
Undergraduate Honors Theses
Opioid misuse has been identified to be related to problematic release of dopamine in the brain that is otherwise satiated by other alternative rewards. As mediated by patterns of positive and negative reinforcement, prolonged opioid use may transition into misuse and development of opioid use disorder. In human populations, men and women differ in their acquisition of drug use and escalation to drug misuse. Women quickly surpass their male counterparts in their transition from use to misuse in what is coined the telescoping effect. In this four core genotype model of oral oxycodone self administration, males were hypothesized to consume …
Variation In Sign-Tracking And Goal-Tracking Behaviors In A Genetically Diverse Inbred Panel Of Mice, Emily A. Schoenblum
Variation In Sign-Tracking And Goal-Tracking Behaviors In A Genetically Diverse Inbred Panel Of Mice, Emily A. Schoenblum
Undergraduate Honors Theses
No abstract provided.
Race In The Relationship Quality Of Sexual Minority People Of Color: A Meta-Analytic Review, Olivia M. Lawrence
Race In The Relationship Quality Of Sexual Minority People Of Color: A Meta-Analytic Review, Olivia M. Lawrence
Undergraduate Honors Theses
No abstract provided.
Effect Of Motivational Music On Peak Knee Torque, Perceived Exertion, And Enjoyment In College-Aged Individuals, Arianna Cole
Effect Of Motivational Music On Peak Knee Torque, Perceived Exertion, And Enjoyment In College-Aged Individuals, Arianna Cole
Undergraduate Honors Theses
There is a general consensus in previous and current literature that the incorporation of music in exercise has the potential to benefit performance (Karageorghis 2020; Terry et al. 2019). Research on the potential benefits of music in rehabilitative exercise has become more prevalent but has mainly focused on music and the rehabilitation of neurological conditions such as Parkinson's disease or stroke (Craig et al. 2015; De Bartolo et al. 2020; Grau-Sánchez et al. 2022; Katlen da Silva et al. 2021; Särkämö 2018). Research in a more general rehabilitative setting has not been explored as widely and this is the aim …
Effects Of Acute And Repeated Alcohol Exposure On Expression Of Synaptic-Associated Genes In The Male And Female Mouse Mpfc, Dhruba Podder
Effects Of Acute And Repeated Alcohol Exposure On Expression Of Synaptic-Associated Genes In The Male And Female Mouse Mpfc, Dhruba Podder
Undergraduate Honors Theses
Alcohol use disorder (AUD) is a serious chronic brain disease; in 2021 there were ~29.5 million people in the U.S. diagnosed with AUD. Individuals with AUD often show cognitive impairment such as risky decision-making, difficulties with impulse control, and working memory deficits. This impairment is associated with structural and functional changes in the prefrontal cortex (PFC), an extensively interconnected region of the frontal lobe involved in executive control of goal-directed behaviors. Chronic alcohol exposure in rodents has been seen to cause deficits in performance in behavioral tasks which assess mPFC function such as working memory and behavioral flexibility. It is …
From “Calling” To “Just Talking": An Exploration Of Changing Relationship Terminology As A Linguistic Societal Phenomenon, Leora Wasserman
From “Calling” To “Just Talking": An Exploration Of Changing Relationship Terminology As A Linguistic Societal Phenomenon, Leora Wasserman
Undergraduate Honors Theses
This thesis will explore the correlation between societal and linguistic change,
specifically relating to the usage of the colloquialism “Just Talking” in 21st Century courtship vernacular. The usage of this term seems to be relatively new and does not appear in many scientific articles. In 2019, at the beginning of the research project which prompted this paper, there were no scientific articles that attempted to discuss this phenomenon. Since then, only two articles on the subject have been published. This thesis will attempt to understand why this term is being used and how it relates to the terms which have …
Synthesis And Characterization Of Nanocomposite Sensing Films For Breath Sensors, Tara Mercer
Synthesis And Characterization Of Nanocomposite Sensing Films For Breath Sensors, Tara Mercer
Undergraduate Honors Theses
