Psychiatry and Psychology Commons^™

Query Theory - Knowing What We Want By Arguing With Ourselves, Elke Weber

Psychology Colloquia

Psychologists and behavioral economists agree that many of our preferences are constructed, rather than innate or pre-computed and stored. Little research, however, has explored the implications that established facts about human attention and memory have when people marshal evidence for their decisions. This talk provides an introduction to Query Theory, a psychological process model of preference construction that explains a broad range of phenomena in individual choice with important personal and social consequences, including our reluctance to change and excessive impatience when asked to delay consumption.

Concordance Of Meg And Fmri Patterns In Adolescents During Verb Generation, Yingying Wang, Scott K. Holland, Jennifer Vannest

Center for Brain, Biology, and Behavior: Faculty Publications

In this study we focused on direct comparison between the spatial distributions of activation detected by functional magnetic resonance imaging (fMRI) and localization of sources detected by magnetoencephalography (MEG) during identical language tasks. We examined the spatial concordance between MEG and fMRI results in 16 adolescents performing a three-phase verb generation task that involves repeating the auditorily presented concrete noun and generating verbs either overtly or covertly in response to the auditorily presented noun. MEG analysis was completed using a synthetic aperture magnetometry (SAM) technique, while the fMRI data were analyzed using the general linear model approach with random-effects. To …

Differential Relationships Of Internal And External Networking Behaviors With Turnover, Caitlin M. Porter

Open Access Theses

Although networking behaviors are proven to be beneficial for career success, less is known about how networking influences organizational outcomes such as turnover. Using a professional and an academic sample of "stayers" and "leavers", the present study addresses how two types of networking behaviors, networking focused either internal or external to the organization, differentially influence the voluntary turnover process. Data gathered from "stayers" suggested that internal networking behaviors were positively associated with perceived desirability of movement (i.e., job satisfaction), whereas external networking behaviors were associated with perceived (i.e., perceived employment opportunity) and actual (i.e., job offers) ease of movement. For …

Norepinephrine Involvement In The Intermittent Swim Stress-Induced Deficit In Spatial Learning And Memory, Emily Elgert

Honors Theses and Capstones

Learning and memory impairments are often caused by stress disorders including depression. The present study investigated the involvement of norepinephrine in the swim stress-induced deficits of spatial learning and memory. Exposure to intermittent swim stress (ISS) followed by learning and memory tests in the Morris water maze (MWM) were used to investigate this relationship. The ISS paradigm consists of intermittent exposure to cold water, producing stress responses in rats. Reboxetine, a norepinephrine selective reuptake inhibitor (NSRI), was employed to investigate whether this compound reverses the ISS-induced deficit. In other words, rats exposed to the ISS, were hypothesized to experience impaired …

Neuroinflammation And Psychiatric Illness, Souhel Najjar, Daniel M. Pearlman, Kenneth Alper, Amanda Najjar, Orrin Devinsky

Dartmouth Scholarship

Multiple lines of evidence support the pathogenic role of neuroinflammation in psychiatric illness. While systemic autoimmune diseases are well-documented causes of neuropsychiatric disorders, synaptic autoimmune encephalitides with psychotic symptoms often go under-recognized. Parallel to the link between psychiatric symptoms and autoimmunity in autoimmune diseases, neuroimmunological abnormalities occur in classical psychiatric disorders (for example, major depressive, bipolar, schizophrenia, and obsessive-compulsive disorders). Investigations into the pathophysiology of these conditions traditionally stressed dysregulation of the glutamatergic and monoaminergic systems, but the mechanisms causing these neurotransmitter abnormalities remained elusive. We review the link between autoimmunity and neuropsychiatric disorders, and the human and experimental evidence …

The Mathematics Of Drug Dose Individualization Should Be Built With Random-Effects Linear Models, Francisco J. Diaz, Jose De Leon

Psychiatry Faculty Publications

No abstract provided.

Two-Legged Hopping In Autism Spectrum Disorders, Matthew F. Moran, John T. Foley, Mary E. Parker, Michael J. Weiss

All PTHMS Faculty Publications

Sensory processing deficits are common within autism spectrum disorders (ASD). Deficits have a heterogeneous dispersion across the spectrum and multimodal processing tasks are thought to magnify integration difficulties. Two-legged hopping in place in sync with an auditory cue (2.3, 3.0 Hz) was studied in a group of six individuals with expressive language impaired ASD (ELI-ASD) and an age-matched control group. Vertical ground reaction force data were collected and discrete Fourier transforms were utilized to determine dominant hopping cadence. Effective leg stiffness was computed through a mass-spring model representation. The ELI-ASD group were unsuccessful in matching their hopping cadence (2.21 ± …

Substance Abuse And Insecure Attachment Styles: A Relational Study, Yasmin Borhani

LUX: A Journal of Transdisciplinary Writing and Research from Claremont Graduate University

The attachment styles an individual forms while they are growing up can impact the type of relationships they form as adults. Research has shown insecure attachment styles can be correlated to substance abuse, emotional distress, and interpersonal problems. More specifically, this study focuses on the correlation between insecure attachment styles and substance abuse. Nineteen participants (nine male, ten female) between the ages of 18 to 32 were selected. Participants were given a 20-question survey that measured substance abuse and attachment styles. A t-test was conducted to compare the differences between participants who abuse substances and participants who do not abuse …

Nothing But The Truth: Forensic Psychologist Ann Leblanc Manages Cases Where Crime And Mental Illness Overlap, Douglas Rooks

Colby Magazine

Forensic psychologist Ann LeBlanc '74 manages cases in which crime and mental illness overlap.

