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Articles 31 - 60 of 175
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Paediatric Pharmacotherapy And Drug Regulation: Moving Past The Therapeutic Orphan, Charlotte Moore-Hepburn, Michael Rieder
Paediatric Pharmacotherapy And Drug Regulation: Moving Past The Therapeutic Orphan, Charlotte Moore-Hepburn, Michael Rieder
Paediatrics Publications
The development of specific drug therapy for children was a paradigm-changing event that transformed paediatric medical practice. However, a series of tragedies involving drug treatment for children resulted in a gap developing between drug regulation and practice, with the majority of drugs used in child healthcare being used off-label, rendering children therapeutic orphans. Over the past two decades changes in drug regulation led by the US Food and Drug Administration and followed by the European Union's European Medicines Agency have led to substantial changes in how new drugs with potential use in children are studied and labelled. While these changes …
Addendum - Coronavirus Disease 2019: What Could Be The Effects On Road Safety?, Evelyn Vingilis, Jennifer Johnson, Mark J. Rapoport, Doug Beirness, Paul Boase, Patrick A. Byrne, Brian Jonah, Robert E. Mann, Jane Seeley, Christine M. Wickens, David L. Wiesenthal
Addendum - Coronavirus Disease 2019: What Could Be The Effects On Road Safety?, Evelyn Vingilis, Jennifer Johnson, Mark J. Rapoport, Doug Beirness, Paul Boase, Patrick A. Byrne, Brian Jonah, Robert E. Mann, Jane Seeley, Christine M. Wickens, David L. Wiesenthal
Paediatrics Publications
No abstract provided.
Crescent: Cancer Single Cell Expression Toolkit, Suluxan Mohanraj, J. Javier Díaz-Mejía, Martin D. Pham, Hillary Elrick, Mia Husić, Shaikh Rashid, Ping Luo, Prabnur Bal, Kevin Lu, Samarth Patel, Alaina Mahalanabis, Alaine Naidas, Erik Christensen, Danielle Croucher, Laura M. Richards, Parisa Shooshtari, Michael Brudno, Arun K. Ramani, Trevor J. Pugh
Crescent: Cancer Single Cell Expression Toolkit, Suluxan Mohanraj, J. Javier Díaz-Mejía, Martin D. Pham, Hillary Elrick, Mia Husić, Shaikh Rashid, Ping Luo, Prabnur Bal, Kevin Lu, Samarth Patel, Alaina Mahalanabis, Alaine Naidas, Erik Christensen, Danielle Croucher, Laura M. Richards, Parisa Shooshtari, Michael Brudno, Arun K. Ramani, Trevor J. Pugh
Paediatrics Publications
CReSCENT: CanceR Single Cell ExpressioN Toolkit (https://crescent.cloud), is an intuitive and scalable web portal incorporating a containerized pipeline execution engine for standardized analysis of singlecell RNA sequencing (scRNA-seq) data. While scRNA-seq data for tumour specimens are readily generated, subsequent analysis requires highperformance computing infrastructure and user expertise to build analysis pipelines and tailor interpretation for cancer biology. CReSCENT uses public data sets and preconfigured pipelines that are accessible to computational biology non-experts and are user-editable to allow optimization, comparison, and reanalysis for specific experiments. Users can also upload their own scRNA-seq data for analysis and results can be kept private …
Machine Learning Identifies Clinical And Genetic Factors Associated With Anthracycline Cardiotoxicity In Pediatric Cancer Survivors, Marie A. Chaix, Neha Parmar, Caroline Kinnear, Myriam Lafreniere-Roula, Oyediran Akinrinade, Roderick Yao, Anastasia Miron, Emily Lam, Guoliang Meng, Anne Christie, Ashok Kumar Manickaraj, Stacey Marjerrison, Rejane Dillenburg, Mylène Bassal, Jane Lougheed, Shayna Zelcer, Herschel Rosenberg, David Hodgson, Leonard Sender, Paul Kantor, Cedric Manlhiot, James Ellis, Luc Mertens, Paul C. Nathan, Seema Mital
Machine Learning Identifies Clinical And Genetic Factors Associated With Anthracycline Cardiotoxicity In Pediatric Cancer Survivors, Marie A. Chaix, Neha Parmar, Caroline Kinnear, Myriam Lafreniere-Roula, Oyediran Akinrinade, Roderick Yao, Anastasia Miron, Emily Lam, Guoliang Meng, Anne Christie, Ashok Kumar Manickaraj, Stacey Marjerrison, Rejane Dillenburg, Mylène Bassal, Jane Lougheed, Shayna Zelcer, Herschel Rosenberg, David Hodgson, Leonard Sender, Paul Kantor, Cedric Manlhiot, James Ellis, Luc Mertens, Paul C. Nathan, Seema Mital
Paediatrics Publications
Background: Despite known clinical risk factors, predicting anthracycline cardiotoxicity remains challenging. Objectives: This study sought to develop a clinical and genetic risk prediction model for anthracycline cardiotoxicity in childhood cancer survivors. Methods: We performed exome sequencing in 289 childhood cancer survivors at least 3 years from anthracycline exposure. In a nested case-control design, 183 case patients with reduced left ventricular ejection fraction despite low-dose doxorubicin (≤250 mg/m2), and 106 control patients with preserved left ventricular ejection fraction despite doxorubicin >250 mg/m2 were selected as extreme phenotypes. Rare/low-frequency variants were collapsed to identify genes differentially enriched for variants between case patients …
