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The Effect Of Human Recombinant Epidermal Growth Factor On Neovascularization And Pedicle Division Time In A Rat Interpolation Flap Model, Aziz Parspanci, Yavuz Keçeci̇, Peyker Temi̇z
The Effect Of Human Recombinant Epidermal Growth Factor On Neovascularization And Pedicle Division Time In A Rat Interpolation Flap Model, Aziz Parspanci, Yavuz Keçeci̇, Peyker Temi̇z
Turkish Journal of Medical Sciences
Background/aim: In practice, waiting 2–3 weeks for interpolation flaps pedicle division result in certain morbidities and discomfort for patient. The division time of flap pedicle depends on neovascularization from the recipient bed and includes wound healing stages. We aimed to investigate the effect of recombinant human epidermal growth factor (rhEGF) on the flap viability during early pedicle division.Materials and methods: Thirty-six rats were allocated to two main groups as control and study. A cranial based flap measuring 5 × 5 cm was elevated from the back, including all layers of the skin. While the cranial half of the defect was …
The Stereological And Morphometrical Investigation Of Pars Lumbalis Of The Spinal Cord Innew Zealand Rabbit, Berna Duman, İftar Gürbüz
The Stereological And Morphometrical Investigation Of Pars Lumbalis Of The Spinal Cord Innew Zealand Rabbit, Berna Duman, İftar Gürbüz
Turkish Journal of Veterinary & Animal Sciences
In the study, 12 (6 females, 6 males) healthy adult New Zealand rabbits were used to examine the morphometrical andstereological values. White matter, gray matter and total segment volume of the segments in the pars lumbalis were calculated byCavalieri’s principle. The findings were grouped according to sexand statistically evaluated. As a result, 38% of the length of the spinalcord in rabbits belonged to the pars lumbalis. The morphometric parameters were not statistically different between male and femalerabbits (p > 0.05). The segment with the biggest volume was L5. White matter’s greatest volume was the L4 segment. The volume of graymatter was …
Clinical Characteristics And Disease Course Before And After Sars-Cov-2 Infection In A Large Cohort Of Systemic Sclerosis Patients, Aslıhan Avanoğlu Güler, Büşra Özçi̇men, Mesude Seda Aydoğdu, Alper Sari, Aliyeva Numune, Nazife Tüzün Ersan, Seda Çolak, Hazan Karadeni̇z, İbrahim Vasi̇, Hamit Küçük, Yasemin Yalçinkaya, Abdulsamet Erden, Mehmet Kayaalp, Mehmet Akif Öztürk, Berna Göker, Ahmet Omma, Sedat Yilmaz, Süleyman Serdar Koca, Murat İnanç, Ali Akdoğan, Abdurrahman Tufan
Clinical Characteristics And Disease Course Before And After Sars-Cov-2 Infection In A Large Cohort Of Systemic Sclerosis Patients, Aslıhan Avanoğlu Güler, Büşra Özçi̇men, Mesude Seda Aydoğdu, Alper Sari, Aliyeva Numune, Nazife Tüzün Ersan, Seda Çolak, Hazan Karadeni̇z, İbrahim Vasi̇, Hamit Küçük, Yasemin Yalçinkaya, Abdulsamet Erden, Mehmet Kayaalp, Mehmet Akif Öztürk, Berna Göker, Ahmet Omma, Sedat Yilmaz, Süleyman Serdar Koca, Murat İnanç, Ali Akdoğan, Abdurrahman Tufan
Turkish Journal of Medical Sciences
The objective of this study is to evaluate the clinical presentations and adverse outcomes of Coronavirus Disease 2019 (COVID-19) in patients with systemic sclerosis (SSc) and assess the impact of SSc features on the clinical course of COVID-19.Materials and methods: In this multicenter, retrospective study, SSc patients with COVID-19 were included. Clinical features of SSc, along with detailed COVID-19 data, were extracted from medical records and patient interviews.Results: The study included 112 patients (mean age 51.4 ± 12.8 years; 90.2% female). SSc-associated interstitial lung disease (ILD) was evident in 57.1% of the patients. The findings revealed hospitalization in 25.5%, respiratory …
The Relationship Between Trunk Control, Spinal Posture, And Spinal Mobility In Patients With Multiple Sclerosis: A Cross-Sectional Study, Taşkın Özkan, Nezehat Özgül Ünlüer, Mustafa Ertuğrul Yaşa, Buse Korkmaz, Gönül Vural
The Relationship Between Trunk Control, Spinal Posture, And Spinal Mobility In Patients With Multiple Sclerosis: A Cross-Sectional Study, Taşkın Özkan, Nezehat Özgül Ünlüer, Mustafa Ertuğrul Yaşa, Buse Korkmaz, Gönül Vural
Turkish Journal of Medical Sciences
