Mechanism-Based Strategies To Enhance The Actions Of A, 2010 University of Texas Graduate School of Biomedical Sciences at Houston
Mechanism-Based Strategies To Enhance The Actions Of A, Fabiola C. Gomez
Dissertations & Theses (Open Access)
Heat shock protein 90 (HSP90) is an abundant molecular chaperone that regulates the functional stability of client oncoproteins, such as STAT3, Raf-1 and Akt, which play a role in the survival of malignant cells. The chaperone function of HSP90 is driven by the binding and hydrolysis of ATP. The geldanamycin analog, 17-AAG, binds to the ATP pocket of HSP90 leading to the degradation of client proteins. However, treatment with 17-AAG results in the elevation of the levels of antiapoptotic proteins HSP70 and HSP27, which may lead to cell death resistance. The increase in HSP70 and HSP27 protein levels is due …
Optimization Algorithms For Functional Deimmunization Of Therapeutic Proteins, 2010 Dartmouth College
Optimization Algorithms For Functional Deimmunization Of Therapeutic Proteins, Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chris Bailey-Kellogg
Dartmouth Scholarship
To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the response is the recognition and surface display by antigen-presenting cells of epitopes, short peptide fragments derived from the foreign protein. Thus, developing minimal-epitope variants represents a powerful approach to deimmunizing protein therapeutics. Critically, mutations selected to reduce immunogenicity must not interfere with the protein's therapeutic activity.
Role Stress, Emotional Exhaustion, And Job Satisfaction In The Hotel Industry: The Moderating Role Of Supervisory Support, 2010 Eastern Mediterranean University
Role Stress, Emotional Exhaustion, And Job Satisfaction In The Hotel Industry: The Moderating Role Of Supervisory Support, Osman M. Karatepe
Hospitality Review
The purpose of this study is to investigate supervisory support as a moderator of the effects of role conflict and role ambiguity on emotional exhaustion and job satisfaction. This study also examines the moderating role of supervisory support on the relationship between emotional exhaustion and job satisfaction. Data were collected from a sample of frontline hotel employees in Northern Cyprus. The aforementioned relationships were tested based on hierarchical multiple regression analysis. The results demonstrate that supervisory support mitigates the impact of role conflict on emotional exhaustion and further reveal that supervisory support reduces the effect of emotional exhaustion on job …
Assessing Impact Of Affect Recognition On Therapeutic Relationship, 2010 University of Kentucky
Assessing Impact Of Affect Recognition On Therapeutic Relationship, Julianne V. Sutter
University of Kentucky Master's Theses
Therapeutic alliance and its relationship to client nonverbal behavior, specifically facial expressions, were examined. Therapist interpretation of the client nonverbal behavior, or affect, influences the therapeutic alliance and process. Based on a sample of clients from a graduate school therapy training facility, results suggest therapist training in facial expressions, and how they relate to client emotion, improve the therapeutic alliance between therapist and client. After a micro-expression training for therapists, clients reported higher life functioning on the Outcome Rating Scale (ORS) and an improved therapeutic alliance on the Session Rating Scale (SRS). Overall, these findings support the benefit of incorporating …
Evaluation Of Pharmacy-Implemented Medication Reconciliation Directed At Antiretroviral Therapy In Hospitalized Hiv/Aids Patients [Letter], 2010 Butler University
Evaluation Of Pharmacy-Implemented Medication Reconciliation Directed At Antiretroviral Therapy In Hospitalized Hiv/Aids Patients [Letter], Megan A. Corrigan, Kendra Atkinson, Beverly E. Sha, Christopher W. Crank
Scholarship and Professional Work – COPHS
Short communications published in Annals of Pharmacotherapy, 44(1).
Cardiac Regeneration, 2010 Touro College
Cardiac Regeneration, Sara Leah Abraham
The Science Journal of the Lander College of Arts and Sciences
The following is an excerpt from the introduction to this article: Cardiovascular disease is a generic term that refers to any illness or disorder that involves the heart and its vessels or the blood vessels of the body. Cardiovascular disease has been accepted as the leading cause of death worldwide. According to the Centers for Disease Control’s National Vital Statistics Reports, twenty six percent of deaths in 2006, 631,636 in total, were caused by diseases of the heart (Heron et al. 2009).
One of the most common of all cardiovascular diseases is Ischaemic Heart Disease. This coronary artery disease often …
Cardiac Tissue Regeneration - The Use Of Stem Cells, 2010 Touro College
Cardiac Tissue Regeneration - The Use Of Stem Cells, Chavy Friedlander
The Science Journal of the Lander College of Arts and Sciences
The following is the introduction to the article: Cardiovascular disease is the leading cause of illness and fatality. Diseases such as coronary artery disease, myocardial infarction and subsequent congestive heart failure pose a serious problem to much of the population in the Unites States and all over the world. The heart’s compromised function that results from the above conditions is so influential as the heart has little capacity to repair its lost tissue; once the cardiac myocytes are destroyed its effects are amplified by a drastic decrease in cardiac function. Until recently with the advent of stem cell technology, researchers …
Excitoxicity In Retinal Ischemia And Treatment Using Non-Competitive Receptor Antagonists, 2010 Touro College
Excitoxicity In Retinal Ischemia And Treatment Using Non-Competitive Receptor Antagonists, Jacob Rube
The Science Journal of the Lander College of Arts and Sciences
The following is an excerpt from the article: Ischemia is defined as an inadequacy of blood flow to tissue. Ischemia can deprive tissue of oxygen and metabolic substrates and it can also prevent the removal of waste products. If the ischemia is maintained over enough time the tissue will lose its homeostasis and eventually die causing an infarct. Retinal ischemia occurs when the blood supply to the retina does not meet the metabolic needs that are required to sustain the retina. This can lead to retinal damage and severe vision loss. Ischemia is caused by occluded blood vessels.
