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A Crossroad Between Placental And Tumor Biology: What Have We Learnt?, Peeyush K. Lala, Pinki Nandi, Ali Hadi, Chidambra Halari
A Crossroad Between Placental And Tumor Biology: What Have We Learnt?, Peeyush K. Lala, Pinki Nandi, Ali Hadi, Chidambra Halari
Paediatrics Publications
Placenta in certain species including the human has evolved as a highly invasive tumor-like organ invading the uterus aned its vasculature to derive oxygen and nutrients for the fetus and exchange waste products. While several excellent reviews have been written comparing hemochorial placentation with tumors, no comprehensive review is available dealing with mechanistic insights into what makes them different, and what tumor biologists can learn from placental biologists, and vice versa. In this review, we analyze the structure-function relationship of the human placenta, emphasizing the functional need of the spatio-temporally orchestrated trophoblast invasiveness for fetal development and growth, and pathological …
Decorin Production By The Human Decidua: Role In Decidual Cell Maturation, C. D. Halari, P. Nandi, M. J. Jeyarajah, S. J. Renaud, P. K. Lala
Decorin Production By The Human Decidua: Role In Decidual Cell Maturation, C. D. Halari, P. Nandi, M. J. Jeyarajah, S. J. Renaud, P. K. Lala
Paediatrics Publications
Decidualization involves the proliferation and differentiation of fibroblast-like endometrial stromal cells into epithelioid-shaped and secretory ‘decidual’ cells in response to steroid hormones. Human decidual cells produce insulin-like growth factor-binding protein-1 and prolactin (PRL), two well-recognized markers of decidual cell maturation and a proteoglycan decorin (DCN). We reported that DCN restrains the human trophoblast renewal, migration, invasion and endovascular differentiation needed for uterine arterial remodeling during normal pregnancy. DCN overproduction by the decidua is associated with a hypo-invasive placenta and a serious pregnancy disorder, pre-eclampsia (PE). Furthermore, elevated maternal plasma DCN levels during the second trimester is a predictive biomarker of …
Natural Killer-Cell Deficiency Alters Placental Development In Rats, Stephen J. Renaud, Regan L. Scott, Damayanti Chakraborty, Mohammad A.K. Rumi, Michael J. Soares
Natural Killer-Cell Deficiency Alters Placental Development In Rats, Stephen J. Renaud, Regan L. Scott, Damayanti Chakraborty, Mohammad A.K. Rumi, Michael J. Soares
Paediatrics Publications
Natural killer (NK) cells are the most prevalent leukocyte population in the uterus during early pregnancy. Natural killer cells contribute to uterine vascular (spiral artery) remodeling in preparation for the increased demand on these vessels later in pregnancy. A second wave of spiral artery modification is directed by invasive trophoblast cells. The significance of the initial wave of NK-cell-mediated vascular remodeling in species exhibiting deep trophoblast invasion such as humans and rats is not known. The purpose of this study was to generate a genetic model of NK-cell deficiency in rats, and determine the consequences of NK-cell deficiency on spiral …
Chromosome-Substituted Rat Strains Provide Insights Into The Genetics Of Placentation, Toshihiro Konno, Lea A. Rempel, M. A. Karim Rumi, Amanda R. Graham, Kazuo Asanoma, Stephen J. Renaud, Michael J. Soares
Chromosome-Substituted Rat Strains Provide Insights Into The Genetics Of Placentation, Toshihiro Konno, Lea A. Rempel, M. A. Karim Rumi, Amanda R. Graham, Kazuo Asanoma, Stephen J. Renaud, Michael J. Soares
Paediatrics Publications
The rat possesses a hemochorial form of placentation. Pronounced intrauterine trophoblast cell invasion and vascular remodeling characterize this type of placentation. Strain-specific patterns of placentation are evident in the rat. Some rat strains exhibit deep intrauterine trophoblast invasion and an expanded junctional zone [Holtzman Sprague-Dawley (HSD), Dahl salt sensitive (DSS)], whereas placentation sites of other rat strains are characterized by shallow invasion and a restricted junctional zone [Brown Norway (BN)]. In this report, we identified a quantitative trait that was used to distinguish strain-specific features of rat placentation. Junctional zone prolactin family 5, subfamily a, member 1 (Prl5a1) transcript levels …
Ifpa Meeting 2010 Workshops Report Ii: Placental Pathology; Trophoblast Invasion; Fetal Sex; Parasites And The Placenta; Decidua And Embryonic Or Fetal Loss; Trophoblast Differentiation And Syncytialisation, A. Al-Khan, I. L. Aye, I. Barsoum, A. Borbely, E. Cebral, G. Cerchi, V. L. Clifton, S. Collins, T. Ross, Bruce C. Carleton, Michael R. Hayden, Martin Hosking, Sean Virani, Stuart Macleod, Rod Rassekh, Anne Smith, Liam Brunham, Neil H. Shear, Gideon Koren, Geoffrey Liu, Michael J. Rieder, Richard Kim, Maurica Maher, David Flockhart, Lawrence Lesko, Jenna Rhoades
Ifpa Meeting 2010 Workshops Report Ii: Placental Pathology; Trophoblast Invasion; Fetal Sex; Parasites And The Placenta; Decidua And Embryonic Or Fetal Loss; Trophoblast Differentiation And Syncytialisation, A. Al-Khan, I. L. Aye, I. Barsoum, A. Borbely, E. Cebral, G. Cerchi, V. L. Clifton, S. Collins, T. Ross, Bruce C. Carleton, Michael R. Hayden, Martin Hosking, Sean Virani, Stuart Macleod, Rod Rassekh, Anne Smith, Liam Brunham, Neil H. Shear, Gideon Koren, Geoffrey Liu, Michael J. Rieder, Richard Kim, Maurica Maher, David Flockhart, Lawrence Lesko, Jenna Rhoades
Paediatrics Publications
Workshops are an important part of the IFPA annual meeting. At IFPA Meeting 2010 diverse topics were discussed in twelve themed workshops, six of which are summarized in this report. 1. The placental pathology workshop focused on clinical correlates of placenta accreta/percreta. 2. Mechanisms of regulation of trophoblast invasion and spiral artery remodeling were discussed in the trophoblast invasion workshop. 3. The fetal sex and intrauterine stress workshop explored recent work on placental sex differences and discussed them in the context of whether boys live dangerously in the womb.4. The workshop on parasites addressed inflammatory responses as a sign of …