Trunk control, which plays a key role in balance and mobility, decreases in patients with multiple sclerosis (PwMS) and many parameters such as sensory, motor, and musculoskeletal systems affect trunk control. The aim of this study was to compare trunk control, spinal mobility, and spinal posture in PwMS with healthy controls and investigate the relationship between trunk control with spinal posture and spinal mobility in PwMS.Materials and methods: The study was completed with 38 PwMS and 38 healthy controls with matched age and sex. Trunk control was evaluated with the Trunk Impairment Scale (TIS). Spinal posture and mobility were evaluated …
Risk Factors Of Congenital Nomalies Of The Kidney And Urinary Tract (Cakut): Exposureto Mobile Phones During Pregnancy, Kübra Çeleğen, Esra Özgül, Zeynep Yeşi̇ldağ, Erdem Yusuf Çamirci, Mehmet Çeleğen, Ayşegül Bükülmez
Risk Factors Of Congenital Nomalies Of The Kidney And Urinary Tract (Cakut): Exposureto Mobile Phones During Pregnancy, Kübra Çeleğen, Esra Özgül, Zeynep Yeşi̇ldağ, Erdem Yusuf Çamirci, Mehmet Çeleğen, Ayşegül Bükülmez
Turkish Journal of Medical Sciences
Congenital anomalies of the kidney and urinary tract(CAKUT) are the leading causes of childhood chronic kidney disease (CKD). The etiology of most of the cases is thought to be multifactorial. In this study, risk factors for CAKUT and the effect of mobile phone-related electromagnetic field (EMF) exposure during pregnancy were investigated.Materials and methods: Fifty-seven cases and 57 healthy controls under 2 years of age were included and their mothers were subjected to a questionnaire. Groups were compared for parents’ demographics, pregestational (chronic disease, body mass index, use of the folic acid supplements) and antenatal variables (gestational disease, weight gain during …
Predictive Values Of Mallampati Score, Tonsillar Size, And Bmi Z-Score In The Presence And Severity Of Obstructive Sleep Apnea In Pediatric Population, Ayşe Kaçar Bayram, Ahu Paketçi̇, Melek Nur Şahbaz, Sevde Daşdelen, Serkan Bilge Koca
Predictive Values Of Mallampati Score, Tonsillar Size, And Bmi Z-Score In The Presence And Severity Of Obstructive Sleep Apnea In Pediatric Population, Ayşe Kaçar Bayram, Ahu Paketçi̇, Melek Nur Şahbaz, Sevde Daşdelen, Serkan Bilge Koca
Turkish Journal of Medical Sciences
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder in children. Determination of riskfactors for the development of OSA is essential for early diagnosis and treatment of the disease and decreases the risk of negativeconsequences. This study aimed to investigate the predictive values of Mallampati score, tonsillar size, and BMI z-score in the presenceand severity of OSA in children.Materials and methods: This prospective cross-sectional study included 114 children with OSA symptoms. All children were assessedby BMI z-score, Mallampati score, and tonsillar size and underwent overnight polysomnography. They were consecutively selected andassigned to 4 groups as follows: Group 1 included …
Evaluation Of Accompanying Allergic Disease In Children With Proven Drug Allergies, Şule Büyük Yaytokgi̇l, Kezban İpek Demi̇r, Özge Yılmaz Topal, Azize Pınar Metbulut, İlknur Külhaş Çeli̇k, Müge Toyran, Ersoy Ci̇velek, Emine Di̇bek Misirlioğlu
Evaluation Of Accompanying Allergic Disease In Children With Proven Drug Allergies, Şule Büyük Yaytokgi̇l, Kezban İpek Demi̇r, Özge Yılmaz Topal, Azize Pınar Metbulut, İlknur Külhaş Çeli̇k, Müge Toyran, Ersoy Ci̇velek, Emine Di̇bek Misirlioğlu
Turkish Journal of Medical Sciences
Data on the prevalence of allergic diseases in children with proven drug allergies are limited. We aim to evaluate thefrequency of allergic comorbidity in children with proven common drug allergies.Materials and methods: Children with drug hypersensitivity confirmed by diagnostic allergy tests at our center between January 2010and December 2020 were screened retrospectively. Patients with the most common drug allergies (due to antibiotics, nonsteroidalantiinflammatory drugs [NSAIDs], and antiepileptic drugs) were selected for analysis. Age, sex, the culprit drug, initial reactioncharacteristics, diagnostic test results, and the study physician who diagnosed concomitant allergic diseases were noted.Results: A total of 168 patients (boys, 51.2%) …
Minipuberty Period Of Children With Atopic Dermatitis Compared To Healthy Children, Serkan Bilge Koca, Hatice Eke Güngör, Murat Cansever
Minipuberty Period Of Children With Atopic Dermatitis Compared To Healthy Children, Serkan Bilge Koca, Hatice Eke Güngör, Murat Cansever
Turkish Journal of Medical Sciences