Lung cancer is one of the most common and fatal cancers today, infecting 1 in 16 people, and killing well over a million patients per year. Currently, lung cancer is detected usually in stages three and four by quite costly and invasive methods, which shows only a survival rate of 10%. Breath sensors provide a low-cost and non-invasive technique for early screening of lung cancer. The breath sensors use assemblies of gold nanoparticles to identify lung cancer, specifically by identifying and quantifying specific volatile organic compound (VOC) concentrations found in the breath of lung cancer patients. This thesis describes a …
Synthesis And Evaluation Of 1-Substituted Imidazo[4,5-C] Quinoline Tlr7 Agonists With Improved Potency, Emma Grace Deyoung
Synthesis And Evaluation Of 1-Substituted Imidazo[4,5-C] Quinoline Tlr7 Agonists With Improved Potency, Emma Grace Deyoung
Undergraduate Honors Theses
TLR7 agonists are small molecules that are useful within cancer immunotherapy due to their ability to stimulate the TLR7 pathway resulting in NFκB activation, and cytokine release.1 Due to the risk of toxicity when delivered systemically, our team has employed a particular type of drug-delivery technology, Antibody Drug Conjugates (ADCs) to deliver these payloads directly to tumor tissue. The initial focus of this work was on E104 (8a), an imidazoquinoline TLR7 agonist, which was synthesized by the Tumey lab.1 However, the agonist was not sufficiently potent for many of the proposed applications of this technology, prompting a need to develop …
The Role Of Culture On Psychological Intimate Partner Violence Victimization Among Latinx Males, Saúl A. Padilla
The Role Of Culture On Psychological Intimate Partner Violence Victimization Among Latinx Males, Saúl A. Padilla
Undergraduate Honors Theses
In this study, I investigated the individual and additive effects of both acculturation and enculturation on experiencing psychological intimate partner violence (IPV) victimization within low-income Latinx males. I hypothesized that there would be a significant positive association between acculturation and psychological IPV victimization, a significant negative association between enculturation and psychological IPV victimization, and a significant negative association between the additive effects of acculturation and enculturation on psychological IPV victimization. To accomplish these aims, this study conducted a secondary analysis of the Future of Families and Child Wellbeing study (FFCWS) data, which assessed low-income mothers and fathers that had just …
Cracked Cans, Bent Wire: Dating Historical Metal At Biry/Ahr House, Castroville, Texas, Maggie Logan
Cracked Cans, Bent Wire: Dating Historical Metal At Biry/Ahr House, Castroville, Texas, Maggie Logan
Graduate Dissertations and Theses
In this work I investigate changes in historical metal consumption practices over time at Biry/Ahr House, a frontier settlement in Castroville, Texas. Alsatian immigrants settled this site in Medina County as part of the empresario system of the 1840s. Biry/Ahr House was home to two families, the Birys (1844-1921) and the Groff/Tschirharts (1921-1972). Using vibrant materialism, consumerism, and collections-based research, I address the ways in which metal usage changed over time at the site as well as the factors behind these changes. I also consider the role that Alsatian heritage has played in the transformation of Biry/Ahr House from a …
Dominance And Radical Submission In Seventeenth-Century Drama: Chastity, Fairness, And Silence In Portrayals Of Mar(R)Iam(Ne), Sophonisba, And Cleopatra, Laura S. Deluca
Dominance And Radical Submission In Seventeenth-Century Drama: Chastity, Fairness, And Silence In Portrayals Of Mar(R)Iam(Ne), Sophonisba, And Cleopatra, Laura S. Deluca
Graduate Dissertations and Theses
This thesis conducts an extensive reading of early modern English playwrights’ interpretation of ancient royalty. I survey a series of seventeenth-century plays concerning Mariamne I, the Carthaginian noblewoman Sophonisba, and Cleopatra VII. I argue that the English stage produced two models of ancient royalty. Mar(r)iam(ne) and Sophonisba personify one model, functioning as white, seemingly obedient figureheads. I document playwrights portraying their men as reducing them to their chastity and fairness, or lack thereof. Despite the inactivity of these objectified women, the qualities that these men obsess over catalyze masculine irrationality. The other model, which Cleopatra embodies, encompasses blackness and defiance. …
The Synthesis Of 3-Formyltyrosine For The Purpose Of In Virto Fluorescent Visualization Of Microtubules, Angelina Bonacasa