The Use Of The Behaviour Change Wheel In The Development Of Participaction's Physical Activity App, Stephanie Truelove, Leigh M. Vanderloo, Patricia Tucker, Katie M. Di Sebastiano, Guy Faulkner
The Use Of The Behaviour Change Wheel In The Development Of Participaction's Physical Activity App, Stephanie Truelove, Leigh M. Vanderloo, Patricia Tucker, Katie M. Di Sebastiano, Guy Faulkner
Paediatrics Publications
The purpose of this study was to provide a detailed and systematic outline of how a theoretical behaviour change framework was applied in the development of ParticipACTION's app to support a more active Canada. The app development process was guided by the Behaviour Change Wheel (BCW) framework, a theoretically-based approach for intervention development, in collaboration with the commercial app industry. Specifically, a behavioural diagnosis was used to understand what needs to change for the targeted behaviour to occur. Current literature, along with a series of surveys, and market research informed app development. Additionally, a validated app behaviour change scale, was …
Habitual Physical Activity Levels And Sedentary Time Of Children In Different Childcare Arrangements From A Nationally Representative Sample Of Canadian Preschoolers, Julie Statler, Piotr Wilk, Brian W. Timmons, Rachel Colley, Patricia Tucker
Habitual Physical Activity Levels And Sedentary Time Of Children In Different Childcare Arrangements From A Nationally Representative Sample Of Canadian Preschoolers, Julie Statler, Piotr Wilk, Brian W. Timmons, Rachel Colley, Patricia Tucker
Paediatrics Publications
Background: Children spend substantial time in childcare, and the reasons parents choose a particular childcare type may differ by family. However, little is known about how childcare type influences habitual (full day) activity levels among children. Therefore, exploring patterns between childcare type and habitual physical activity (PA) (i.e., light, moderate-to-vigorous PA (MVPA), and total PA) and sedentary time (ST) in young Canadian children is needed. Methods: A nationally representative sample of preschoolers from Cycles 3 and 4 of the Canadian Health Measures Survey was used in this cross-sectional study. Childcare type (e.g., center-based childcare, home-based childcare, home with parent, kindergarten) …
Personal Protective Equipment Availability And Usage Amongst Pediatric Otorhinolaryngologists During The Covid-19 Pandemic: An International Survey, Dong Hyun Kim, Neil K. Chadha, Lily Hp Nguyen, Murad Husein
Personal Protective Equipment Availability And Usage Amongst Pediatric Otorhinolaryngologists During The Covid-19 Pandemic: An International Survey, Dong Hyun Kim, Neil K. Chadha, Lily Hp Nguyen, Murad Husein
Paediatrics Publications
Objectives: To survey a group of global pediatric otolaryngology specialists to assess their usage and access to personal protective equipment during the COVID-19 pandemic. Methods: A survey of 13 questions was created collecting information on: basic demographics of practice, types of PPE used for procedures of varying aerosolization risk, access to positive air-purifying respirator (PAPR) and patient testing for SARS-CoV-2. Pediatric otolaryngologists were invited to complete the survey via Whatsapp™. Results: 96 responses were collected from 17 different countries. N95 was the most commonly utilized PPE when dealing with COVID-19 patients (64.2%–81.9% depending on aerosolization risk of the procedure). Significantly …
The Marine Compound And Elongation Factor 1a1 Inhibitor, Didemnin B, Provides Benefit In Western Diet-Induced Non-Alcoholic Fatty Liver Disease, Rachel B. Wilson, Yun Jin Chen, Brian G. Sutherland, Cynthia G. Sawyez, Richard Zhang, Taylor Woolnough, Alexandra M. Hetherington, Kia M. Peters, Krisha Patel, John P. Kennelly, Kelly Ann Leonard, Meg Schuurman, René L. Jacobs, Rennian Wang, Nica M. Borradaile
The Marine Compound And Elongation Factor 1a1 Inhibitor, Didemnin B, Provides Benefit In Western Diet-Induced Non-Alcoholic Fatty Liver Disease, Rachel B. Wilson, Yun Jin Chen, Brian G. Sutherland, Cynthia G. Sawyez, Richard Zhang, Taylor Woolnough, Alexandra M. Hetherington, Kia M. Peters, Krisha Patel, John P. Kennelly, Kelly Ann Leonard, Meg Schuurman, René L. Jacobs, Rennian Wang, Nica M. Borradaile