Atopic dermatitis (AD) is an inflammatory, pruritic, noncontagious, chronic relapsing skin disease. Skin barrierabnormalities, excessive T helper 2 activity, and immune dysregulation are held responsible. Androgens have a negative effect on theintegrity of the epidermal skin barrier, while estrogen has a positive effect. We aimed to investigate whether hormones make a differencebetween healthy children and children with AD during minipuberty.Materials and methods: A total of 96 infants (postnatal 4–13 weeks), 48 diagnosed with AD and 48 controls, were included. Each groupconsisted of 23 girls (47.9%) and 25 boys (52.1%). Anthropometric examinations and hormone measurements were compared.Results: The two groups, having …
Virological And Pathological Investigation Of Canine Parvovirus-2 (Cpv-2) With The Assessment Of The Genetic Variability Of Field Strains, Zeynep Karapinar, Musa Karaman, İhsan Kisadere, Mustafa Usta, Mehmet Özkan Ti̇murkan
Virological And Pathological Investigation Of Canine Parvovirus-2 (Cpv-2) With The Assessment Of The Genetic Variability Of Field Strains, Zeynep Karapinar, Musa Karaman, İhsan Kisadere, Mustafa Usta, Mehmet Özkan Ti̇murkan
Turkish Journal of Veterinary & Animal Sciences
Canine parvovirus-2 (CPV-2), which is common worldwide, is a highly contagious pathogen in domestic dogs and some wild carnivore species. The agent causes a multisystemic infection in affected animals, especially acute hemorrhagic enteritis and fatal myocarditis in puppies. The study aimed to reveal the presence of virus in dogs with clinical symptoms of CPV-2 infection using virological, pathological, and immunohistochemical methods and make molecular characterization based on partial VP-2 gene of strains circulating in the region. As a result of PCR studies, 9 out of 16 rectal swab samples and 17 out of 38 blood samples were positive. A phylogenetic …
The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca
The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca
Turkish Journal of Medical Sciences
Background/aim: Temporomandibular Disorders (TMD), as in the occurrence of many diseases, have been associated with oxidative stress (OS) resulting from the disruption of antioxidant mechanisms and the accumulation of reactive oxygen species in tissues. This study was designed to compare salivary and serum OS and inflammation markers of individuals with TMD and healthy subjects. Materials and methods: A prospective cross-sectional study was conducted. Twenty-seven TMD patients diagnosed with disc displacement (DD) according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and 17 healthy subjects were enrolled in the study. Prior to any treatment, serum, and saliva samples were taken from …
Is Electrophysiological Study A Novel Predictor For Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation?, Zeki̇ Çeti̇nkaya, Deni̇z Elçi̇k, Şaban Keleşoğlu, Burak Cesur, Mustafa Yaşan, Uğur Karabiyik, Bi̇lge Bi̇ngöl, Ni̇hat Kalay, Ramazan Topsakal, Aydin Tunçay, Ali̇ Doğan, Mehmet Tuğrul İnanç
Is Electrophysiological Study A Novel Predictor For Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation?, Zeki̇ Çeti̇nkaya, Deni̇z Elçi̇k, Şaban Keleşoğlu, Burak Cesur, Mustafa Yaşan, Uğur Karabiyik, Bi̇lge Bi̇ngöl, Ni̇hat Kalay, Ramazan Topsakal, Aydin Tunçay, Ali̇ Doğan, Mehmet Tuğrul İnanç
Turkish Journal of Medical Sciences
Background/aim: Despite advancements in valve technology and increased clinical experience, complications related to conduction defects after transcatheter aortic valve implantation (TAVR) have not improved as rapidly as expected. In this study, we aimed to predict the development of complete atrioventricular (AV) block and bundle branch block during and after the TAVR procedure and to investigate any changes in the cardiac conduction system before and after the procedure using electrophysiological study. Materials and methods: A total of 30 patients who were scheduled for TAVR at our cardiovascular council were planned to be included in the study. TAVR was performed on patients …
Comparison Of The Effectiveness Of Instrument-Assisted Soft Tissue Mobilization And Extracorporeal Shock Wave Therapy In Myofascial Pain Syndrome, Şeyda Candeni̇z, Seyi̇t Çitaker, Gökhan Maraş, Hati̇ce Esra Yavuzer, Hasan Yildirim, Zafer Günendi̇
Comparison Of The Effectiveness Of Instrument-Assisted Soft Tissue Mobilization And Extracorporeal Shock Wave Therapy In Myofascial Pain Syndrome, Şeyda Candeni̇z, Seyi̇t Çitaker, Gökhan Maraş, Hati̇ce Esra Yavuzer, Hasan Yildirim, Zafer Günendi̇
