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Effects Of Acute And Repeated Alcohol Exposure On Expression Of Synaptic-Associated Genes In The Male And Female Mouse Mpfc, Dhruba Podder

Undergraduate Honors Theses

Alcohol use disorder (AUD) is a serious chronic brain disease; in 2021 there were ~29.5 million people in the U.S. diagnosed with AUD. Individuals with AUD often show cognitive impairment such as risky decision-making, difficulties with impulse control, and working memory deficits. This impairment is associated with structural and functional changes in the prefrontal cortex (PFC), an extensively interconnected region of the frontal lobe involved in executive control of goal-directed behaviors. Chronic alcohol exposure in rodents has been seen to cause deficits in performance in behavioral tasks which assess mPFC function such as working memory and behavioral flexibility. It is …

Thiamine Deficiency And Alcohol Exposure Both Lead To An Impulsive Phenotype, Robin J. Zimmer

Graduate Dissertations and Theses

The detrimental effects of alcohol consumption, including impulsivity, cognitive inflexibility, and neuropathology, are due to a confluence of factors that often occur in addition to alcoholism. We examined the effects of chronic alcohol exposure and thiamine deficiency (or supplementation) in isolation, as well as in concert, to further our understanding of the independent effects of each treatment and how they interact. Our results demonstrated that both chronic alcohol exposure and moderate thiamine deficiency induce an impulsive phenotype. Importantly, the increased impulsivity induced by thiamine deficiency was protracted as compared to that exhibited after chronic alcohol alone. Additionally, differential pathology was …

Cognitive Modeling Analysis Of Decision-Making Processes In Young Adults At-Risk And Not At-Risk For Alcohol Dependence, Lori Anne Wagner

Graduate Dissertations and Theses

This study used the Valence-Expectancy Learning model, a mathematical cognitive model, to dissect young adult performance on the Iowa Gambling Task (IGT). Drinking behavior and monetary incentive were examined as predictors of performance on the IGT. No differences were found among groups when data were analyzed using traditional behavioral analyses. However, when the Expectancy-Valence Learning model was applied to the data, differences between groups were found related to attention and choice consistency. Importantly, the cognitive model was not a good fit for fifty-seven percent of the data, meaning that it did not succeed in explaining how the participants' choices were …

The Psychopharmacogenetics Of Ethanol And Its Relation To Brain Catecholamines, Allen C. Church

Graduate Dissertations and Theses

A review of the evidence linking gene action with the behavioral response of laboratory mammals to ethanol has been attempted. Studies examining the relationship between an animal’s genotype and its preference for alcohol are dealt with first. Genetic factors were found to strongly affect the magnitude of alcohol consumption exhibited by both mice and rats. A second section reviews the work which has studied the influence of genetics on the behavioral response that follows an acute alcohol dose. A major role of genetics in determining the psychopharmacological response to alcohol is indicated.

The sections dealing with genetics and alcohol are …