Paediatrics Publications
Inhibition of eukaryotic elongation factor 1A1 (EEF1A1) with the marine compound didemnin B decreases lipotoxic HepG2 cell death in vitro and improves early stage non-alcoholic fatty liver disease (NAFLD) in young genetically obese mice. However, the effects of didemnin B on NAFLD in a model of long-term diet-induced obesity are not known. We investigated the effects of didemnin B on NAFLD severity and metabolic parameters in western diet-induced obese mice, and on the cell types that contribute to liver inflammation and fibrosis in vitro. Male 129S6 mice were fed either standard chow or western diet for 26 weeks, followed by …
Decorin Production By The Human Decidua: Role In Decidual Cell Maturation, C. D. Halari, P. Nandi, M. J. Jeyarajah, S. J. Renaud, P. K. Lala
Decorin Production By The Human Decidua: Role In Decidual Cell Maturation, C. D. Halari, P. Nandi, M. J. Jeyarajah, S. J. Renaud, P. K. Lala
Paediatrics Publications
Decidualization involves the proliferation and differentiation of fibroblast-like endometrial stromal cells into epithelioid-shaped and secretory ‘decidual’ cells in response to steroid hormones. Human decidual cells produce insulin-like growth factor-binding protein-1 and prolactin (PRL), two well-recognized markers of decidual cell maturation and a proteoglycan decorin (DCN). We reported that DCN restrains the human trophoblast renewal, migration, invasion and endovascular differentiation needed for uterine arterial remodeling during normal pregnancy. DCN overproduction by the decidua is associated with a hypo-invasive placenta and a serious pregnancy disorder, pre-eclampsia (PE). Furthermore, elevated maternal plasma DCN levels during the second trimester is a predictive biomarker of …
Functional Annotation Of Genomic Variation: Dna Methylation Episignatures In Neurodevelopmental Mendelian Disorders, Bekim Sadikovic, Michael A. Levy, Erfan Aref-Eshghi
Functional Annotation Of Genomic Variation: Dna Methylation Episignatures In Neurodevelopmental Mendelian Disorders, Bekim Sadikovic, Michael A. Levy, Erfan Aref-Eshghi
Paediatrics Publications
The breadth and complexity of genetic testing in patients with suspected Mendelian neurodevelopmental disorders has rapidly expanded in the past two decades. However, in spite of advances in genomic technologies, genetic diagnosis remains elusive in more than half of these patients. Epigenomics, and in particular genomic DNA methylation profiles, are now known to be associated with the underpinning genetic defects in a growing number of Mendelian disorders. These often highly specific and sensitive molecular biomarkers have been used to screen these patient populations, resolve ambiguous clinical cases and interpret genetic variants of unknown clinical significance. Increasing the diagnostic yield beyond …
Coronavirus Disease 2019: What Could Be The Effects On Road Safety?, Evelyn Vingilis, Doug Beirness, Paul Boase, Patrick Byrne, Jennifer Johnson, Brian Jonah, Robert E. Mann, Mark J. Rapoport, Jane Seeley, Christine M. Wickens, David L. Wiesenthal
Coronavirus Disease 2019: What Could Be The Effects On Road Safety?, Evelyn Vingilis, Doug Beirness, Paul Boase, Patrick Byrne, Jennifer Johnson, Brian Jonah, Robert E. Mann, Mark J. Rapoport, Jane Seeley, Christine M. Wickens, David L. Wiesenthal
Paediatrics Publications
In March 2020, the World Health Organization declared COVID-19 a world-wide pandemic. Countries introduced public health measures to contain and reduce its spread. These measures included closures of educational institutions, non-essential businesses, events and activities, as well as working from and staying at home requirements. These measures have led to an economic downturn of unprecedented proportions. Generally, as economic activity declines, travel decreases and drivers are exposed to a lower risk of collisions. However, research on previous economic downturns suggests economic downturns differentially affect driver behaviours and situations. COVID-19 pandemic effects on road safety are currently unknown. However, preliminary information …
Impact Of Beta-Blockers On Birth Weight In A High-Risk Cohort Of Pregnant Women With Cvd, Jasmine Grewal, Samuel C. Siu, Terry Lee, Rohan D'Souza, Merav Dvir, Joel Singer, Valerie Rychel, Marla Kiess, Mathew Sermer, Candice K. Silversides
Impact Of Beta-Blockers On Birth Weight In A High-Risk Cohort Of Pregnant Women With Cvd, Jasmine Grewal, Samuel C. Siu, Terry Lee, Rohan D'Souza, Merav Dvir, Joel Singer, Valerie Rychel, Marla Kiess, Mathew Sermer, Candice K. Silversides
Paediatrics Publications
No abstract provided.