Small Intestine Submucosa For Repair Of Injured Rabbit Cornea: A Pilot Study, 2010 Philadelphia College of Osteopathic Medicine
Small Intestine Submucosa For Repair Of Injured Rabbit Cornea: A Pilot Study, Mark Nicholas Perenich
PCOM Biomedical Studies Student Scholarship
Corneal injuries blind approximately 15 million people worldwide annually. Current methods of treatment have several disadvantages with respect to cost and availability. This study evaluated a small intestine submucosa (SIS) xenograft treatment for a severe corneal injury. SIS could be a favorable alternative to the current treatment methods, because it is inexpensive to produce and abundant where pigs are consumed. A severe ocular injury was created in the right eye of 5 rabbits by n-heptanol and mechanical debridement of the cornea and limbus. The cornea was then evaluated with fluorescence stain and a SIS xenograft was used for treatment. Clinical …
The Power Of Empowerment: An Icf-Based Model To Improve Self-Efficacy And Upper Extremity Function Of Survivors Of Breast Cancer, 2010 University of Dayton
The Power Of Empowerment: An Icf-Based Model To Improve Self-Efficacy And Upper Extremity Function Of Survivors Of Breast Cancer, Mary Insana Fisher, Dana Howell
Physical Therapy Faculty Publications
Breast cancer is one of the most frequently diagnosed cancers among women. Breast cancer treatments often negatively impact the function of the arm, and quality of life and upper extremity function does not always return to a prediagnosis level. Survivors of breast cancer may also experience feelings of diminished self-efficacy related to functional deficits resulting from their physical limitations. The International Classification of Functioning (ICF) provides a framework for rehabilitation practitioners to address physical and psychological impairments, activity limitations, and participation restrictions. Patient outcomes may be improved by fostering self-efficacy through empowerment. This paper explores how the ICF model and …
Does Intra-Amniotic Inflammation Influence Pregnancy Outcome After Cerclage Orprogesterone (17ohp-C) Therapy For Midtrimester Short Cervix?, 2010 Lehigh Valley Health Network
Does Intra-Amniotic Inflammation Influence Pregnancy Outcome After Cerclage Orprogesterone (17ohp-C) Therapy For Midtrimester Short Cervix?, Orion Rust Md, Daniel Kiefer Md, Sean M. Keeler Md, Morgan R. Peltier Phd, Jolene C. Muscat Md, Nazeeh Hanna Md, Anthony M. Vintzileos Md, Cande V. Ananth Phd, Mph
Department of Obstetrics & Gynecology
No abstract provided.
Intravenous Artesunate For Severe Malaria, 2010 Western University of Health Sciences
Intravenous Artesunate For Severe Malaria, Karl M. Hess, Jeffery A. Goad, Paul M. Arguin
Pharmacy Faculty Articles and Research
OBJECTIVE: To review the pharmacodynamics and pharmacotherapeutic use of intravenous artesunate for the treatment of severe malaria.
DATA SOURCES: Literature was retrieved through PubMed (1999 March 2010), MEDLINE (1996 March 2010), and the Centers for Disease Control and Prevention (CDC), using the search terms artemisinin, artesunate, malaria, and severe malaria. In addition, reference citations from publications identified were reviewed.
STUDY SELECTION AND DATA EXTRACTION: All articles in English that were identified from the data sources were reviewed. Focus was placed on post-marketing trials examining the safety and efficacy of artesunate in comparison with other regimens.
DATA SYNTHESIS …
Effect Of The Tyrosine Kinase Inhibitors (Sunitinib, Sorafenib, Dasatinib, And Imatinib) On Blood Glucose Levels In Diabetic And Non-Diabetic Patients In General Clinical Practice (Poster), 2010 Lehigh Valley Health Network
Effect Of The Tyrosine Kinase Inhibitors (Sunitinib, Sorafenib, Dasatinib, And Imatinib) On Blood Glucose Levels In Diabetic And Non-Diabetic Patients In General Clinical Practice (Poster), Nicole M. Agostino Do, Vernon M. Chinchilli Phd, Christopher J. Lynch Phd, Anita M. Koszyk-Szewczyk Md, Rebecca Gingrich Rn, Ms, Ocn, Jeffery Sivik D Pharma, Joseph J. Darbick Md, Facp
Department of Medicine
No abstract provided.