Dynamics Of Vocalization-Induced Modulation Of Auditory Cortical Activity At Mid-Utterance, Zhaocong Chen, Jeffery A. Jones, Peng Liu, Weifeng Li, Dongfeng Huang, Hanjun Liu

Psychology Faculty Publications

Background: Recent research has addressed the suppression of cortical sensory responses to altered auditory feedback that occurs at utterance onset regarding speech. However, there is reason to assume that the mechanisms underlying sensorimotor processing at mid-utterance are different than those involved in sensorimotor control at utterance onset. The present study attempted to examine the dynamics of event-related potentials (ERPs) to different acoustic versions of auditory feedback at mid-utterance.

Methodology/Principal findings: Subjects produced a vowel sound while hearing their pitch-shifted voice (100 cents), a sum of their vocalization and pure tones, or a sum of their vocalization and white noise at …

Auditory-Motor Adaptation To Frequency-Altered Auditory Feedback Occurs When Participants Ignore Feedback, Dwayne Nicholas Keough, Colin Hawco, Jeffery A. Jones

Psychology Faculty Publications

Background

Auditory feedback is important for accurate control of voice fundamental frequency (F0). The purpose of this study was to address whether task instructions could influence the compensatory responding and sensorimotor adaptation that has been previously found when participants are presented with a series of frequency-altered feedback (FAF) trials. Trained singers and musically untrained participants (nonsingers) were informed that their auditory feedback would be manipulated in pitch while they sang the target vowel [/ɑ /]. Participants were instructed to either ‘compensate’ for, or ‘ignore’ the changes in auditory feedback. Whole utterance auditory feedback manipulations were either gradually presented …

Describing Teacher–Student Interactions: A Qualitative Assessment Of Teacher Implementation Of The 7th Grade Keepin’ It Real Substance Use Intervention, Jonathan Pettigrew, Michelle Miller-Day, Young Ju Shin, Michael L. Hecht, Janice L. Krieger, John W. Graham

Communication Faculty Articles and Research

Variations in the delivery of school-based substance use prevention curricula affect students' acquisition of the lesson content and program outcomes. Although adaptation is sometimes viewed as a lack of fidelity, it is unclear what types of variations actually occur in the classroom. This observational study investigated teacher and student behaviors during implementation of a middle school-based drug prevention curriculum in 25 schools across two Midwestern states. Trained observers coded videos of 276 lessons, reflecting a total of 31 predominantly Caucasian teachers (10 males and 21 females) in 73 different classes. Employing qualitative coding procedures, the study provides a working typology …

Warum Gesunde Menchen Immer Häufiger Fur Psychisch Krank Erklärt Werden, Lisa Cosgrove

Counseling, School Psychology & Sport Faculty Publication Series

zuerst einmal nicht schaden": Das ist der wohl wichtigste Grundsatz der Medizin. Aber diese Mission droht durch den Einfluss großer Pharmafirmen unterhöhlt zu werden. Der Vorwurf einer Verstrickung von Ärzten und Arzneimittelherstellern ist schon in fast allen medizinischen Fachrichtungen aufgekommen. Vor allem aber die Psychiatrie steckt in einer Glaubwürdigkeitskrise. Das zeigt sich in der aktuellen Debatte um die neue Auflage des "Diagnostischen und Statistischen Manual Psychischer Störungen" (DSM).

Dieses von der US-Psychiater-Vereinigung APA herausgegebene Handbuch definiert, was eine psychische Erkrankung ist. Die Bedeutung dieser Wertung geht weit über die USA hinaus - das Handbuch nimmt oft Definitionen der Weltgesundheitsorganisation vorweg. …

Is Brain-Derived Neurotrophic Factor A Possible Mechanism Underlying Risperidone Sensitization In Adolescent Rats?, Qing Shu, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

Risperidone is one of the most widely used atypical antipsychotic drugs and is approved for the treatment of mental disorders (eg. schizophrenia, autism) in children and adolescents. The present study investigated the repeated treatment effect of risperidone and associated neurotropic mechanism in the phencyclidine (PCP)-induced hyperlocomotion model in adolescent rats. We examined whether repeated risperidone treatment would cause a sensitized inhibition of PCP-induced hyperlocomotion in adolescent rats, and whether such a sensitization effect was mediated by risperidone-induced alterations in Brain-Derived Neurotrophic Factor (BDNF), an important biomarker which plays a role in neuropathology of schizophrenia and action of antipsychotic medications. Male …

Suggestive Evidence For Association Between L-Type Voltage-Gated Calcium Channel (Cacna1c) Gene Haplotypes And Bipolar Disorder In Latinos: A Family-Based Association Study, Suzanne Gonzalez, Chun Xu, Mercedes Ramirez, Juan Zavala, Regina Armas, Salvador A. Contreras, Javier Contreras, Albana Dassori, Robin J. Leach, Michael A. Escamilla

Health & Biomedical Sciences Faculty Publications

Objectives: Through recent genome-wide association studies (GWASs), several groups have reported significant association between variants in the calcium channel, voltage-dependent, L-type, alpha 1C subunit (CACNA1C) and bipolar disorder (BP) in European and European-American cohorts. We performed a family-based association study to determine whether CACNA1C is associated with BP in the Latino population.