Arachidonic Acid Inhibits Inflammatory Responses By Binding To Myeloid Differentiation Factor-2 (Md2) And Preventing Md2/Toll-Like Receptor 4 Signaling Activation, Yali Zhang, Hongjin Chen, Wenxin Zhang, Yan Cai, Peiren Shan, Di Wu, Bing Zhang, Hui Liu
Arachidonic Acid Inhibits Inflammatory Responses By Binding To Myeloid Differentiation Factor-2 (Md2) And Preventing Md2/Toll-Like Receptor 4 Signaling Activation, Yali Zhang, Hongjin Chen, Wenxin Zhang, Yan Cai, Peiren Shan, Di Wu, Bing Zhang, Hui Liu
Paediatrics Publications
Arachidonic acid (AA) plays a fundamental role in the function of all cells. Metabolites of AA contribute to inflammation as well as for resolving inflammation. Although AA-derived metabolites exhibit well-substantiated bioactivity, it is not known whether AA regulates inflammatory responses independent of its metabolites. With the recent discovery that saturated fatty acids activate toll-like receptor-4 (TLR4), we tested the hypothesis that AA directly regulates inflammatory responses through modulating the activity of TLR4. In cultured cardiomyocytes and macrophages, we found that AA prevents saturated fatty acid-induced TLR4 complex formation with accessory proteins and the induction of proinflammatory cytokines. We discovered that …
Exploring The Use Of The Verbal Intelligence Quotient As A Proxy For Language Ability In Autism Spectrum Disorder, Leticia Ribeiro De Oliveira, Jessica Brian, Elizabeth Kelley, Deryk Beal, Robert Nicolson, Stelios Georgiades, Alana Iaboni, Susan Day Fragiadakis
Exploring The Use Of The Verbal Intelligence Quotient As A Proxy For Language Ability In Autism Spectrum Disorder, Leticia Ribeiro De Oliveira, Jessica Brian, Elizabeth Kelley, Deryk Beal, Robert Nicolson, Stelios Georgiades, Alana Iaboni, Susan Day Fragiadakis
Paediatrics Publications
Background: There is growing interest in understanding the brain and language associations in Autism Spectrum Disorder (ASD). A considerable number of studies investigating these associations have used the verbal intelligence quotient (VIQ) as their primary measure of language form and content. Given this current trend, we aimed to establish whether the VIQ could reliably be used as a measure of receptive and expressive language form and content in individuals with ASD and in typical development (TD). Method: We examined the VIQ standard scores derived from a Wechsler cognitive battery as well as receptive and expressive language standard scores from the …
Summer Season And Recommended Vitamin D Intake Support Adequate Vitamin D Status Throughout Pregnancy In Healthy Canadian Women And Their Newborns, Maude Perreault, Stephanie A. Atkinson, David Meyre, Gerhard Fusch, Michelle F. Mottola
Summer Season And Recommended Vitamin D Intake Support Adequate Vitamin D Status Throughout Pregnancy In Healthy Canadian Women And Their Newborns, Maude Perreault, Stephanie A. Atkinson, David Meyre, Gerhard Fusch, Michelle F. Mottola
Paediatrics Publications
Background: Vitamin D deficiency in pregnancy is reported as a prevalent public health problem. Objectives: We aimed to evaluate, in pregnant Canadian women, 1) vitamin D intake, 2) maternal and cord serum 25-hydroxycholecalciferol [25(OH)D] and maternal 1,25-dihydroxycholecalciferol [1,25(OH)2D], and 3) factors associated with maternal serum 25(OH)D. Methods: Women (n = 187; mean prepregnancy BMI 24.4 kg/m2, mean age 31 y) recruited to the Be Healthy in Pregnancy study provided fasting blood samples and nutrient intake at 12-17 (early) and 36-38 (late) weeks of gestation, and cord blood. Vitamin D intakes (Nutritionist Pro™) and serum 25(OH)D and 1,25(OH)2D concentrations (LC-tandem MS) …
Preventing Complications In Pregnant Women With Cardiac Disease, Birgit Pfaller, Gnalini Sathananthan, Jasmine Grewal, Jennifer Mason, Rohan D'Souza, Danna Spears, Marla Kiess, Samuel C. Siu, Candice K. Silversides