Turkish Journal of Medical Sciences
Background/aim: To compare the effectiveness of instrument-assisted soft tissue mobilization (IASTM) and extracorporeal shock wave therapy (ESWT) used in myofascial pain syndrome (MPS) and to determine whether they are superior to conservative treatment (CT). Materials and methods: A total of 42 female patients (aged 18-60 years) diagnosed with MPS were enrolled and randomly assigned to either the CT (n = 14), CT+IASTM (n = 14), or CT+ESWT group (n = 14). All of the groups received treatment for 3 weeks (CT: 5 sessions per week, 15 sessions in total, ESWT and IASTM: 2 sessions per week, 6 sessions in total). …
Development Of A Gestational Diabetes Risk Assessment Scale: A Validity And Reliability Study, Selma Dağci, Besey Ören
Development Of A Gestational Diabetes Risk Assessment Scale: A Validity And Reliability Study, Selma Dağci, Besey Ören
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to develop a gestational diabetes risk assessment scale (GEDRISK). Materials and methods: This methodological study included 652 pregnant women who presented to six public health institutions in İstanbul between September 2021 and February 2022. Content validity was evaluated using the content validity index, while construct validity was assessed through exploratory and confirmatory factor analyses. Item discrimination was examined using Cronbach's alpha coefficients, Spearman-Brown and Guttman coefficients, item-total correlation tests, and 27% lower and upper quartile t tests. Reliability was determined through test-retest analysis methods. Results: The scale-level content validity index demonstrated strong coherence …
Individualized Hemodialysis: Is Similar Hemodialysis Adequacy Possible Using Less Water?, Ali̇ Aktaş, Hakan Özer, İsmai̇l Baloğlu, Hali̇l Zeki̇ Tonbul, İbrahi̇m Güney, Nedi̇m Yilmaz Selçuk
Individualized Hemodialysis: Is Similar Hemodialysis Adequacy Possible Using Less Water?, Ali̇ Aktaş, Hakan Özer, İsmai̇l Baloğlu, Hali̇l Zeki̇ Tonbul, İbrahi̇m Güney, Nedi̇m Yilmaz Selçuk
Turkish Journal of Medical Sciences
Background and aim: There are over 60,000 hemodialysis (HD) patients in Türkiye, and the number of patients is increasing yearly. Dialysate flow rate (Qd) is a factor in HD adequacy. Approximately 150 L of water are consumed per session to prepare the dialysate. We aimed to investigate whether HD effectiveness can be achieved at a low Qd in different patient groups for the purpose of saving water. Materials and methods: This prospective study included 81 HD patients from 2 centers. The patients underwent an aggregate total of 486 HD sessions, including 3 sessions at a Qd of 500 mL/min and …
The Diagnostic Profile And Clinical Course Of Patients With Rheumatic Diseases In The Medical Intensive Care Unit, Kani̇ye Aydin, İpek Türk
The Diagnostic Profile And Clinical Course Of Patients With Rheumatic Diseases In The Medical Intensive Care Unit, Kani̇ye Aydin, İpek Türk
Turkish Journal of Medical Sciences
Background/aim: Immunosuppressive and immunomodulatory treatments developed in recent years as a result of a better understanding of the pathophysiology of systemic rheumatic diseases (SRDs) improve the prognosis. Despite medical advances, individuals with SRDs at any stage may require intensive care and have a high mortality rate. The aim of this study was to investigate the demographic and clinical characteristics of patients with rheumatic diseases admitted to the intensive care unit (ICU), and the factors associated with the risk of mortality. Materials and methods: This was a retrospective, cross-sectional study that included patients with rheumatic diseases in the medical ICU. Factors …
Clinical Characteristics And Predictors For Recurrence In Chronic Nonbacterial Osteomyelitis: A Retrospective Multicenter Analysis, Kadi̇r Ulu, Rana İşgüder, Şeri̇fe Gül Karadağ, Esra Bağlan, Gülşah Kavrul Kayaalp, Gülçi̇n Otar Yener, Kübra Öztürk, Hafi̇ze Emi̇ne Sönmez, Semanur Özdel, Ferhat Demi̇r, Balahan Makay, Şevket Erbi̇l Ünsal, Betül Sözeri̇, Nuray Aktay Ayaz, Mustafa Çakan
Clinical Characteristics And Predictors For Recurrence In Chronic Nonbacterial Osteomyelitis: A Retrospective Multicenter Analysis, Kadi̇r Ulu, Rana İşgüder, Şeri̇fe Gül Karadağ, Esra Bağlan, Gülşah Kavrul Kayaalp, Gülçi̇n Otar Yener, Kübra Öztürk, Hafi̇ze Emi̇ne Sönmez, Semanur Özdel, Ferhat Demi̇r, Balahan Makay, Şevket Erbi̇l Ünsal, Betül Sözeri̇, Nuray Aktay Ayaz, Mustafa Çakan