The Synthesis Of 3-Formyltyrosine For The Purpose Of In Virto Fluorescent Visualization Of Microtubules, Angelina Bonacasa
Undergraduate Honors Theses
Microtubules and the desire to visualize them has been of utmost importance in understanding the behavior of the cytoskeleton. Even further, scientists are using this knowledge to elucidate cancerous activities as they occur within cells. In order to acquire this knowledge, the following methods have been established: the expression of tubulin after it has been fused with a fluorescent protein, the insertion of tubulin that has been exogenously labeled, and the use of fluorescent-probe conjugated microtubule ligands, such as paclitaxel. These methods, however, tend to distort the protein’s native function, thereby preventing an accurate analysis. This concern drives the need …
Characterization Of Bimetallic Silver-Copper Nanoinks With Hydroxyethyl-Cellulose Additives, Daniel Brunick
Characterization Of Bimetallic Silver-Copper Nanoinks With Hydroxyethyl-Cellulose Additives, Daniel Brunick
Undergraduate Honors Theses
Coinage metal nanoparticles remain an intriguing subject for research due to their industrial versatility. Primary applications of coinage metal nanoparticles include printed electronics, solar panels, and sensors. Inks formulated with the nanoparticles are conductive and thus useful for fabricating sensors. Silver-copper nanoalloy inks are viable for the fabrication of flexible sensing devices for the detection of volatile organic compounds. One of the challenges is the ability to synthesize composition-controllable alloy nanoparticles at room temperature through wet chemical methods and achieve controllable sintering at room temperature. This work addresses the challenges by investigating the room-temperature synthesis of silver-copper alloy nanoparticles and …
Synthesis And Characterization Of Hydrazine Derivatives Of Coumarin For Bioorthogonal Chemistry Inside Cells, Akiva J. Grimaldi
Synthesis And Characterization Of Hydrazine Derivatives Of Coumarin For Bioorthogonal Chemistry Inside Cells, Akiva J. Grimaldi
Undergraduate Honors Theses
Protein carbonylation is one manifestation of oxidative stress, which is characteristic of many diseases. Our lab has developed several coumarin-hydrazine based fluorescent probes capable of detecting carbonylation in live cells via the formation of hydrazone conjugates. As an effort to expand and improve on these achievements, this work presents new data regarding the synthesis and characterization of three such probes. Two of the probes—julolidine coumarin hydrazide (JCH) and trifluoromethyl coumarin hydrazine (TFCH)—were previously synthesized by our lab. Here, JCH is studied in terms of its reaction speed and fluorescence enhancement in acylhydrazone formation with aldehydes under various conditions and catalytic …
Optimization Of Paper-Based Substrates For Surface Enhanced Raman Spectroscopic Biosensor Development, Kaylee M. Cappuccio
Optimization Of Paper-Based Substrates For Surface Enhanced Raman Spectroscopic Biosensor Development, Kaylee M. Cappuccio
Undergraduate Honors Theses
Advancements in the field of analytical chemistry have greatly expanded the development of biosensors for the detection of a wide array of diseases. This study aims to optimize an affordable paper-based nanocomposite biosensor that utilizes surface-enhanced Raman spectroscopy (SERS). Specifically, it investigates the preparation parameters for a paper-based SERS substrate, including nanoparticle administration and drying procedures. A particular focus of this work is to assess how the wax-defined paper channels can effectively enhance SERS intensity. The results revealed that while the wax-printed wells can define the nanoparticle administration for SERS detection, wax backing may reduce the sensitivity of SERS by …
Computational Investigation Of Calmodulin Photocontrol With The Help Of An Azobenzene Derivative, Jeremy Wells
Computational Investigation Of Calmodulin Photocontrol With The Help Of An Azobenzene Derivative, Jeremy Wells
Undergraduate Honors Theses
The ability to control the activity and binding capability of enzymes in a reversible manner offers tremendous control over biological processes. Photocontrol, in particular, is promising in that electromagnetic radiation can be fine-tuned in terms of its strength, location, and duration. Photosensitive compounds, such as the azobenzene family, experience an isomerization at certain wavelengths, and attaching these compounds to enzymes has the potential to alter their structure and activity. Calmodulin (CaM) is a Ca2+ -sensitive signaling protein that has the ability to affect several downstream processes in eukaryotes and is an excellent target for photocontrol due to its small size …