Preventing Complications In Pregnant Women With Cardiac Disease, Birgit Pfaller, Gnalini Sathananthan, Jasmine Grewal, Jennifer Mason, Rohan D'Souza, Danna Spears, Marla Kiess, Samuel C. Siu, Candice K. Silversides
Paediatrics Publications
Background: Pregnancy can lead to complications in women with heart disease, and these complications can be life threatening. Understanding serious complications and how they can be prevented is important. Objectives: The primary objectives were to determine the incidence of serious cardiac events (SCEs) in pregnant women with heart disease, whether they were preventable, and their impact on fetal and neonatal outcomes. Serious obstetric events were also examined. Methods: A prospectively assembled cohort of 1,315 pregnancies in women with heart disease was studied. SCEs included cardiac death or arrest, ventricular arrhythmias, congestive heart failure or arrhythmias requiring admission to an intensive …
Context-Dependent Activation Of Sirt3 Is Necessary For Anchorage-Independent Survival And Metastasis Of Ovarian Cancer Cells, Yeon Soo Kim, Piyushi Gupta Vallur, Victoria M. Jones, Beth L. Worley, Sara Shimko, Dong Hui Shin, La Taijah C. Crawford, Chi Wei Chen, Katherine M. Aird, Thomas Abraham, Trevor G. Shepherd, Joshua I. Warrick, Nam Y. Lee, Rebecca Phaeton, Karthikeyan Mythreye, Nadine Hempel
Context-Dependent Activation Of Sirt3 Is Necessary For Anchorage-Independent Survival And Metastasis Of Ovarian Cancer Cells, Yeon Soo Kim, Piyushi Gupta Vallur, Victoria M. Jones, Beth L. Worley, Sara Shimko, Dong Hui Shin, La Taijah C. Crawford, Chi Wei Chen, Katherine M. Aird, Thomas Abraham, Trevor G. Shepherd, Joshua I. Warrick, Nam Y. Lee, Rebecca Phaeton, Karthikeyan Mythreye, Nadine Hempel
Paediatrics Publications
Tumor cells must alter their antioxidant capacity for maximal metastatic potential. Yet the antioxidant adaptations required for ovarian cancer transcoelomic metastasis, which is the passive dissemination of cells in the peritoneal cavity, remain largely unexplored. Somewhat contradicting the need for oxidant scavenging are previous observations that expression of SIRT3, a nutrient stress sensor and regulator of mitochondrial antioxidant defenses, is often suppressed in many primary tumors. We have discovered that this mitochondrial deacetylase is specifically upregulated in a context-dependent manner in cancer cells. SIRT3 activity and expression transiently increased following ovarian cancer cell detachment and in tumor cells derived from …
Dietary Intake Of Sodium By Children: Why It Matters, Manjula Gowrishankar, Becky Blair, Michael J. Rieder
Dietary Intake Of Sodium By Children: Why It Matters, Manjula Gowrishankar, Becky Blair, Michael J. Rieder
Paediatrics Publications
Dietary sodium is required in very small amounts to support circulating blood volume and blood pressure (BP). Available nutritional surveillance data suggest that most Canadian children consume sodium in excess of their dietary requirements. Approximately 80% of the sodium Canadians consume comes from processed and packaged foods. High sodium intakes in children may be an indicator of poor diet quality. Results from systematic reviews and meta-analyses have demonstrated that decreasing dietary sodium in children leads to small but clinically insignificant decreases in BP. However, population-level strategies to reduce sodium consumption, such as food product reformulation, modifying food procurement processes, and …
L'Importance De L'Apport Alimentaire En Sodium Chez Les Enfants, Manjula Gowrishankar, Becky Blair, Michael J. Rieder
L'Importance De L'Apport Alimentaire En Sodium Chez Les Enfants, Manjula Gowrishankar, Becky Blair, Michael J. Rieder
Paediatrics Publications
No abstract provided.
