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Behavioral Economic Demand: Investigation Of Sex Differences In Four Core Genotype Model Of Oral Oxycodone Self-Administration, Michelle Elsmore, David Jentsch, Joshua Peck, Anushree Karkhanis May 2023

Behavioral Economic Demand: Investigation Of Sex Differences In Four Core Genotype Model Of Oral Oxycodone Self-Administration, Michelle Elsmore, David Jentsch, Joshua Peck, Anushree Karkhanis

Undergraduate Honors Theses

Opioid misuse has been identified to be related to problematic release of dopamine in the brain that is otherwise satiated by other alternative rewards. As mediated by patterns of positive and negative reinforcement, prolonged opioid use may transition into misuse and development of opioid use disorder. In human populations, men and women differ in their acquisition of drug use and escalation to drug misuse. Women quickly surpass their male counterparts in their transition from use to misuse in what is coined the telescoping effect. In this four core genotype model of oral oxycodone self administration, males were hypothesized to consume …


Variation In Sign-Tracking And Goal-Tracking Behaviors In A Genetically Diverse Inbred Panel Of Mice, Emily A. Schoenblum May 2023

Variation In Sign-Tracking And Goal-Tracking Behaviors In A Genetically Diverse Inbred Panel Of Mice, Emily A. Schoenblum

Undergraduate Honors Theses

No abstract provided.


Race In The Relationship Quality Of Sexual Minority People Of Color: A Meta-Analytic Review, Olivia M. Lawrence May 2023

Race In The Relationship Quality Of Sexual Minority People Of Color: A Meta-Analytic Review, Olivia M. Lawrence

Undergraduate Honors Theses

No abstract provided.


Effect Of Motivational Music On Peak Knee Torque, Perceived Exertion, And Enjoyment In College-Aged Individuals, Arianna Cole May 2023

Effect Of Motivational Music On Peak Knee Torque, Perceived Exertion, And Enjoyment In College-Aged Individuals, Arianna Cole

Undergraduate Honors Theses

There is a general consensus in previous and current literature that the incorporation of music in exercise has the potential to benefit performance (Karageorghis 2020; Terry et al. 2019). Research on the potential benefits of music in rehabilitative exercise has become more prevalent but has mainly focused on music and the rehabilitation of neurological conditions such as Parkinson's disease or stroke (Craig et al. 2015; De Bartolo et al. 2020; Grau-Sánchez et al. 2022; Katlen da Silva et al. 2021; Särkämö 2018). Research in a more general rehabilitative setting has not been explored as widely and this is the aim …


Effects Of Acute And Repeated Alcohol Exposure On Expression Of Synaptic-Associated Genes In The Male And Female Mouse Mpfc, Dhruba Podder May 2023

Effects Of Acute And Repeated Alcohol Exposure On Expression Of Synaptic-Associated Genes In The Male And Female Mouse Mpfc, Dhruba Podder

Undergraduate Honors Theses

Alcohol use disorder (AUD) is a serious chronic brain disease; in 2021 there were ~29.5 million people in the U.S. diagnosed with AUD. Individuals with AUD often show cognitive impairment such as risky decision-making, difficulties with impulse control, and working memory deficits. This impairment is associated with structural and functional changes in the prefrontal cortex (PFC), an extensively interconnected region of the frontal lobe involved in executive control of goal-directed behaviors. Chronic alcohol exposure in rodents has been seen to cause deficits in performance in behavioral tasks which assess mPFC function such as working memory and behavioral flexibility. It is …


Synthesis And Characterization Of Nanocomposite Sensing Films For Breath Sensors, Tara Mercer May 2023

Synthesis And Characterization Of Nanocomposite Sensing Films For Breath Sensors, Tara Mercer

Undergraduate Honors Theses

Lung cancer is one of the most common and fatal cancers today, infecting 1 in 16 people, and killing well over a million patients per year. Currently, lung cancer is detected usually in stages three and four by quite costly and invasive methods, which shows only a survival rate of 10%. Breath sensors provide a low-cost and non-invasive technique for early screening of lung cancer. The breath sensors use assemblies of gold nanoparticles to identify lung cancer, specifically by identifying and quantifying specific volatile organic compound (VOC) concentrations found in the breath of lung cancer patients. This thesis describes a …


From “Calling” To “Just Talking": An Exploration Of Changing Relationship Terminology As A Linguistic Societal Phenomenon, Leora Wasserman May 2023

From “Calling” To “Just Talking": An Exploration Of Changing Relationship Terminology As A Linguistic Societal Phenomenon, Leora Wasserman

Undergraduate Honors Theses

This thesis will explore the correlation between societal and linguistic change,
specifically relating to the usage of the colloquialism “Just Talking” in 21st Century courtship vernacular. The usage of this term seems to be relatively new and does not appear in many scientific articles. In 2019, at the beginning of the research project which prompted this paper, there were no scientific articles that attempted to discuss this phenomenon. Since then, only two articles on the subject have been published. This thesis will attempt to understand why this term is being used and how it relates to the terms which have …


Synthesis And Evaluation Of 1-Substituted Imidazo[4,5-C] Quinoline Tlr7 Agonists With Improved Potency, Emma Grace Deyoung Apr 2023

Synthesis And Evaluation Of 1-Substituted Imidazo[4,5-C] Quinoline Tlr7 Agonists With Improved Potency, Emma Grace Deyoung

Undergraduate Honors Theses

TLR7 agonists are small molecules that are useful within cancer immunotherapy due to their ability to stimulate the TLR7 pathway resulting in NFκB activation, and cytokine release.1 Due to the risk of toxicity when delivered systemically, our team has employed a particular type of drug-delivery technology, Antibody Drug Conjugates (ADCs) to deliver these payloads directly to tumor tissue. The initial focus of this work was on E104 (8a), an imidazoquinoline TLR7 agonist, which was synthesized by the Tumey lab.1 However, the agonist was not sufficiently potent for many of the proposed applications of this technology, prompting a need to develop …


The Role Of Culture On Psychological Intimate Partner Violence Victimization Among Latinx Males, Saúl A. Padilla Apr 2023

The Role Of Culture On Psychological Intimate Partner Violence Victimization Among Latinx Males, Saúl A. Padilla

Undergraduate Honors Theses

In this study, I investigated the individual and additive effects of both acculturation and enculturation on experiencing psychological intimate partner violence (IPV) victimization within low-income Latinx males. I hypothesized that there would be a significant positive association between acculturation and psychological IPV victimization, a significant negative association between enculturation and psychological IPV victimization, and a significant negative association between the additive effects of acculturation and enculturation on psychological IPV victimization. To accomplish these aims, this study conducted a secondary analysis of the Future of Families and Child Wellbeing study (FFCWS) data, which assessed low-income mothers and fathers that had just …