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Osteoporotic Fractures And Vertebral Body Reshaping In Children With Glucocorticoid-Treated Rheumatic Disorders, Leanne M. Ward, Jinhui Ma, Marie Eve Robinson, Maya Scharke, Josephine Ho, Kristin Houghton, Adam Huber, Rosie Scuccimarri, Julie Barsalou, Johannes Roth, Nazih Shenouda, Mary Ann Matzinger, Brian Lentle, Jacob L. Jaremko, Khaldoun Koujok, Karen Watanabe Duffy, Robert Stein, Anne Marie Sbrocchi, Celia Rodd, Paivi M. Miettunen, Claire M.A. Leblanc, Maggie Larche, Roman Jurencak, Elizabeth A. Cummings, Robert Couch, David A. Cabral
Osteoporotic Fractures And Vertebral Body Reshaping In Children With Glucocorticoid-Treated Rheumatic Disorders, Leanne M. Ward, Jinhui Ma, Marie Eve Robinson, Maya Scharke, Josephine Ho, Kristin Houghton, Adam Huber, Rosie Scuccimarri, Julie Barsalou, Johannes Roth, Nazih Shenouda, Mary Ann Matzinger, Brian Lentle, Jacob L. Jaremko, Khaldoun Koujok, Karen Watanabe Duffy, Robert Stein, Anne Marie Sbrocchi, Celia Rodd, Paivi M. Miettunen, Claire M.A. Leblanc, Maggie Larche, Roman Jurencak, Elizabeth A. Cummings, Robert Couch, David A. Cabral
Paediatrics Publications
Context: Osteoporotic fractures are an important cause of morbidity in children with glucocorticoid-treated rheumatic disorders. Objective: This work aims to evaluate the incidence and predictors of osteoporotic fractures and potential for recovery over six years following glucocorticoid (GC) initiation in children with rheumatic disorders. Methods: Children with GC-treated rheumatic disorders were evaluated through a prospective inception cohort study led by the Canadian STeroid-induced Osteoporosis in the Pediatric Population (STOPP) Consortium. Clinical outcomes included lumbar spine bone mineral density (LS BMD), vertebral fractures (VF), non-VF, and vertebral body reshaping. Results: A total of 136 children with GC-treated rheumatic disorders were enrolled …
Hair Analysis Provides A Historical Record Of Cortisol Levels In Cushing's Syndrome, S. Thomson, G. Koren, L. A. Fraser, M. Rieder, T. C. Friedman, S. H.M. Van Uum
Hair Analysis Provides A Historical Record Of Cortisol Levels In Cushing's Syndrome, S. Thomson, G. Koren, L. A. Fraser, M. Rieder, T. C. Friedman, S. H.M. Van Uum
Paediatrics Publications
The severity of Cushing's Syndrome (CS) depends on the duration and extent of the exposure to excess glucocorticoids. Current measurements of cortisol in serum, saliva and urine reflect systemic cortisol levels at the time of sample collection, but cannot assess past cortisol levels. Hair cortisol levels may be increased in patients with CS, and, as hair grows about 1cm/month, measurement of hair cortisol may provide historical information on the development of hypercortisolism. We attempted to measure cortisol in hair in relation to clinical course in six female patients with CS and in 32 healthy volunteers in 1cm hair sections. Hair …