Drugs Used To Treat Pediatric Emergencies, Rohit P. Shenoi, Nathan Timm, Bridgette Jones, Kathleen Neville, Jennifer Foster, Connie Houck, Matthew Laughon, Ian Paul, Routt J. Reigart, Janice Sullivan, John Van Den Anker, John J. Alexander, Janet D. Cragan, Angela Gantt, Phillip Heine, Michael Rieder, Adelaide Robb, Hari Sachs, Geert W. T Jong, Timothy Wilens, Anne Zajicek, Perdita Taylor-Zapata, Raymond J. Koteras, James Baumberger, Tamar Margarik Haro, Joseph Wright
Drugs Used To Treat Pediatric Emergencies, Rohit P. Shenoi, Nathan Timm, Bridgette Jones, Kathleen Neville, Jennifer Foster, Connie Houck, Matthew Laughon, Ian Paul, Routt J. Reigart, Janice Sullivan, John Van Den Anker, John J. Alexander, Janet D. Cragan, Angela Gantt, Phillip Heine, Michael Rieder, Adelaide Robb, Hari Sachs, Geert W. T Jong, Timothy Wilens, Anne Zajicek, Perdita Taylor-Zapata, Raymond J. Koteras, James Baumberger, Tamar Margarik Haro, Joseph Wright
Paediatrics Publications
This clinical report is a revision of “Preparing for Pediatric Emergencies: Drugs to Consider.” It updates the list, indications, and dosages of medications used to treat pediatric emergencies in the prehospital, pediatric clinic, and emergency department settings. Although it is not an all-inclusive list of medications that may be used in all emergencies, this resource will be helpful when treating a vast majority of pediatric medical emergencies. Dosage recommendations are consistent with current emergency references such as the Advanced Pediatric Life Support and Pediatric Advanced Life Support textbooks and American Heart Association resuscitation guidelines.
Identifying Candidate Biomarkers For Pleomorphic Adenoma: A Case–Control Study, Matthew D. Morrison, Linda Jackson-Boeters, Zia A. Khan, Michael S. Shimizu, Jason H. Franklin, Kevin Fung, John H.J. Yoo, Mark R. Darling
Identifying Candidate Biomarkers For Pleomorphic Adenoma: A Case–Control Study, Matthew D. Morrison, Linda Jackson-Boeters, Zia A. Khan, Michael S. Shimizu, Jason H. Franklin, Kevin Fung, John H.J. Yoo, Mark R. Darling
Paediatrics Publications
Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Kallikrein-related peptidases have been identified as biomarkers in many human tumors and may influence tumor behavior. We investigated KLK1−15 messenger ribonucleic acid and proteins in PA specimens to determine a KLK expression profile for this tumor. Fresh frozen PA tissue specimens (n = 26) and matched controls were subjected to quantitative real-time reverse transcription polymerase chain reaction to detect KLK1−15 mRNA. Expression of KLK1, KLK12, KLK13, and KLK8 proteins were then evaluated via immunostaining techniques. Statistical analyses were performed with the level of significance set at P <.05. We observed downregulation of KLK1, KLK12, and KLK13 mRNA expression, and immunostaining studies revealed downregulation of the corresponding proteins. Histologic evidence of capsular perforation was associated with increased KLK1 protein expression. Tumor size was not associated with capsular invasion and/or perforation. This study is the first to detail a KLK expression profile for PA at both the transcriptional level and the protein level. Future work is required to develop clinical applications of these findings.
Nutritional Lifestyle Intervention In Obese Pregnant Women, Including Lower Carbohydrate Intake, Is Associated With Increased Maternal Free Fatty Acids, 3-B-Hydroxybutyrate, And Fasting Glucose Concentrations: A Secondary Factorial Analysis Of The European Multicenter, Randomized Controlled Dali Lifestyle Intervention Trial, Jürgen Harreiter, David Simmons, Gernot Desoye, Rosa Corcoy, Juan M. Adelantado, Roland Devlieger, Sander Galjaard, Peter Damm
Nutritional Lifestyle Intervention In Obese Pregnant Women, Including Lower Carbohydrate Intake, Is Associated With Increased Maternal Free Fatty Acids, 3-B-Hydroxybutyrate, And Fasting Glucose Concentrations: A Secondary Factorial Analysis Of The European Multicenter, Randomized Controlled Dali Lifestyle Intervention Trial, Jürgen Harreiter, David Simmons, Gernot Desoye, Rosa Corcoy, Juan M. Adelantado, Roland Devlieger, Sander Galjaard, Peter Damm
Paediatrics Publications
OBJECTIVE In our randomized controlled trial, we investigated the impact of healthy eating (HE) aiming for restricted gestational weight gain (GWG) and physical activity (PA) interventions on maternal and neonatal lipid metabolism. RESEARCH DESIGN AND METHODS Obese pregnant women (n = 436) were included before 20 weeks' gestation and underwent glucose testing (oral glucose tolerance test) and lipid profiling at baseline and 24-28 and 35-37 gestational weeks after an at least 10-h overnight fast. This secondary analysis had a factorial design with comparison of HE (n = 221) versus no HE (n = 215) and PA (n = 218) versus …
Improving Paediatric Medications: A Prescription For Canadian Children And Youth, Charlotte Moore Hepburn, Andrea Gilpin, Julie Autmizguine, Avrum Denburg, L. Lee Dupuis, Yaron Finkelstein, Emily Gruenwoldt, Shinya Ito, Geert't Jong, Thierry Lacaze-Masmonteil, Deborah Levy, Stuart Macleod, Steven P. Miller, Martin Offringa, Maury Pinsk, Barry Power, Michael Rieder, Catherine Litalien
Improving Paediatric Medications: A Prescription For Canadian Children And Youth, Charlotte Moore Hepburn, Andrea Gilpin, Julie Autmizguine, Avrum Denburg, L. Lee Dupuis, Yaron Finkelstein, Emily Gruenwoldt, Shinya Ito, Geert't Jong, Thierry Lacaze-Masmonteil, Deborah Levy, Stuart Macleod, Steven P. Miller, Martin Offringa, Maury Pinsk, Barry Power, Michael Rieder, Catherine Litalien
Paediatrics Publications
No abstract provided.