Turkish Journal of Medical Sciences
Background/aim: Chronic nonbacterial osteomyelitis (CNO) is a rare disease of unknown etiology and most commonly occurs during childhood or adolescence. The purpose of this study is to collect data on the clinical features, outcomes, and management of the disease and to identify the factors affecting recurrence. Materials and methods: This is a retrospective multicenter cross-sectional study of pediatric patients diagnosed with CNO. A total of 87 patients with a diagnosis of CNO followed for at least 6 months in 8 pediatric rheumatology centers across the country between January 2010 and December 2021 were included in this study. Results: The study …
Awareness And Acceptability Of Monkeypox Vaccine In Men Who Have Sex With Men, Arda Karapinar, Damla Akdağ, Ayşe Deni̇z Gökengi̇n
Awareness And Acceptability Of Monkeypox Vaccine In Men Who Have Sex With Men, Arda Karapinar, Damla Akdağ, Ayşe Deni̇z Gökengi̇n
Turkish Journal of Medical Sciences
Background/aim: To determine the knowledge about and acceptance level of monkeypox vaccine in men who have sex with men (MSM). Materials and methods: A 14-item questionnaire, developed by the European Centers for Disease Control (ECDC), was presented online to MSM, aged ?18 years old, via smartphone applications (Grindr and Hornet), between June 30th and August 12th, 2022. Results: Of the 737 participants who completed the survey, 678 were born in Türkiye and 59 were migrants/visitors born in different countries. All of the participants were living in Türkiye. The median age was 31 (range 18?68) years. Overall, 21.9% were HIV-positive, 94.9% …
Impact Of 24-Week Dapagliflozin Treatment On Body Weight, Body Composition, And Cardiac Risk Indicators Of Patients With Type-2 Diabetes Mellitus, Pinar Akhanli, Sema Hepşen, İsmai̇l Emre Arslan, Hakan Düğer, Hayri̇ Bostan, Muhammed Kizilgül, Beki̇r Uçan, Erman Çakal
Impact Of 24-Week Dapagliflozin Treatment On Body Weight, Body Composition, And Cardiac Risk Indicators Of Patients With Type-2 Diabetes Mellitus, Pinar Akhanli, Sema Hepşen, İsmai̇l Emre Arslan, Hakan Düğer, Hayri̇ Bostan, Muhammed Kizilgül, Beki̇r Uçan, Erman Çakal
Turkish Journal of Medical Sciences
Background/aim: To reveal the impacts of dapagliflozin, a sodium glucose transporter-2 inhibitor (SGLT-2i), on body weight and body composition, cardiovascular risk indices, and carotid intima-media thickness (CIMT). Materials and methods: The data of patients with type-2 diabetes mellitus (T2DM) who applied to Department of Endocrinology and Metabolic Disorders between September 2019 and 2020, and had started dapagliflozin treatment along with their current medications were recorded retrospectively. Body weights, body compositions measured through bioelectrical impedance, and CIMT with T2DM receiving SGLT-2i treatment and medication were measured at weeks 1, 12, and 24 of 42. The visceral adiposity index (VAI), lipid accumulation …
Pathobiological Alterations Affecting The Distinct Clinical Courses Of Pediatric Versus Adult Covid-19 Syndrome, Emrah Şenel, Seyhan Türk, Ümi̇t Yavuz Malkan, Mustafa Çağri Peker, Can Türk, Hati̇ce Rahmet Güner, Gülberk Uçar, Seval İzdeş, Bi̇rcan Kayaaslan, Gülsüm İclal Bayhan, Serhat Emeksi̇z, İmran Hasanoğlu, Şeri̇fe Gökbulut Bektaş, Şeyma Bütün Türk, Serhan Özcan
Pathobiological Alterations Affecting The Distinct Clinical Courses Of Pediatric Versus Adult Covid-19 Syndrome, Emrah Şenel, Seyhan Türk, Ümi̇t Yavuz Malkan, Mustafa Çağri Peker, Can Türk, Hati̇ce Rahmet Güner, Gülberk Uçar, Seval İzdeş, Bi̇rcan Kayaaslan, Gülsüm İclal Bayhan, Serhat Emeksi̇z, İmran Hasanoğlu, Şeri̇fe Gökbulut Bektaş, Şeyma Bütün Türk, Serhan Özcan
Turkish Journal of Medical Sciences
Background/aim: The clinical presentation of pediatric coronavirus disease 2019 (COVID-19) is associated with a milder disease course than the adult COVID-19 syndrome. The disease course of COVID-19 has three clinicobiological phases: initiation, propagation, and complication. This study aimed to assess the pathobiological alterations affecting the distinct clinical courses of COVID-19 in pediatric age groups versus the adult population. We hypothesized that critical biogenomic marker expressions drive the mild clinical presentations of pediatric COVID-19. Materials and methods: Blood samples were obtained from 72 patients with COVID-19 hospitalized at Ankara City Hospital between March and July 2021. Peripheral blood mononuclear cells were …