Computational Analysis Of A Mn-Based Electrocatalyst With Primary Amine Substituents In The Secondary Coordination Sphere For Co2 Reduction, Erin Urban
Undergraduate Honors Theses
The purpose of this research was to report the mechanism for the two-electron, two-proton conversion of CO 2 to CO and H 2 O using a manganese(I) electrocatalyst, Mn(L)(CO) 3 Br (where L = bipyridyl ligand with aryl-amine moieties installed at the 6 position of 2,2’-bipyridine), synthesized by the Jurss group, including any other competing reactions, such as the hydrogen evolution reaction (HER). The “protonation- first” and “reduction-first” pathways were considered for CO 2 RR. Density functional theory (DFT) calculations were performed to determine the redox potentials and Gibb’s free energies for each step in the mechanism for CO 2 …
Synthesis And Characterization Of Ternary Pt Nanoally Catalysts For Fuel Cells, Ylith Peck
Synthesis And Characterization Of Ternary Pt Nanoally Catalysts For Fuel Cells, Ylith Peck
Undergraduate Honors Theses
A hydrogen fuel cell is an electrochemical device that converts oxygen and hydrogen into electrical energy while producing water as the only by-product, which has attracted growing interest, especially in the automotive industry. This technology is efficient and has zero pollution to the environment, in contrast to the direct use of fossil fuels in combustion engines which produce pollution and greenhouse gas emissions. One of the key components for hydrogen fuel cells is the catalyst that operates at the cathode, which currently use platinum. Due to the scarce amount of platinum in the world, the manufacturing cost for fuel cells …
Glypro As A Self-Immolative Spacer For The Release Of Payloads From Antibody-Drug Conjugates, Justin Michael Howe
Glypro As A Self-Immolative Spacer For The Release Of Payloads From Antibody-Drug Conjugates, Justin Michael Howe
Undergraduate Honors Theses
Antibody-drug conjugates (ADCs) are an increasingly popular modality for targeted drug delivery in many oncological and immunological applications. The paratope of a monoclonal antibody (mAb) directs the delivery of a conjugated therapeutic payload to antigen expressing cells, resulting in a controlled transport of payload to a desired cell type. Internalization of the ADC followed by lysosomal degradation results in the release of a payload to perform its biochemical function. A chemical linker between the drug and the antibody is responsible for the stability of the conjugate in circulation alongside mediating the release of an unmodified payload under lysosomal conditions. Currently, …
Using Tattoo Inks To Develop Undergraduate General Chemistry And High School Level Chemistry Students’ Understanding Of Atomic Emission, Emma Horoszewski
Using Tattoo Inks To Develop Undergraduate General Chemistry And High School Level Chemistry Students’ Understanding Of Atomic Emission, Emma Horoszewski
Undergraduate Honors Theses
An effective way to promote student engagement in the laboratory is to substitute traditional reagents for recognizable, real-world products. In this work, two laboratory experiments are outlined – one geared toward undergraduate general chemistry students and one for high school introductory level chemistry students – which replace solutions of metal salts with tattoo inks in the classic flame test experiment. The main objective of both experiments is to familiarize students with the subatomic mechanism occurring during atomic emission. Additionally, the undergraduate level experiment features the use of spectroscopy to identify metals present within tattoo inks through analysis of atomic emission …
Egyptian Stasis And Imperial Quick-Time: Recursive Xenophobia Cloaked In Mysticism, Laura S. Deluca
Egyptian Stasis And Imperial Quick-Time: Recursive Xenophobia Cloaked In Mysticism, Laura S. Deluca
Undergraduate Honors Theses
I will be examining temporality in British texts about Egypt across time. In order to achieve this, I analyze the play Antony and Cleopatra (1606) by William Shakespeare, and put it in conversation with Pharos, the Egyptian (1899) by Guy Newell Boothby. I will also be discussing Alexandria (2009) by Lindsey Davis, as a demonstration that the pattern in my findings is enduring. I will be dissecting the portrayal of Egyptian temporality, which I have found to be conveyed as a stasis, as contrasted by the quick-time of dominating imperial powers. These sources will allow me to compare depictions of …