Improving Paediatric Medications: A Prescription For Canadian Children And Youth, Charlotte Moore Hepburn, Andrea Gilpin, Julie Autmizguine, Avram Denburg, L. Lee Dupuis, Yaron Finkelstein, Emily Gruenwoldt, Shinya Ito, Geert't Jong, Thierry Lacaze-Masmonteil, Deborah Levy, Stuart Macleod, Steven P. Miller, Martin Offringa, Maury Pinsk, Barry Power, Michael Rieder, Catherine Litalien
Improving Paediatric Medications: A Prescription For Canadian Children And Youth, Charlotte Moore Hepburn, Andrea Gilpin, Julie Autmizguine, Avram Denburg, L. Lee Dupuis, Yaron Finkelstein, Emily Gruenwoldt, Shinya Ito, Geert't Jong, Thierry Lacaze-Masmonteil, Deborah Levy, Stuart Macleod, Steven P. Miller, Martin Offringa, Maury Pinsk, Barry Power, Michael Rieder, Catherine Litalien
Paediatrics Publications
No abstract provided.
Muscle Problems In Juvenile-Onset Acid Maltase Deficiency (Pompe Disease), Eugenio Zapata-Aldana, Hugh J. Mcmillan, Tony Rupar, Catherine Brunel-Guitton, Pranesh Chakraborty, John J. Mitchell, Johannes Roth, Mark A. Tarnopolsky
Muscle Problems In Juvenile-Onset Acid Maltase Deficiency (Pompe Disease), Eugenio Zapata-Aldana, Hugh J. Mcmillan, Tony Rupar, Catherine Brunel-Guitton, Pranesh Chakraborty, John J. Mitchell, Johannes Roth, Mark A. Tarnopolsky
Paediatrics Publications
No abstract provided.
Teething Necklaces And Bracelets Pose Significant Danger To Infants And Toddlers, Farah Abdulsatar, Doreen Matsui, Michael Miller, Sepideh Taheri
Teething Necklaces And Bracelets Pose Significant Danger To Infants And Toddlers, Farah Abdulsatar, Doreen Matsui, Michael Miller, Sepideh Taheri
Paediatrics Publications
No abstract provided.