Novel Parameters For Predicting Fluid Responsiveness During The Mini Fluid Challenge And Ability Of The Cardiac Power Index: An Observational Cohort Study, Taner Abdullah, Hürü Ceren Gökduman, İşbara Alp Eni̇şte, Ayşe Gülşah Atasever, Achmet Ali, Funda Gümüş Özcan
Novel Parameters For Predicting Fluid Responsiveness During The Mini Fluid Challenge And Ability Of The Cardiac Power Index: An Observational Cohort Study, Taner Abdullah, Hürü Ceren Gökduman, İşbara Alp Eni̇şte, Ayşe Gülşah Atasever, Achmet Ali, Funda Gümüş Özcan
Turkish Journal of Medical Sciences
Background/aim: The percentage change in the stroke volume index (SVI) due to the mini fluid challenge (MFC) (MFC-?SVI%) is used commonly in daily practice. However, up to 20% of patients remain in the gray zone of this variable. Thus, it was aimed to compare the MFC-?SVI% and the percentage change in the cardiac power index (CPI) due to the MFC (MFC-?CPI%) with the baseline values of the pulse pressure variation (PPV) and stroke volume variation (SVV) in terms of their abilities to predict fluid responsiveness. Materials and methods: The SVI, CPI, SVV, and PPV were recorded before 100 mL of …
Effect Of Thoracic Mobilization Exercises On Hamstring Flexibility: A Randomized Controlled Trial, Aybüke Ersi̇n, Meltem Kaya
Effect Of Thoracic Mobilization Exercises On Hamstring Flexibility: A Randomized Controlled Trial, Aybüke Ersi̇n, Meltem Kaya
Turkish Journal of Medical Sciences
Background and aim: The aim was to investigate the effect of thoracic mobilization exercises on hamstring flexibility. Materials and methods: One hundred twenty individuals with hamstring tightness were included in the study. The participants were randomized into two groups: the experimental group (EG) (n = 60) or the control group (CG) (n = 60). The EG performed a homebased thoracic mobilization exercise program comprising 2 sets with 10 repetitions, once a day, 3 days a week, for 4 weeks. The CG performed active-assisted stretching of the hamstring comprising 3 sets with 10 repetitions for 15 seconds. The active knee extension …
Evaluation Of Diaphragm Functions With Diaphragm Ultrasound And Pulmonary Function Tests In Individuals With Friedreich?S Ataxia, Nur Aleyna Yetki̇n, Mehmet Fati̇h Yetki̇n, Burcu Baran Ketenci̇oğlu, Fatma Sema Oymak, İnci̇ Gülmez, İnsu Yilmaz, Nuri̇ Tutar
Evaluation Of Diaphragm Functions With Diaphragm Ultrasound And Pulmonary Function Tests In Individuals With Friedreich?S Ataxia, Nur Aleyna Yetki̇n, Mehmet Fati̇h Yetki̇n, Burcu Baran Ketenci̇oğlu, Fatma Sema Oymak, İnci̇ Gülmez, İnsu Yilmaz, Nuri̇ Tutar
Turkish Journal of Medical Sciences
Background/aim: It is known that the correlation of pulmonary function tests (PFT) with muscle dysfunction is insufficient. Here, we aimed to evaluate the diaphragm functions in individuals with Friedreich?s ataxia (FRDA) and to examine its relationship with respiratory parameters and disease severity. Materials and methods: This prospective study, conducted between November and December 2022, at Erciyes University, included 14 individuals with genetically confirmed FRDA and an age- and gender-matched healthy control group of eight individuals. We examined pulmonary functions with spirometric methods and evaluated diaphragm excursion, and diaphragm thickness-expiratory (Tde) and ? end of inspiration (Tdi) with ultrasonography during calm …
Evaluation Of Syringin?S Neuroprotective Effect In A Model Of Neonatal Hypoxic-Ischemic Brain Injury, Ezgi̇ Yangin Ergon, Asli Çeli̇k, Ayşe Gülden Di̇ni̇z Ünlü, Rüya Çolak, Senem Alkan Özdemi̇r, Şebnem Çalkavur, Osman Yilmaz
Evaluation Of Syringin?S Neuroprotective Effect In A Model Of Neonatal Hypoxic-Ischemic Brain Injury, Ezgi̇ Yangin Ergon, Asli Çeli̇k, Ayşe Gülden Di̇ni̇z Ünlü, Rüya Çolak, Senem Alkan Özdemi̇r, Şebnem Çalkavur, Osman Yilmaz
Turkish Journal of Medical Sciences
Background/aim: A significant cause of mortality and morbidity in the neonatal era is hypoxic-ischemic encephalopathy (HIE). This study examined the histopathological analysis and neuroprotective impact of syringin (SYR) in an experimental HIE rat model. Material and methods: On the 7th postnatal day, 24 Wistar albino rats were evaluated in 3 groups using the HIE model under gas anesthesia. In the experiment, Group A received 10 mg/kg SYR plus dimethyl sulfoxide (DMSO), Group B received DMSO only, and Group C served as a sham group. Immunohistochemical techniques were used to assess apoptotic cell measurement and proinflammatory cytokines (TNF-? and IL-1ß primary …