Identity In The Late Woodland Northeast: Interpreting Communities Of Practice From Paste Composition At The Thomas/Luckey And The Losey 3 Sites, Douglas S. Riethmuller
Identity In The Late Woodland Northeast: Interpreting Communities Of Practice From Paste Composition At The Thomas/Luckey And The Losey 3 Sites, Douglas S. Riethmuller
Graduate Dissertations and Theses
Thomas/Luckey’s 13th -15th and Losey 3’s 14th-17th century occupations in the Late Woodland Northeast contain assemblages with incongruous regional pottery types; Kelso Corded and an assumed non-local Shenks Ferry. I argue the presence of Shenks Ferry vessels at these two sites indicates the movement of people who reproduced their natal designs upon arrival, rather than trade. The question of whether identity and communities of practice can be discerned from pottery decorations and paste was answered by analyzing sherds with pXRF. While pottery types are based on visual attributes, pXRF looks at elemental composition. Decoration is mimicable, but paste is not; …
D-Glucose-6-Phosphate Stimulates Sags-Dependent Biofilm Formation In Pseudomonas Aeruginosa, Madison Gowett
D-Glucose-6-Phosphate Stimulates Sags-Dependent Biofilm Formation In Pseudomonas Aeruginosa, Madison Gowett
Undergraduate Honors Theses
The SagS protein is a two-component regulatory system in Pseudomonas aeruginosa that works to independently regulate biofilm formation and antibiotic tolerance. Previous work found that these two pathways are controlled by two distinct sets of amino acids within the sensory domain of SagS that are thought to be potential ligand binding sites. Despite the extensive research done on the structure and function of SagS, the signals that activate this protein have yet to be identified. In this study we aimed to identify ligands that stimulate SagS-dependent biofilm formation. To do this we utilized ΔsagS mutants, one harboring wild-type sagS under …
The Analysis Of Honor Killings In Pakistan And How It Is Related To The Notion Of “What Will Other People Say?", Mahum Nazar
The Analysis Of Honor Killings In Pakistan And How It Is Related To The Notion Of “What Will Other People Say?", Mahum Nazar
Undergraduate Honors Theses
No abstract provided.
Acculturative Stress And Aspects Of Well-Being Among Chinese International Students In U.S. Higher Education, Liam G. Lane
Acculturative Stress And Aspects Of Well-Being Among Chinese International Students In U.S. Higher Education, Liam G. Lane
Undergraduate Honors Theses
Chinese international students have been the largest demographic of international students in the U.S. for the past decade. In our increasingly globalized world, it is inevitable that more international students will immigrate to the U.S. for educational opportunities, among many others, and it is important to consider the challenges that these students may face, to ease their cultural transition. Already we have seen our world changed by the presence of the COVID-19 pandemic and it is inevitable that this will shape the experiences of all students, let alone international students, in the near future, and possibly the foreseeable future. While …
Electrophysiological Characterization Of The Inhibitory Effects Of 2-Amino-4-Bis (Aryloxy Benzyl) Amino Butanoic Acids On Alanine Serine Cysteine Transporter 2 And Sodium Coupled Neutral Amino Acid Transporter 2, Paul Serguei Zakrepine
Electrophysiological Characterization Of The Inhibitory Effects Of 2-Amino-4-Bis (Aryloxy Benzyl) Amino Butanoic Acids On Alanine Serine Cysteine Transporter 2 And Sodium Coupled Neutral Amino Acid Transporter 2, Paul Serguei Zakrepine
Undergraduate Honors Theses
Alanine Serine Cysteine Transporter 2 (ASCT2) is a member of the solute carrier 1A (SLC1A) family of transport proteins. It is a Na+ dependent, obligatory neutral amino acid exchanger with the capability to transport glutamine and it is a primary glutamine transport protein in cancer cells. This glutamine transport capability confers an important physiological role for ASCT2 in the maintenance of intracellular amino acid pools for various metabolic and cell signaling pathways. Because of this, ASCT2 is found to be overexpressed in many cancers, which rely heavily on glutamine as an essential nutrient for cell survival and growth. A wealth …