Involving Stakeholders In Informing The Development Of A Knowledge Translation (Kt) Intervention To Improve The Vaccination Experience At School, Tamlyn Freedman, Anna Taddio, C. Meghan Mcmurtry, Horace Wong, Noni Macdonald, Tori Mcdowall, Christene Devlaming-Kot, Leslie Alderman, Cotechini, A. Davey, J. Flores-Martin, T. Fournier, A. M. Franchi, R. E. Fretes, C. H. Graham, G. Godbole, S. R. Hansson, P. L. Headley, C. Ibarra, A. Jawerbaum, U. Kemmerling, Y. Kudo, P. K. Lala, L. Lassance, R. M. Lewis, E. Menkhorst
Involving Stakeholders In Informing The Development Of A Knowledge Translation (Kt) Intervention To Improve The Vaccination Experience At School, Tamlyn Freedman, Anna Taddio, C. Meghan Mcmurtry, Horace Wong, Noni Macdonald, Tori Mcdowall, Christene Devlaming-Kot, Leslie Alderman, Cotechini, A. Davey, J. Flores-Martin, T. Fournier, A. M. Franchi, R. E. Fretes, C. H. Graham, G. Godbole, S. R. Hansson, P. L. Headley, C. Ibarra, A. Jawerbaum, U. Kemmerling, Y. Kudo, P. K. Lala, L. Lassance, R. M. Lewis, E. Menkhorst
Paediatrics Publications
Objective: Pain, fear, and fainting management during school-based vaccinations is suboptimal. The objective was to examine stakeholder perceptions of barriers and facilitators to better practices. Method: Six semi-structured focus groups were conducted in Niagara Region, Ontario: Two parent groups (n=7); one grade 7 to 8 student group (n=9); two nurse groups (n=12); and one school staff group (n=6). Participants shared perceptions about school vaccination clinics and the implementation of specific strategies and tools. Focus groups were audio recorded and transcribed. The Consolidated Framework for Implementation Research (CFIR) was used as the framework for analysis. Results: Feedback from stakeholders was categorized …
Overview Of A Knowledge Translation (Kt) Project To Improve The Vaccination Experience At School: The Card™ System, Anna Taddio Bscphm, C. Meghan Mcmurtry, Lucie M. Bucci, Noni Macdonald, Anthony N.T. Ilersich, Angelo L.T. Ilersich, Angela Alfieri-Maiolo, Christene Devlaming-Kot
Overview Of A Knowledge Translation (Kt) Project To Improve The Vaccination Experience At School: The Card™ System, Anna Taddio Bscphm, C. Meghan Mcmurtry, Lucie M. Bucci, Noni Macdonald, Anthony N.T. Ilersich, Angelo L.T. Ilersich, Angela Alfieri-Maiolo, Christene Devlaming-Kot
Paediatrics Publications
Background: Students experience fear, pain, and fainting during vaccinations at school. While evidence-based interventions exist, no Knowledge Translation (KT) interventions have been developed to mitigate these symptoms. A multidisciplinary team-the Pain Pain Go Away Team- was assembled to address this knowledge-to-care gap. This manuscript provides an overview of the methodology, knowledge products, and impact of an evidence-based KT program developed and implemented to improve the vaccination experience at school. Methods: We adapted knowledge and assessed the barriers to knowledge use via focus group interviews with key stakeholder groups involved in school-based vaccinations: Students, nurses, school staff, and parents. Next, we …
Piloting The Card™ System For Education Of Students About Vaccination: Does It Improve The Vaccination Experience At School?, Anna Taddio, Anthony N.T. Ilersich, Angelo L.T. Ilersich, Cathryn Schmidt, Garth Chalmers, Evelyn Wilson, C. Meghan Mcmurtry, Noni Macdonald
Piloting The Card™ System For Education Of Students About Vaccination: Does It Improve The Vaccination Experience At School?, Anna Taddio, Anthony N.T. Ilersich, Angelo L.T. Ilersich, Cathryn Schmidt, Garth Chalmers, Evelyn Wilson, C. Meghan Mcmurtry, Noni Macdonald
Paediatrics Publications
Objective: Many students are fearful of vaccine injection-associated pain. In prior research, we created Knowledge Translation (KT) tools to address school vaccinations and associated pain, fear, and fainting. The objectives of this pilot implementation project were to determine the acceptability and impact of these KT tools on student knowledge, attitudes, and perceptions of their vaccination experience. Methods: Pre-post mixed methods design. Students in an independent school in the Greater Toronto Area, Ontario, participated in two separate focus groups before and after school vaccinations. In both sessions, they independently completed a knowledge and attitudes survey, reviewed three KT tools (two videos …
Stakeholder Feedback On The Card™ System To Improve The Vaccination Experience At School, Anna Taddio, Tamlyn Freedman, Horace Wong, C. Meghan Mcmurtry, Noni Macdonald, Anthony N.T. Ilersich, Angelo L.T. Ilersich, Tori Mcdowall
Stakeholder Feedback On The Card™ System To Improve The Vaccination Experience At School, Anna Taddio, Tamlyn Freedman, Horace Wong, C. Meghan Mcmurtry, Noni Macdonald, Anthony N.T. Ilersich, Angelo L.T. Ilersich, Tori Mcdowall
Paediatrics Publications
Objective: School-based vaccination programs can be a source of distress for many students due to the pain from the needle injection and related fears. We created a multifaceted Knowledge Translation (KT) intervention to address vaccination and pain, fear, and fainting called The CARD™ System. The objectives were to document acceptability of key tools included in the multifaceted KT intervention and their effectiveness in improving knowledge and attitudes about vaccination pain and fear. Methods: Quantitative and qualitative methods were used. Students, school staff, public health nurses, and parents participated in separate focus groups whereby they independently completed a knowledge and attitudes …