Reporting The Clinical Spectrum Of Children With Igav In A Retrospective 24-Year Cohort: Influences Of Age And Sex On Clinical Presentation, Sema Yildirim, Müferet Ergüven
Reporting The Clinical Spectrum Of Children With Igav In A Retrospective 24-Year Cohort: Influences Of Age And Sex On Clinical Presentation, Sema Yildirim, Müferet Ergüven
Turkish Journal of Medical Sciences
Background/aim: Immunoglobulin A vasculitis (IgAV) is one of the most common types of vasculitis in children. The aims of this study were to investigate the clinical characteristics of the disease, and the effects of age and sex on the clinical course in children with IgAV. Materials and methods: This was a retrospective study including pediatric patients diagnosed with IgAV who attended follow-ups at the pediatric rheumatology department of a tertiary healthcare institution between January 1997 and December 2020. The patients were grouped and compared according to sex and age at diagnosis (<7 years vs. ?7 years). Results: The study included 709 children with IgAV, 392 (55.3%) of whom were male. The mean age at diagnosis was 7.9 ± 3.2 years. The most common disease onset season was autumn (31.2%). Upper respiratory infections (27.8%) were the most common predisposing factors. Gastrointestinal system (GIS), joint, and renal involvement were observed in 52.8%, 47.5%, and 17.5% of patients, respectively. Renal involvement, GIS involvement, and disease relapse were significantly more common among those diagnosed after 7 years of age compared to those diagnosed before the age of 7 (p < 0.001, p = 0.033, and p < 0.001, respectively). Scrotal involvement and subcutaneous edema were more common among those diagnosed at younger than 7 years compared to those aged ?7 years at diagnosis (p < 0.001 and p = 0.016, respectively). GIS involvement was more frequently seen in males compared to females (p = 0.046). Conclusion: It was demonstrated that being ?7 years of age at diagnosis or being a male were associated with higher likelihood of renal and GIS involvement in children with IgAV.
Comparison Of The Effect Of Postweaning Social Isolation, Enriched Environment, And Exercise Training On Learning And Memory Functions In Rats, Hati̇ce Eki̇nalan Kayhan, Ni̇lsel Okudan, Muaz Belvi̇ranli
Comparison Of The Effect Of Postweaning Social Isolation, Enriched Environment, And Exercise Training On Learning And Memory Functions In Rats, Hati̇ce Eki̇nalan Kayhan, Ni̇lsel Okudan, Muaz Belvi̇ranli
Turkish Journal of Medical Sciences
Background/aim: To assess the effects of postweaning social isolation, an enriched environment, and exercise training on learning and memory functions in rats, as well as their relation with the brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) concentrations in the hippocampus. Materials and methods: Randomly assigned into 4 groups were 35 female postweaning rats (25 day old), as the control (C), social isolation (SI), enriched environment (EE), and exercise training (E) groups. The SI and the EE groups were housed under their specific conditions and the E and the C groups were housed under standard conditions for 6 weeks. …
The Importance Of Length And Area Estimate For Forensic Medicine Without Using A Measurement Tool, Ahmet Turla, Hüseyi̇n Kara, Ni̇lay Cankurt Ayar, Berna Aydin, Fulya Zeynep Levent, Oğuzhan Külbaz
The Importance Of Length And Area Estimate For Forensic Medicine Without Using A Measurement Tool, Ahmet Turla, Hüseyi̇n Kara, Ni̇lay Cankurt Ayar, Berna Aydin, Fulya Zeynep Levent, Oğuzhan Külbaz
Turkish Journal of Medical Sciences
Background/aim: Accurately measuring and recording the length or area of lesions affects the judgement of the forensic report, surgical wound management and, in some countries, the billing of health care services. The aim of this study was to determine whether the length and area of lesions described by physicians by estimation are accurate. Materials and methods: This study was designed as a cross-sectional descriptive study and was conducted with 494 participants consisting of internists and physicians at Ondokuz Mayıs University, Faculty of Medicine. The participants were asked to estimate the lengths or areas of 6 different shapes in the questionnaire …