Methods: This study included 913 individuals from 215 Latino pedigrees recruited from the USA, Mexico, Guatemala, and Costa Rica. The Illumina GoldenGate Genotyping Assay was used to genotype 58 single-nucleotide polymorphisms (SNPs) that spanned a 602.9-kb region encompassing the CACNA1C gene including two SNPs (rs7297582 and rs1006737) previously …

Adjunctive Atypical Antipsychotic Treatment For Major Depressive Disorder: A Meta-Analysis Of Depression, Quality Of Life, And Safety Outcomes, Glen I. Spielmans, Margit I. Berman, Eftihia Linardatos, Nicholas. Z. Rosenlicht

Dartmouth Scholarship

Atypical antipsychotic medications are widely prescribed for the adjunctive treatment of depression, yet their total risk-benefit profile is not well understood. We thus conducted a systematic review of the efficacy and safety profiles of atypical antipsychotic medications used for the adjunctive treatment of depression.

The Impact Of Social Contagion On Non-Suicidal Self-Injury: A Review Of The Literature, Stephanie Jarvi Steele, Benita Jackson, Lance P. Swenson, Heather Crawford

Psychology: Faculty Publications

In this review, we explore social contagion as an understudied risk factor for non-suicidal self-injury (NSSI) among adolescents and young adults, populations with a high prevalence of NSSI. We review empirical studies reporting data on prevalence and risk factors that, through social contagion, may influence the transmission of NSSI. Findings in this literature are consistent with social modeling/learning of NSSI increasing risk of initial engagement in NSSI among individuals with certain individual and/or psychiatric characteristics. Preliminary research suggests iatrogenic effects of social contagion of NSSI through primary prevention are not likely. Thus, social contagion factors may warrant considerable empirical attention. …

Predictors Of Adherence To Home Rehabilitation Exercises Following Anterior Cruciate Ligament Reconstruction, Howard A. Tennen

UCHC Articles - Research

Purpose/Objective

Although home exercises are commonly prescribed following anterior cruciate ligament (ACL) reconstruction and are considered important in obtaining successful rehabilitation outcomes, little is known about factors associated with the completion of such exercises. Consequently, this study was designed to identify predictors of adherence to home rehabilitation exercises after ACL surgery.

Research Method/Design

Participants (33 women, 58 men) completed indices of athletic identity, neuroticism, optimism, and pessimism before ACL surgery and measures of daily pain, negative mood, stress, and home exercise completion for 42 days postoperatively.

Results

Participants reported a high level of adherence to the prescribed regimen. Home exercise …

蓬瀛仙館 : 探討患有「抑鬱症」長者的服務提供狀況 - 早期防治工作的成效評估, Asia-Pacific Institute Of Ageing Studies, Lingnan University 嶺南大學亞太老年學研究中心

APIAS Research Report 研究報告

是次計劃希望全面地評估蓬瀛仙館現時為長者所提供的抑鬱症前期服務，並提出服務建議，作日後改善及發展長者抑鬱症服務之參考，計劃目標如下：

一. 評估機構現時對長者抑鬱症前期服務提供的狀況；

二. 了解服務使用者對長者抑鬱症服務的期望與現時機構提供的前期服務兩者之間的差距，作為日後服務改進以及發展之參考；

三. 對機構提供之長者抑鬱症前期服務提出改善方案，以及為將來機構發展全方位的長者抑鬱症服務提供發展框架；

四. 為機構提供系統性之長者抑鬱症服務評估框架，以便機構日後作定期的服務評估。

Clobazam Therapeutic Drug Monitoring: A Comprehensive Review Of The Literature With Proposals To Improve Future Studies, Jose De Leon, Edoardo Spina, Francisco J. Diaz

Psychiatry Faculty Publications

Background: Clobazam was recently approved for Lennox–Gastaut syndrome in the United States. There is no published review article focused on clobazam therapeutic drug monitoring (TDM) in English.

Methods: More than 200 clobazam articles identified by a PubMed search were carefully reviewed for information on clobazam pharmacokinetics. Clobazam is mainly metabolized by a cytochrome P450 (CYP) isoenzyme, CYP3A4, to its active metabolite, N-desmethylclobazam. Then, N-desmethylclobazam is mainly metabolized by CYP2C19 unless the individual has no CYP2C19 activity [poor metabolizer (PM)].

Results: Using a mechanistic approach to reinterpret the published findings of steady-state TDM and single-dosing pharmacokinetic studies, 4 different serum clobazam …