Evaluation Of Chronic Pruritus And Associated Skin Findings In Patients With Diabetes Mellitus, Fatma Avci Merdi̇n, Ahmet Taha Aydemi̇r, Fatma Nur Korkmaz, Fatma Tuğçe Şah Ünal, Asena Gökçay Canpolat, Ayşe Öktem, Özgür Demi̇r, Mustafa Şahi̇n, Rifat Emral, Murat Fai̇k Erdoğan, Sevi̇m Güllü, Aydin Vedi̇a Gedi̇k, Peli̇n Koçyi̇ği̇t, Demet Çorapçioğlu
Evaluation Of Chronic Pruritus And Associated Skin Findings In Patients With Diabetes Mellitus, Fatma Avci Merdi̇n, Ahmet Taha Aydemi̇r, Fatma Nur Korkmaz, Fatma Tuğçe Şah Ünal, Asena Gökçay Canpolat, Ayşe Öktem, Özgür Demi̇r, Mustafa Şahi̇n, Rifat Emral, Murat Fai̇k Erdoğan, Sevi̇m Güllü, Aydin Vedi̇a Gedi̇k, Peli̇n Koçyi̇ği̇t, Demet Çorapçioğlu
Turkish Journal of Medical Sciences
Background/aim: To explore the dermatological lesions associated with chronic pruritus in patients who were followed up at our clinic for type 1 and type 2 diabetes mellitus (DM). Materials and methods: The study population consisted of 249 patients with DM, who presented to the endocrinology clinic at Ankara University Faculty of Medicine between January 2022, and March 2022, regardless of whether they had reported experiencing pruritus symptoms. The visual analog scale and 5-D itch scale were used to determine the severity of itching in patients. Dermatological examination findings were also evaluated. Results: Of the 249 patients with DM, mean duration …
Radiographic Pelvimetry In Scottish Fold Cats: Sex-Related Differences, Osman Yilmaz, Davut Koca, Talha Avcilar
Radiographic Pelvimetry In Scottish Fold Cats: Sex-Related Differences, Osman Yilmaz, Davut Koca, Talha Avcilar
Turkish Journal of Veterinary & Animal Sciences
This study was carried out to obtain osteometric measurements of the pelvis of Scottish Fold cats using X-ray images and reveal the biometric differences of these measurement values in terms of sexual dimorphism. Radiographic images of the pelvis in the laterolateral and ventrodorsal direction were used in male and female Scottish Fold cats aged 2-4 years with dystocia and eutocia. The measurements of 18 osteometric parameters and 36 parameters, such as the height/width ratio of the cat pelvis, were taken, and statistical analysis of the measurements was initiated. When the pelvimetric data were examined, it was observed that all of …
Is Cancer Risk Reduced In Multiple Sclerosis? Results From A Tertiary Referral Center, Yasemi̇n Bahar, Egemen Yildiz, Abdul Rasheed Bahar, Rana Karabudak
Is Cancer Risk Reduced In Multiple Sclerosis? Results From A Tertiary Referral Center, Yasemi̇n Bahar, Egemen Yildiz, Abdul Rasheed Bahar, Rana Karabudak
Turkish Journal of Medical Sciences
Background/aim: Multiple sclerosis (MS) patients may be protected against cancer because of increased immune surveillance. However, aberrant T/B cell functioning in MS may increase the risk of cancer. We aimed to compare the frequency of cancer among patients with MS with an appropriate control group matched by the variables such as age, gender, tobacco smoking history, body mass index (BMI), and family history of cancer. Materials and methods: The MS patients who were registered and followed up at the MS Center in Hacettepe University Hospitals and appropriately matched with controls were included. A self-administered questionnaire with links to the online …
Retrospective Analysis Of Children Diagnosed With Kawasaki Disease, Fati̇h Varol, Reyhan Dedeoğlu, Azi̇z Kiliç, Murat Tuğberk Bakar, Amra Adrovi̇c, Sezgi̇n Şahi̇n, Mehmet Yildiz, Kenan Barut, Hali̇t Çam, Özgür Kasapçopur
Retrospective Analysis Of Children Diagnosed With Kawasaki Disease, Fati̇h Varol, Reyhan Dedeoğlu, Azi̇z Kiliç, Murat Tuğberk Bakar, Amra Adrovi̇c, Sezgi̇n Şahi̇n, Mehmet Yildiz, Kenan Barut, Hali̇t Çam, Özgür Kasapçopur
Turkish Journal of Medical Sciences
Background/aim:The aim of our study was to evaluate the long-term impacts of Kawasaki disease on our patients regarding coronary involvement demographic characteristics, treatment regimens, and clinical course. Materials and methods: Our study included 104 patients diagnosed and hospitalized with Kawasaki disease in our center, from January 2004 to January 2019. In our study, patients were divided into three groups according to coronary artery involvement. Patients in group 1 had no echocardiographic findings, while the ones in group 2 had coronary artery dilatation and ones in group 3 had coronary artery aneurysm (CAA). Results:Among 104 patients, the median age was 9.15 …